Explanipedia

Evaluation of antiviral activity of organic-polyoxometalate hybrids based on Berberine against Encephalomyocarditis virus <em>in vitro</em> Open

Chunxia Tan, Jing Zhao, Zizhen Huang, Jean Hou, Tengyu Zhang , et al. · 2025

Gallic acid inhibits EMCV infection via targeting the interaction between TBK1 and IRF3 to promote IFN-β expression Open

Yan Zhang, Yanqiao Wen, Wanjiang Xue, Tengyu Zhang, Jean Hou , et al. · 2025

Encephalomyocarditis virus (EMCV) is an important zoonotic pathogen with global distribution, which has caused huge serious economic losses to the development of the livestock industry. Gallic acid (GA) is an active ingredient of tradition…

An RNAi Therapy That Attenuates Multi-Organ Viremia and Improves Animal Survival in a Lethal EMCV Challenge Model Open

Yaxin Zhang, Jiayu Yue, Bei Wu, Jingying Xie, Jiying Xu , et al. · 2025

Encephalomyocarditis virus (EMCV) is an important zoonotic pathogen that infects many animals with mild symptoms. However, swine is the most receptive host and causes acute and lethal myocarditis and/or encephalitis, and induces sudden dea…

FinGAIA: A Chinese Benchmark for AI Agents in Real-World Financial Domain Open

Lingfeng Zeng, F. Lou, Zixuan Wang, Jiajie Xu, Junfeng Niu , et al. · 2025

The booming development of AI agents presents unprecedented opportunities for automating complex tasks across various domains. However, their multi-step, multi-tool collaboration capabilities in the financial sector remain underexplored. T…

ICAM-1-mediated Src signaling pathway plays a pivotal role in encephalomyocarditis virus entry Open

Ruiya Lian, Xueer Dou, Na Wang, Shasha Li, Jingying Xie , et al. · 2025

Encephalomyocarditis virus (EMCV), a potential zoonotic pathogen with a broad host range, has been reported to enter cells via caveolin-mediated endocytosis (CavME), a process initiated by caveolae detachment from the plasma membrane. Howe…

Encephalomyocarditis virus non-structural protein 2C degrades NDP52 autophagy protein to promote its own survival Open

Rongqian Mo, Rongrong Cheng, Ping Dong, Tingting Ma, Yaxin Zhang , et al. · 2024

Encephalomyocarditis virus (EMCV) is an important zoonotic pathogen that causes encephalitis and myocarditis, primarily in pigs and in some mammals. Nuclear dot protein (NDP) 52 is an important autophagy adaptor protein that is known to ta…

EMCV VP2 degrades IFI16 through Caspase-dependent apoptosis to evade IFI16-STING pathway Open

Ruofei Feng, Dianyu Li, Zhenfang Yan, Xiangrong Li, Jingying Xie · 2024

The complex interplay between encephalomyocarditis virus and the host defence system Open

Jingying Xie, Adi Idris, Ruofei Feng · 2024

A variety of animals can be infected by encephalomyocarditis virus (EMCV). EMCV is the established causative agent of myocarditis and encephalitis in some animals. EMCV causes high fatality in suckling and weaning piglets, making pigs the …

Encephalomyocarditis Virus Structural Protein VP3 Interacts with MAVS and Promotes its Autophagic Degradation to Interfere with the Type I Interferon Signaling Pathway Open

Xu Zhao, Zhengyang Hou, Yaxin Zhang, Daoqin Mao, Zhenfang Yan , et al. · 2024

Background: Understanding the mechanisms through which interferon (IFN) signaling is negatively regulated is crucial for preserving the equilibrium of innate immune reactions, as the innate immune system functions, such as the original bar…

Pseudorabies virus VHS protein abrogates interferon responses by blocking NF-κB and IRF3 nuclear translocation Open

Zhenfang Yan, Jiayu Yue, Yaxin Zhang, Zhengyang Hou, Dianyu Li , et al. · 2024

Mammalian orthoreovirus capsid protein σ3 antagonizes RLR-mediated antiviral responses by degrading MAVS Open

Dianyu Li, Rongqian Mo, Xiaoyi Li, Rongrong Cheng, Jingying Xie , et al. · 2024

Mammalian orthoreovirus (MRV) outer capsid protein σ3 is a multifunctional protein containing a double-stranded RNA-binding domain, which facilitates viral entry and assembly. We reasoned that σ3 has an innate immune evasion function. Here…

Pseudorabies virus UL38 attenuates the cGAS-STING signaling pathway by recruiting Tollip to promote STING for autophagy degradation Open

Zhenfang Yan, Jingying Xie, Zhengyang Hou, Yaxin Zhang, Jiayu Yue , et al. · 2024

Mammalian reovirus µ1 protein attenuates RIG-I and MDA5-mediated signaling transduction by blocking IRF3 phosphorylation and nuclear translocation Open

Bei Wu, Dianyu Li, Huisheng Bai, Rongqian Mo, Hongshan Li , et al. · 2024

Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-β Signaling Pathway Open

Y.F. Song, Huixia Li, Ruiya Lian, Xueer Dou, Shasha Li , et al. · 2024

Histone H1.2 is a member of the linker histone family, which plays extensive and crucial roles not only in the regulation of chromatin dynamics, cell cycle, and cell apoptosis, but also in viral diseases and innate immunity response. Recen…

