Rufei Lu
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View article: Integrative omics identify increase of pattern recognition and ubiquitin related signatures specific to ANA+ at risk of SLE individuals 2370
Integrative omics identify increase of pattern recognition and ubiquitin related signatures specific to ANA+ at risk of SLE individuals 2370 Open
Description Anti-nuclear autoantibodies (ANA) appear years before SLE classification, however, most healthy ANA+ individuals will never develop clinical illness. We sought to identify molecular profiles driving transitions during preclinic…
View article: Dysregulated soluble immune mediators and lupus-associated autoantibody specificities inform the development of immune indexes that characterise classified SLE transition and SLE disease activity
Dysregulated soluble immune mediators and lupus-associated autoantibody specificities inform the development of immune indexes that characterise classified SLE transition and SLE disease activity Open
Objectives Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Significant morbidity and early mortality necessitate early intervention. This study harnessed SLE-associated immune dysregulation to create a Lupus Classificat…
View article: NONINVASIVE HIGH-THROUGHPUT SERUM PROTEOMICS FOR DISTINGUISHING SUBTYPES OF LUPUS NEPHRITIS
NONINVASIVE HIGH-THROUGHPUT SERUM PROTEOMICS FOR DISTINGUISHING SUBTYPES OF LUPUS NEPHRITIS Open
PT006 / #521 Topic: AS15 - Lupus Nephritis-Clinical POSTER TOUR 02: RECENT INSIGHTS ON THE PATHOGENESIS OF LUPUS NEPHRITIS 23-05-2025 10:00 AM - 10:40 AM Background/Purpose Lupus nephritis (LN) treatment decisions are commonly guided by hi…
View article: PROTEOMIC ANALYSIS OF SERUM OVER TIME TO FORECAST TREATMENT RESPONSE IN LUPUS NEPHRITIS
PROTEOMIC ANALYSIS OF SERUM OVER TIME TO FORECAST TREATMENT RESPONSE IN LUPUS NEPHRITIS Open
O061 / #515 Topic: AS15 - Lupus Nephritis-Clinical ABSTRACT CONCURRENT SESSION 10: INTEGRATING PROTEOMIC & TRANSCRIPTOMICS IN SLE 24-05-2025 10:40 AM - 11:40 AM Background/Purpose Lupus nephritis (LN) can cause severe complications and ear…
View article: INVESTIGATING PREDICTIVE SERUM SOLUBLE MEDIATORS SPECIFIC TO ANA+ INDIVIDUALS AT RISK OF SYSTEMIC LUPUS ERYTHEMATOSUS WITH HIGH-THROUGHPUT PROTEOMICS
INVESTIGATING PREDICTIVE SERUM SOLUBLE MEDIATORS SPECIFIC TO ANA+ INDIVIDUALS AT RISK OF SYSTEMIC LUPUS ERYTHEMATOSUS WITH HIGH-THROUGHPUT PROTEOMICS Open
O060 / #518 Topic: AS08 - Cytokines and Cell Trafficking ABSTRACT CONCURRENT SESSION 10: INTEGRATING PROTEOMIC & TRANSCRIPTOMICS IN SLE 24-05-2025 10:40 AM - 11:40 AM Background/Purpose Anti-nuclear autoantibodies (ANAs) are detected years…
View article: Increased SOX10, p16, and Cyclin D1 Immunoreactivity Differentiates MAP Kinase-activated Low-grade Gliomas From Piloid Gliosis
Increased SOX10, p16, and Cyclin D1 Immunoreactivity Differentiates MAP Kinase-activated Low-grade Gliomas From Piloid Gliosis Open
Low-grade gliomas and reactive piloid gliosis can present with overlapping features on conventional histology. Given the large implications for patient treatment, there is a need for effective methods to discriminate these morphologically …
View article: Searching for a cut-off point for p53 immunohistochemistry as evidence of TP53 mutations
Searching for a cut-off point for p53 immunohistochemistry as evidence of TP53 mutations Open
View article: Successful Treatment of <i>Balamuthia mandrillaris</i> Granulomatous Amebic Encephalitis with Nitroxoline
Successful Treatment of <i>Balamuthia mandrillaris</i> Granulomatous Amebic Encephalitis with Nitroxoline Open
A patient in California, USA, with rare and usually fatal Balamuthia mandrillaris granulomatous amebic encephalitis survived after receiving treatment with a regimen that included the repurposed drug nitroxoline. Nitroxoline, which is a qu…
