Explanipedia

scFv intrabody targeting wildtype TDP-43 presents protective effects in a cellular model of TDP-43 proteinopathy Open

Yara Al Ojaimi, Rudolf Hergesheimer, Anna A. Chami, Hugo Alarcan, Johanna Augros , et al. · 2025

TDP-43 proteinopathies are neurological disorders marked by the abnormal accumulation of TDP-43 in the cytoplasm. This mislocalization disrupts the normal function of the protein. In most cases, it is the wildtype (wt) form of the protein …

scFv intrabody targeting wildtype TDP-43 presents protective effects in a cellular model of TDP-43 proteinopathy Open

Yara Al Ojaimi, Rudolf Hergesheimer, Anna A. Chami, Hugo Alarcan, Johanna Augros , et al. · 2025

TDP-43 proteinopathies are a set of neurological disorders characterized by the abnormal accumulation and mislocalization of TDP-43 in the cytoplasm, leading to the disruption of the normal function of the protein. In most of the cases, it…

TDP43 aggregates: the ‘Schrödinger’s cat’ in amyotrophic lateral sclerosis Open

Débora Lanznaster, Rudolf Hergesheimer, Patrick Vourc’h, Philippe Corcia, Hélène Blasco · 2021

Recombinant Intrabodies as Molecular Tools and Potential Therapeutics for Amyotrophic Lateral Sclerosis Open

Dênis Reis de Assis, Anna A. Chami, Rudolf Hergesheimer, Judith Halewa, Séyédéh Tayébéh Ahmad Pour , et al. · 2021

This is the final version of the article, which has been published in final form at : http://www.lestudium-ias.com/content/recombinant-intrabodies-molecular-tools-and-potential-therapeutics-amyotrophic-lateral

Conditioned Medium from Cells Overexpressing TDP-43 Alters the Metabolome of Recipient Cells Open

Rudolf Hergesheimer, Débora Lanznaster, Jérôme Bourgeais, Olivier Hérault, Patrick Vourc’h , et al. · 2020

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by the progressive death of both upper and lower motor neurons. The disease presents a poor prognosis, and patients usually die 2–5 years after the onset of symptoms…

Aβ1-42 and Tau as Potential Biomarkers for Diagnosis and Prognosis of Amyotrophic Lateral Sclerosis Open

Débora Lanznaster, Rudolf Hergesheimer, Salah Eddine Bakkouche, S. Beltran, Patrick Vourc’h , et al. · 2020

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease, but its definitive diagnosis delays around 12 months. Although the research is highly active in the biomarker field, the absence of specific biomarkers for diagno…

TDP-43-Mediated Toxicity in HEK293T Cells: A Fast and Reproducible Protocol To Be Employed in the Search of New Therapeutic Options against Amyotrophic Lateral Sclerosis Open

Débora Lanznaster, Jérôme Bourgeais, Clément Bruno, Rudolf Hergesheimer, Rose‐Anne Thépault , et al. · 2019

Cytoplasmic TDP-43 aggregates are a hallmark of amyotrophic lateral sclerosis (ALS). Today, only two drugs are available for ALS treatment, and their modest effect prompts researchers to search for new therapeutic options. TDP-43 represent…

The debated toxic role of aggregated TDP-43 in amyotrophic lateral sclerosis: a resolution in sight? Open

Rudolf Hergesheimer, Anna A. Chami, Dênis Reis de Assis, Patrick Vourc’h, Christian Andrés , et al. · 2019

Transactive response DNA-binding protein-43 (TDP-43) is an RNA/DNA binding protein that forms phosphorylated and ubiquitinated aggregates in the cytoplasm of motor neurons in amyotrophic lateral sclerosis, which is a hallmark of this disea…

The Relevancy of Data Regarding the Metabolism of Iron to Our Understanding of Deregulated Mechanisms in ALS; Hypotheses and Pitfalls Open

Camille Petillon, Rudolf Hergesheimer, Hervé Puy, Philippe Corcia, Patrick Vourc’h , et al. · 2019

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by the loss of motor neurons. Its etiology remains unknown, but several pathophysiological mechanisms are beginning to explain motor neuronal death, as well as oxida…

How Can a Ketogenic Diet Improve Motor Function? Open

Charlotte Veyrat‐Durebex, Pascal Reynier, Vincent Procaccio, Rudolf Hergesheimer, Philippe Corcia , et al. · 2018

A ketogenic diet (KD) is a normocaloric diet composed by high fat (80-90%), low carbohydrate, and low protein consumption that induces fasting-like effects. KD increases ketone body (KBs) production and its concentration in the blood, prov…

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