Richard Holubkov
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View article: Plant-based dietary index on the Mediterranean and a vegan diet: a secondary analysis of a randomized, cross-over trial
Plant-based dietary index on the Mediterranean and a vegan diet: a secondary analysis of a randomized, cross-over trial Open
Objective The plant-based diet index (PDI) has been proposed as a gauge of diet healthfulness. This study assessed the relationship between the PDI, and the “healthful” hPDI and “unhealthful” uPDI, and weight loss in the context of Mediter…
View article: Vegan Diet, Greenhouse Gas Emissions, and Cumulative Energy Demand
Vegan Diet, Greenhouse Gas Emissions, and Cumulative Energy Demand Open
This secondary analysis of a randomized clinical trial examined the environmental effect of adopting a low-fat vegan diet on greenhouse gas emissions and cumulative energy demand.
View article: Can a vegan diet help people with type 1 diabetes save on insulin? A secondary analysis of a 12-Week randomized clinical trial
Can a vegan diet help people with type 1 diabetes save on insulin? A secondary analysis of a 12-Week randomized clinical trial Open
ClinicalTrials.gov , NCT04944316, registered on June 29, 2021.
View article: Normalizing daily awakening and breathing coordination at 15 heterogenous ICUs: a multicenter post-implementation survey
Normalizing daily awakening and breathing coordination at 15 heterogenous ICUs: a multicenter post-implementation survey Open
Unresolved questions or concerns may persist regarding implementation of a C-SAT/SBT protocol among certain population subgroups despite current high practice adherence and high levels of perceived acceptability, including ease of use, use…
View article: Dietary acid load on the Mediterranean and a vegan diet: a secondary analysis of a randomized, cross-over trial
Dietary acid load on the Mediterranean and a vegan diet: a secondary analysis of a randomized, cross-over trial Open
Background Evidence suggests that changes in dietary acid load may influence body weight, and the purpose of this secondary analysis was to assess its role in the context of the Mediterranean and a vegan diet in overweight adults. Methods …
View article: <b>Dietary Acid Load and Body Weight in Type 1 Diabetes: A Randomized Clinical Trial</b>
<b>Dietary Acid Load and Body Weight in Type 1 Diabetes: A Randomized Clinical Trial</b> Open
The purpose of this secondary analysis was to assess the potential role of dietary acid load in people with type 1 diabetes. Participants were randomly assigned to either a vegan or a portion-controlled diet group for 12 weeks, and 3-day d…
View article: Dietary Acid Load and Body Weight in Type 1 Diabetes: A Randomized Clinical Trial
Dietary Acid Load and Body Weight in Type 1 Diabetes: A Randomized Clinical Trial Open
The purpose of this secondary analysis was to assess the potential role of dietary acid load in people with type 1 diabetes. Participants were randomly assigned to either a vegan or a portion-controlled diet group for 12 weeks, and 3-day d…
View article: <b>Dietary Acid Load and Body Weight in Type 1 Diabetes: A Randomized Clinical Trial</b>
<b>Dietary Acid Load and Body Weight in Type 1 Diabetes: A Randomized Clinical Trial</b> Open
The purpose of this secondary analysis was to assess the potential role of dietary acid load in people with type 1 diabetes. Participants were randomly assigned to either a vegan or a portion-controlled diet group for 12 weeks, and 3-day d…
View article: The Hydrocephalus Association Patient-Powered Interactive Engagement Registry (HAPPIER): Design and Initial Baseline Report
The Hydrocephalus Association Patient-Powered Interactive Engagement Registry (HAPPIER): Design and Initial Baseline Report Open
HAPPIER is a novel database that addresses gaps in data on non-clinical outcomes of hydrocephalus, which are critical to clinical care and understanding hydrocephalus. Patient perspectives and outcomes remain historically underrepresented.…
View article: Processed foods in the context of a vegan diet, and changes in body weight and severe hot flashes in postmenopausal women: a secondary analysis of a randomized clinical trial
