Explanipedia

Additively manufactured WE43 for biodegradable urinary devices: Exploring the corrosion profile under in vitro urinary tract conditions Open

Margarida Pacheco, F. D’Elia, Hanna Nilsson-Åhman, Estêvão Lima, Alexandre A. Barros , et al. · 2025

Fast-gelling gellan gum-based microparticulate powder for the treatment of complex cutaneous wounds Open

Lucília P. da Silva, Joana Pires, Cristiana Costa, Albina R. Franco, Rui L. Reis , et al. · 2025

Hard-to-heal complex wounds remain a clinical challenge due to the involvement of multiple tissue types and limited accessibility. In this study, gellan gum (GG)-based dry microparticulate powders were synthesized via spray-drying, incorpo…

Biomimetic hydrogel micro-/nanofibers for in situ soft tissue repair and regeneration Open

Bingcheng Yi, Xiaoyu Wang, Jiajia Yu, Jianbo Diao, Guangjun Wang , et al. · 2025

To effectively harness the regenerative potential of the body and orchestrate cellular responses for in situ tissue repair, the design of biomaterials requires careful consideration of precise modulation of biophysical and biochemic…

TNF-α driven inflammation in bone tissues using an anatomical- and bio-integrated hydroxyapatite-enriched spongy-like hydrogel 3D model Open

Ana Raquel Bastos, Lucília P. da Silva, Diana Soares da Costa, Rui L. Reis, Mariana Caldas · 2025

Inflammatory bone diseases like osteoporosis affect over 200 million people globally, yet the mechanisms by which acute inflammation progresses to chronic remain poorly understood. To address this, we developed an in vitro 3D cortical-spon…

Reinforced plant-derived lipid nanoparticles for oral precise epigenome editing in colonic diseases Open

Qiang Gao, Yunxia Gao, Yingui Cao, Haiting Xu, Ya Ma , et al. · 2025

The clinical application of CRISPR-Cas9 remains limited by delivery challenges, particularly for oral administration. Lysine-specific demethylase 1 ( Lsd1 ) plays a key role in colonic inflammation and tumorigenesis. Here, we developed an …

Implementation of a fully biodegradable and biomimetic epicardial patch providing synergic physico-chemical, mechanical and electrical cues for myocardial infarction therapy Open

Caterina Cristallini, Daniela Rossin, Niccoletta Barbani, Roberto Vanni, M. Labardi , et al. · 2025

The intrinsic limitation of myocardial tissue to self-repair after damage underscores the need for innovative approaches in addressing cardiac tissue damage post-myocardial infarction (MI). We aimed to develop an acellular, bioartificial, …

EFEITO FITOTERÁPICO DAS FAMÍLIAS LAMIACEAE MARTINOV E PASSIFLORACEAE NO AUXÍLIO DE TRATAMENTO DA ANSIEDADE: UMA REVISÃO DE LITERATURA Open

VICENTE IGHOR SILVA ITAPIREMA, ELISAMALIA MARQUES MELO, GISELE RODRIGUES CARVALHO, Marilisa Berti de Azevedo Barros, C. T. Sousa , et al. · 2025

Correction: PARP1 inhibitor combined with oxaliplatin efficiently suppresses oxaliplatin resistance in gastric cancer-derived organoids via homologous recombination and the base excision repair pathway Open

Huafu Li, Chunming Wang, Linxiang Lan, Wenhui Wu, Ian M. Evans , et al. · 2025

[This corrects the article DOI: 10.3389/fcell.2021.719192.].

Assessment of Lumbar Vertebrae L1–L7 and Proximal Femur Microstructure in Sheep as a Large Animal Model for Osteoporosis Research Open

José Arthur de Abreu Camassa, VERA A. BARROS, Pedro S. Babo, F.A.M. Pereira, J.J.L. Morais , et al. · 2025

Sheep have been widely used as a model for osteoporosis research. This study aimed to characterise changes in microstructure and composition in lumbar vertebrae L1–L7 and the proximal femur after implementation of a bone loss induction pro…

7. Valorização da Cortiça Orientada para a Inovação e Sustentabilidade Open

Ana R. Araújo, Emanuel M. Fernandes, Ana R. Araújo, Rui L. Reis · 2025

Ceragenin Nanogel Coating Prevents Biofilms Formation on Urinary Catheters Open

Antonio Puertas‐Segura, Antonio Laganà, Garima Rathee, Paul B. Savage, Katerina Todorovа , et al. · 2025

Catheter-associated urinary tract infections (CAUTIs) account for 40% of hospital-acquired infections, increasing health risks, patient discomfort, morbidity, and hospitalisation time. Bacterial colonisation may occur both during catheter …

Oral oncolytic magnetotactic bacteria elicit anti-colorectal tumor immunity and reprogram microbiota metabolism Open

Aodi Jiang, Baoyi Li, Menghang Zu, Li Chen, Chan Zhao , et al. · 2025

NPR1 Promotes Lipid Droplet Lipolysis to Enhance Mitochondrial Oxidative Phosphorylation and Fuel Gastric Cancer Metastasis Open

Huafeng Fu, Jie Zhang, Hengxing Chen, Haobin Hou, Huanjie Chen , et al. · 2025

Metabolic reprogramming driven by oncogenes plays a critical role in promoting and sustaining multiple steps of gastric cancer metastasis. However, the key metabolic driver of metastasis that can lead to the development of targeted therapi…

Use of Augmented Reality in the Design of Land Facilities Supporting Nuclear-Powered Submarines Open

Cristiane Lopes Canuto, Rui L. Reis, Paulo Caixeta de Oliveira, Douglas Brandão Baroni, Thiago Rampim de Marcos , et al. · 2025

