Explanipedia

Distribution of copy number alterations and impact of chromosome arm call thresholds for meningioma Open

Ruchit V. Patel, Hia S. Ghosh, David M. Meredith, Scott Ryall, Elizabeth B. Claus , et al. · 2025

Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism Open

Michelle Bridi, Nancy Luo, Grace Kim, Benjamin J Menarchek, R. Lee , et al. · 2025

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The Impact of TERT Promoter Mutation on Meningioma Outcome is Context-Dependent: Implications for Clinical Grading and Risk Stratification Open

Karenna J. Groff, Ruchit V. Patel, Yang Feng, Hia S. Ghosh, Miguel A. Millares Chavez , et al. · 2025

Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism Open

Michelle Bridi, Nancy Luo, Grace Kim, Benjamin J Menarchek, R. Lee , et al. · 2024

Canonical amplifications and CDKN2A/B loss refine IDH1/2-mutant astrocytoma prognosis Open

Hia S. Ghosh, Ruchit V. Patel, Elizabeth B. Claus, L. Nicolas Gonzalez Castro, Patrick Y. Wen , et al. · 2024

Background Molecular features have been incorporated alongside histologic criteria to improve glioma diagnostics and prognostication. CDKN2A/B homozygous-loss associates with worse survival in IDH1/2-mutant astrocytomas (IDHmut-astrocytoma…

Role of Hospital Connectedness in Brain Metastasis Outcomes Open

Lilin Tong, Ruchit V. Patel, Ayal A. Aizer, Amar Dhand, Wenya Linda Bi · 2024

Importance Although patients with brain metastases receive interdisciplinary and multi-institutional care, the association between neuro-oncologic care networks and patient outcomes remains unknown. As patients often interact with multiple…

Sustainability of a PICU Situation Awareness Intervention: A Qualitative Study Open

Maya Dewan, Jonelle Prideaux, Daniel D. Loeb, Ruchit V. Patel, Matthew Zackoff , et al. · 2024

Introduction: We aimed to investigate facilitators and barriers that impact the sustainability of an interprofessional situation awareness bundle. Methods: This is a single-center qualitative study at a tertiary care pediatric center exami…

Contemporary prognostic signatures and refined risk stratification of gliomas: An analysis of 4400 tumors Open

Hia S. Ghosh, Ruchit V. Patel, E. L. Woodward, Noah F. Greenwald, Varun Bhave , et al. · 2024

Background With the significant shift in the classification, risk stratification, and standards of care for gliomas, we sought to understand how the overall survival of patients with these tumors is impacted by molecular features, clinical…

Interhospital transfer dynamics for patients with intracranial hemorrhage in Massachusetts Open

Ruchit V. Patel, Lilin Tong, Bradley J. Molyneaux, Nirav J. Patel, Mohammad Ali Aziz‐Sultan , et al. · 2024

Introduction Intracranial hemorrhages present across a spectrum of clinical phenotypes, with many patients transferred across hospitals to access higher levels of neurocritical care. We sought to characterize patient dispositions following…

Neurosurgical gene therapy for central nervous system diseases Open

Ruchit V. Patel, Pranav Nanda, R. Mark Richardson · 2024

Generation and applications of synthetic computed tomography images for neurosurgical planning Open

Yiheng Tan, Ruchit V. Patel, Zongming Wang, Yu Luo, Jinping Chen , et al. · 2024

OBJECTIVE CT and MRI are synergistic in the information provided for neurosurgical planning. While obtaining both types of images lends unique data from each, doing so adds to cost and exposes patients to additional ionizing radiation afte…

Distribution of Copy Number Variants and Impact of Chromosome Arm Call Thresholds for Meningioma Open

Wenya Linda Bi, Ruchit V. Patel, Hia S. Ghosh, David M. Meredith, Scott Ryall , et al. · 2024

Chromosome-arm copy number variants (CNVs) are an important component of cancer molecular classifiers. CNVs are often translated into binary chromosome arm calls (arm gain/loss) using an arm call threshold before integration into classific…

PATH-35. SHIFTS IN GLIOMA PROGNOSTIC MOLECULAR FEATURES ACROSS THE LIFESPAN Open

Ruchit V. Patel, Hia S. Ghosh, E. Antonio Chiocca, David A. Reardon, Patrick Y. Wen , et al. · 2023

INTRODUCTION Epidemiological studies examining glioma prognostic features have consistently identified older age as a negative predictor of survival. Accumulation and co-occurrence of favorable or deleterious molecular alterations across t…

PATH-12. CONTEMPORARY MOLECULAR LANDSCAPE, SURVIVAL, AND PROGNOSTIC FACTORS IN OVER 4,000 GLIOMAS Open

Hia S. Ghosh, Ruchit V. Patel, E. L. Woodward, Noah F. Greenwald, Varun Bhave , et al. · 2023

