Rui Geng
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View article: Molecular mechanisms of melatonin in mitigating compound salt stress in Sophora alopecuroides revealed by physiological and transcriptomic profiling
Molecular mechanisms of melatonin in mitigating compound salt stress in Sophora alopecuroides revealed by physiological and transcriptomic profiling Open
View article: Stable Maintenance of Two-Cell-Like Cells from Embryonic Stem Cells Reveals Chromatin and Super Enhancer Regulation of MERVL Elements
Stable Maintenance of Two-Cell-Like Cells from Embryonic Stem Cells Reveals Chromatin and Super Enhancer Regulation of MERVL Elements Open
Mouse embryonic stem cells (ESCs) occasionally transit into a rare two-cell-like (2C) state characterized by transient activation of endogenous retroviruses such as MERVL and expression of 2C-specific genes including the Zscan4 cluster. Th…
View article: Automated Image-Based Profiling of Pluripotent Stem Cell Colonies
Automated Image-Based Profiling of Pluripotent Stem Cell Colonies Open
Quantitative image analysis is essential for advancing stem cell biology, developmental studies, and drug discovery, yet most workflows still rely on manual or semi-quantitative scoring that is slow, subjective, and poorly scalable. A majo…
View article: β-Sitosterol improves murine ulcerative colitis by inhibiting the expression of ribosomal proteins and the attempted polarization of type 1 macrophages
β-Sitosterol improves murine ulcerative colitis by inhibiting the expression of ribosomal proteins and the attempted polarization of type 1 macrophages Open
View article: Akkermansia muciniphila Enhances Resistance to Infectious Bronchitis Virus in Chickens Through γ-Aminobutyric Acid-Mediated Anti-Inflammatory Pathways
Akkermansia muciniphila Enhances Resistance to Infectious Bronchitis Virus in Chickens Through γ-Aminobutyric Acid-Mediated Anti-Inflammatory Pathways Open
Background Infectious bronchitis virus (IBV) is a major viral pathogen causing substantial economic losses in the global poultry industry. However, the limited efficacy of commercial vaccines and the absence of approved antiviral drugs und…
View article: Characterization and pathogenic evaluation of a novel S-INDEL PEDV CH/JSHA2024 isolated in China
Characterization and pathogenic evaluation of a novel S-INDEL PEDV CH/JSHA2024 isolated in China Open
Porcine epidemic diarrhea virus (PEDV), an enteropathogenic coronavirus of significant veterinary importance, induces severe watery diarrhea and dehydration in swine populations, with mortality rates approaching 100% in neonatal piglets. A…
View article: Neutralizing antibody levels as a key factor in determining the immunogenic efficacy of the novel PEDV alpha coronavirus vaccine
Neutralizing antibody levels as a key factor in determining the immunogenic efficacy of the novel PEDV alpha coronavirus vaccine Open
Porcine epidemic diarrhea virus (PEDV) causes significant global agricultural losses. Despite commercial inactivated and live attenuated vaccines, persistent outbreaks underscore the need for more effective solutions. Here, we isolated a n…
View article: CRISPR mutant rapid identification in B. napus: RNA-Seq functional profiling and breeding technology application
CRISPR mutant rapid identification in B. napus: RNA-Seq functional profiling and breeding technology application Open
Introduction Traditional rapeseed breeding is inefficient and imprecise. CRISPR genome editing offers a precise alternative for trait improvement. Here, we edited the Bnaida gene in elite rapeseed cultivar ZS11 to study its role in floral …
View article: The Optimized HaloTag Technology Provides a Versatile Tool for Cell Imaging in Plants
The Optimized HaloTag Technology Provides a Versatile Tool for Cell Imaging in Plants Open
The innovative HaloTag is a labeling technology that plays a crucial role in advanced fluorescence imaging. However, due to the complexity of plant materials, the application of HaloTag technology in the field of plants is still in its inf…
View article: Dual-Targeting CD44 and Golgi-Directed Lipid Nanoparticles as Metabolic Nanoblockers for Precise Mitoxantrone Delivery and Cascade Eradication of Triple-Negative Breast Cancer
Dual-Targeting CD44 and Golgi-Directed Lipid Nanoparticles as Metabolic Nanoblockers for Precise Mitoxantrone Delivery and Cascade Eradication of Triple-Negative Breast Cancer Open
View article: Molecular mechanisms of melatonin in mitigating compound salt stress in Sophora alopecuroides revealed by physiological and transcriptomic profiling
