Rudi G. J. Westendorp
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View article: Cardiovascular disease and the risk of incident falls and mortality among adults aged ≥ 65 years presenting to the emergency department: a cohort study from national registry data in Denmark
Cardiovascular disease and the risk of incident falls and mortality among adults aged ≥ 65 years presenting to the emergency department: a cohort study from national registry data in Denmark Open
View article: The potential benefit of statin prescription based on prediction of treatment responsiveness in older individuals: an application to the PROSPER randomized controlled trial
The potential benefit of statin prescription based on prediction of treatment responsiveness in older individuals: an application to the PROSPER randomized controlled trial Open
Aims Clinical guidelines often recommend treating individuals based on their cardiovascular risk. We revisit this paradigm and quantify the efficacy of three treatment strategies: (i) overall prescription, i.e. treatment to all individuals…
View article: Incidence and Determinants of Spontaneous Normalization of Subclinical Hypothyroidism in Older Adults
Incidence and Determinants of Spontaneous Normalization of Subclinical Hypothyroidism in Older Adults Open
Context With age, the prevalence of subclinical hypothyroidism rises. However, incidence and determinants of spontaneous normalization remain largely unknown. Objective To investigate incidence and determinants of spontaneous normalization…
View article: The optimal healthy ranges of thyroid function defined by the risk of cardiovascular disease and mortality: systematic review and individual participant data meta-analysis
The optimal healthy ranges of thyroid function defined by the risk of cardiovascular disease and mortality: systematic review and individual participant data meta-analysis Open
View article: Machine learning models of healthcare expenditures predicting mortality: A cohort study of spousal bereaved Danish individuals
Machine learning models of healthcare expenditures predicting mortality: A cohort study of spousal bereaved Danish individuals Open
Background The ability to accurately predict survival in older adults is crucial as it guides clinical decision making. The added value of using health care usage for predicting mortality remains unexplored. The aim of this study was to in…
View article: Long-term exposure to air pollution and risk of SARS-CoV-2 infection and COVID-19 hospitalisation or death: Danish nationwide cohort study
Long-term exposure to air pollution and risk of SARS-CoV-2 infection and COVID-19 hospitalisation or death: Danish nationwide cohort study Open
Background Early ecological studies have suggested links between air pollution and risk of coronavirus disease 2019 (COVID-19), but evidence from individual-level cohort studies is still sparse. We examined whether long-term exposure to ai…
View article: Danish Pathology Life Course (PATHOLIFE) cohort: a register based cohort extending upon a national tissue biobank
Danish Pathology Life Course (PATHOLIFE) cohort: a register based cohort extending upon a national tissue biobank Open
Purpose The Danish Pathology Life Course (PATHOLIFE) cohort was established to facilitate epidemiological research relating histological and cytological features extracted from patient tissue specimens to the rich life course histories, in…
View article: Sex differences in health care expenditures and mortality after spousal bereavement: A register-based Danish cohort study
Sex differences in health care expenditures and mortality after spousal bereavement: A register-based Danish cohort study Open
Background Spousal bereavement is a life event that affects older people differently. We investigated the impact of spousal bereavement on medical expenditures and mortality in the general population, emphasizing on age and sex. Methods Da…
View article: Long-term exposure to elemental components of fine particulate matter and all-natural and cause-specific mortality in a Danish nationwide administrative cohort study
Long-term exposure to elemental components of fine particulate matter and all-natural and cause-specific mortality in a Danish nationwide administrative cohort study Open
We present novel results of the relevance of different PM2.5 components for different causes of death, with K and Si seeming to be most consistently associated with mortality in Denmark.
View article: Predicting mortality and visualizing health care spending by predicted mortality in Danes over age 65
Predicting mortality and visualizing health care spending by predicted mortality in Danes over age 65 Open
Health care expenditure in the last year of life makes up a high proportion of medical spending across the world. This is often framed as waste, but this framing is only meaningful if it is known at the time of treatment who will go on to …
View article: The effect of thyroid hormone therapy on muscle function, strength and mass in older adults with subclinical hypothyroidism—an ancillary study within two randomized placebo controlled trials
The effect of thyroid hormone therapy on muscle function, strength and mass in older adults with subclinical hypothyroidism—an ancillary study within two randomized placebo controlled trials Open
Background loss of skeletal muscle function, strength and mass is common in older adults, with important socioeconomic impacts. Subclinical hypothyroidism is common with increasing age and has been associated with reduced muscle strength. …
View article: Inflammatory markers, lung function, and respiratory events in relation to indoor and ambient air pollution
Inflammatory markers, lung function, and respiratory events in relation to indoor and ambient air pollution Open
BACKGROUND AND AIM: Ambient air pollution causes a range of adverse health effects, whereas effects of indoor sources of air pollution are not well described in high-income countries. We compared hazards of ambient air pollution and indoor…
View article: Investigating Population Exposure Assignment Methods for Air Pollution from Google Street View Polyline Data in Copenhagen, Denmark
Investigating Population Exposure Assignment Methods for Air Pollution from Google Street View Polyline Data in Copenhagen, Denmark Open
BACKGROUND AND AIM: Google Street View (GSV) cars provide air pollution (AP) data across thousands of streets in multiple cities. Various methods exist for linkage of such vector data with populations. While rasterization or near-analysis …
View article: Long-term exposure to air pollution and incidence of 922 health outcomes in a phenome-wide association study: Danish nationwide administrative cohort
