Rudolf Hatz
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View article: COPD Severity as an Independent Predictor of Long-Term Survival in Operable Lung Cancer: A Retrospective Analysis from a High-Volume Thoracic Surgery Center
COPD Severity as an Independent Predictor of Long-Term Survival in Operable Lung Cancer: A Retrospective Analysis from a High-Volume Thoracic Surgery Center Open
COPD severity independently predicts perioperative morbidity and long-term survival in operable NSCLC patients. Comprehensive assessment of COPD severity can help in identifying high-risk patients and optimizing perioperative care.
View article: Cholesterol Regulates Airway Epithelial Cell Differentiation by Inhibiting p53 Nuclear Translocation
Cholesterol Regulates Airway Epithelial Cell Differentiation by Inhibiting p53 Nuclear Translocation Open
Cholesterol is an essential plasma membrane component, and altered cholesterol metabolism has been linked to cholesterol accumulation in the airways of COPD and cystic fibrosis patients. However, its role in airway epithelial differentiati…
View article: The impact of comorbidities on the all-cause mortality of surgically treated non-small cell lung cancer patients - visualization with the aid of a comorbidome
The impact of comorbidities on the all-cause mortality of surgically treated non-small cell lung cancer patients - visualization with the aid of a comorbidome Open
Backgrounds Lung cancer patients often have multiple comorbidities. This study aimed to determine which comorbidities had an impact on all-cause mortality in lung cancer patients who had undergone surgical treatment. Methods This retrospec…
View article: Association of HLA Mismatch With Adverse Cardiovascular Events Following Lung Transplantation: A Single‐Center Study
Association of HLA Mismatch With Adverse Cardiovascular Events Following Lung Transplantation: A Single‐Center Study Open
Aims Coronary artery disease (CAD) is a frequent comorbidity in lung transplant (LuTx) candidates. The impact of allogenic organ transplantation and the corresponding alterations in immune response on the progression of CAD remains poorly …
View article: Thirty years of lung transplantation: development of postoperative outcome and survival over three decades
Thirty years of lung transplantation: development of postoperative outcome and survival over three decades Open
Data analysis demonstrates that the field of LuTX has undergone enormous progress over the years. Therapeutic advances and improvements in interdisciplinary cooperation, pre- and postoperative management, changes in immunosuppressive medic…
View article: Perioperative Predictive Factors for Tumor Regression and Survival in Non-Small Cell Lung Cancer Patients Undergoing Neoadjuvant Treatment and Lung Resection
Perioperative Predictive Factors for Tumor Regression and Survival in Non-Small Cell Lung Cancer Patients Undergoing Neoadjuvant Treatment and Lung Resection Open
Our study aimed to identify predictors for the effectiveness of tumor regression in lung cancer patients undergoing neoadjuvant treatment and cancer resections. Patients admitted between 2016 and 2022 were included in the study. Based on t…
View article: Histology of the Primary Tumor, Lymph Node, and Tumor Size upon Neoadjuvant Treatment Predict Effectiveness of Complete Pathologic Response in Patients Undergoing Primary Lung Cancer Resections
Histology of the Primary Tumor, Lymph Node, and Tumor Size upon Neoadjuvant Treatment Predict Effectiveness of Complete Pathologic Response in Patients Undergoing Primary Lung Cancer Resections Open
Our study aimed to identify predictors for the effectiveness of tumor regression in lung cancer patients undergoing neoadjuvant treatment and cancer resections. Patients admitted between 2016 and 2022 were included in the study. Based on t…
View article: Mind the gap! Interdisciplinary approach to anterior chest wall reconstruction after total sternectomy
Mind the gap! Interdisciplinary approach to anterior chest wall reconstruction after total sternectomy Open