Molecular mechanisms of melatonin in mitigating compound salt stress in Sophora alopecuroides revealed by physiological and transcriptomic profiling Open
View article: Dynamic Evolution and Impact Mechanism Analysis of China-Eu New Energy Vehicle Trade Network
Dynamic Evolution and Impact Mechanism Analysis of China-Eu New Energy Vehicle Trade Network Open
View article: Data mining and neural network modeling for teaching and learning in vocational education: promoting innovation in academic management and teaching reforms
Data mining and neural network modeling for teaching and learning in vocational education: promoting innovation in academic management and teaching reforms Open
In order to provide students with dynamic and personalized academic early warning services, and at the same time provide university administrators with data-supported decision-making, this paper uses data cleaning, transformation and norma…
View article: Genomic characterization and tissue tropism variations of two porcine delta coronavirus strains isolated in China
Genomic characterization and tissue tropism variations of two porcine delta coronavirus strains isolated in China Open
The porcine delta coronavirus (PDCoV) is a member of the Delta coronavirus genus, which can lead to diarrhea, vomiting, and mortality in piglets. First detected in Hong Kong in 2012, PDCoV has since spread globally. In January 2024, two st…
View article: The <i>BnaBPs</i> gene regulates flowering time and leaf angle in <scp><i>Brassica napus</i></scp>
The <i>BnaBPs</i> gene regulates flowering time and leaf angle in <span><i>Brassica napus</i></span> Open
The flowering time and plant architecture of Brassica napus were significantly associated with yield. In this study, we found that the BREVIPEDICELLUS / KNAT1 ( BP ) gene regulated the flowering time and plant architecture of B. napus . Ho…
View article: Research progress on the physiological response and molecular mechanism of cold response in plants
Research progress on the physiological response and molecular mechanism of cold response in plants Open
Low temperature is a critical environmental stress factor that restricts crop growth and geographical distribution, significantly impacting crop quality and yield. When plants are exposed to low temperatures, a series of changes occur in t…
View article: Contralateral prophylactic mastectomy for unilateral breast cancer in Chinese female population: a retrospective cohort study
Contralateral prophylactic mastectomy for unilateral breast cancer in Chinese female population: a retrospective cohort study Open
CPM was practiced for the first time since 2007 in our hospital. CPM does not provide any OS and DFS benefits compared to UM and the appearance satisfaction procedure was relatively low. Therefore, clinicians should fully communicate with …
View article: Integrative transcriptomic profiling of mRNA, miRNA, circRNA, and lncRNA in alveolar macrophages isolated from PRRSV-infected porcine
Integrative transcriptomic profiling of mRNA, miRNA, circRNA, and lncRNA in alveolar macrophages isolated from PRRSV-infected porcine Open
Introduction The porcine reproductive and respiratory syndrome virus (PRRSV) continues to pose a significant threat to the global swine industry, attributed largely to its immunosuppressive properties and the chronic nature of its infectio…
View article: Prognosis and Decision-making Analysis of Contralateral Prophylactic Mastectomy among female patients with stage 0–III unilateral breast cancer in Chinese population: a retrospective cohort study
Prognosis and Decision-making Analysis of Contralateral Prophylactic Mastectomy among female patients with stage 0–III unilateral breast cancer in Chinese population: a retrospective cohort study Open
Purpose It was demonstrated that contralateral prophylactic mastectomy (CPM) provides no survival benefit for patients with average risk breast cancer, but the application in patients with early-stage breast cancer has increased. This stud…
View article: Protective effects of hsa_circ_0072568 on interleukin‑1β‑stimulated human chondrocytes are mediated via the miR‑382‑5p/TOP1 axis
Protective effects of hsa_circ_0072568 on interleukin‑1β‑stimulated human chondrocytes are mediated via the miR‑382‑5p/TOP1 axis Open
Circular RNA (circRNA) dysregulation has been linked to osteoarthritis (OA). The present study investigated the involvement of hsa_circ_0072568 (circ0072568) in OA. The expression of circ0072568 was detected in OA tissues and interleukin (…
View article: Transcriptome Profiling of Vero E6 Cells during Original Parental or Cell-Attenuated Porcine Epidemic Diarrhea Virus Infection
