Rui Wang
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View article: Long-term Remission After Cilta-Cel in Multiple Myeloma Is Linked to Diverse T Cells and Low Myeloid Suppression
Long-term Remission After Cilta-Cel in Multiple Myeloma Is Linked to Diverse T Cells and Low Myeloid Suppression Open
View article: Combined multi-omics and brain pathology reveal novel biomarkers for alzheimer’s disease
Combined multi-omics and brain pathology reveal novel biomarkers for alzheimer’s disease Open
View article: Analysis of factors affecting smooth extubation in delayed extubation patients following intracranial surgery: an ambispective cohort study
Analysis of factors affecting smooth extubation in delayed extubation patients following intracranial surgery: an ambispective cohort study Open
Of 157 patients (mean BMI 23.88 ± 3.25 kg/m2, 33.1% male), adverse extubation occurred in 80 (51.0%). Univariate analysis showed several significant variables (P < 0.05): age, FOURE, FOURM, airway patency, …
View article: Colonization by Porphyromonas gingivalis in cervical squamous cell carcinomas promotes metastasis through FimA/CD151/ITGB1 signaling
Colonization by Porphyromonas gingivalis in cervical squamous cell carcinomas promotes metastasis through FimA/CD151/ITGB1 signaling Open
This study identifies P. gingivalis as a tumor-associated bacterium that promotes CSCC metastasis through direct interaction between its fimbrial adhesin FimA and the host CD151/ITGB1 complex. This interaction activates JNK/paxillin signal…
View article: Heterogeneous and lateralized cervical vascular responses to a 7-day head-down tilt bed rest
Heterogeneous and lateralized cervical vascular responses to a 7-day head-down tilt bed rest Open
This study aimed to investigate cervical vessel hemodynamics during 7 days of -6° head-down tilt (HDT) bed rest (BR) and 5 days of recovery in 40 healthy males, focusing on bilateral analysis and dynamic temporal monitoring. Diameter, flow…
View article: CXCR7-TAGLN2 protein complex regulates invasion and metastasis in papillary thyroid carcinoma: a potential therapeutic target
CXCR7-TAGLN2 protein complex regulates invasion and metastasis in papillary thyroid carcinoma: a potential therapeutic target Open
Objective To investigate the expression and clinical significance of CXCR7 and TAGLN2 in papillary thyroid carcinoma (PTC), and to explore the molecular mechanisms underlying the interaction between CXCR7 and TAGLN2 in regulating PTC invas…
View article: Room-Temperature Magnetoelectrical Skyrmions in LiNbO₃ with Suppressed DC drift and Enhanced Electro-Optic Functionality
Room-Temperature Magnetoelectrical Skyrmions in LiNbO₃ with Suppressed DC drift and Enhanced Electro-Optic Functionality Open
Skyrmions—topologically protected chiral spin textures—are promising candidates for energy-efficient spintronics, yet their practical deployment has been hindered by challenges in achieving robust electric-field control and room-temperatur…
View article: Correlation Between Hemodynamic Characterizations of Cervical Arteries and Changes in Cerebral Microcirculation Under Dobutamine Stress: A Self- Controlled Study
Correlation Between Hemodynamic Characterizations of Cervical Arteries and Changes in Cerebral Microcirculation Under Dobutamine Stress: A Self- Controlled Study Open
Background Dobutamine, an inotropic agent, is known to enhance cardiac function. However, its concurrent effects on cervical artery hemodynamics and cerebral microcirculation, along with their potential correlation, remain unclear. This st…
View article: Neoadjuvant treatment of IBI310 plus sintilimab in locally advanced MSI-H/dMMR colon cancer: A randomized phase 1b study
Neoadjuvant treatment of IBI310 plus sintilimab in locally advanced MSI-H/dMMR colon cancer: A randomized phase 1b study Open
Although neoadjuvant immunotherapy showed promising efficacy in locally advanced microsatellite instability-high or mismatch repair-deficient (MSI-H/dMMR) colon cancer, whether dual immune checkpoint inhibition provides additional benefit …
View article: Smart tumor-penetrating nanocluster for dual-enhanced magnetic resonance imaging and synergistic photothermal-chemodynamic treatment for oral squamous cell carcinoma
Smart tumor-penetrating nanocluster for dual-enhanced magnetic resonance imaging and synergistic photothermal-chemodynamic treatment for oral squamous cell carcinoma Open
View article: Cholesterol-HDL-glucose index and type 2 diabetes risk in middle-aged and older adults: Evidence from a nationwide Chinese cohort
Cholesterol-HDL-glucose index and type 2 diabetes risk in middle-aged and older adults: Evidence from a nationwide Chinese cohort Open
