Rui Tang
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View article: Aging represses oncogenic KRAS-driven lung tumorigenesis and alters tumor suppression
Aging represses oncogenic KRAS-driven lung tumorigenesis and alters tumor suppression Open
Most cancers are diagnosed in people over 60 years of age, but little is known about how age impacts tumorigenesis. While aging is accompanied by mutation accumulation (widely understood to contribute to cancer risk) it is associated with …
View article: Generative neural physics enables quantitative volumetric ultrasound of tissue mechanics
Generative neural physics enables quantitative volumetric ultrasound of tissue mechanics Open
Tissue mechanics--stiffness, density and impedance contrast--are broadly informative biomarkers across diseases, yet routine CT, MRI, and B-mode ultrasound rarely quantify them directly. While ultrasound tomography (UT) is intrinsically su…
View article: Learning database optimization techniques: the state-of-the-art and prospects
Learning database optimization techniques: the state-of-the-art and prospects Open
Artificial intelligence-enabled database technology, known as AI4DB (Artificial Intelligence for Databases), is an active research area attracting significant attention and innovation. This survey first introduces the background of learnin…
View article: Cell cycle dysregulation of globally important SAR11 bacteria resulting from environmental perturbation
Cell cycle dysregulation of globally important SAR11 bacteria resulting from environmental perturbation Open
Genome streamlining is hypothesized to occur in bacteria as an adaptation to resource-limited environments, but can result in gene losses affecting fundamental aspects of cellular physiology. The most abundant marine microorganisms, SAR11 …
View article: Metabolomic insights into variable antihistamine responses in allergic rhinitis: unveiling biomarkers for precision treatment
Metabolomic insights into variable antihistamine responses in allergic rhinitis: unveiling biomarkers for precision treatment Open
Background The clinical response to antihistamine therapy exhibits substantial heterogeneity among individuals with allergic rhinitis (AR). While these medications represent a cornerstone in AR management, the molecular basis underlying di…
View article: Distinct metabolomic signatures in allergic rhinitis with concurrent chronic spontaneous urticaria: an untargeted metabolomics analysis reveals novel biomarkers and pathway alterations
Distinct metabolomic signatures in allergic rhinitis with concurrent chronic spontaneous urticaria: an untargeted metabolomics analysis reveals novel biomarkers and pathway alterations Open
Background Although allergic rhinitis (AR) and chronic spontaneous urticaria (CSU) share overlapping immunological pathways, their distinct clinical manifestations imply the involvement of unique underlying mechanisms. This study aimed to …
View article: Phased-Array Antenna Beam Control System Design Based on HLS Plus RTL Mode
Phased-Array Antenna Beam Control System Design Based on HLS Plus RTL Mode Open
Background: In recent years, the rising demand for high-performance radar systems in aeronautics, astronautics, national defense, and civil communication has driven the widespread application of phased-array technology. The design of beam …
View article: Glucocorticoid receptor inhibits Th2 immune responses by down-regulating Pparg and Gata3 in schistosomiasis
Glucocorticoid receptor inhibits Th2 immune responses by down-regulating Pparg and Gata3 in schistosomiasis Open
Introduction The Th2 immune response plays a pivotal role in the pathogenesis of schistosomiasis, contributing to the formation of hepatic granulomas and fibrosis. While the glucocorticoid receptor (GR) is a ubiquitously expressed nuclear …
View article: Explicit-Time Trajectory Tracking for a State-Constraint Continuum Free-Floating Space Robot with Smooth Joint-Path and Low Input
Explicit-Time Trajectory Tracking for a State-Constraint Continuum Free-Floating Space Robot with Smooth Joint-Path and Low Input Open
For the problem of large joint angular velocity and high input in the trajectory planning and control of robots, an explicit-time trajectory tracking for a state-constraint continuum free-floating space robot with smooth joint-path and low…
View article: Systematic evaluation and meta-analysis of acupuncture combined with prescription medicine or modern rehabilitation therapy for stroke-related pneumonia
Systematic evaluation and meta-analysis of acupuncture combined with prescription medicine or modern rehabilitation therapy for stroke-related pneumonia Open
View article: FTO Suppresses Perivascular Adipose Tissue Browning and Exacerbates Vascular Injury via m6a-Mediated Destabilization of Irx3 mRNA and the IRX3/UCP1
FTO Suppresses Perivascular Adipose Tissue Browning and Exacerbates Vascular Injury via m6a-Mediated Destabilization of Irx3 mRNA and the IRX3/UCP1 Open
View article: Cross-Cultural Adaptation and Validation of the Central Sensitization Inventory Among Chinese Patients with Chronic Non-Specific Low Back Pain
Cross-Cultural Adaptation and Validation of the Central Sensitization Inventory Among Chinese Patients with Chronic Non-Specific Low Back Pain Open
The CSI-CV exhibits excellent internal consistency, factor structure, and reliability. Its successful cultural adaptation offers valuable insights for improving treatment approaches for patients with CNSLBP.