Background There are various reconstructive methods after total sternectomy. Reproducibility is scarce due to overall small patient numbers. Therefore we present a standardized, interdisciplinary approach for thoracic and plastic surgery. …
View article: Multimodal Treatment of Pleural Mesothelioma with Cytoreductive Surgery and Hyperthermic Intrathoracic Chemotherapy: Impact of Additive Chemotherapy
Multimodal Treatment of Pleural Mesothelioma with Cytoreductive Surgery and Hyperthermic Intrathoracic Chemotherapy: Impact of Additive Chemotherapy Open
Cytoreductive surgery (CRS) combined with hyperthermic intrathoracic chemoperfusion (HITOC) is a promising treatment strategy for pleural mesothelioma (PM). The aim of this study was to evaluate the impacts of this multimodal approach in c…
View article: COPD basal cells are primed towards secretory to multiciliated cell imbalance driving increased resilience to environmental stressors
COPD basal cells are primed towards secretory to multiciliated cell imbalance driving increased resilience to environmental stressors Open
Introduction Environmental pollutants injure the mucociliary elevator, thereby provoking disease progression in chronic obstructive pulmonary disease (COPD). Epithelial resilience mechanisms to environmental nanoparticles in health and dis…
View article: Mass spectrometry-based autoimmune profiling reveals predictive autoantigens in idiopathic pulmonary fibrosis
Mass spectrometry-based autoimmune profiling reveals predictive autoantigens in idiopathic pulmonary fibrosis Open
Autoimmunity plays a role in certain types of lung fibrosis, notably connective tissue disease-associated interstitial lung disease (CTD-ILD). In idiopathic pulmonary fibrosis (IPF), an incurable and fatal lung disease, diagnosis typically…
View article: Histology of the Primary Tumor Correlates with False Positivity of Integrated 18F-FDG-PET/CT Lymph Node Staging in Resectable Lung Cancer Patients
Histology of the Primary Tumor Correlates with False Positivity of Integrated 18F-FDG-PET/CT Lymph Node Staging in Resectable Lung Cancer Patients Open
This study aimed to evaluate the diagnostic accuracy and false positivity rate of lymph node (LN) staging assessed by integrated 18F-fluorodeoxyglucose positron emission computed tomography (18F-FDG-PET/CT) in patients with operable lung c…
View article: Cytokine signaling converging on IL11 in ILD fibroblasts provokes aberrant epithelial differentiation signatures
Cytokine signaling converging on IL11 in ILD fibroblasts provokes aberrant epithelial differentiation signatures Open
Introduction Interstitial lung disease (ILD) is a heterogenous group of lung disorders where destruction and incomplete regeneration of the lung parenchyma often results in persistent architectural distortion of the pulmonary scaffold. Con…
View article: Influence of dental status on outcome after lung transplantation
Influence of dental status on outcome after lung transplantation Open
Introduction Poor oral hygiene can cause infections and inflammatory diseases. Data on its impact on outcome after lung transplantation (LuTX) is scarce. Most transplant centers have individual standards regarding dental care as there is n…
View article: <i>Ex vivo</i>tissue perturbations coupled to single cell RNA-seq reveal multi-lineage cell circuit dynamics in human lung fibrogenesis
<i>Ex vivo</i>tissue perturbations coupled to single cell RNA-seq reveal multi-lineage cell circuit dynamics in human lung fibrogenesis Open
Pulmonary fibrosis develops as a consequence of failed regeneration after injury. Analyzing mechanisms of regeneration and fibrogenesis directly in human tissue has been hampered by the lack of organotypic models and analytical techniques.…
View article: Cytokine signaling converging on<i>IL11</i>in ILD fibroblasts provokes aberrant epithelial differentiation signatures
Cytokine signaling converging on<i>IL11</i>in ILD fibroblasts provokes aberrant epithelial differentiation signatures Open
Interstitial lung disease (ILD) is a heterogenous group of lung disorders where destruction and incomplete regeneration of the lung parenchyma often results in persistent architectural distortion of the pulmonary scaffold. Continuous mesen…
