Explanipedia

Causes of Death After Surgery Among Cancer Patients: A Population-based Cohort Study Open

Yuantao Hao, Chengcai Liang, Yifang Zhang, Xin Huang, Zhoukai Zhao , et al. · 2025

Introduction: Recent advancements in surgical techniques and perioperative care have improved cancer survival rates, yet postoperative comorbidity and mortality remain a critical concern. Despite progress in cancer control, systematic anal…

Phase separation of ERCC6L2–CtIP regulates the extent of DNA end resection Open

Yixin Yin, Jinlong Lin, Xiaoxia Cai, Run‐Cong Nie, Jiliang Lin , et al. · 2025

Novel surveillance protocol for gastric cancer based on CEA: a high-volume multi-center study Open

Ruopeng Zhang, Xiaojiang Chen, Guoming Chen, Zhoukai Zhao, Feiyang Zhang , et al. · 2025

Tumor markers are commonly used in gastric cancer patients, but their effectiveness in monitoring recurrences is not optimal. This study aims to evaluate the recurrence predictive performance of carcinoembryonic antigen (CEA) across differ…

Oxidative Stress Score as a Simplified Surrogate for Prognostic Stratification and Therapeutic Decision-Making in Multiple Myeloma Open

Qi Liang, Limei Zhang, Qianqian Huang, Weiran Lv, Zhijian Liang , et al. · 2025

Background: Oxidative stress contributes to the initiation and progression of multiple myeloma and can be reflected by various biochemical indicators. However, whether systemic oxidative stress level can serve as a simple and effective alt…

Safety and efficacy of perioperative dual PD-1 and HER2 blockade in HER2-positive gastric cancer Open

Run‐Cong Nie, Xiaojiang Chen, Chengcai Liang, Baiwei Zhao, Wei Wang , et al. · 2025

The use of trastuzumab and programmed death-1 (PD-1) inhibitor is effective in patients with HER2-positive advanced gastric or gastro-esophageal junction cancer; however, their use has not been investigated in patients with localized disea…

Hemostasis in Children with Chronic Liver Disease and Peri-liver Transplant Management Open

Run‐Cong Nie, Yixiao Pan, Zhifeng Xi, 康八郎古賀 · 2025

Hemostasis is significantly impaired in end-stage liver disease (ESLD), leading to frequent unexpected bleeding, thrombosis, or both, even with minimal irritation. Although conventional coagulation tests are insufficient to accurately asse…

TAOK1 promotes filament formation in HR repair through phosphorylating USP7 Open

Tian-Chen Zhu, Zhangping He, Shuting Li, Lin Zheng, X.F. Steven Zheng , et al. · 2025

Poly-ADP-ribose polymerase (PARP) inhibitors are vital therapeutic agents that exploit synthetic lethality, particularly effective in tumors with homologous recombination (HR) defects. However, broadening their clinical utility remains a s…

A circRNA–mRNA pairing mechanism regulates tumor growth and endocrine therapy resistance in ER-positive breast cancer Open

Yi Jia, Jiao Du, Xue Chen, Run‐Cong Nie, Guo-Sheng Hu , et al. · 2025

The molecular mechanisms underlying estrogen receptor (ER)-positive breast carcinogenesis and drug resistance remain incompletely understood. Elevated expression of CCND1 is linked to enhanced invasiveness, poorer prognosis, and resistance…

Perioperative tislelizumab plus chemotherapy for locally advanced gastroesophageal junction adenocarcinoma (NEOSUMMIT-03): a prospective, nonrandomized, open-label, phase 2 trial Open

Run‐Cong Nie, Shuqiang Yuan, Ya Ding, Yong-Ming Chen, Yuanfang Li , et al. · 2025

This prospective, nonrandomized, open-label phase 2 trial (Chinese Clinical Trial Registry, ChiCTR2200061906) aimed to evaluate the effectiveness of adding the PD-1 antibody tislelizumab to perioperative chemotherapy in patients with local…

ALKBH5 suppresses gastric cancer tumorigenesis and metastasis by inhibiting the translation of uncapped WRAP53 RNA isoforms in an m6A-dependent manner Open

