Ruhang Tang
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View article: Global, regional, and national burdens of lower extremity peripheral arterial disease from 1990 to 2021 and projections to 2050: global burden of disease study 2021
Global, regional, and national burdens of lower extremity peripheral arterial disease from 1990 to 2021 and projections to 2050: global burden of disease study 2021 Open
Background The global and regional burden of lower extremity peripheral artery disease (LEPAD) and its trends have not been systematically studied. Utilizing data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2…
View article: Integrating UHPLC-QE-MS and Bioinformatics with Experimental Validation Reveals MAPK/FOS-Mediated Podocyte Apoptosis as the Key Mechanism of Alpiniae oxyphyllae and Saposhnikovia divaricata in Treating Diabetic Kidney Disease
Integrating UHPLC-QE-MS and Bioinformatics with Experimental Validation Reveals MAPK/FOS-Mediated Podocyte Apoptosis as the Key Mechanism of Alpiniae oxyphyllae and Saposhnikovia divaricata in Treating Diabetic Kidney Disease Open
Background: Alpiniae oxyphyllae-Saposhnikovia divaricata (AS), a traditional Chinese dietary supplement, exhibits potential therapeutic effects against diabetic kidney disease (DKD), though its active compounds and mechanisms require eluci…
View article: Tree-Based Surrogate Model for Predicting Aerodynamic Coefficients of Iced Transmission Conductor Lines
Tree-Based Surrogate Model for Predicting Aerodynamic Coefficients of Iced Transmission Conductor Lines Open
Ultra-high-voltage (UHV) transmission lines are prone to galloping and oscillations under ice and wind loads, posing risks to system reliability and safety. Accurate aerodynamic coefficients are essential for evaluating these effects, but …
View article: Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain
Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain Open
Obesity is a risk factor for osteoarthritis (OA), and leptin is among the adipokines implicated in obesity-induced OA. However, the specific role of leptin in OA severity and pain is not known. Using lipodystrophic (LD) mice, we show that …
View article: PIEZO1-mediated mechanotransduction regulates collagen synthesis on nanostructured 2D and 3D models of fibrosis
PIEZO1-mediated mechanotransduction regulates collagen synthesis on nanostructured 2D and 3D models of fibrosis Open
Progressive fibrosis can lead to tissue malfunction and organ failure due to the pathologic accumulation of a collagen-rich extracellular matrix. In vitro models provide useful tools for deconstructing the roles of specific biomechanical o…
View article: Gene therapy for <i>fat-1</i> prevents obesity-induced metabolic dysfunction, cellular senescence, and osteoarthritis
Gene therapy for <i>fat-1</i> prevents obesity-induced metabolic dysfunction, cellular senescence, and osteoarthritis Open
Obesity is one of the primary risk factors for osteoarthritis (OA), acting through cross talk among altered biomechanics, metabolism, adipokines, and dietary free fatty acid (FA) composition. Obesity and aging have been linked to cellular …
View article: Designer fat cells: adipogenic differentiation of CRISPR-Cas9 genome-engineered induced pluripotent stem cells
Designer fat cells: adipogenic differentiation of CRISPR-Cas9 genome-engineered induced pluripotent stem cells Open
Adipose tissue is an active endocrine organ that can signal bidirectionally to many tissues and organ systems in the body. With obesity, adipose tissue can serve as a source of low-level inflammation that contributes to various co-morbidit…
View article: Designer Fat Cells: Adipogenic Differentiation of CRISPR-Cas9 Genome-Engineered Induced Pluripotent Stem Cells
Designer Fat Cells: Adipogenic Differentiation of CRISPR-Cas9 Genome-Engineered Induced Pluripotent Stem Cells Open
Adipose tissue is an active endocrine organ that can signal bidirectionally to many tissues and organ systems in the body. With obesity, adipose tissue is a source of low-level inflammation that contributes to various co-morbidities and da…
View article: Membrane stretch as the mechanism of activation of PIEZO1 ion channels in chondrocytes
Membrane stretch as the mechanism of activation of PIEZO1 ion channels in chondrocytes Open
Osteoarthritis is a chronic disease that can be initiated by altered joint loading or injury of the cartilage. The mechanically sensitive PIEZO ion channels have been shown to transduce injurious levels of biomechanical strain in articular…
View article: Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes
Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes Open
Mutations in the TRPV4 ion channel can lead to a range of skeletal dysplasias. However, the mechanisms by which TRPV4 mutations lead to distinct disease severity remain unknown. Here, we use CRISPR-Cas9-edited human-induced pluripotent ste…
View article: Author response: Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes
Author response: Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Mutations i…
View article: Inhibitory kappa B kinase-β is a target for specific nuclear factor kappa B-mediated delayed cardioprotection
Inhibitory kappa B kinase-β is a target for specific nuclear factor kappa B-mediated delayed cardioprotection Open
Myocardial ischemia/reperfusion injury remains a vexing problem. Translating experimental strategies that deliver protective agents before the ischemic insult limits clinical applicability. We targeted 2 proteins in the nuclear factor-κB p…
View article: Regression of pressure-induced left ventricular hypertrophy is characterized by a distinct gene expression profile
Regression of pressure-induced left ventricular hypertrophy is characterized by a distinct gene expression profile Open