INTRODUCTION Molecular glioma classification and advances in treatment modalities have expanded therapeutic options for patients. We sought to capture the genomic landscape, prognostic features, and contemporary outcomes of gliomas. METHOD…

Advances and Evolving Challenges in Spinal Deformity Surgery Open

Ruchit V. Patel, Alexander G. Yearley, Hannah Isaac, Eric Chalif, Joshua I. Chalif , et al. · 2023

Background: Surgical intervention is a critical tool to address adult spinal deformity (ASD). Given the evolution of spinal surgical techniques, we sought to characterize developments in ASD correction and barriers impacting clinical outco…

Dendrimer nanotherapy targeting of glial dysfunction improves inflammation and neurobehavioral phenotype in adult female Mecp2‐heterozygous mouse model of Rett syndrome Open

Elizabeth Smith Khoury, Ruchit V. Patel, Caroline O’Ferrall, Amanda Fowler, Nirnath Sah , et al. · 2023

Rett syndrome is an X‐linked neurodevelopmental disorder caused by mutation of Mecp2 gene and primarily affects females. Glial cell dysfunction has been implicated in in Rett syndrome (RTT) both in patients and in mouse models of this diso…

Molecular Landscape and Contemporary Prognostic Signatures of Gliomas Open

Hia S. Ghosh, Ruchit V. Patel, E. L. Woodward, Noah F. Greenwald, Varun Bhave , et al. · 2023

Molecularly-driven treatments are expanding options for patients with gliomas, driving a need for molecularly-informed prognostic information. To characterize the genomic landscape and contemporary outcomes of gliomas, we analyzed 4,400 gl…

Impact of H3K27 trimethylation loss in meningiomas: a meta-analysis Open

Gregory Cello, Ruchit V. Patel, James T. McMahon, Sandro Santagata, Wenya Linda Bi · 2023

Trimethylation of lysine 27 on histone 3 (H3K27me3) loss has been implicated in worse prognoses for patients with meningiomas. However, there have been challenges in measuring H3K27me3 loss, quantifying its impact, and interpreting its cli…

Application of radiomics to meningiomas: A systematic review Open

Ruchit V. Patel, Shun Yao, Raymond Y. Huang, Wenya Linda Bi · 2023

Background Quantitative imaging analysis through radiomics is a powerful technology to non-invasively assess molecular correlates and guide clinical decision-making. There has been growing interest in image-based phenotyping for meningioma…

Machine Learning in the Classification of Pediatric Posterior Fossa Tumors: A Systematic Review Open

Alexander G. Yearley, Sarah E. Blitz, Ruchit V. Patel, Alvin Chan, Lissa Baird , et al. · 2022

Background: Posterior fossa tumors (PFTs) are a morbid group of central nervous system tumors that most often present in childhood. While early diagnosis is critical to drive appropriate treatment, definitive diagnosis is currently only ac…

Non-pharmacological interventions for sleep promotion in hospitalized children Open

Sapna R. Kudchadkar, Jéssica Berger, Ruchit V. Patel, Sean Barnes, Claire Twose , et al. · 2022

The included studies were heterogeneous, so we could not quantitatively synthesize the results. Our narrative summary found inconsistent, low to very low-certainty evidence. Therefore, we are unable to determine how non-pharmacologic sleep…

Chemogenetics as a neuromodulatory approach to treating neuropsychiatric diseases and disorders Open

Jingwei Song, Ruchit V. Patel, Massoud Sharif, Anagha Ashokan, Michael Michaelides · 2021

Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism Open

Michelle Bridi, Nancy Luo, Grace Kim, Caroline O’Ferrall, Ruchit V. Patel , et al. · 2021

Alterations to the balance between excitation and inhibition (E/I ratio) are postulated to underlie behavioral phenotypes in autism spectrum disorder (ASD) patients and mouse models. However, in wild type mice the E/I ratio is not constant…

Early Mobilization in a PICU: A Qualitative Sustainability Analysis of PICU Up!* Open

Ruchit V. Patel, Juliana Redivo, Archana Nelliot, Michelle N. Eakin, Beth Wieczorek , et al. · 2020

Objectives: To identify staff-reported factors and perceptions that influenced implementation and sustainability of an early mobilization program (PICU Up!) in the PICU. Design: A qualitative study using semistructured phone interviews to …

Blood-brain barrier dysfunction in aging induces hyper-activation of TGF-beta signaling and chronic yet reversible neural dysfunction Open

Vladimir V. Senatorov, A.R. Friedman, Dan Z. Milikovsky, Jonathan Ofer, Rotem Saar‐Ashkenazy , et al. · 2019

Aging involves a decline in neural function that contributes to cognitive impairment and disease. However, the mechanisms underlying the transition from a young-and-healthy to aged-and-dysfunctional brain are not well understood. Here, we …

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