Ruichao Li
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View article: Genomic Features of Antimicrobial Resistance and Virulence in Multidrug-Resistant Vibrio furnissii
Genomic Features of Antimicrobial Resistance and Virulence in Multidrug-Resistant Vibrio furnissii Open
V. furnissii is a marine bacterium capable of infecting both invertebrates and humans. However, the mechanisms underlying its drug resistance and virulence remain largely elusive. In this study, we isolated a multidrug-resistant V. furniss…
View article: Plasmid-associated clonal expansion drives department-preference transmission of carbapenem-resistant Klebsiella pneumoniae in Xi’an, China: a genomic epidemiology study
Plasmid-associated clonal expansion drives department-preference transmission of carbapenem-resistant Klebsiella pneumoniae in Xi’an, China: a genomic epidemiology study Open
Background The drivers of expanding carbapenem-resistant Klebsiella pneumoniae (CRKP) infections in Northwest China remain poorly understood. This study aimed to investigate the clinical and molecular epidemiology of CRKP infections in Xi’…
View article: The applications and advantages of nanopore sequencing in bacterial antimicrobial resistance surveillance and research
The applications and advantages of nanopore sequencing in bacterial antimicrobial resistance surveillance and research Open
Genomics research is essential for understanding the transmission and evolution of bacterial antimicrobial resistance. The development of nanopore long-read sequencing has revolutionized our understanding of the prevalence, spread, and dyn…
View article: Dissemination of antimicrobial resistance in Klebsiella spp. from urban aquatic environments: a multi-country genomic perspective
Dissemination of antimicrobial resistance in Klebsiella spp. from urban aquatic environments: a multi-country genomic perspective Open
Our findings highlight significant regional disparities in CRKP prevalence and ARG dissemination across urban aquatic environments, with Nepal showing the highest prevalence, particularly in untreated rivers. China exhibited lower prevalen…
View article: Hybrid EEG Feature Learning Method for Cross-Session Human Mental Attention State Classification
Hybrid EEG Feature Learning Method for Cross-Session Human Mental Attention State Classification Open
Background: Decoding mental attention states from electroencephalogram (EEG) signals is crucial for numerous applications such as cognitive monitoring, adaptive human–computer interaction, and brain–computer interfaces (BCIs). However, con…
View article: Global emergence and transmission dynamics of carbapenemase-producing Citrobacter freundii sequence type 22 high-risk international clone: a retrospective, genomic, epidemiological study
Global emergence and transmission dynamics of carbapenemase-producing Citrobacter freundii sequence type 22 high-risk international clone: a retrospective, genomic, epidemiological study Open
National Natural Science Foundation of China, National Health Commission Scientific Research Fund-Zhejiang Provincial Major Health Science and Technology Plan Project, Zhejiang Province Natural Science Foundation Project, Outstanding Youth…
View article: <i>MTS1</i> regulates rice plant architecture by mediating phosphoinositide metabolism
<i>MTS1</i> regulates rice plant architecture by mediating phosphoinositide metabolism Open
Summary Plant architecture is an agronomically important trait affecting grain yield in rice ( Oryza sativa L.). Here, we identified a gene, Moderate‐tillering and Semi‐dwarf 1 ( MTS1 ), which encodes a type II Inositol polyphosphate 5‐pho…
View article: Detection of SXT/R391 integrative conjugative elements carrying tigecycline resistance genes in <i>Shewanella</i> spp. isolated from retail seafood
Detection of SXT/R391 integrative conjugative elements carrying tigecycline resistance genes in <i>Shewanella</i> spp. isolated from retail seafood Open
Tigecycline is a last resort antibiotic that is used to treat serious infections; however, some bacteria have developed tigecycline resistance by producing a tigecycline-inactivating enzyme or tigecycline resistance efflux pump, encoded by…
View article: Asterinas: A Linux ABI-Compatible, Rust-Based Framekernel OS with a Small and Sound TCB
Asterinas: A Linux ABI-Compatible, Rust-Based Framekernel OS with a Small and Sound TCB Open
How can one build a feature-rich, general-purpose, Rust-based operating system (OS) with a minimal and sound Trusted Computing Base (TCB) for memory safety? Existing Rust-based OSes fall short due to their improper use of unsafe Rust in ke…
View article: Genomic Insights into Carbapenem-Resistant Organisms Producing New Delhi Metallo-β-Lactamase in Live Poultry Markets
Genomic Insights into Carbapenem-Resistant Organisms Producing New Delhi Metallo-β-Lactamase in Live Poultry Markets Open
New Delhi metallo-β-lactamase (NDM) is an enzyme that can degrade a wide range of β-lactam antibiotics. The widespread dissemination of the blaNDM gene, which encodes NDM, in animal-derived settings poses a threat to public health security…