Left ventricular hypertrophy (LVH) is a highly prevalent and robust predictor of cardiovascular morbidity and mortality. Existing studies have finely detailed mechanisms involved with its development, yet clinical translation of these find…
View article: Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes
Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes Open
Mutations in the TRPV4 ion channel can lead to a range of skeletal dysplasias. However, the mechanisms by which TRPV4 mutations lead to distinct disease severity remain unknown. Here, we use CRISPR-Cas9-edited human induced pluripotent ste…
View article: Single‐cell RNA sequencing reveals the induction of novel myeloid and myeloid‐associated cell populations in visceral fat with long‐term obesity
Single‐cell RNA sequencing reveals the induction of novel myeloid and myeloid‐associated cell populations in visceral fat with long‐term obesity Open
Macrophages and other immune cells are important contributors to obesity‐associated inflammation; however, the cellular identities of these specific populations remain unknown. In this study, we identified individual populations of myeloid…
View article: Adipose tissue is a critical regulator of osteoarthritis
Adipose tissue is a critical regulator of osteoarthritis Open
Significance Obesity is a primary risk factor for osteoarthritis, involving complex interactions among the metabolic, biomechanical, and inflammatory factors caused by increased adiposity. Using a mouse model of lipodystrophy, we demonstra…
View article: Regression of pressure-induced left ventricular hypertrophy is characterized by a distinct gene expression profile
Regression of pressure-induced left ventricular hypertrophy is characterized by a distinct gene expression profile Open
Left ventricular hypertrophy (LVH) is a highly prevalent and robust predictor of cardiovascular morbidity and mortality. Existing studies have finely detailed mechanisms involved with its development, yet clinical translation of these find…
View article: Acetylation of Myocardin Is Required for the Activation of Cardiac and Smooth Muscle Genes
Acetylation of Myocardin Is Required for the Activation of Cardiac and Smooth Muscle Genes Open
Myocardin belongs to the SAF-A/B, Acinus, PIAS (SAP) domain family of transcription factors and is specifically expressed in cardiac and smooth muscle. Myocardin functions as a transcriptional coactivator of SRF and is sufficient and neces…
View article: Post-Natal Knockdown of Fukutin-Related Protein Expression in Muscle by Long-Term RNA Interference Induces Dystrophic Pathology
Post-Natal Knockdown of Fukutin-Related Protein Expression in Muscle by Long-Term RNA Interference Induces Dystrophic Pathology Open
Limb-girdle muscular dystrophy 2I (LGMD2I) is caused by mutations in the fukutin-related protein (FKRP) gene. Unlike its severe allelic forms, LGMD2I usually involves slower onset and milder course without defects in the central nervous sy…
View article: Overcoming Insulin Insufficiency by Forced Follistatin Expression in β -cells of db/db Mice
Overcoming Insulin Insufficiency by Forced Follistatin Expression in β -cells of db/db Mice Open
Diabetes poses a substantial burden to society as it can lead to serious complications and premature death. The number of cases continues to increase worldwide. Two major causes of diabetes are insulin resistance and insulin insufficiency.…
View article: Enhancing Muscle Membrane Repair by Gene Delivery of MG53 Ameliorates Muscular Dystrophy and Heart Failure in δ-Sarcoglycan-deficient Hamsters
Enhancing Muscle Membrane Repair by Gene Delivery of MG53 Ameliorates Muscular Dystrophy and Heart Failure in δ-Sarcoglycan-deficient Hamsters Open
Muscular dystrophies (MDs) are caused by genetic mutations in over 30 different genes, many of which encode for proteins essential for the integrity of muscle cell structure and membrane. Their deficiencies cause the muscle vulnerable to m…
View article: IKK-β inhibition prevents adaptive left ventricular hypertrophy
IKK-β inhibition prevents adaptive left ventricular hypertrophy Open
Most cardiovascular studies have implicated the central transcription factor nuclear factor kappa B (NF-κB) as contributing to the detrimental effects of cardiac injury. This ostensibly negative view of NF-κB competes with its important ro…
View article: Recovery from decompensated heart failure is associated with a distinct, phase-dependent gene expression profile
Recovery from decompensated heart failure is associated with a distinct, phase-dependent gene expression profile Open
Clinical and experimental studies have traditionally focused on understanding the mechanisms for why a heart fails. We hypothesize that the pathways involved with myocardial recovery are not simply the reverse of those that cause heart fai…
View article: MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice Open
MicroRNAs (miRNAs) are a class of small noncoding RNAs that have gained status as important regulators of gene expression. Here, we investigated the function and molecular mechanisms of the miR-208 family of miRNAs in adult mouse heart phy…
View article: Single Tyrosine Mutation in AAV8 and AAV9 Capsids Is Insufficient to Enhance Gene Delivery to Skeletal Muscle and Heart
Single Tyrosine Mutation in AAV8 and AAV9 Capsids Is Insufficient to Enhance Gene Delivery to Skeletal Muscle and Heart Open
Site-directed mutations of tyrosine (Y) to phenylalanine (F) on the surface of adeno-associated viral (AAV) capsids have been reported as a simple method to greatly enhance gene transfer in vitro and in vivo. To determine whether the Y-to-…
View article: Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5
Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5 Open
The pacemaker is composed of specialized cardiomyocytes located within the sinoatrial node (SAN), and is responsible for originating and regulating the heart beat. Recent advances towards understanding the SAN development have been made on…