Ruichen Liu
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View article: Strategies for Precision Cancer Therapy via Active Delivery Systems: Recent Progress in Protein, Peptide, and Small-Molecule Ligands
Strategies for Precision Cancer Therapy via Active Delivery Systems: Recent Progress in Protein, Peptide, and Small-Molecule Ligands Open
Malignant tumors are one of the major diseases threatening human health. Although traditional surgery, radiotherapy, and chemotherapy have improved patient survival to some extent, their efficacy is limited and accompanied by severe side e…
View article: Multimodal radiomics of cerebellar subregions for machine learning-driven Alzheimer’s disease diagnosis
Multimodal radiomics of cerebellar subregions for machine learning-driven Alzheimer’s disease diagnosis Open
Objective This study aimed to develop a machine learning model based on multimodal radiomics features from cerebellar subregions, utilizing the complementarity of cerebellar structural and metabolic imaging data for accurate diagnosis of A…
View article: Mediation analysis for integrating motor symptoms of Parkinson’s disease, cognitive function, and gait characteristics
Mediation analysis for integrating motor symptoms of Parkinson’s disease, cognitive function, and gait characteristics Open
Background In Parkinson’s disease (PD) patients, the severity of motor symptoms is closely related to the degree of gait disorder and cognitive impairment; notably, the latter also exhibits a significant correlation with gait disorder. Evi…
View article: Quantitative analysis of gait parameters in Parkinson’s disease and the clinical significance
Quantitative analysis of gait parameters in Parkinson’s disease and the clinical significance Open
Background Gait disorder is one of the clinical manifestations of Parkinson’s disease (PD). Investigating the characteristics of gait disorder in patients with PD and the changes in gait before and after taking levodopa is crucial for the …
View article: GPU-Accelerated Monte Carlo Simulation and Experimental Study of Radiative Transfer in Multiple Scattering Media
GPU-Accelerated Monte Carlo Simulation and Experimental Study of Radiative Transfer in Multiple Scattering Media Open
Addressing the problem of photon multiple scattering interference caused by turbid media in optical measurements, biomedical imaging, environmental monitoring and other fields, existing Monte Carlo light scattering simulations widely adopt…
View article: <i><b>In Silico</b></i> Investigation of BTK as a Potent Immunomodulatory Target: Exploring Novel Therapeutic Approaches for Multiple Sclerosis
<i><b>In Silico</b></i> Investigation of BTK as a Potent Immunomodulatory Target: Exploring Novel Therapeutic Approaches for Multiple Sclerosis Open
Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease characterized by progressive neurological impairment. Bruton's tyrosine kinase (BTK) has emerged as a crucial therapeutic target due to its role in B-cell activation and…
View article: Nuclear p62/SQSTM1 facilitates ubiquitin-independent proteasomal degradation of BMAL1
Nuclear p62/SQSTM1 facilitates ubiquitin-independent proteasomal degradation of BMAL1 Open
Brain and muscle arnt-like protein 1(BMAL1) is a critical regulator of circadian rhythm. Although transcriptional regulation of BMAL1 has been extensively studied, the mechanisms governing the stability of BMAL1 at the protein level remain…
View article: Quantitative liquid chromatography-tandem mass spectrometric analysis of 11dH-TXB2 and creatinine in urine
Quantitative liquid chromatography-tandem mass spectrometric analysis of 11dH-TXB2 and creatinine in urine Open
View article: Engineering in-plane heterostructures on MoS2 by doping CoS for efficient hydrodeoxygenation
Engineering in-plane heterostructures on MoS2 by doping CoS for efficient hydrodeoxygenation Open
View article: Gpu-Accelerated Monte Carlo Simulation and Experimental Study of Radiative Transfer in Multiple Scattering Media
Gpu-Accelerated Monte Carlo Simulation and Experimental Study of Radiative Transfer in Multiple Scattering Media Open
View article: Visible light-driven selective oxidative transformation of vicinal diols using ZnS-based photocatalyst in the presence of molecular oxygen
Visible light-driven selective oxidative transformation of vicinal diols using ZnS-based photocatalyst in the presence of molecular oxygen Open
View article: Discovery of Orally Active Phenylquinoline-Based Soluble Epoxide Hydrolase Inhibitors with Anti-Inflammatory and Analgesic Activity
Discovery of Orally Active Phenylquinoline-Based Soluble Epoxide Hydrolase Inhibitors with Anti-Inflammatory and Analgesic Activity Open
Currently, there are no specific drugs for treating acute pancreatitis. Soluble epoxide hydrolase (sEH) inhibitors show promise, but face challenges like low blood drug concentrations and potential adverse effects on CYP enzymes and the hu…
View article: The Impact of K-pop Merchandise on the Consumer Behavior of University Students in Shanghai
The Impact of K-pop Merchandise on the Consumer Behavior of University Students in Shanghai Open
K-pop merchandise, as one of the main trends in current fashion development, is continuously expanding its audience and influence, particularly among teenagers. This paper conducts a comprehensive study on the impact of K-pop merchandise o…
View article: Research on Vegetables Sales Profit Based on Machine Learning
Research on Vegetables Sales Profit Based on Machine Learning Open
The sales volume of different vegetables in supermarkets is different, and the profit is different. The research on the profit of each category of vegetables can help supermarkets predict the sales revenue more accurately to improve invent…
View article: Research and Design of One-stop Intelligent Elderly Care Comprehensive Service Platform Based on Event-driven Architecture
