Rufus Cartwright
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View article: Effectiveness of different de-implementation strategies in primary care: systematic review and meta-analysis
Effectiveness of different de-implementation strategies in primary care: systematic review and meta-analysis Open
Objective To evaluate the effectiveness of various de-implementation interventions in primary care, targeting care (treatments or tests) that provides no or limited value for patients (low value care). Design Systematic review and meta-ana…
View article: Women suffering from overactive bladder syndrome exhibit a higher urethral viral abundance compared to healthy controls: a pilot study
Women suffering from overactive bladder syndrome exhibit a higher urethral viral abundance compared to healthy controls: a pilot study Open
The interactions between the human bacterial microbiome and essential bodily functions are well established for organ systems such as the oral cavity, gut, and female reproductive tract. However, the urinary microbiome, particularly its vi…
View article: The views of women and their physicians on decision-making for stress urinary incontinence
The views of women and their physicians on decision-making for stress urinary incontinence Open
Introduction Treatment decisions for stress urinary incontinence (SUI) are preference sensitive, because the disease is non-lethal and there are multiple reasonable treatment options. However, little is known about patients’ and physicians…
View article: Post‐Operative Pain After Pelvic Organ Prolapse Surgery (POPPOP): A Double Blind Randomised Multicentre Study to Assess the Effect of Local Anaesthesia During Vaginal Hysterectomy
Post‐Operative Pain After Pelvic Organ Prolapse Surgery (POPPOP): A Double Blind Randomised Multicentre Study to Assess the Effect of Local Anaesthesia During Vaginal Hysterectomy Open
Objective To compare local anaesthetic with adrenaline (LAA) with normal saline for hydrodissection at vaginal hysterectomy. Design A double‐blind, two parallel group multicentre randomised controlled trial (RCT) was planned. Setting 217 w…
View article: Shared Decision-Making (SDM) for Female SUI: Current Practice in Three Western Countries
Shared Decision-Making (SDM) for Female SUI: Current Practice in Three Western Countries Open
Introduction Different decision-making styles can be used to provide counselling for the multiple reasonable treatment options for patients with stress urinary incontinence (SUI). Shared decision-making (SDM) is currently advocated as the …
View article: Associated factors of vaginal laxity and female sexual function: a cross-sectional study
Associated factors of vaginal laxity and female sexual function: a cross-sectional study Open
Background Female sexual dysfunction (FSD), including vaginal laxity (VL), can lead to a decrease in quality of life and affect partner relationships. Aim We aimed to investigate the associated factors of VL and FSD and their relationship …
View article: VDR, CXCR1, CXCR2, PSCA Polymorphisms and Recurrent Urinary Tract Infections in Women: Genetic Association Study
VDR, CXCR1, CXCR2, PSCA Polymorphisms and Recurrent Urinary Tract Infections in Women: Genetic Association Study Open
Introduction and hypothesis Urinary tract infection (UTI) is one of the most common human infections. Evidence suggests that there might be a genetic predisposition to UTI. Previous small candidate gene studies have suggested that common v…
View article: Exploring nurse-led cystoscopy: A systematic review of safety, efficacy, and applicability in urogynecology
Exploring nurse-led cystoscopy: A systematic review of safety, efficacy, and applicability in urogynecology Open
Cystoscopy is traditionally performed by doctors with specialist training. Increasing demand and workforce challenges have led to prolonged wait times for cystoscopy. Nurse-led clinics have been successful in many medical fields, but their…
View article: Risk of thrombosis and bleeding in gynecologic noncancer surgery: systematic review and meta-analysis
Risk of thrombosis and bleeding in gynecologic noncancer surgery: systematic review and meta-analysis Open
The risk for venous thromboembolism in gynecologic noncancer surgery varied between procedures and patients. Venous thromboembolism risks exceeded the bleeding risks only among selected patients and procedures. Although most of the evidenc…
View article: Risk of thrombosis and bleeding in gynecologic cancer surgery: systematic review and meta-analysis
Risk of thrombosis and bleeding in gynecologic cancer surgery: systematic review and meta-analysis Open
Venous thromboembolism reduction with thromboprophylaxis likely outweighs the increase in bleeding requiring reintervention in many gynecologic cancer procedures (eg, open surgery for ovarian cancer and pelvic exenteration). In some proced…
View article: Systematic Reviews and Meta-analyses of the Procedure-specific Risks of Thrombosis and Bleeding in General Abdominal, Colorectal, Upper Gastrointestinal, and Hepatopancreatobiliary Surgery
Systematic Reviews and Meta-analyses of the Procedure-specific Risks of Thrombosis and Bleeding in General Abdominal, Colorectal, Upper Gastrointestinal, and Hepatopancreatobiliary Surgery Open
Objective: To provide procedure-specific estimates of symptomatic venous thromboembolism (VTE) and major bleeding after abdominal surgery. Background: The use of pharmacological thromboprophylaxis represents a trade-off that depends on VTE…
View article: A Molecular Landscape of Stress Urinary Incontinence in Women Suggests an Important Role of Beta-Catenin Signaling in Disease Etiology
A Molecular Landscape of Stress Urinary Incontinence in Women Suggests an Important Role of Beta-Catenin Signaling in Disease Etiology Open
Purpose: Stress urinary incontinence (SUI) represents a major health burden in women, but a thorough understanding of the underlying molecular mechanisms is lacking. Our aim was to further elucidate these mechanisms to ultimately find new …
View article: Molecular Landscape of Pelvic Organ Prolapse Provides Insights into Disease Etiology
Molecular Landscape of Pelvic Organ Prolapse Provides Insights into Disease Etiology Open
Pelvic organ prolapse (POP) represents a major health care burden in women, but its underlying pathophysiological mechanisms have not been elucidated. We first used a case-control design to perform an exome chip study in 526 women with POP…
View article: Timing of symptomatic venous thromboembolism after surgery: meta-analysis
Timing of symptomatic venous thromboembolism after surgery: meta-analysis Open
Background The timing at which venous thromboembolism (VTE) occurs after major surgery has major implications for the optimal duration of thromboprophylaxis. The aim of this study was to perform a systematic review and meta-analysis of the…
View article: Evidence-based Urology: When Is a Study or Meta-analysis Big Enough?
Evidence-based Urology: When Is a Study or Meta-analysis Big Enough? Open
Both designing a clinical study and drawing conclusions from studies about the effect of treatments require justification of the sample size via judicious choice of the endpoint and power. Such an a priori power calculation limits the chan…
View article: Systematic review and meta-analysis of genetic association studies of pelvic organ prolapse
Systematic review and meta-analysis of genetic association studies of pelvic organ prolapse Open
Introduction and hypothesis Family and twin studies demonstrate that pelvic organ prolapse (POP) is heritable, but the genetic etiology is poorly understood. This review aimed to identify genetic loci and specific polymorphisms associated …
View article: Issue Information
Issue Information Open
Clinical effectiveness of first trimester combined screening for pre-eclampsia • Evidence summary and expert opinion on preventing spontaneous preterm birth • Child outcomes after amnioinfusion compared with no intervention after secondtri…