Rui T. Peixoto
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View article: Early postnatal dysfunction of ACC PV interneurons in Shank3B−/− mice
Early postnatal dysfunction of ACC PV interneurons in Shank3B−/− mice Open
Anterior cingulate cortex (ACC) dysfunction is implicated in the cognitive and social deficits associated with autism spectrum disorder (ASD), yet the developmental trajectory of ACC circuit maturation in ASD remains poorly understood. Her…
View article: Late onset of striatal projection neuron hyperexcitability in <i>Fmr1</i> -/y mice
Late onset of striatal projection neuron hyperexcitability in <i>Fmr1</i> -/y mice Open
Fragile X Syndrome (FXS), the most common genetic cause of intellectual disability and autism spectrum disorder (ASD), results from silencing of the FMR1 gene and consequent loss of Fragile X Messenger Ribonucleoprotein (FMRP). FMRP defici…
View article: Electroporation-Based Gene Delivery and Whole-Organoid Imaging in Human Retinal Organoids
Electroporation-Based Gene Delivery and Whole-Organoid Imaging in Human Retinal Organoids Open
Summary Human retinal organoids (hRetOrg) derived from human induced pluripotent stem cells (hiPSCs) have emerged as powerful in vitro systems for studying retinal development, modeling retinal diseases, and evaluating therapeutic strategi…
View article: Early Postnatal Dysfunction of ACC PV Interneurons in Shank3B<sup>-/-</sup>Mice
Early Postnatal Dysfunction of ACC PV Interneurons in Shank3B<sup>-/-</sup>Mice Open
Anterior cingulate cortex (ACC) dysfunction is implicated in the cognitive and social deficits associated with autism spectrum disorder (ASD) , yet the developmental trajectory of ACC circuit maturation in ASD remains poorly understood. He…
View article: Striatal output regulates the postnatal maturation of cortical circuits
Striatal output regulates the postnatal maturation of cortical circuits Open
The dorsomedial prefrontal cortex (dmPFC) is interconnected with the basal ganglia (BG) through large-scale circuit loops that regulate critical motor and cognitive functions. In mice, these circuits undergo extensive postnatal maturation …
View article: Decision letter: Maturation of cortical input to dorsal raphe nucleus increases behavioral persistence in mice
Decision letter: Maturation of cortical input to dorsal raphe nucleus increases behavioral persistence in mice Open
Full text Figures and data Peer review Side by side Abstract Editor's evaluation Introduction Results Discussion Methods Data availability References Article and author information Metrics Abstract The ability to persist toward a desired o…
View article: Late onset and regional heterogeneity of synaptic deficits in cortical PV interneurons of<i>Shank3B<sup>−/−</sup></i>mice
Late onset and regional heterogeneity of synaptic deficits in cortical PV interneurons of<i>Shank3B<sup>−/−</sup></i>mice Open
Epilepsy and epileptiform patterns of cortical activity are highly prevalent in autism spectrum disorders (ASDs), but the neural substrates and pathophysiological mechanisms underlying the onset of cortical dysfunction in ASD remains elusi…
View article: Raw data of manuscript "Tapered fibertrodes for opto-electrical neural interfacing in small brain volumes with reduced artefacts"
Raw data of manuscript "Tapered fibertrodes for opto-electrical neural interfacing in small brain volumes with reduced artefacts" Open
This dataset contains the raw data for the paper titled "Tapered fibertrodes for opto-electrical neural interfacing in small brain volumes with reduced artefacts".
View article: Raw data of manuscript "Tapered fibertrodes for opto-electrical neural interfacing in small brain volumes with reduced artefacts"
Raw data of manuscript "Tapered fibertrodes for opto-electrical neural interfacing in small brain volumes with reduced artefacts" Open
This dataset contains the raw data for the paper titled "Tapered fibertrodes for opto-electrical neural interfacing in small brain volumes with reduced artefacts".
View article: Raw data of manuscript "Tapered fibertrodes for opto-electrical neural interfacing in small brain volumes with reduced artefacts"
Raw data of manuscript "Tapered fibertrodes for opto-electrical neural interfacing in small brain volumes with reduced artefacts" Open
This dataset contains the raw data for the paper titled "Tapered fibertrodes for opto-electrical neural interfacing in small brain volumes with reduced artefacts"
View article: Tapered fibertrodes for optoelectrical neural interfacing in small brain volumes with reduced artefacts
Tapered fibertrodes for optoelectrical neural interfacing in small brain volumes with reduced artefacts Open
Deciphering the neural patterns underlying brain functions is essential to understanding how neurons are organized into networks. This deciphering has been greatly facilitated by optogenetics and its combination with optoelectronic devices…
View article: Transsynaptic Signaling by Activity-Dependent Cleavage of Neuroligin-1
Transsynaptic Signaling by Activity-Dependent Cleavage of Neuroligin-1 Open
Adhesive contact between pre- and postsynaptic neurons initiates synapse formation during brain development and provides a natural means of trans-synaptic signaling. Numerous adhesion molecules and their role during synapse development hav…
View article: Transcriptional regulation of MGE progenitor proliferation by PRDM16 controls cortical GABAergic interneuron production
Transcriptional regulation of MGE progenitor proliferation by PRDM16 controls cortical GABAergic interneuron production Open
The mammalian cortex is populated by neurons derived from neural progenitors located throughout the embryonic telencephalon. Excitatory neurons are derived from the dorsal telencephalon, while inhibitory interneurons are generated in its v…
View article: Transcriptional regulation of MGE progenitor proliferation by PRDM16 controls cortical GABAergic interneuron production
Transcriptional regulation of MGE progenitor proliferation by PRDM16 controls cortical GABAergic interneuron production Open
SUMMARY The mammalian cortex is populated by neurons derived from neural progenitors located throughout the embryonic telencephalon. Excitatory neurons are derived from progenitors located in the dorsal telencephalon, while inhibitory inte…
View article: Abnormal Striatal Development Underlies the Early Onset of Behavioral Deficits in Shank3B Mice
Abnormal Striatal Development Underlies the Early Onset of Behavioral Deficits in Shank3B Mice Open
The neural substrates and pathophysiological mechanisms underlying the onset of cognitive and motor deficits in autism spectrum disorders (ASDs) remain unclear. Mutations in ASD-associated SHANK3 in mice (Shank3B-/-) result in the accelera…