Research and Design of One-stop Intelligent Elderly Care Comprehensive Service Platform Based on Event-driven Architecture Open
In the context of an aging population, innovative development of smart elderly care as a pension model not only offers a novel solution to address the increasing aging issue but also provides an alternative choice to cater to the expanding…
View article: Establishment of a method for the determination of hydrogen sulfide in human serum by liquid chromatography-tandem mass spectrometry and evaluation of its clinical application
Establishment of a method for the determination of hydrogen sulfide in human serum by liquid chromatography-tandem mass spectrometry and evaluation of its clinical application Open
View article: Discovery of a novel lead characterized by a stilbene-extended scaffold against sepsis as soluble epoxide hydrolase inhibitors
Discovery of a novel lead characterized by a stilbene-extended scaffold against sepsis as soluble epoxide hydrolase inhibitors Open
View article: Multiple Fault Detection and Appliance Classification Using Shuttle Attention-Based Model
Multiple Fault Detection and Appliance Classification Using Shuttle Attention-Based Model Open
View article: Result Prediction of Wordle Word Guessing Game Based on SVM And BP Neural Network Multi-Input-Multi-Output Regression Prediction Model
Result Prediction of Wordle Word Guessing Game Based on SVM And BP Neural Network Multi-Input-Multi-Output Regression Prediction Model Open
Wordle is a popular daily puzzle game in which players can guess a five-letter word in six or fewer attempts. In order to predict the distribution column of user participation and guessing results, this paper established a support vector m…
View article: The predictive value of preoperative luteinizing hormone to follicle stimulating hormone ratio for ovulation abnormalities recovery after laparoscopic sleeve gastrectomy: A prospective cohort study
The predictive value of preoperative luteinizing hormone to follicle stimulating hormone ratio for ovulation abnormalities recovery after laparoscopic sleeve gastrectomy: A prospective cohort study Open
Introduction Obesity-related ovulation abnormalities (OA) affect fertility. LSG is the most frequent bariatric operation. However, no research has identified a reliable indicator for predicting OA recovery after LSG. The purpose of this re…
View article: Efficient Load Identification Method Based on Time-Image Features and Dsdcn Model
Efficient Load Identification Method Based on Time-Image Features and Dsdcn Model Open
View article: Advances in traditional Chinese medicine as adjuvant therapy for diabetic foot
Advances in traditional Chinese medicine as adjuvant therapy for diabetic foot Open
Diabetes mellitus (DM) is a complex disease that often causes multiple systemic complications that have become a major international public health problem. Diabetic foot (DF) is one of the severe and frequent chronic complications of DM du…
View article: Vegetation Changes in Alberta Oil Sands, Canada, Based on Remotely Sensed Data from 1995 to 2020
Vegetation Changes in Alberta Oil Sands, Canada, Based on Remotely Sensed Data from 1995 to 2020 Open
There are rich oil and gas resources in Alberta oil sand mining area in Canada. In the 1960s, the Canadian government decided to increase the mining intensity. However, the exploitation will bring many adverse effects. In recent years, mor…
View article: Effect of Aerobic Exercise on Lipid Metabolism in Rats With NAFLD
Effect of Aerobic Exercise on Lipid Metabolism in Rats With NAFLD Open
This work aimed to study the intervention effect of exercise on lipid metabolism in NAFLD rats, provide a more scientific experimental basis for exploring and improving the theoretical system of exercise intervention in NAFLD, and further …
View article: [Retracted] Effect of Aerobic Exercise on Liver Tissue in Rats with NAFLD
[Retracted] Effect of Aerobic Exercise on Liver Tissue in Rats with NAFLD Open
Objective . To observe the improvement effect of aerobic exercise on liver tissue of rats with NAFLD, explore whether it can reduce NAFLD symptoms without drug dependence, and provide certain data support for the relief of NAFLD by aerobic…
View article: Design of Fuel Molecules Based on Variational Autoencoder
Design of Fuel Molecules Based on Variational Autoencoder Open
View article: Regulations of Glycolytic Activities on Macrophages Functions in Tumor and Infectious Inflammation
Regulations of Glycolytic Activities on Macrophages Functions in Tumor and Infectious Inflammation Open
Macrophages differentiated into a classically activated (M1) or alternatively activated phenotype (M2) in infection and tumor, but the precise effects of glycolysis and oxidative phosphorylation (OXPHOS) metabolic pathway remain unclear. H…
View article: Glucocorticoids Promote the Onset of Acute Experimental Colitis and Cancer by Upregulating mTOR Signaling in Intestinal Epithelial Cells
Glucocorticoids Promote the Onset of Acute Experimental Colitis and Cancer by Upregulating mTOR Signaling in Intestinal Epithelial Cells Open
The therapeutic effects of glucocorticoids on colitis and colitis-associated cancer are unclear. In this study, we investigated the therapeutic roles of glucocorticoids in acute experimental ulcerative colitis and colitis-associated cancer…
View article: Crucial role of histone deacetylase SIRT1 in myeloid-derived suppressor cell-mediated reprogramming of CD4+ T-cell differentiation
Crucial role of histone deacetylase SIRT1 in myeloid-derived suppressor cell-mediated reprogramming of CD4+ T-cell differentiation Open
View article: Metabolic regulation of inflammasomes in inflammation
Metabolic regulation of inflammasomes in inflammation Open
Summary Inflammasome activation and subsequent inflammatory cytokine secretion are essential for innate immune defence against multiple stimuli and are regarded as a link to adaptive immune responses. Dysfunction of inflammasome activation…