Ruhi Deshmukh
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View article: Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments
Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments Open
Altered cellular metabolism has been associated with the acquisition of invasive phenotypes during metastasis. To study this, we combined a genetically engineered mouse model of mammary carcinoma with syngeneic transplantation and primary …
View article: Increased mRNA translation delays lung adenocarcinoma initiation and exposes a therapeutic vulnerability to MEK inhibitors
Increased mRNA translation delays lung adenocarcinoma initiation and exposes a therapeutic vulnerability to MEK inhibitors Open
Although protein synthesis inhibitors are being evaluated as anti-cancer agents, the dynamics of mRNA translation in early tumorigenesis are still poorly understood. We report that deletion of the mRNA-translation repressor, eIF4A2 in earl…
View article: Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis
Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis Open
The limited availability of therapeutic options for patients with triple-negative breast cancer (TNBC) contributes to the high rate of metastatic recurrence and poor prognosis. Ferroptosis is a type of cell death caused by iron-dependent l…
View article: Physiologically relevant culture medium Plasmax improves human placental trophoblast stem cell function
Physiologically relevant culture medium Plasmax improves human placental trophoblast stem cell function Open
Human trophoblast cultures provide powerful tools to model key processes of placental development. In vitro trophoblast studies to date have relied on commercial media that contains nonphysiological levels of nutrients, and the impact of t…