Long-term exposure to air pollution and incidence of 922 health outcomes in a phenome-wide association study: Danish nationwide administrative cohort Open
View article: Evaluating Predictions of ELAPSE and Google Air View-based Mixed-effects LUR Models for Air Pollution in Copenhagen, Denmark
Evaluating Predictions of ELAPSE and Google Air View-based Mixed-effects LUR Models for Air Pollution in Copenhagen, Denmark Open
BACKGROUND AND AIM: Fine scale exposure-assessment is needed for epidemiological studies on long-term health effects of air pollution (AP). We aimed to evaluate a) predictions of hyperlocal Google Air View-based mixed-effects land use regr…
View article: Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies
Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies Open
Objective Few prospective studies have assessed whether individuals with subclinical thyroid dysfunction are more likely to develop diabetes, with conflicting results. In this study, we conducted a systematic review of the literature and a…
View article: Nuclear morphology is a deep learning biomarker of cellular senescence
Nuclear morphology is a deep learning biomarker of cellular senescence Open
View article: Use of candles and risk of cardiovascular and respiratory events in a Danish cohort study
Use of candles and risk of cardiovascular and respiratory events in a Danish cohort study Open
Burning candles at home emit small particles and gases that pollute indoor air. Exposure to fine particles in outdoor air has been convincingly linked to cardiovascular and respiratory events, while the associations with fine and ultrafine…
View article: Thyroid antibodies and levothyroxine effects in subclinical hypothyroidism: A pooled analysis of two randomized controlled trials
Thyroid antibodies and levothyroxine effects in subclinical hypothyroidism: A pooled analysis of two randomized controlled trials Open
Background Antithyroid antibodies increase the likelihood of developing overt hypothyroidism, but their clinical utility remains unclear. No large randomized controlled trial (RCT) has assessed whether older adults with subclinical hypothy…
View article: Long-term exposure to air pollution and mortality in a Danish nationwide administrative cohort study: Beyond mortality from cardiopulmonary disease and lung cancer
Long-term exposure to air pollution and mortality in a Danish nationwide administrative cohort study: Beyond mortality from cardiopulmonary disease and lung cancer Open
Long-term exposure to PM2.5, NO2, and/or BC in Denmark were associated with mortality beyond cardiorespiratory diseases, including diabetes, dementia, psychiatric disorders, asthma, and ALRI.
View article: Dynamical indicators in time series of healthcare expenditures predict mortality risk of older adults following spousal bereavement
Dynamical indicators in time series of healthcare expenditures predict mortality risk of older adults following spousal bereavement Open
Background The process of aging renders older people susceptible for adverse outcomes upon stress. Various indicators derived from complex systems theory have been proposed for quantifying resilience in living organisms, including humans. …
View article: Bone geometry in older adults with subclinical hypothyroidism upon levothyroxine therapy: A nested study within a randomized placebo controlled trial
Bone geometry in older adults with subclinical hypothyroidism upon levothyroxine therapy: A nested study within a randomized placebo controlled trial Open
The effect of levothyroxine (LT4) therapy for subclinical hypothyroidism (SHypo) on appendicular bone geometry and volumetric density has so far not been studied. In a nested study within the randomized, placebo-controlled Thyroid Hormone …
View article: Do changes in frailty, physical functioning, and cognitive functioning predict mortality in old age? Results from the Longitudinal Aging Study Amsterdam
Do changes in frailty, physical functioning, and cognitive functioning predict mortality in old age? Results from the Longitudinal Aging Study Amsterdam Open
View article: No Effect of Levothyroxine on Hemoglobin in Older Adults With Subclinical Hypothyroidism: Pooled Results From 2 Randomized Controlled Trials
No Effect of Levothyroxine on Hemoglobin in Older Adults With Subclinical Hypothyroidism: Pooled Results From 2 Randomized Controlled Trials Open
Context Subclinical thyroid dysfunction and anemia are common disorders, and both have increasing prevalence with advancing age. Objective The aim of this study was to assess whether levothyroxine treatment leads to a rise in hemoglobin le…
View article: Polypharmacy occurrence and the related risk of premature death among older adults in Denmark: A nationwide register-based cohort study
Polypharmacy occurrence and the related risk of premature death among older adults in Denmark: A nationwide register-based cohort study Open
Background Polypharmacy, defined as the concurrent use of ≥5 medications, increases the risk of drug-drug and drug-disease interactions as well as non-adherence to drug therapy. This may have negative health consequences particularly among…
View article: Incorporating Baseline Outcome Data in Individual Participant Data Meta-Analysis of Non-randomized Studies
Incorporating Baseline Outcome Data in Individual Participant Data Meta-Analysis of Non-randomized Studies Open
Background In non-randomized studies (NRSs) where a continuous outcome variable (e.g., depressive symptoms) is assessed at baseline and follow-up, it is common to observe imbalance of the baseline values between the treatment/exposure grou…
View article: Inflammatory markers and lung function in relation to indoor and ambient air pollution
Inflammatory markers and lung function in relation to indoor and ambient air pollution Open
View article: Meeting Report: Aging Research and Drug Discovery
Meeting Report: Aging Research and Drug Discovery Open
Aging is the single largest risk factor for most chronic diseases, and thus possesses large socioeconomic interest to continuously aging societies. Consequently, the field of aging research is expanding alongside a growing focus from the i…
View article: Long-term exposure to road traffic noise and all-cause and cause-specific mortality: a Danish Nurse Cohort study
Long-term exposure to road traffic noise and all-cause and cause-specific mortality: a Danish Nurse Cohort study Open
View article: Sex Dimorphism in Health Expenditures and Mortality after Spousal Bereavement: A Retrospective, Register-Based Danish Cohort Study
Sex Dimorphism in Health Expenditures and Mortality after Spousal Bereavement: A Retrospective, Register-Based Danish Cohort Study Open