This paper addresses the potential applications of Augmented Reality (AR) in the design and operation of nuclear facilities, focusing on terrestrial support facilities for nuclear-powered submarines. The inherent complexity in developing t…

Blades and barriers: Oral vaccines for conquering cancers and warding off infectious diseases Open

Kun Yang, Jinhua Liu, Yi‐Chang Zhao, Haiting Xu, Menghang Zu , et al. · 2025

Global public health faces substantial challenges from malignant tumors and infectious diseases. Vaccination provides an approach for treating and preventing these diseases. Oral vaccinations are particularly advantageous in disease treatm…

Desenvolvimento e avaliação de um aplicativo para autoconsciência e prevenção em saúde pública Open

Mayara Beatriz Marenda Narita, Monique Schreiner, Kawaljeet Singh, Katianne Thaiz de Sousa, R. Fraga , et al. · 2025

Objetivo: Desenvolver e avaliar o aplicativo JOIA®, analisando seu impacto na autoconsciência e prevenção em saúde, além de sua usabilidade, segurança e privacidade no sistema público de saúde. Métodos: O estudo ocorreu em duas etapas: 1) …

Conductive biological materials for in vitro models: properties and sustainability implications Open

Aleksandra Serafin, César R. Casanova, Arvind K. Singh Chandel, Rui L. Reis, Joaquím M. Oliveira , et al. · 2025

The integration of conductive biological materials into in vitro models represents a transformative approach to advancing biomedical research while addressing critical sustainability challenges. Traditional materials used in tissue enginee…

3D tubular constructs based on natural polysaccharides and recombinant polypeptide synergistic blends as potential candidates for blood vessel solutions Open

Luísa C. Rodrigues, Joana M. Gomes, Diana Soares da Costa, Emanuel M. Fernandes, Rui R. Costa , et al. · 2025

The development of versatile tubular structures is critical for tissue engineering (TE) applications where vascularization is necessary. This study investigates the fabrication of tubular shaped biomaterials focused on chitosan (CHT) combi…

Light-stimulated smart thermo-responsive constructs for enhanced wound healing: A streamlined command approach Open

Bingcheng Yi, Lei Yu, Yating Yang, Carlos F. Guimarães, Ruijie Xu , et al. · 2025

IMPORTÂNCIA DO RASTREIO PRECOCE PARA O TRANSTORNO DO ESPECTRO AUTISTA Open

Maria Clara de Oliveira Machado, Thales José Macedo Figueiredo, Otacylio Fernando Marinho Rodrigues Nicácio, Rui L. Reis, Joselina Luzia Menezes Oliveira · 2025

A biodegradable, microstructured, electroconductive and nano-integrated drug eluting patch (MENDEP) for myocardial tissue engineering Open

Caterina Cristallini, Daniela Rossin, Roberto Vanni, Niccoletta Barbani, Chiara Bulgheresi , et al. · 2025

Correction to “3D Protein-Based Bilayer Artificial Skin for the Guided Scarless Healing of Third-Degree Burn Wounds in Vivo” Open

Mazaher Gholipourmalekabadi, Alexander M. Seifalian, Aleksandra M. Urbanska, Mir Davood Omrani, John G. Hardy , et al. · 2025

O software de gestão educacional como contribuição tecnológica à gestão de um programa Open

Fabrício Magalhães Pereira, Rui L. Reis, Neilton da Silva · 2025

O gerenciamento da informação em ambientes educativos, com o uso das novas tecnologias digitais, tem contribuído para a melhoria da qualidade dos processos de ensino, aprendizagem e gestão, na medida em que acontece a articulação dos compo…

Correction: Enhanced effects of slowly co-released TGF-β3 and BMP-2 from biomimetic calcium phosphate-coated silk fibroin scaffolds in the repair of osteochondral defects Open

Jiping Chen, Yanyi Wang, Tianyi Tang, Baochao Li, Banani Kundu , et al. · 2025

Progress in enzyme-powered micro/nanomotors in diagnostics and therapeutics Open

Jinpeng Zhao, Banghui Wang, Mingzhe Yan, Yuxin Liu, Rongxuan Zhao , et al. · 2025

Bioaugmented design and functional evaluation of low damage implantable array electrodes Open

Ling Wang, Chenrui Zhang, Zhiyan Hao, Siqi Yao, Luge Bai , et al. · 2025

The effect of conditioned medium from human amniotic membrane-derived mesenchymal stem cells on thymus involution Open

Catarina S. Silva, Marta R. Casanova, Pedro Ferreirinha, Alain da Silva Morais, Hugo Osório , et al. · 2025

Experimental findings support the potential role of hAMMSC CM as a cell-free therapeutic strategy for thymus involution.

Bioinspired helical systems with defined chirality assembled from discrete peptide and glycan amphiphiles Open

Vânia I. B. Castro, Rui L. Reis, Ricardo A. Pires, Iva Pashkuleva · 2025

Development of supramolecular helices with controlled handedness is of upmost interest for better understanding of the chirality in bioenvironments and creation of functional artificial systems.

Bioprinting with Kidney Derived-Ecm for Extracellular Vesicle-Based Advanced Therapies Open

Rita Quinteira, Sara Gimondi, Maria Elena Melica, David Caballero, Ana Castanheira , et al. · 2025

SUSTENTABILIDADE EM SUA DIMENSÃO AMBIENTAL: IMPACTO AMBIENTAL DE UMA USINA SOLAR FOTOVOLTAICA DE 1 MW EM JUAZEIRINHO - PB Open

María Bernardo, Rui L. Reis, Monica Carvalho · 2025

Rui L. Reis YOU? Author Swipe