Type 2 diabetes mellitus (T2DM) poses a significant global health challenge. This study aims to evaluate the ability of the cholesterol-HDL-glucose (CHG) index, as a novel indicator, to predict the risk of type 2 diabetes in the Chinese po…
View article: Tryptophan catabolites from microbiota ameliorate immune-mediated hepatitis through activating aryl hydrocarbon receptor of T cells
Tryptophan catabolites from microbiota ameliorate immune-mediated hepatitis through activating aryl hydrocarbon receptor of T cells Open
Intestinal dysbiosis and T cell-mediated immune attack are implicated in the pathogenesis of autoimmune hepatitis (AIH). However, the mechanisms by which microbiota-derived metabolites modulate immune homeostasis in AIH remain elusive. Her…
View article: Terahertz electrodynamics in a zero-field Wigner crystal
Terahertz electrodynamics in a zero-field Wigner crystal Open
In clean two-dimensional (2D) systems, electrons are expected to self-organize into a regular lattice, a Wigner crystal, when their mutual Coulomb repulsion overwhelms kinetic energy. Understanding the Wigner crystal at zero magnetic field…
View article: Efficacy and safety of guselkumab in Chinese patients with moderate-to-severe plaque psoriasis: A randomized, double-blind, placebo-controlled trial
Efficacy and safety of guselkumab in Chinese patients with moderate-to-severe plaque psoriasis: A randomized, double-blind, placebo-controlled trial Open
Background: Guselkumab is effective in treating moderate-to-severe plaque psoriasis; however, data from randomized controlled trials in the Chinese population are limited. This study evaluated and verified the efficacy and safety profile o…
View article: Gastrointestinal stromal tumor of the rectum: A case report with emphasis on MRI-pathologic correlation
Gastrointestinal stromal tumor of the rectum: A case report with emphasis on MRI-pathologic correlation Open
View article: Improvement of Quality of Sour Camel Milk by Extract of Sparassis crispa: Physicochemical Properties, Sensory Quality and Metabolic Changes
Improvement of Quality of Sour Camel Milk by Extract of Sparassis crispa: Physicochemical Properties, Sensory Quality and Metabolic Changes Open
Sour camel milk, as a nutritious fermented dairy product, faces challenges in terms of quality stability. Sparassis crispa, due to its antioxidant and antibacterial properties, shows potential in improving food quality. This study aimed to…
View article: Brain Insulin Signaling Pathway Regulation of Hippocampal Neuroplasticity in Neurocognitive Disorders: Mechanisms and Therapeutic Implications
Brain Insulin Signaling Pathway Regulation of Hippocampal Neuroplasticity in Neurocognitive Disorders: Mechanisms and Therapeutic Implications Open
Neurocognitive disorders represent a significant global health challenge and are characterized by progressive cognitive decline across conditions including Alzheimer’s disease, mild cognitive impairment, and diabetes-related cognitive impa…
View article: Discrimination and Integration of Phonological Features in Children with Autism Spectrum Disorder: An Exploratory Multi-Feature Oddball Protocol
Discrimination and Integration of Phonological Features in Children with Autism Spectrum Disorder: An Exploratory Multi-Feature Oddball Protocol Open
Background/Objectives: Children with Autism Spectrum Disorder (ASD) often display heightened sensitivity to simple auditory stimuli, but have difficulty discriminating and integrating multiple phonological features (segmental: consonants a…
View article: Risk prediction of recurrent ischemic stroke based on Carotid Plaque-RADS: construction and validation of a nomogram model
Risk prediction of recurrent ischemic stroke based on Carotid Plaque-RADS: construction and validation of a nomogram model Open
Background and purpose Ischemic stroke (IS) is characterized by a high recurrence rate and more serious repercussions. Recently, the Carotid Plaque Reporting and Data System (Carotid Plaque-RADS) has been introduced to gauge and forecast t…
View article: Evaluating the impact of an evidence-based standardized nursing protocol on lower-extremity deep vein thrombosis prevention in acute stroke patients: A retrospective analysis
Evaluating the impact of an evidence-based standardized nursing protocol on lower-extremity deep vein thrombosis prevention in acute stroke patients: A retrospective analysis Open
Acute stroke remains a major global health concern, contributing significantly to mortality and long-term disability. Due to factors such as immobility, endothelial injury, and hypercoagulability, these patients face an elevated risk of de…