Processed foods in the context of a vegan diet, and changes in body weight and severe hot flashes in postmenopausal women: a secondary analysis of a randomized clinical trial Open
Objectives: A plant-based diet has been shown to reduce hot flashes, partly by weight loss. Because some plant-based foods are highly processed, this secondary analysis assessed associations between consumption of processed foods, body wei…
View article: Plant-based dietary index and body weight in people with type 1 diabetes: a secondary analysis of a randomized clinical trial
Plant-based dietary index and body weight in people with type 1 diabetes: a secondary analysis of a randomized clinical trial Open
Objective This secondary analysis tested the relationship of a plant-based diet index (PDI), healthful PDI (hPDI), and unhealthful PDI (uPDI), with weight loss in adults with type 1 diabetes. Methods Fifty-eight adults with type 1 diabetes…
View article: Feasibility and Efficacy of a Plant-Based Nutrition Intervention for Type 2 Diabetes in a Primary Care Setting
Feasibility and Efficacy of a Plant-Based Nutrition Intervention for Type 2 Diabetes in a Primary Care Setting Open
Objective: To determine the feasibility and efficacy of a plant-based nutrition intervention for type 2 diabetes in a primary care setting. Methods: Adults (n = 76) with type 2 diabetes were enrolled in a self-paid, online nutrition interv…
View article: Sotalol Dosing and Outcomes Among Patients Undergoing Intravenous Loading for Atrial Arrhythmias—A PEAKS Registry Substudy
Sotalol Dosing and Outcomes Among Patients Undergoing Intravenous Loading for Atrial Arrhythmias—A PEAKS Registry Substudy Open
Background Sotalol is used for the maintenance of sinus rhythm among patients with atrial fibrillation. However, there is discretion regarding dosing of chronic therapy, and the target oral dose dictates infusion doses for intravenous sota…
View article: Vegan diet, processed foods, and body weight: a secondary analysis of a randomized clinical trial
Vegan diet, processed foods, and body weight: a secondary analysis of a randomized clinical trial Open
Low-fat plant-based diets cause weight loss in clinical trials. However, many foods are highly processed, raising the question as to their effect on body weight. This secondary analysis assessed the associations between changes in processe…
View article: Correlation between mobile and 12-lead ECG among patients loading with intravenous sotalol: A PEAKS substudy
Correlation between mobile and 12-lead ECG among patients loading with intravenous sotalol: A PEAKS substudy Open
NCT05247320.
View article: Population Pharmacokinetics and Pharmacodynamics of Sotalol Following Expedited Intravenous Loading in Patients With Atrial Arrhythmias
Population Pharmacokinetics and Pharmacodynamics of Sotalol Following Expedited Intravenous Loading in Patients With Atrial Arrhythmias Open
Sotalol, a class III antiarrhythmic agent, is used to maintain sinus rhythm in patients with atrial fibrillation or atrial flutter (AFIB/AFL). Despite its efficacy, sotalol's use is limited by its potential to cause life‐threatening ventri…
View article: Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia
Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia Open
Importance Fostamatinib, a spleen tyrosine kinase inhibitor, has been reported to improve outcomes of COVID-19. Objective To evaluate the efficacy and safety of fostamatinib in adults hospitalized with COVID-19 and hypoxemia. Design, Setti…
View article: Diet quality, body weight, and postmenopausal hot flashes: a secondary analysis of a randomized clinical trial
Diet quality, body weight, and postmenopausal hot flashes: a secondary analysis of a randomized clinical trial Open
ClinicalTrials.gov, NCT04587154, registered on Oct 14, 2020.
View article: Food Costs of a Low-Fat Vegan Diet vs a Mediterranean Diet
Food Costs of a Low-Fat Vegan Diet vs a Mediterranean Diet Open
This ad hoc secondary analysis of a randomized clinical trial compares the food costs in the United States of a low-fat vegan diet and a Mediterranean diet.