View article: <i>RPAD</i> locus controls prostrate growth habit in <i>Oryza nivara</i>
<i>RPAD</i> locus controls prostrate growth habit in <i>Oryza nivara</i> Open
The development of ideal plant architecture is crucial for optimizing grain yield in crop breeding. The transition from prostrate growth habit in wild rice to erect growth habit in cultivated rice is one of the important events during rice…
View article: Genomic Insights into Carbapenem-Resistant Organisms Producing New Delhi Metallo-β-Lactamase in Live Poultry Markets
Genomic Insights into Carbapenem-Resistant Organisms Producing New Delhi Metallo-β-Lactamase in Live Poultry Markets Open
The widespread dissemination of the blaNDM gene, which encodes New Delhi metallo-β-lactamase, in animal-derived settings poses a threat to public health security. Live poultry markets represent critical nodes in public health surveillance.…
View article: Neurological and Cardiac Adverse Events in Cervical Cancer Treatment: A Case of Postoperative Sintilimab-Induced Encephalitis and Myocarditis
Neurological and Cardiac Adverse Events in Cervical Cancer Treatment: A Case of Postoperative Sintilimab-Induced Encephalitis and Myocarditis Open
BACKGROUND Immune checkpoint inhibitors (ICIs) have shown considerable promise in enhancing patient outcomes and improving survival rates, offering a new frontier in cancer treatment. As a result, their use in clinical practice has become …
View article: Selenomethionine combined with allicin delays reactive oxidative stress-induced apoptosis, inflammation, endoplasmic reticulum stress, and barrier damage in IPEC-J2 cells via the GPX4 signaling pathway
Selenomethionine combined with allicin delays reactive oxidative stress-induced apoptosis, inflammation, endoplasmic reticulum stress, and barrier damage in IPEC-J2 cells via the GPX4 signaling pathway Open
To increase livestock productivity and improve economic efficiency, farms tend to focus on the growth rate of livestock and poultry. This strategy can result in a reduced resistance to reactive oxidative stress (ROS) and heat stress. Selen…
View article: Emergence of plasmid-mediated fosfomycin resistance among <i>Escherichia coli</i> harboring <i>fosA4</i> , <i>tet</i> (X4), and <i>mcr-1</i> genes in wild birds
Emergence of plasmid-mediated fosfomycin resistance among <i>Escherichia coli</i> harboring <i>fosA4</i> , <i>tet</i> (X4), and <i>mcr-1</i> genes in wild birds Open
Fosfomycin represents a last-line reserve antibiotic for the treatment of infections caused by multidrug-resistant (MDR) bacteria. Nevertheless, the advent of plasmid-mediated fosfomycin resistance among bacteria from humans and food anima…
View article: Tracing the evolution: the rise of <i>Salmonella</i> Thompson co-resistant to clinically important antibiotics in China, 1997–2020
Tracing the evolution: the rise of <i>Salmonella</i> Thompson co-resistant to clinically important antibiotics in China, 1997–2020 Open
As clinical Salmonella enterica serovar Thompson ( S . Thompson) emerged among the top ten prevalent serovars in China, understanding the distribution and origin of its multidrug-resistant (MDR) strains becomes imperative. This study emplo…
View article: Self-assembled and intestine-targeting florfenicol nano-micelles effectively inhibit drug-resistant Salmonella typhimurium, eradicate biofilm, and maintain intestinal homeostasis
Self-assembled and intestine-targeting florfenicol nano-micelles effectively inhibit drug-resistant Salmonella typhimurium, eradicate biofilm, and maintain intestinal homeostasis Open
Antimicrobial resistance (AMR) is a growing public health crisis that requires innovative solutions. Emerging multidrug resistant (MDR) Salmonella typhimurium has raised concern for its effect on pathogenic infection and mortality in human…
View article: Effects of amino acid value-added urea on rice growth and nitrogen utilization
Effects of amino acid value-added urea on rice growth and nitrogen utilization Open
To investigate the impact of amino acid value-added urea on rice growth and nitrogen utilization, this study aimed to provide insights into enhancing the quality and efficiency of traditional nitrogen fertilizers using small molecule activ…
View article: Potential role of vitamin C in mitigating perfluoroalkyl substances-induced immunotoxicity
Potential role of vitamin C in mitigating perfluoroalkyl substances-induced immunotoxicity Open
Perfluoroalkyl substances (PFAS) are a group of persistent environmental pollutants that pose significant risks to the human immune system and increase the likelihood of various immune-related diseases. Vitamin C is a common antioxidant th…
View article: Genomic Diversity and Coexistence of Multidrug‐Resistance Mechanisms of <i>Klebsiella pneumoniae</i> in Poultry Farms
Genomic Diversity and Coexistence of Multidrug‐Resistance Mechanisms of <i>Klebsiella pneumoniae</i> in Poultry Farms Open
Klebsiella pneumoniae is an opportunistic pathogen and poses a serious threat to the livestock industry and human health. Therefore, it is necessary to investigate the prevalence of K. pneumoniae in agricultural settings. In this study, fe…