Rui Bernardes
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View article: Joint contribution of adaptation and neuronal population recruitment to response level in visual area MT: a computational model
Joint contribution of adaptation and neuronal population recruitment to response level in visual area MT: a computational model Open
Adaptation is a form of short-term plasticity triggered by prolonged stimulus exposure, altering perceptual sensitivity to stimulus features through reduced neuronal firing rates. Our previous studies investigated adaptation to bistable st…
View article: Retinal OCT-Derived Texture Features as Potential Biomarkers for Early Diagnosis and Progression of Diabetic Retinopathy
Retinal OCT-Derived Texture Features as Potential Biomarkers for Early Diagnosis and Progression of Diabetic Retinopathy Open
The effects of diabetes on the retina can be spotted through retinal texture analysis in the early stages of the disease. Changes in retinal texture are concomitant with biological retinal changes, thus unlocking the potential of texture a…
View article: Direct crosstalk between adult human retinas as suggested by interocular transfer of neurovascular coupling through photic stimulation
Direct crosstalk between adult human retinas as suggested by interocular transfer of neurovascular coupling through photic stimulation Open
Crosstalk mechanisms between retinas were never documented in humans despite being documented for several other species, including non-human primates. Here, we report the results of the first-in-human study that documents the crosstalk bet…
View article: Crosstalk between adult human retinas: exploring neurovascular coupling through photic stimulation for contralateral retina reflex insights.
Crosstalk between adult human retinas: exploring neurovascular coupling through photic stimulation for contralateral retina reflex insights. Open
Crosstalk mechanisms between retinas were never documented in humans despite being documented for several other species, including non-human primates. Here, we report the results of the first-in-human study that documents the crosstalk bet…
View article: Crosstalk between adult human retinas: exploring neurovascular coupling through photic stimulation for contralateral retina reflex insights.
Crosstalk between adult human retinas: exploring neurovascular coupling through photic stimulation for contralateral retina reflex insights. Open
Crosstalk mechanisms between retinas were never documented in humans despite being documented for several other species, including non-human primates. Here, we report the results of the first-in-human study that documents the crosstalk bet…
View article: Corrigendum: Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease
Corrigendum: Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease Open
[This corrects the article DOI: 10.3389/fnagi.2023.1161847.].
View article: Joint contribution of adaptation and neuronal population recruitment to response level in visual area MT: a computational model
Joint contribution of adaptation and neuronal population recruitment to response level in visual area MT: a computational model Open
Adaptation is a form of short-term plasticity triggered by prolonged exposure to a stimulus, often resulting in altered perceptual sensitivity to stimulus features through a reduction in neuronal firing rates. Experimental studies have exp…
View article: The hemodynamic response function as a type 2 diabetes biomarker: a data-driven approach
The hemodynamic response function as a type 2 diabetes biomarker: a data-driven approach Open
Introduction There is a need to better understand the neurophysiological changes associated with early brain dysfunction in Type 2 diabetes mellitus (T2DM) before vascular or structural lesions. Our aim was to use a novel unbiased data-dri…
View article: When Sex Matters: Differences in the Central Nervous System as Imaged by OCT through the Retina
When Sex Matters: Differences in the Central Nervous System as Imaged by OCT through the Retina Open
Background: Retinal texture has gained momentum as a source of biomarkers of neurodegeneration, as it is sensitive to subtle differences in the central nervous system from texture analysis of the neuroretina. Sex differences in the retina …
View article: Subtractive adaptation is a more effective and general mechanism in binocular rivalry than divisive adaptation
Subtractive adaptation is a more effective and general mechanism in binocular rivalry than divisive adaptation Open
The activity of neurons is influenced by random fluctuations and can be strongly modulated by firing rate adaptation, particularly in sensory systems. Still, there is ongoing debate about the characteristics of neuronal noise and the mecha…
View article: Phase-Resolved Optical Coherence Elastography: An Insight into Tissue Displacement Estimation
Phase-Resolved Optical Coherence Elastography: An Insight into Tissue Displacement Estimation Open
Robust methods to compute tissue displacements in optical coherence elastography (OCE) data are paramount, as they play a significant role in the accuracy of tissue elastic properties estimation. In this study, the accuracy of different ph…
View article: Retinal imaging in animal models: Searching for biomarkers of neurodegeneration
Retinal imaging in animal models: Searching for biomarkers of neurodegeneration Open
There is a pressing need for novel diagnostic and progression biomarkers of neurodegeneration. However, the inability to determine disease duration and stage in patients with Alzheimer’s disease (AD) hinders their discovery. Because animal…