View article: Posterior reversible encephalopathy syndrome after lung transplantation: Risk factors and management
Posterior reversible encephalopathy syndrome after lung transplantation: Risk factors and management Open
Introduction : Posterior reversible encephalopathy syndrome is a rare neurologic complication that can occur under immunosuppressive therapy with CNI after organ transplantation. Methods : We retrospectively reviewed medical records of 545…
View article: Effects of immunophilin inhibitors and non-immunosuppressive analogs on coronavirus replication in human infection models
Effects of immunophilin inhibitors and non-immunosuppressive analogs on coronavirus replication in human infection models Open
Rationale Human coronaviruses (HCoVs) seriously affect human health by causing respiratory diseases ranging from common colds to severe acute respiratory diseases. Immunophilins, including peptidyl-prolyl isomerases of the FK506-binding pr…
View article: FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis
FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis Open
Antibodies are central effectors of the adaptive immune response, widespread used therapeutics, but also potentially disease-causing biomolecules. Antibody folding catalysts in the plasma cell are incompletely defined. Idiopathic pulmonary…
View article: Anti-Gr-1 Antibody Provides Short-Term Depletion of MDSC in Lymphodepleted Mice with Active-Specific Melanoma Therapy
Anti-Gr-1 Antibody Provides Short-Term Depletion of MDSC in Lymphodepleted Mice with Active-Specific Melanoma Therapy Open
Lymphodepletion, reconstitution and active-specific tumor cell vaccination (LRAST) enhances the induction of tumor-specific T cells in a murine melanoma model. Myeloid-derived suppressor cells (MDSC) may counteract the induction of tumor-r…
View article: An In Vivo Inflammatory Loop Potentiates KRAS Blockade
An In Vivo Inflammatory Loop Potentiates KRAS Blockade Open
KRAS (KRAS proto-oncogene, GTPase) inhibitors perform less well than other targeted drugs in vitro and fail clinical trials. To investigate a possible reason for this, we treated human and murine tumor cells with KRAS inhibitors deltarasin…
View article: Prognostic phenotypes of early-stage lung adenocarcinoma
Prognostic phenotypes of early-stage lung adenocarcinoma Open
Background Survival after curative resection of early-stage lung adenocarcinoma (LUAD) varies and prognostic biomarkers are urgently needed. Methods Large-format tissue samples from a prospective cohort of 200 patients with resected LUAD w…
View article: Validation of in vitro models for smoke exposure of primary human bronchial epithelial cells
Validation of in vitro models for smoke exposure of primary human bronchial epithelial cells Open
The bronchial epithelium is constantly challenged by inhalative insults including cigarette smoke (CS), a key risk factor for lung disease. In vitro exposure of bronchial epithelial cells using CS extract (CSE) is a widespread alternative …
View article: Hyperthermic Intrathoracic Chemotherapy (HITOC) after Cytoreductive Surgery for Pleural Malignancies—A Retrospective, Multicentre Study
Hyperthermic Intrathoracic Chemotherapy (HITOC) after Cytoreductive Surgery for Pleural Malignancies—A Retrospective, Multicentre Study Open
In the context of quality assurance, the objectives were to describe the surgical treatment and postoperative morbidity (particularly renal insufficiency). A retrospective, multicentre study of patients who underwent cytoreductive surgery …
View article: Anti-Gr-1 Antibody Provides Short-term Depletion of MDSC in Lymphodepleted Mice With Active-specific Melanoma Therapy
Anti-Gr-1 Antibody Provides Short-term Depletion of MDSC in Lymphodepleted Mice With Active-specific Melanoma Therapy Open
BackgroundLymphodepletion, reconstitution and active-specific tumor cell vaccination (LRAST) enhances the induction of tumor-specific T cells in a murine melanoma model. Myeloid-derived suppressor cells (MDSC, Gr-1+ CD11b+) may counteract th…