Renhao Li
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View article: Changes of N6-methyladenosine modification and unfolded protein response in renal cell injury induced by cadmium
Changes of N6-methyladenosine modification and unfolded protein response in renal cell injury induced by cadmium Open
Roles and changes of m6A modification and unfolded protein response (UPR) signaling molecules have not been clarified in the renal cell injury induced by cadmium. Our present results indicated that cell apoptosis rate and oxidative stress …
View article: A packaging-regulated adenoviral vector for rAAV production
A packaging-regulated adenoviral vector for rAAV production Open
Recombinant adeno-associated virus (rAAV) holds immense potential for gene therapy, yet scalability, yield, and quality remain critical challenges. Herein, we describe a packaging-regulated adenovirus for rAAV production by integrating the…
View article: HiMATE: A Hierarchical Multi-Agent Framework for Machine Translation Evaluation
HiMATE: A Hierarchical Multi-Agent Framework for Machine Translation Evaluation Open
The advancement of Large Language Models (LLMs) enables flexible and interpretable automatic evaluations. In the field of machine translation evaluation, utilizing LLMs with translation error annotations based on Multidimensional Quality M…
View article: Exploring the Impact of Personality Traits on LLM Bias and Toxicity
Exploring the Impact of Personality Traits on LLM Bias and Toxicity Open
With the different roles that AI is expected to play in human life, imbuing large language models (LLMs) with different personalities has attracted increasing research interests. While the "personification" enhances human experiences of in…
View article: Unraveling antibody-induced structural dynamics in the ADAMTS13 CUB1-2 domains via HDX-MS
Unraveling antibody-induced structural dynamics in the ADAMTS13 CUB1-2 domains via HDX-MS Open
Allosteric regulation of ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type-1 motif, member 13) activity involves an interaction between its spacer (S) and 2 complement C1r/C1s, Uegf and BMP1 (CUB; CUB1-2) domains to ke…
View article: Hollow Structured‐Controllable Polyimide Nanofibers with Extreme Conditions Tolerance for Efficient Thermal Insulation
Hollow Structured‐Controllable Polyimide Nanofibers with Extreme Conditions Tolerance for Efficient Thermal Insulation Open
The rational use of efficient thermal insulation materials is one of the effective strategies for energy management. However, existing thermal insulation materials often exhibit poor stability, suboptimal thermal insulation performance, an…
View article: Collective Identity and Ethical Dilemmas Among College Students in Chinese Anonymous Online Communities: Sensory Stimulation and Media Effects of Online Exposure Discourse
Collective Identity and Ethical Dilemmas Among College Students in Chinese Anonymous Online Communities: Sensory Stimulation and Media Effects of Online Exposure Discourse Open
This paper explores the dynamics of viral social media exposure posts within anonymous online communities in China, specifically concentrating on college students. Based on theories of effervescence and collective frenzy, this research pro…
View article: Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module
Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module Open
Activation of von Willebrand factor (VWF) is a tightly controlled process governed primarily by local elements around its A1 domain. Recent studies suggest that the O-glycosylated sequences flanking the A1 domain constitute a discontinuous…
View article: The Variable Heavy Chain Antibody Syn-VWFA1 Inhibits the Interaction of Platelets to Von Willebrand Factor in Solution but Not to Immobilized Von Willebrand Factor Thereby Inhibiting 3-Dimensional but Not 2-Dimensional Thrombus Formation
The Variable Heavy Chain Antibody Syn-VWFA1 Inhibits the Interaction of Platelets to Von Willebrand Factor in Solution but Not to Immobilized Von Willebrand Factor Thereby Inhibiting 3-Dimensional but Not 2-Dimensional Thrombus Formation Open
Neutralizing the interaction between GP1bα and von Willebrand Factor (VWF) is an attractive strategy for treatment and prevention of platelet-VWF agglutinate formation in von Willebrand disease type 2B and thrombotic thrombocytopenic purpu…
View article: Specific O-glycans in the mechanosensory domain of glycoprotein Ibα are important for its stability and function
Specific O-glycans in the mechanosensory domain of glycoprotein Ibα are important for its stability and function Open
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View article: Molecular Mechanocytometry Using Tension-activated Cell Tagging (TaCT)
Molecular Mechanocytometry Using Tension-activated Cell Tagging (TaCT) Open
Flow cytometry is routinely used to measure single-cell gene expression by staining cells with fluorescent antibodies and nucleic acids. Here we present Tension-activated Cell Tagging (TaCT) to fluorescently label cells based on the magnit…
View article: Survey on Satisfaction of Elderly Residents in Shanghai Communities
Survey on Satisfaction of Elderly Residents in Shanghai Communities Open
A total number of 4700 survey questionnaires were distributed to community residents aged 60 or above in 20 communities as the research subjects, including Hongkou District and Putuo District in Shanghai. Based on questionnaire survey data…
View article: Type 2B von Willebrand disease mutations differentially perturb autoinhibition of the A1 domain
Type 2B von Willebrand disease mutations differentially perturb autoinhibition of the A1 domain Open
Type 2B von Willebrand disease (VWD) is an inherited bleeding disorder in which a subset of point mutations in the von Willebrand factor (VWF) A1 domain and recently identified autoinhibitory module (AIM) cause spontaneous binding to glyco…