View article: Using machine learning to identify risk factors for pancreatic cancer: a retrospective cohort study of real-world data
Using machine learning to identify risk factors for pancreatic cancer: a retrospective cohort study of real-world data Open
Objectives This study aimed to identify the risk factors for pancreatic cancer through machine learning. Methods We investigated the relationships between different risk factors and pancreatic cancer using a real-world retrospective cohort…
View article: MiR-4769-3p suppresses adipogenesis in systemic sclerosis by negatively regulating the USP18/VDAC2 pathway
MiR-4769-3p suppresses adipogenesis in systemic sclerosis by negatively regulating the USP18/VDAC2 pathway Open
View article: A Bayesian network meta-analysis of EGFR-tyrosine kinase inhibitor treatments in patients with EGFR mutation-positive non-small cell lung cancer
A Bayesian network meta-analysis of EGFR-tyrosine kinase inhibitor treatments in patients with EGFR mutation-positive non-small cell lung cancer Open
View article: S1PR3 inhibition protects against LPS-induced ARDS by inhibiting NF-κB and improving mitochondrial oxidative phosphorylation
S1PR3 inhibition protects against LPS-induced ARDS by inhibiting NF-κB and improving mitochondrial oxidative phosphorylation Open
Background Inflammation and endothelial barrier dysfunction are the major pathophysiological changes in acute respiratory distress syndrome (ARDS). Sphingosine-1-phosphate receptor 3 (S1PR3), a G protein-coupled receptor, has been found to…
View article: Aging represses lung tumorigenesis and alters tumor suppression
Aging represses lung tumorigenesis and alters tumor suppression Open
Most cancers are diagnosed in persons over the age of sixty, but little is known about how age impacts tumorigenesis. While aging is accompanied by mutation accumulation — widely understood to contribute to cancer risk — it is also associa…
View article: Silica's silent threat: Contributing to skin fibrosis in systemic sclerosis by targeting the HDAC4/Smad2/3 pathway
Silica's silent threat: Contributing to skin fibrosis in systemic sclerosis by targeting the HDAC4/Smad2/3 pathway Open
Nowadays, silica products are widely used in daily life, especially in skin applications, which inevitably increases the risk of silica exposure in general population. However, inadequate awareness of silica's potential hazards and lack of…
View article: Efficient and multiplexed somatic genome editing with Cas12a mice
Efficient and multiplexed somatic genome editing with Cas12a mice Open
Somatic genome editing in mouse models has increased our understanding of the in vivo effects of genetic alterations in areas ranging from neuroscience to cancer biology and beyond. However, existing models are limited in their ability to …
View article: TGF-β1 induces PD-1 expression in macrophages through SMAD3/STAT3 cooperative signaling in chronic inflammation
TGF-β1 induces PD-1 expression in macrophages through SMAD3/STAT3 cooperative signaling in chronic inflammation Open
Programmed cell death protein 1 (PD-1), a coinhibitory T cell checkpoint, is also expressed on macrophages in pathogen- or tumor-driven chronic inflammation. Increasing evidence underscores the importance of PD-1 on macrophages for dampeni…
View article: In-Situ Experiments of Dynamic Microscopic Reaction for Co2-Brine-Carbonate System
In-Situ Experiments of Dynamic Microscopic Reaction for Co2-Brine-Carbonate System Open
View article: CD1d protects against hepatocyte apoptosis in non-alcoholic steatohepatitis
CD1d protects against hepatocyte apoptosis in non-alcoholic steatohepatitis Open
Excessive and/or sustained hepatocyte apoptosis is critical in driving liver inflammation and injury. The mechanisms underlying the regulation of hepatocyte apoptosis in non-alcoholic steatohepatitis (NASH) remain largely unclear. Here, we…
View article: Prognostic value of IKBIP in papillary renal cell carcinoma
Prognostic value of IKBIP in papillary renal cell carcinoma Open
View article: Supplementary Table S2 from An LKB1–SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation
Supplementary Table S2 from An LKB1–SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation Open
Summary of published human lung adenocarcinoma datasets for which genotype and histological subtype annotations are available.
View article: Supplementary Table S5 from An LKB1–SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation
Supplementary Table S5 from An LKB1–SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation Open
Summary of GSEA analysis on Sik-targeted tumors using gene sets from previous publications centered on transcriptional profiling of the Lkb1-deficient state.
View article: Table S1 from A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS–Driven Lung Cancer
Table S1 from A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS–Driven Lung Cancer Open
Table S1. Mutation data of the genes that we selected for investigation.
View article: Supplementary Table S7 from An LKB1–SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation
Supplementary Table S7 from An LKB1–SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation Open
Summary of differences in Sik1-3 mRNA abundance between Lkb1-proficient and deficient contexts.
View article: Supplementary Table S5 from An LKB1–SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation
Supplementary Table S5 from An LKB1–SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation Open
Summary of GSEA analysis on Sik-targeted tumors using gene sets from previous publications centered on transcriptional profiling of the Lkb1-deficient state.
View article: Data from A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS–Driven Lung Cancer
Data from A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS–Driven Lung Cancer Open
Cancer genotyping has identified a large number of putative tumor suppressor genes. Carcinogenesis is a multistep process, but the importance and specific roles of many of these genes during tumor initiation, growth, and progression remain…
View article: Table S2 from A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS–Driven Lung Cancer
Table S2 from A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS–Driven Lung Cancer Open
Table S2. The information of sgRNA vectors in the high content Lenti-sgTS102/Cre pool.