Transcriptome Profiling of Vero E6 Cells during Original Parental or Cell-Attenuated Porcine Epidemic Diarrhea Virus Infection Open
Porcine epidemic diarrhea virus (PEDV) has led to significant economic losses in the global porcine industry since the emergence of variant strains in 2010. The high mutability of coronaviruses endows PEDV with the ability to evade the hos…
View article: Necroptosis-Related Modification Patterns Depict the Tumor Microenvironment, Redox Stress Landscape, and Prognosis of Ovarian Cancer
Necroptosis-Related Modification Patterns Depict the Tumor Microenvironment, Redox Stress Landscape, and Prognosis of Ovarian Cancer Open
Necroptosis is one of programmed cell death discovered recently, which involves in tumorigenesis, cancer metastasis, and immune reaction. We studied the necroptosis-related genes (NRGs) in ovarian cancer (OV) tissues using data from public…
View article: LncRNA MIR31HG controls the proliferation and metastasis of gastric cancer by c-CBL-mediated degradation of β-catenin
LncRNA MIR31HG controls the proliferation and metastasis of gastric cancer by c-CBL-mediated degradation of β-catenin Open
View article: Predicting the recurrence-free survival of phyllodes tumor of the breast: a nomogram based on clinicopathology features, treatment, and surgical margin
Predicting the recurrence-free survival of phyllodes tumor of the breast: a nomogram based on clinicopathology features, treatment, and surgical margin Open
Independent predictors related to PT prognosis were selected to establish a nomogram for predicting the RFS of PT. This nomogram was able to objectively stratify PT patients into prognostic groups and performed well in the internal validat…
View article: Exosome-Associated Gene Signature for Predicting the Prognosis of Ovarian Cancer Patients
Exosome-Associated Gene Signature for Predicting the Prognosis of Ovarian Cancer Patients Open
Background. The exosome is of vital importance throughout the entire progression of cancer. Because of the lack of effective biomarkers in ovarian cancer (OV), we intend to investigate the connection between exosomes and tumor immune micro…
View article: High Cycle Fatigue Life Prediction of Single-Crystal Specimen Based on TCD Method and Crystal Plasticity Theory
High Cycle Fatigue Life Prediction of Single-Crystal Specimen Based on TCD Method and Crystal Plasticity Theory Open
This paper performs a comprehensive investigation on the high cycle fatigue (HCF) life prediction of turbine blade with film cooling holes. The modified theory of critical distance (MTCD) method is proposed to estimate the fatigue life of …
View article: A Hypoxia Molecular Signature-Based Prognostic Model for Endometrial Cancer Patients
A Hypoxia Molecular Signature-Based Prognostic Model for Endometrial Cancer Patients Open
Endometrial cancer has the highest incidence of uterine corpus cancer, the sixth most typical cancer in women until 2020. High recurrence rate and frequent adverse events were reported in either standard chemotherapy or combined therapy. H…
View article: Functional Characterization of the Cystine-Rich-Receptor-like Kinases (CRKs) and Their Expression Response to Sclerotinia sclerotiorum and Abiotic Stresses in Brassica napus
Functional Characterization of the Cystine-Rich-Receptor-like Kinases (CRKs) and Their Expression Response to Sclerotinia sclerotiorum and Abiotic Stresses in Brassica napus Open
Cysteine-rich receptor-like kinases (CRKs) are transmembrane proteins that bind to the calcium ion to regulate stress-signaling and plant development-related pathways, as indicated by several pieces of evidence. However, the CRK gene famil…
View article: Plant Disease Resistance-Related Signaling Pathways: Recent Progress and Future Prospects
Plant Disease Resistance-Related Signaling Pathways: Recent Progress and Future Prospects Open
Plant–pathogen interactions induce a signal transmission series that stimulates the plant’s host defense system against pathogens and this, in turn, leads to disease resistance responses. Plant innate immunity mainly includes two lines of …
View article: Metabolomic analysis of porcine intestinal epithelial cells during swine acute diarrhea syndrome coronavirus infection
Metabolomic analysis of porcine intestinal epithelial cells during swine acute diarrhea syndrome coronavirus infection Open
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is an enveloped, positive single-stranded RNA virus belonging to Coronaviridae family , Orthocoronavirinae subfamily , Alphacoronavirus genus. As one of the main causes of swine diarrhea…