BACKGROUND Exosomal microRNAs (miRNAs) have emerged as promising biomarkers for cancer diagnosis due to their stability, tumor specificity, and accessibility. However, the diagnostic potential of serum exosomal miRNAs in metastatic pancreatic cancer remains underexplored. AIM To investigate the diagnostic potential of serum exosomal miRNAs in metastatic pancreatic cancer. METHODS A total of 36 patients were enrolled, comprising 8 patients in the discovery phase (4 with metastatic and 4 with non-metastatic pancreat…

PLK1 plays a crucial role in cell cycle regulation and cancer development, and its dysregulation has been implicated in the prognosis of a variety of malignancies. The potential of PLK1 inhibitors as cancer therapeutics has been extensively investigated. However, the underlying biology and mechanisms of PLK1 remain incompletely understood. In recent years, numerous studies have demonstrated that PLK1 overexpression is associated with resistance to certain chemotherapeutic agents, while its inhibition can enhance t…

Our data reveal a previously undescribed role for LSCC-sEVs in the regulation of M2 polarization of TAMs and immune cell function through STC1 mediated metabolic reprogramming.

This study suggests TIMP4 may serve as a novel complementary biomarker and potential therapeutic target in MN. Systematic integration of multi-omics and clinical data provides promising insights for future drug development and mechanistic exploration.

Background Advanced solid tumors in children have limited maintenance treatment options. This study assessed the effectiveness and safety of anlotinib in conjunction with sintilimab as maintenance therapy for advanced pediatric solid tumors in real-world settings. Methods This single-institution retrospective study was conducted at the Affiliated Cancer Hospital of Zhengzhou University from November 2019 to October 2023. Forty-six patients with advanced pediatric solid tumors who achieved partial response or stabl…