Zi‐Qi Zheng, Feizhi Lin, Baiwei Zhao, Guoming Chen, Chengzhi Wei , et al. · 2025

Transcriptional landscape and predictive potential of long noncoding RNAs in peritoneal recurrence of gastric cancer Open

Xiaoxia Cai, Guo-Ming Chen, Zi‐Qi Zheng, Yixin Yin, Shuang Wang , et al. · 2024

Development and validation of a programmed cell death index to predict the prognosis and drug sensitivity of gastric cancer Open

Feizhi Lin, Xiaojiang Chen, Chengcai Liang, Ruopeng Zhang, Guoming Chen , et al. · 2024

Aim Programmed cell death (PCD) critically influences the tumor microenvironment (TME) and is intricately linked to tumor progression and patient prognosis. This study aimed to develop a novel prognostic indicator and marker of drug sensit…

CAF-macrophage crosstalk in tumour microenvironments governs the response to immune checkpoint blockade in gastric cancer peritoneal metastases Open

Yuanfang Li, Yongqiang Zheng, Jiaqian Huang, Run‐Cong Nie, Qi‐Nian Wu , et al. · 2024

Background Peritoneal metastasis is the most common metastasis pattern of gastric cancer. Patients with gastric cancer peritoneal metastasis (GCPM) have a poor prognosis and respond poorly to conventional treatments. Recently, immune check…

Novel Surveillance Protocol for Gastric Cancer Based on CEA: A high-volume multi-center study Open

Ruopeng Zhang, Xiaojiang Chen, Guoming Chen, Zhoukai Zhao, Feiyang Zhang , et al. · 2024

Tumor markers are commonly used in gastric cancer patients, but their effectiveness in monitoring recurrences is not optimal. This study aims to evaluate the recurrence predictive performance of carcinoembryonic antigen (CEA) across differ…

Multiple cell-death patterns predict the prognosis and drug sensitivity of melanoma patients Open

Zewei Chen, Ruopeng Zhang, Zhoukai Zhao, Baiwei Zhao, Feiyang Zhang , et al. · 2024

Background Melanoma, a malignant tumor of the skin, presents challenges in its treatment process involving modalities such as surgery, chemotherapy, and targeted therapy. However, there is a need for an ideal model to assess prognosis and …

Single-cell and spatial transcriptome analyses reveal tertiary lymphoid structures linked to tumour progression and immunotherapy response in nasopharyngeal carcinoma Open

Yang Liu, Shuangyan Ye, Shuai He, Dongmei Chi, Xiuzhi Wang , et al. · 2024

The efficacy of neoadjuvant immunotherapy combined with chemotherapy in elderly patients with gastric cancer: A subgroup analysis of the <span>NEOSUMMIT</span>‐01 study Open

Nan An, Run‐Cong Nie, Feng Wang, Shuqiang Yuan · 2024

Based on a subanalysis of the NEOSUMMIT-01 study, it was revealed that perioperative immune checkpoint blockade (ICB) combined with chemotherapy has therapeutic effects in elderly patients with locally advanced gastric cancer, providing a …

First-line immune checkpoint inhibitors in low programmed death-ligand 1-expressing population Open

Feiyang Zhang, Guoming Chen, Yixin Yin, Xiao‐Jiang Chen, Run‐Cong Nie , et al. · 2024

Introduction: Inhibitors of programmed cell death 1 (PD1) and its ligand (PDL1) have exhibited favorable long-term survival in many types of advanced-stage cancer and current approvals have to date been granted in certain tumour types irre…

Hyperactivation of mTOR/eIF4E Signaling Pathway Promotes the Production of Tryptophan‐To‐Phenylalanine Substitutants in EBV‐Positive Gastric Cancer Open

Zi‐Qi Zheng, Chengrui Zhong, Cheng‐Zhi Wei, Xiao‐Jiang Chen, Guo‐Ming Chen , et al. · 2024

Although messenger RNA translation is tightly regulated to preserve protein synthesis and cellular homeostasis, chronic exposure to interferon‐γ (IFN‐γ) in several cancers can lead to tryptophan (Trp) shortage via the indoleamine‐2,3‐dioxy…

Anti–<i>Helicobacter pylori</i> Treatment in Patients With Gastric Cancer After Radical Gastrectomy Open