View article: HCAR3 May Mediate Autism Symptoms: Evidence From RNA-Sequencing of Peripheral Blood Mononuclear Cells
HCAR3 May Mediate Autism Symptoms: Evidence From RNA-Sequencing of Peripheral Blood Mononuclear Cells Open
Objective Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder for which there is currently no effective treatment, and no reliable diagnostic biomarkers are available for ASD.Methods The present study was designed to co…
View article: Recombinant human alpha-N-acetylglucosamine-6-sulfatase delivered to Sanfilippo D mice with repeated intracerebroventricular injections corrects CNS pathology
Recombinant human alpha-N-acetylglucosamine-6-sulfatase delivered to Sanfilippo D mice with repeated intracerebroventricular injections corrects CNS pathology Open
Mucopolysaccharidosis type IIID (MPS IIID; Sanfilippo D) is caused by biallelic pathogenic variants in N-acetylglucosamine-6-sulfatase (GNS), which participates in catabolism of heparan sulfate (HS) glycosaminoglycans. Characterization of …
View article: Commensal Viruses Promote Intestinal Stem Cell Regeneration Following Radiation Damage by Inhibiting Hyperactivation of RIG‐I and Notch Signals
Commensal Viruses Promote Intestinal Stem Cell Regeneration Following Radiation Damage by Inhibiting Hyperactivation of RIG‐I and Notch Signals Open
Radiation‐induced intestinal injury is a common complication of abdominopelvic cancer radiotherapy, often associated with gut bacteriome dysbiosis. However, the involvement of gut virome in this process remains largely underexplored. Here,…
View article: Research on multi-time scale optimization strategy for PV-electrolyzers hydrogen production system based on MPC
Research on multi-time scale optimization strategy for PV-electrolyzers hydrogen production system based on MPC Open
View article: Ketone drink enhances therapeutic efficacy in prostate cancer by targeting EZH2
Ketone drink enhances therapeutic efficacy in prostate cancer by targeting EZH2 Open
It is well established that EZH2, a lysine methyltransferase, is upregulated in most aggressive cancers, highlighting the importance of EZH2 in cancer progression. Recent research has shown that metabolic reprogramming is pivotal in variou…
View article: Retraction Note: microRNA-29b prevents renal fibrosis by attenuating renal tubular epithelial cell–mesenchymal transition through targeting the PI3K/AKT pathway
Retraction Note: microRNA-29b prevents renal fibrosis by attenuating renal tubular epithelial cell–mesenchymal transition through targeting the PI3K/AKT pathway Open
View article: Treatment of relapsed or refractory Hodgkin’s lymphoma with lenalidomide combined with PD-1 monoclonal antibody: a case report and literature review
Treatment of relapsed or refractory Hodgkin’s lymphoma with lenalidomide combined with PD-1 monoclonal antibody: a case report and literature review Open
The current standard treatment for relapsed or refractory Hodgkin’s lymphoma involves salvage chemotherapy followed by high-dose chemotherapy and sequential autologous stem cell transplantation. However, for patients who cannot tolerate in…
View article: Integrated multiomics analysis identifies PHLDA1+ fibroblasts as prognostic biomarkers and mediators of biological functions in pancreatic cancer
Integrated multiomics analysis identifies PHLDA1+ fibroblasts as prognostic biomarkers and mediators of biological functions in pancreatic cancer Open
Background Pancreatic cancer (PC) is marked by extensive heterogeneity, posing significant challenges to effective treatment. The tumor microenvironment (TME), particularly cancer-associated fibroblasts (CAFs), plays a critical role in dri…
View article: Power supply vehicle routing problem: formulation and solution
Power supply vehicle routing problem: formulation and solution Open
Under specialized operational scenarios, the deployment of power supply vehicles (PSVs) for energy replenishment of unmanned equipment has emerged as a predominant technological trend. We formally define this optimization challenge as the …
View article: Efficacy and Safety of Cold Atmospheric Plasma-Assisted Therapy for Herpes Zoster: A Randomized, Parallel, Positive-Controlled, Non-inferiority Multicenter Clinical Trial
Efficacy and Safety of Cold Atmospheric Plasma-Assisted Therapy for Herpes Zoster: A Randomized, Parallel, Positive-Controlled, Non-inferiority Multicenter Clinical Trial Open
This study has been registered at www.chictr.org.cn (ChiCTR2300069993). A graphical abstract is available for this article.