Rugina I. Neuman
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View article: PRERISK Study: A Randomized Controlled Trial Evaluating a sFlt-1/PlGF-Based Calculator for Preeclampsia Hospitalization.
PRERISK Study: A Randomized Controlled Trial Evaluating a sFlt-1/PlGF-Based Calculator for Preeclampsia Hospitalization. Open
URL: https://onderzoekmetmensen.nl/nl/trial/48687; Unique identifier: NL63386.078.17, NL-OMON48687.
View article: Glycosylated fibronectin as a biomarker for preeclampsia and preeclampsia-related complications
Glycosylated fibronectin as a biomarker for preeclampsia and preeclampsia-related complications Open
GlyFn is a novel biomarker for PE diagnosis and its complications, particularly at GA < 37 weeks. Prospective studies should evaluate to what degree it outperforms traditional biomarkers.
View article: Tumor Necrosis Factor Inhibitor Use Increases Birthweight in Pregnant Women With Rheumatoid Arthritis Independently of the Soluble Fms‐Like Tyrosine Kinase‐1/Placental Growth Factor Ratio
Tumor Necrosis Factor Inhibitor Use Increases Birthweight in Pregnant Women With Rheumatoid Arthritis Independently of the Soluble Fms‐Like Tyrosine Kinase‐1/Placental Growth Factor Ratio Open
Background To study whether the use of TNF (tumor necrosis factor) inhibitors (TNFi) by pregnant women with rheumatoid arthritis affects sFlt‐1 (soluble Fms‐like tyrosine kinase‐1), PlGF (placental growth factor), or their impact on birthw…
View article: Statins Prevent the Deleterious Consequences of Placental Chemerin Upregulation in Preeclampsia
Statins Prevent the Deleterious Consequences of Placental Chemerin Upregulation in Preeclampsia Open
BACKGROUND: Chemerin, an inflammatory adipokine, is upregulated in preeclampsia, and its placental overexpression results in preeclampsia-like symptoms in mice. Statins may lower chemerin. METHODS: Chemerin was determined in a prospective …
View article: POS0631 TNF INHIBITOR USE AFFECTS BIRTH WEIGHT INDEPENDENTLY OF THE SFLT-1/PLGF RATIO IN PREGNANT WOMEN WITH RHEUMATOID ARTHRITIS
POS0631 TNF INHIBITOR USE AFFECTS BIRTH WEIGHT INDEPENDENTLY OF THE SFLT-1/PLGF RATIO IN PREGNANT WOMEN WITH RHEUMATOID ARTHRITIS Open
Background TNF inhibitor (TNFi) use during pregnancy is associated with increased birthweight of the offspring of women with Rheumatoid Arthritis (RA). However, the underlying mechanism of the increased birthweight due to TNFi use is unkno…
View article: Disrupted trans-placental thyroid hormone transport in a human model for MCT8 deficiency
Disrupted trans-placental thyroid hormone transport in a human model for MCT8 deficiency Open
Maternal-to-fetal transfer of the thyroid hormone T4 is essential for prenatal neurodevelopment, but the transporter facilitating trans-placental T4 transport is unknown. Mutations in the thyroid hormone transporter MCT8 cause a neurodevel…
View article: Angiogenic imbalance in pre‐eclampsia and fetal growth restriction: enhanced soluble fms‐like tyrosine kinase‐1 binding or diminished production of placental growth factor?
Angiogenic imbalance in pre‐eclampsia and fetal growth restriction: enhanced soluble fms‐like tyrosine kinase‐1 binding or diminished production of placental growth factor? Open
Objectives To assess levels of total placental growth factor (PlGF), soluble fms‐like tyrosine kinase‐1 (sFlt‐1) and free PlGF in women with pre‐eclampsia (PE) with or without a small‐for‐gestational‐age (SGA) neonate in order to establish…
View article: High Renin Concentrations in Severe COVID-19 Are Indicative for a Hypo–Renin–Angiotensin-System State
High Renin Concentrations in Severe COVID-19 Are Indicative for a Hypo–Renin–Angiotensin-System State Open
but neglect to contextualize this against a very sick population with comorbidities and on concomitant medications, as evidenced by adverse events in 91.4% of the placebo patients.Similarly, as the authors point out, serious adverse events…
View article: Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage
Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage Open
Vascular endothelial growth factor antagonism with angiogenesis inhibitors in cancer patients induces a ‘preeclampsia-like’ syndrome including hypertension, proteinuria and elevated endothelin (ET)-1. Cyclo-oxygenase (COX) inhibition with …
View article: Omeprazole Administration in Preterm Preeclampsia: a Randomized Controlled Trial to Study Its Effect on sFlt-1 (Soluble Fms-Like Tyrosine Kinase-1), PlGF (Placental Growth Factor), and ET-1 (Endothelin-1)
Omeprazole Administration in Preterm Preeclampsia: a Randomized Controlled Trial to Study Its Effect on sFlt-1 (Soluble Fms-Like Tyrosine Kinase-1), PlGF (Placental Growth Factor), and ET-1 (Endothelin-1) Open
Background: Low sFlt-1 (soluble Fms-like tyrosine kinase-1) and ET-1 (endothelin-1) levels have been reported in preeclamptic women using proton pump inhibitors. Methods: Here, we examined whether the proton pump inhibitor omeprazole could…
View article: Comment on: The sFlt-1 to PlGF ratio in pregnant women with rheumatoid arthritis: impact of disease activity and sulfasalazine use. Reply