View article: Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease
Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease Open
Animal models of disease are paramount to understand retinal development, the pathophysiology of eye diseases, and to study neurodegeneration using optical coherence tomography (OCT) data. In this study, we present a comprehensive normativ…
View article: Subtractive adaptation is a more effective and general mechanism in binocular rivalry than divisive adaptation
Subtractive adaptation is a more effective and general mechanism in binocular rivalry than divisive adaptation Open
The activity of neurons is influenced by random fluctuations and can be strongly modulated by firing rate adaptation, especially in sensory systems. Still, there is an ongoing debate about the characteristics of neuronal noise and the mech…
View article: Textural properties of microglial activation in Alzheimer’s disease as measured by (R)-[11C]PK11195 PET
Textural properties of microglial activation in Alzheimer’s disease as measured by (R)-[11C]PK11195 PET Open
Alzheimer’s disease is the most common form of dementia worldwide, accounting for 60–70% of diagnosed cases. According to the current understanding of molecular pathogenesis, the main hallmarks of this disease are the abnormal accumulation…
View article: Retinal Aging in 3× Tg-AD Mice Model of Alzheimer's Disease
Retinal Aging in 3× Tg-AD Mice Model of Alzheimer's Disease Open
The retina, as part of the central nervous system (CNS), can be the perfect target for in vivo, in situ , and noninvasive neuropathology diagnosis and assessment of therapeutic efficacy. It has long been established that several age-relate…
View article: Intraocular implants loaded with A3R agonist rescue retinal ganglion cells from ischemic damage
Intraocular implants loaded with A3R agonist rescue retinal ganglion cells from ischemic damage Open
Retinal ganglion cell (RGC) loss underlies several conditions which give rise to significant visual compromise, including glaucoma and ischaemic optic neuropathies. Neuroprotection of RGCs is a clinical well-defined unmet need in these dis…
View article: Texture Analysis and Its Applications in Biomedical Imaging: A Survey
Texture Analysis and Its Applications in Biomedical Imaging: A Survey Open
Texture analysis describes a variety of image analysis techniques that quantify the variation in intensity and pattern. This paper provides an overview of several texture analysis approaches addressing the rationale supporting them, their …
View article: Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3×Tg-AD mice model of Alzheimer's disease
Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3×Tg-AD mice model of Alzheimer's disease Open
Mice are widely used as models for many diseases, including eye and neurodegenerative diseases. However,
\nthere is a lack of normative data for retinal thickness over time, especially at young ages. In this work, we
\npresent a normative …
View article: The Retinal Inner Plexiform Synaptic Layer Mirrors Grey Matter Thickness of Primary Visual Cortex with Increased Amyloid <i>β</i> Load in Early Alzheimer’s Disease
The Retinal Inner Plexiform Synaptic Layer Mirrors Grey Matter Thickness of Primary Visual Cortex with Increased Amyloid <i>β</i> Load in Early Alzheimer’s Disease Open
The retina may serve as putative window into neuropathology of synaptic loss in Alzheimer’s disease (AD). Here, we investigated synapse-rich layers versus layers composed by nuclei/cell bodies in an early stage of AD. In addition, we exami…
View article: Characterization of the retinal changes of the 3×Tg-AD mouse model of Alzheimer’s disease
Characterization of the retinal changes of the 3×Tg-AD mouse model of Alzheimer’s disease Open
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder whose diagnosis remains a notable challenge. The literature suggests that cerebral changes precede AD symptoms by over two decades, implying a significantly advanced stag…
View article: Is the Retina a Mirror of the Aging Brain? Aging of Neural Retina Layers and Primary Visual Cortex Across the Lifespan
Is the Retina a Mirror of the Aging Brain? Aging of Neural Retina Layers and Primary Visual Cortex Across the Lifespan Open
How aging concomitantly modulates the structural integrity of the brain and retina in healthy individuals remains an outstanding question. Given the strong bottom-up retinocortical connectivity, it is important to study how these structure…
View article: Interplay Between Macular Retinal Changes and White Matter Integrity in Early Alzheimer’s Disease
Interplay Between Macular Retinal Changes and White Matter Integrity in Early Alzheimer’s Disease Open
This study aims to investigate the relationship between structural changes in the retina and white matter in the brain, in early Alzheimer's disease (AD). Twenty-three healthy controls (mean age = 63.4±7.5 years) and seventeen AD patients …
View article: Retinal texture biomarkers may help to discriminate between Alzheimer’s, Parkinson’s, and healthy controls
Retinal texture biomarkers may help to discriminate between Alzheimer’s, Parkinson’s, and healthy controls Open
A top priority in biomarker development for Alzheimer's disease (AD) and Parkinson's disease (PD) is the focus on early diagnosis, where the use of the retina is a promising avenue of research. We computed fundus images from optical cohere…