Zhoukai Zhao, Ruopeng Zhang, Guoming Chen, Man Nie, Feiyang Zhang , et al. · 2024

Importance Whether anti– Helicobacter pylori treatment can provide survival benefits for patients with gastric cancer who are diagnosed with H pylori infection is an area with limited research. Objective To explore the potential survival b…

An interpretable deep learning model for identifying the morphological characteristics of dMMR/MSI-H gastric cancer Open

Xueyi Zheng, Bingzhong Jing, Zihan Zhao, Ruixuan Wang, Xinke Zhang , et al. · 2024

Accurate tumor diagnosis by pathologists relies on identifying specific morphological characteristics. However, summarizing these unique morphological features in tumor classifications can be challenging. Although deep learning models have…

Author Correction: Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial Open

Shuqiang Yuan, Run‐Cong Nie, Ying Jin, Chengcai Liang, Yuanfang Li , et al. · 2024

The role of computed tomography features in assessing response to neoadjuvant chemotherapy in locally advanced gastric cancer Open

Chengzhi Wei, Yun He, Ma Luo, Guoming Chen, Run‐Cong Nie , et al. · 2023

Objective To compare the computed tomography (CT) images of patients with locally advanced gastric cancer (GC) before and after neoadjuvant chemotherapy (NAC) in order to identify CT features that could predict pathological response to NAC…

STAG2 Regulates Homologous Recombination Repair and Sensitivity to ATM Inhibition Open

Jie Zhou, Run‐Cong Nie, Zhangping He, Xiao‐Xia Cai, Jie‐Wei Chen , et al. · 2023

Stromal antigen 2 (STAG2), a subunit of the cohesin complex, is recurrently mutated in various tumors. However, the role of STAG2 in DNA repair and its therapeutic implications are largely unknown. Here it is reported that knockout of STAG…

Residual circulating tumor DNA after adjuvant chemotherapy effectively predicts recurrence of stage II‐III gastric cancer Open

Shuqiang Yuan, Run‐Cong Nie, You‐Sheng Huang, Yingbo Chen, Siyu Wang , et al. · 2023

Background Circulating tumor DNA (ctDNA) is a promising biomarker for predicting relapse in multiple solid cancers. However, the predictive value of ctDNA for disease recurrence remains indefinite in locoregional gastric cancer (GC). Here,…

ASO Visual Abstract: Combined Use of Tumor Markers in Gastric Cancer—A Novel Method with Promising Prognostic Accuracy and Practicality Open

Ruopeng Zhang, Xiaojiang Chen, Guoming Chen, Zhoukai Zhao, Yicheng Wei , et al. · 2023

Correction: Preoperative diagnosis of metastatic lymph nodes by CT-histopathologic matching analysis in gastric adenocarcinoma using dual-layer spectral detector CT Open

Ma Luo, Guoming Chen, Hui Xie, Rong Zhang, Ping Yang , et al. · 2023

Prognostic Significance of PD-L1 Expression in Gastric Cancer Patients with Peritoneal Metastasis Open

Xiao‐Jiang Chen, Chengzhi Wei, Jun Lin, Ruo-Peng Zhang, Guoming Chen , et al. · 2023

Background: Recently, many studies have explored the relationship between the expression of programmed death ligand 1 (PD-L1) and prognosis in gastric cancer, but there is still controversy. Additionally, few studies have specifically inve…

Evaluating relapse-free survival as an endpoint for overall survival in adjuvant immunotherapy trials Open

Yuanfang Li, Shuqiang Yuan, Ying-Bo Chen, Man Nie, Jibin Li , et al. · 2023

Background Relapse-free survival (RFS) has been considered a primary endpoint to assess the effects of immunotherapy in the adjuvant setting among patients with early-stage disease. However, it is not clear whether RFS is a valid surrogate…

Combined use of tumor markers in gastric cancer: A novel method with promising prognostic accuracy and practicality Open

R. Zhang, Xiao‐Jiang Chen, Guoming Chen, Zhoukai Zhao, Yi-Cheng Wei , et al. · 2023

Background The effect of a single tumor marker on the prognosis of gastric cancer patients is not ideal. This study explored a novel prognostic assessment method for gastric cancer (GC) patients using a combination of three important tumor…

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