View article: PATH-07. MULTIPLATFORM MOLECULAR ANALYSES REFINE CLASSIFICATION AND PROGNOSTICATION OF GLIOMAS ARISING IN PATIENTS WITH NEUROFIBROMATOSIS TYPE 1
PATH-07. MULTIPLATFORM MOLECULAR ANALYSES REFINE CLASSIFICATION AND PROGNOSTICATION OF GLIOMAS ARISING IN PATIENTS WITH NEUROFIBROMATOSIS TYPE 1 Open
BACKGROUND Gliomas arising in patients with neurofibromatosis type 1 (NF1) are heterogeneous, occurring from childhood through adulthood, can be histologically low-grade (LG) or high-grade (HG), and follow an indolent or aggressive clinica…
View article: Successful treatment of Balamuthia mandrillaris granulomatous amoebic encephalitis with the novel agent nitroxoline
Successful treatment of Balamuthia mandrillaris granulomatous amoebic encephalitis with the novel agent nitroxoline Open
This case report describes a survivor of Balamuthia mandrillaris granulomatous amoebic encephalitis (GAE) after treatment with the novel agent nitroxoline, a drug typically used to treat urinary tract infections. Nitroxoline was previously…
View article: COVID-19 Pandemic Spurs Evolution of an Academic Pathology Department and Laboratory
COVID-19 Pandemic Spurs Evolution of an Academic Pathology Department and Laboratory Open
View article: A case of invasive pulmonary mucormycosis resulting from short courses of corticosteroids in a well-controlled diabetic patient
A case of invasive pulmonary mucormycosis resulting from short courses of corticosteroids in a well-controlled diabetic patient Open
View article: Autoantibody-positive healthy individuals with lower lupus risk display a unique immune endotype
Autoantibody-positive healthy individuals with lower lupus risk display a unique immune endotype Open
View article: Author Correction: Immunologic findings precede rapid lupus flare after transient steroid therapy
Author Correction: Immunologic findings precede rapid lupus flare after transient steroid therapy Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: 233 Autoantibody-positive healthy individuals constrain T cell pathways to regulate autoimmune disease
233 Autoantibody-positive healthy individuals constrain T cell pathways to regulate autoimmune disease Open
Background Anti-nuclear antibody (ANA) positivity is a principal feature of individuals with an autoimmune disease, yet up to one in five healthy individuals are ANA-positive (ANA+) and will never develop overt disease. Understanding diffe…
View article: FRI0287 Serologic evidence of viral reactivation and increased disease activity in patients with systemic lupus erythematosus
FRI0287 Serologic evidence of viral reactivation and increased disease activity in patients with systemic lupus erythematosus Open
View article: SAT0423 Molecular profiles associate with clinical disease activity and inform patient subsetting in adult systemic lupus erythematosus
SAT0423 Molecular profiles associate with clinical disease activity and inform patient subsetting in adult systemic lupus erythematosus Open
View article: Case of Neonatal Fatality from Neuromuscular Variant of Glycogen Storage Disease Type IV
Case of Neonatal Fatality from Neuromuscular Variant of Glycogen Storage Disease Type IV Open
View article: Dysregulation of innate and adaptive serum mediators precedes systemic lupus erythematosus classification and improves prognostic accuracy of autoantibodies
Dysregulation of innate and adaptive serum mediators precedes systemic lupus erythematosus classification and improves prognostic accuracy of autoantibodies Open
View article: Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification
Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification Open