View article: The Hydrocephalus Association Patient-Powered Interactive Engagement Registry (HAPPIER): Design and Initial Baseline Report
The Hydrocephalus Association Patient-Powered Interactive Engagement Registry (HAPPIER): Design and Initial Baseline Report Open
Objective Hydrocephalus is a neurological condition characterized by an accumulation of cerebrospinal fluid with no cure and limited treatments. There is a significant gap in hydrocephalus research where patients lack opportunities to voic…
View article: Risk factors for prolonged infection and secondary infection in pediatric severe sepsis
Risk factors for prolonged infection and secondary infection in pediatric severe sepsis Open
View article: Dietary advanced glycation end-products and their associations with body weight on a Mediterranean diet and low-fat vegan diet: a randomized, cross-over trial
Dietary advanced glycation end-products and their associations with body weight on a Mediterranean diet and low-fat vegan diet: a randomized, cross-over trial Open
Objective Evidence suggests that changes in dietary advanced glycation end-products (AGEs) may influence body weight, but the effects of different dietary patterns remain to be explored. The aim of this study was to compare the effects of …
View article: Comparing ventriculoatrial and ventriculopleural shunts in pediatric hydrocephalus: a Hydrocephalus Clinical Research Network study
Comparing ventriculoatrial and ventriculopleural shunts in pediatric hydrocephalus: a Hydrocephalus Clinical Research Network study Open
OBJECTIVE When the peritoneal cavity cannot serve as the distal shunt terminus, nonperitoneal shunts, typically terminating in the atrium or pleural space, are used. The comparative effectiveness of these two terminus options has not been …
View article: PO-01-047 CORRELATION OF MOBILE ECG WITH 12-LEAD ECG FINDINGS DURING INTRAVENOUS SOTALOL LOADING FOR ATRIAL FIBRILLATION
PO-01-047 CORRELATION OF MOBILE ECG WITH 12-LEAD ECG FINDINGS DURING INTRAVENOUS SOTALOL LOADING FOR ATRIAL FIBRILLATION Open
View article: <b>Effect of a Dietary Intervention on Insulin Requirements and Glycemic Control in Type 1 Diabetes: </b><b>A 12-Week Randomized Clinical Trial</b>
<b>Effect of a Dietary Intervention on Insulin Requirements and Glycemic Control in Type 1 Diabetes: </b><b>A 12-Week Randomized Clinical Trial</b> Open
This study compared the effects of a low-fat vegan diet to those of a portion-controlled diet in people with type 1 diabetes. Over 12 weeks, the average total daily dose of insulin decreased significantly and insulin sensitivity increased …
View article: Effect of a Dietary Intervention on Insulin Requirements and Glycemic Control in Type 1 Diabetes: A 12-Week Randomized Clinical Trial
Effect of a Dietary Intervention on Insulin Requirements and Glycemic Control in Type 1 Diabetes: A 12-Week Randomized Clinical Trial Open
This study compared the effects of a low-fat vegan diet to those of a portion-controlled diet in people with type 1 diabetes. Over 12 weeks, the average total daily dose of insulin decreased significantly and insulin sensitivity increased …
View article: <b>Effect of a Dietary Intervention on Insulin Requirements and Glycemic Control in Type 1 Diabetes: </b><b>A 12-Week Randomized Clinical Trial</b>
<b>Effect of a Dietary Intervention on Insulin Requirements and Glycemic Control in Type 1 Diabetes: </b><b>A 12-Week Randomized Clinical Trial</b> Open
This study compared the effects of a low-fat vegan diet to those of a portion-controlled diet in people with type 1 diabetes. Over 12 weeks, the average total daily dose of insulin decreased significantly and insulin sensitivity increased …
View article: Expedited loading with intravenous sotalol is safe and feasible—primary results of the Prospective Evaluation Analysis and Kinetics of IV Sotalol (PEAKS) Registry
Expedited loading with intravenous sotalol is safe and feasible—primary results of the Prospective Evaluation Analysis and Kinetics of IV Sotalol (PEAKS) Registry Open
IV sotalol loading is safe and feasible for atrial arrhythmias, with low rates of adverse events, and yields shorter hospitalizations. More data are needed on the minimal duration required for monitoring in the hospital.
View article: Viral DNAemia and DNA Virus Seropositivity and Mortality in Pediatric Sepsis
Viral DNAemia and DNA Virus Seropositivity and Mortality in Pediatric Sepsis Open
Importance Sepsis is a leading cause of pediatric mortality. Little attention has been paid to the association between viral DNA and mortality in children and adolescents with sepsis. Objective To assess the association of the presence of …
View article: Does diet quality matter? A secondary analysis of a randomized clinical trial
Does diet quality matter? A secondary analysis of a randomized clinical trial Open
This secondary analysis assessed the association of a plant-based index (PDI), healthful (hPDI), and unhealthful (uPDI), with weight loss in overweight adults. Participants ( n = 244) were randomly assigned to a vegan ( n = 122) or control…