Explanipedia

Cerebral lesions in the central pain matrix are associated with headache in multiple sclerosis Open

Kilian Fröhlich, Kosmas Macha, Gabriela Siedler, Alexander Sekita, David Haupenthal , et al. · 2025

Pre-existing parasympathetic dominance seems to cause persistent heart rate slowing after 6 months of fingolimod treatment in patients with multiple sclerosis Open

Max J. Hilz, Federico Canavese, Carmen de Rojas-Leal, De-Hyung Lee, Ralf A. Linker , et al. · 2024

Pre-existing parasympathetic dominance seems to account for heart rate slowingafter six months of Fingolimod-treatment in patients with multiple sclerosis Open

Max J. Hilz, Federico Canavese, Carmen de Rojas Leal, De-Hyung Lee, Ralf A. Linker , et al. · 2024

Purpose: Vagomimetic Fingolimod effects cause heart-rate (HR) slowing upon treatment-initiation but wear off with Sphingosine-1-phosphate-receptor downregulation. Yet, prolonged HR-slowing may persist after months of Fingolimod-treatment. …

Correction to: Erectile Dysfunction Open

Max J. Hilz, Ruihao Wang, David B. Vodušek · 2024

The regulatory effects of the apelin/APJ system on depression: A prospective therapeutic target Open

Yanjun Tian, Ruihao Wang, Lin Liu, Wenhuan Zhang, Haiqing Liu , et al. · 2023

Depression is a debilitating neuropsychological disorder characterized by high incidence, high recurrence, high suicide, and high disability rates, which poses serious threats to human health and imposes heavy psychological and economic bu…

Cerebral lesions sites in neurosarcoidosis: a lesion mapping study Open

Kilian Fröhlich, Anne Mrochen, Ruihao Wang, David Haupenthal, Kosmas Macha , et al. · 2023

Cardiovascular autonomic regulation correlates with cognitive performance in patients with a history of traumatic brain injury Open

Ruihao Wang, Dafin F. Mureșanu, Katharina M. Hösl, Max J. Hilz · 2023

Atrial Fibrillation Detected before or after Stroke: Role of Anticoagulation Open

Flurina Lyrer, Annaelle Zietz, David Seiffge, Masatoshi Koga, Bastian Volbers , et al. · 2023

Background Atrial fibrillation (AF) known before ischemic stroke (KAF) has been postulated to be an independent category with a recurrence risk higher than that of AF detected after stroke (AFDAS). However, it is unknown whether this risk …

Role of STAT3 and NRF2 in Tumors: Potential Targets for Antitumor Therapy Open

Yanjun Tian, Haiqing Liu, Mengwei Wang, Ruihao Wang, Guandong Yi , et al. · 2022

Signal transducer and activator of transcription 3 (STAT3) and nuclear factor erythroid-derived 2-like 2 (NRF2, also known as NFE2L2), are two of the most complicated transcription regulators, which participate in a variety of physiologica…

Different functional lung-sparing strategies and radiotherapy techniques for patients with esophageal cancer Open

Pixiao Zhou, Ruihao Wang, Hui Yu, Ying Zhang, Guo-Qian Zhang , et al. · 2022

Background Integration of 4D-CT ventilation function images into esophageal cancer radiation treatment planning aimed to assess dosimetric differences between different functional lung (FL) protection strategies and radiotherapy techniques…

Automatic depression recognition by intelligent speech signal processing: A systematic survey Open

Pingping Wu, Ruihao Wang, Han Lin, Fanlong Zhang, Juan Tu , et al. · 2022

Depression has become one of the most common mental illnesses in the world. For better prediction and diagnosis, methods of automatic depression recognition based on speech signal are constantly proposed and updated, with a transition from…

Cardiovascular medication seems to promote recovery of autonomic dysfunction after stroke Open

Ruihao Wang, Martin Köhrmann, Rainer Kollmar, Julia Koehn, Stefan Schwab , et al. · 2022

Posterior circulation ischemic stroke not involving the brainstem is associated with cardiovascular autonomic dysfunction Open

Ruihao Wang, Martin Köhrmann, Rainer Kollmar, Julia Koehn, Stefan Schwab , et al. · 2022

Background and purpose Ischemic stroke may induce cardiovascular autonomic dysfunction, but most previous studies have included patients with anterior circulation ischemic stroke or brainstem stroke. It remains unclear whether posterior ci…

Aetiology, secondary prevention strategies and outcomes of ischaemic stroke despite oral anticoagulant therapy in patients with atrial fibrillation Open

Alexandros A. Polymeris, Thomas R. Meinel, Hannah Oehler, Kyra Hölscher, Annaelle Zietz , et al. · 2022

Objective To investigate the aetiology, subsequent preventive strategies and outcomes of stroke despite anticoagulation in patients with atrial fibrillation (AF). Methods We analysed consecutive patients with AF with an index imaging-prove…

Acute care and secondary prevention of stroke with newly detected versus known atrial fibrillation Open

Ruihao Wang, Kosmas Macha, David Haupenthal, Luise Gaßmann, Gabriela Siedler , et al. · 2022

Background and purpose Atrial fibrillation (AF) in stroke patients can be classified as either “known AF” (KAF), defined as AF confirmed before stroke onset, or “AF detected after stroke” (AFDAS), defined as AF diagnosed after stroke onset…

Validation of the Composite Autonomic Symptom Score 31 in the German language Open

