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View article: The paradigm shifts of periodontal regeneration strategy: From reparative manipulation to developmental engineering
The paradigm shifts of periodontal regeneration strategy: From reparative manipulation to developmental engineering Open
Ideal periodontal regeneration requires the integration of alveolar bone, periodontal ligament, and cementum, along with Sharpey's fibers for occlusal force resistance. However, physiological regeneration remains rare due to its intricate …
View article: Mechanoimmunomodulation-based strategy on advancing tissue-engineered nanotopographic structures
Mechanoimmunomodulation-based strategy on advancing tissue-engineered nanotopographic structures Open
The application of nanotopographic structures is considered a promising strategy for improving outcomes in tissue engineering. Nanotopographic structures-mediated immune responses have a more profound influence than the direct modulation o…
View article: Evolution of Biological Hydroxyapatite Modification Strategy: Anti-Inflammation Approach Rescues the Calcium–NOD-Like Receptor–Inflammation Axis-Mediated Periodontal Redevelopment Failure
Evolution of Biological Hydroxyapatite Modification Strategy: Anti-Inflammation Approach Rescues the Calcium–NOD-Like Receptor–Inflammation Axis-Mediated Periodontal Redevelopment Failure Open
Periodontal regenerative medicine is currently undergoing a paradigm shift from dissecting the healing process toward utilization of the developmental program. Biological hydroxyapatite (BHA), a major component of guided tissue regeneratio…
View article: Hypoxia‐Mimicking Mediated Macrophage‐Elimination of Erythrocytes Promotes Bone Regeneration via Regulating Integrin α<sub>v</sub>β<sub>3</sub>/Fe<sup>2+</sup>‐Glycolysis‐Inflammation
Hypoxia‐Mimicking Mediated Macrophage‐Elimination of Erythrocytes Promotes Bone Regeneration via Regulating Integrin α<sub>v</sub>β<sub>3</sub>/Fe<sup>2+</sup>‐Glycolysis‐Inflammation Open
Erythrocytes are the dominant component of a blood clot in terms of volume and number. However, longstanding compacted erythrocytes in blood clots form a physical barrier and make fibrin mesh more anti‐fibrinolytic, thus impeding infiltrat…
View article: Inducing the “re-development state” of periodontal ligament cells via tuning macrophage mediated immune microenvironment
Inducing the “re-development state” of periodontal ligament cells via tuning macrophage mediated immune microenvironment Open
The results of this study could provide some favorable theoretical bases for applying periodontal development engineering strategy in resolving the difficulties in periodontal multi-tissue regeneration.
View article: Nanotopographic micro-nano forces finely tune the conformation of macrophage mechanosensitive membrane protein integrin β2 to manipulate inflammatory responses
Nanotopographic micro-nano forces finely tune the conformation of macrophage mechanosensitive membrane protein integrin β2 to manipulate inflammatory responses Open
Supplementary material (primer sequences of target genes in RT-qPCR assay; the results of solvent accessible surface area during equilibrium simulation, the ligplut results of hydrogen bonds, and hydrophobic interactions; the density of di…