Comment on: The sFlt-1 to PlGF ratio in pregnant women with rheumatoid arthritis: impact of disease activity and sulfasalazine use. Reply Open
View article: A Low Aldosterone/Renin Ratio and High Soluble ACE2 Associate with COVID-19 Severity
A Low Aldosterone/Renin Ratio and High Soluble ACE2 Associate with COVID-19 Severity Open
Background The severity of COVID-19 after SARS-CoV-2 infection is unpredictable. Angiotensin-converting enzyme-2 (ACE2) is the receptor responsible for coronavirus binding, while subsequent cell entry relies on priming by the serine protea…
View article: Accurate Prediction of Total PlGF (Placental Growth Factor) From Free PlGF and sFlt-1 (Soluble Fms-Like Tyrosine Kinase-1): Evidence for Markedly Elevated PlGF Levels in Women With Acute Fatty Liver of Pregnancy
Accurate Prediction of Total PlGF (Placental Growth Factor) From Free PlGF and sFlt-1 (Soluble Fms-Like Tyrosine Kinase-1): Evidence for Markedly Elevated PlGF Levels in Women With Acute Fatty Liver of Pregnancy Open
Acute fatty liver of pregnancy (AFLP) is characterized by elevated circulating sFlt-1 (soluble Fms-like tyrosine kinase-1), although the free circulating levels of its ligand, PlGF (placental growth factor) are not decreased. Here, we hypo…
View article: POS0542 DISEASE ACTIVITY IN PREGNANT WOMEN WITH RHEUMATOID ARTHRITIS: IMPACT ON THE SOLUBLE FMS-LIKE TYROSINE KINASE-1 TO PLACENTAL GROWTH FACTOR RATIO
POS0542 DISEASE ACTIVITY IN PREGNANT WOMEN WITH RHEUMATOID ARTHRITIS: IMPACT ON THE SOLUBLE FMS-LIKE TYROSINE KINASE-1 TO PLACENTAL GROWTH FACTOR RATIO Open
View article: Angiogenic markers during preeclampsia: Are they associated with hypertension 1 year postpartum?
Angiogenic markers during preeclampsia: Are they associated with hypertension 1 year postpartum? Open
Our data indicate that sFlt-1, PlGF or their ratio measured during pregnancy are not suitable for the prediction of hypertension 1 year postpartum and hence guiding follow-up of women with previous preeclampsia.
View article: Prediction of pre‐eclampsia‐related complications in women with suspected or confirmed pre‐eclampsia: development and internal validation of clinical prediction model
Prediction of pre‐eclampsia‐related complications in women with suspected or confirmed pre‐eclampsia: development and internal validation of clinical prediction model Open
Objective A model that can predict reliably the risk of pre‐eclampsia (PE)‐related pregnancy complications does not exist. The aim of this study was to develop and validate internally a clinical prediction model to predict the risk of a co…
View article: PAPP‐A2 and Inhibin A as Novel Predictors for Pregnancy Complications in Women With Suspected or Confirmed Preeclampsia
PAPP‐A2 and Inhibin A as Novel Predictors for Pregnancy Complications in Women With Suspected or Confirmed Preeclampsia Open
Background We aimed to evaluate the value of inhibin A and PAPP‐A2 (pregnancy‐associated plasma protein‐A2) as novel biomarkers in the prediction of preeclampsia‐related complications and how they compare with angiogenic biomarkers. Method…
View article: Copeptin and mid‐regional pro‐atrial natriuretic peptide in women with suspected or confirmed pre‐eclampsia: comparison with sFlt‐1/PlGF ratio
Copeptin and mid‐regional pro‐atrial natriuretic peptide in women with suspected or confirmed pre‐eclampsia: comparison with sFlt‐1/PlGF ratio Open
Objectives Arginine vasopressin (AVP) and atrial natriuretic peptide (ANP) may contribute to the pathogenesis of pre‐eclampsia (PE), but their role remains to be elucidated. Our aims were to evaluate the surrogates of AVP and ANP, C‐termin…
View article: Angiogenic markers are elevated in women with acute fatty liver of pregnancy
Angiogenic markers are elevated in women with acute fatty liver of pregnancy Open
Acute fatty liver of pregnancy (AFLP) is a life-threatening, pregnancy-specific condition with an estimated global incidence of 1 in 7000 to 15 000 pregnancies1. Despite several clinical characteristics unique to the disorder, distinguishi…
View article: Blue toe syndrome as a first sign of systemic sclerosis
Blue toe syndrome as a first sign of systemic sclerosis Open
We describe an unusual case of blue toe syndrome as the primary and solitary manifestation of systemic sclerosis. The possible cause was long-term occupational exposure in construction work. Blue toe syndrome is a small vessel disease, cha…
View article: AMP-activated protein kinase and adenosine are both metabolic modulators that regulate chloride secretion in the shark rectal gland (<i>Squalus acanthias</i>)
AMP-activated protein kinase and adenosine are both metabolic modulators that regulate chloride secretion in the shark rectal gland (<i>Squalus acanthias</i>) Open
The production of endogenous adenosine during secretagogue stimulation of CFTR leads to feedback inhibition limiting further chloride secretion in the rectal gland of the dogfish shark (Squalus acanthias). In the present study, we examined…