Max J. Hilz, Ruihao Wang, Wolfgang Singer · 2021

Oral Anticoagulants in the Oldest Old with Recent Stroke and Atrial Fibrillation Open

Alexandros A. Polymeris, Kosmas Macha, Maurizio Paciaroni, Duncan Wilson, Masatoshi Koga , et al. · 2021

Objective To investigate the safety and effectiveness of direct oral anticoagulants (DOAC) versus vitamin K antagonists (VKA) after recent stroke in patients with atrial fibrillation (AF) aged ≥85 years. Methods Individual patient data ana…

IV-Thrombolysis in Ischemic Stroke With Unknown Time of Onset—Safety and Outcomes in Posterior vs. Anterior Circulation Stroke Open

Kosmas Macha, Philip Hoelter, Gabriela Siedler, Ruihao Wang, Michael Knott , et al. · 2021

Background: rt-PA for ischemic stroke in the unknown or extended time window beyond the first 4. 5 h after symptom onset is safe and effective for certain patients after selection by multimodal neuroimaging. However, the evidence for this …

Correction to: Neck cooling induces blood pressure increase and peripheral vasoconstriction in healthy persons Open

Julia Koehn, Ruihao Wang, Carmen de Rojas Leal, Bernd Kallmünzer, Klemens Winder , et al. · 2021

Prevalence and influencing factors of chronic post-traumatic stress disorder in patients with myocardial infarction, transient ischemic attack (TIA) and stroke – an exploratory, descriptive study Open

Aurora Dollenberg, Sebastian Moeller, Caroline Lücke, Ruihao Wang, Alexandra P. Lam , et al. · 2021

Occurence of Post-Traumatic Stress Symptoms, Anxiety and Depression in the Acute Phase of Transient Ischemic Attack and Stroke Open

Helge Müller, Katharina Czwalinna, Ruihao Wang, Caroline Lücke, Alexandra P. Lam , et al. · 2021

Cardiovascular fingolimod effects on rapid baroreceptor unloading are counterbalanced by baroreflex resetting Open

Max J. Hilz, Sankanika Roy, Carmen de Rojas Leal, Mao Liu, Federico Canavese , et al. · 2021

Occurence of post-traumatic stress symptoms, anxiety and depression in the acute phase of transient ischemic attack and stroke Open

Helge Müller, Katharina Czwalinna, Ruihao Wang, Caroline Lücke, Alexandra P. Lam , et al. · 2020

Background Rates of post-traumatic stress symptoms, anxiety and depression are increased in patients having experienced a transient ischemic attack (TIA) or stroke several months ago. However, data of psychiatric symptoms in the acute phas…

Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP Open

Shi Changhe, Jonathan C. Schisler, Carrie E. Rubel, Song Tan, Bo Song , et al. · 2020

Gordon Holmes syndrome (GHS) is a rare Mendelian neurodegenerative disorder characterized by ataxia and hypogonadism. Recently, it was suggested that disordered ubiquitination underlies GHS though the discovery of exome mutations in the E3…

Neck cooling induces blood pressure increase and peripheral vasoconstriction in healthy persons Open

Julia Koehn, Ruihao Wang, Carmen de Rojas Leal, Bernd Kallmünzer, Klemens Winder , et al. · 2020

Rapid titration protocol – Experiences with a dynamic novel titration regime for vagus nerve stimulation in a group of depressive patients Open

Sebastian Moeller, Ruihao Wang, Merve Aydın, Alexandra P. Lam, Aileen Sitter , et al. · 2019

Vagus nerve stimulation (VNS) is an established tool in the psychiatric armamentarium for patients with therapy-resistant depression (TRD) with response rates of approximately 60%. So far, VNS is titrated slowly during ambulatory in-office…

Cerebral lesion correlates of sympathetic cardiovascular activation in multiple sclerosis Open

Klemens Winder, Ralf A. Linker, Frank Seifert, Ruihao Wang, De‐Hyung Lee , et al. · 2019

Cardiovascular autonomic dysfunction is common in multiple sclerosis (MS) and contributes significantly to disability. We hypothesized that cerebral MS‐lesions in specific areas of the central autonomic network might account for imbalance …

Chorea and the effectiveness of steroids in a patient with the syndrome of transient headache with neurologic deficits and cerebrospinal fluid lymphocytosis: a case report Open

Lu Zhao, Ruihao Wang, Hui Fang, Bo Song, Dongyi Liang , et al. · 2019

Chorea may also present in the HaNDL syndrome. Steroids might relieve the symptoms of the HaNDL syndrome, which indicates the possible treatment strategy for HaNDL and supports the infectious or postinfectious autoimmune etiology hypothesi…

Severity of traumatic brain injury correlates with long-term cardiovascular autonomic dysfunction Open

Max J. Hilz, Ruihao Wang, Jörg Markus, F. Ammon, Katharina M. Hösl , et al. · 2017

After traumatic brain injury (TBI), central autonomic dysfunction might contribute to long-term increased mortality rates. Central autonomic dysfunction might depend on initial trauma severity. This study was performed to evaluate differen…

Nine-hole Peg Test and Ten-meter Walk Test for Evaluating Functional Loss in Chinese Charcot-Marie-Tooth Disease Open

Hui-xia Niu, Ruihao Wang, Hong‐Liang Xu, Bo Song, Jing Yang , et al. · 2017

The 9-HPT and 10-MWT might be useful for functional assessment in Chinese patients with CMT.

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