IFITM2 Presents Antiviral Response through Enhancing Type I IFN Signaling Pathway Open

Lei Chen, Xiangrong Li, Yingying Deng, Yingjie Bi, Zhenfang Yan , et al. · 2023

Interferon (IFN) helps cells fight viral infections by further inducing the expression of many downstream IFN-stimulated genes (ISGs). Human interferon-inducible transmembrane proteins (IFITM) are one of these ISGs. The antiviral function …

HSP27 Attenuates cGAS-Mediated IFN-β Signaling through Ubiquitination of cGAS and Promotes PRV Infection Open

Xiangrong Li, Jingying Xie, Dianyu Li, Hongshan Li, Yuhui Niu , et al. · 2022

Pseudorabies (PR) is a domestic and wild animal infectious disease caused by the pseudorabies virus (PRV) and is one of the major infectious diseases that endanger the global swine industry. Studies have reported that PRV may achieve cross…

DDX56 inhibits PRV replication through regulation of IFN-β signaling pathway by targeting cGAS Open

Jingying Xie, Xiangrong Li, Shunyu Yang, Zhenfang Yan, Lei Chen , et al. · 2022

Pseudorabies virus (PRV) is an agent of Aujeszky's disease, and causes great economic losses to pig farming. Re-outburst of pseudorabies implies that new control measures are urgently needed. We show here that DDX56 possesses the ability t…

Pseudorabies Virus ICP0 Abolishes Tumor Necrosis Factor Alpha-Induced NF-κB Activation by Degrading P65 Open

Xiangbo Zhang, Jingying Xie, Ming Gao, Zhenfang Yan, Lei Chen , et al. · 2022

Nuclear factor κB (NF-κB) is involved in a wide range of innate immune activities in host cells and serves as an important component of a host’s immunity system. To survive in infected cells, viruses have evolved intricate strategies to ev…

DDX56 antagonizes IFN-β production to enhance EMCV replication by inhibiting IRF3 nuclear translocation Open

Shujuan Xu, Jingying Xie, Xiangbo Zhang, Lei Chen, Yingjie Bi , et al. · 2021

HSP27 Protein Dampens Encephalomyocarditis Virus Replication by Stabilizing Melanoma Differentiation-Associated Gene 5 Open

Xiangrong Li, Ruixian Ma, Bei Wu, Yuhui Niu, Hongshan Li , et al. · 2021

Heat shock proteins (HSPs) are a protein family that respond to physiological stress, such as heat, starvation, and infection. As cellular protein chaperones, they play an important role in protein folding, assembly, and degradation. Thoug…

Pseudorabies Virus US3 Protein Inhibits IFN-β Production by Interacting With IRF3 to Block Its Activation Open

Jingying Xie, Xiangbo Zhang, Lei Chen, Yingjie Bi, Adi Idris , et al. · 2021

Pseudorabies virus is a typical swine alphaherpesvirus, which can cause obvious neurological disorders and reproductive failure in pigs. It is capable of evading host antiviral immune response. However, the mechanism by which many PRV prot…

[Application of pegylated recombinant human granulocyte colony stimulating factor in mobilization of autologous peripheral blood stem cells]. Open

T Wang, Ruofei Feng, J T Li, Shangwei Ning, Yanping Yang , et al. · 2021

Encephalomyocarditis Virus Abrogates the Interferon Beta Signaling Pathway via Its Structural Protein VP2 Open

Yumei Han, Jingying Xie, Shujuan Xu, Yingjie Bi, Xiangrong Li , et al. · 2020

Encephalomyocarditis virus is an important pathogen that can cause encephalitis, myocarditis, neurological diseases, and reproductive disorders. It also causes huge economic losses for the swine industry worldwide.

Host antiviral protein IFITM2 restricts pseudorabies virus replication Open

Jingying Xie, Yingjie Bi, Shujuan Xu, Yumei Han, Adi Idris , et al. · 2020

EMCV Replication in BHK-21 in Vitro is Mediated by Caveolin-1, Actin, Dynamin-Dependent Endocytic Pathway Open

Qiongyi Li, Yang Liu, Shujuan Xu, Kexue Zhao, Ying Ling , et al. · 2020

Background: Encephalomycarditis virus is a member of Cardiovirus , belongs to the family Picornaviridae , and can infect different domestic and wild animals. However, the endocytic pathway by which EMCV infected BHK-21 cells remains unclea…

Transmembrane Protein 39A Promotes the Replication of Encephalomyocarditis Virus via Autophagy Pathway Open

Xiangrong Li, Ruixian Ma, Qian Li, Shengjun Li, Haixia Zhang , et al. · 2019

Encephalomyocarditis virus (EMCV) causes encephalitis, myocarditis, neuropathy, reproductive disorders, and diabetes in animals. EMCV is known to induce cell autophagy; however, the molecular mechanisms underlying this remain unclear. Here…

TaqMan real-time PCR for detecting bovine viral diarrhea virus Open

Huipeng Liang, Ji Geng, Shengju Bai, A. Aimuguri, Zhuandi Gong , et al. · 2019

The present study was aimed to establish a novel TaqMan real-time PCR (RTm-PCR) for detecting and typing bovine viral diarrhea virus (BVDV), and also to develop a diagnostic protocol which simplifies sample collection and processing. Unive…

Synchronous Detection of BPV and BVDV with Duplex Taqman qPCR Method Open

Zhuandi Gong, Xiaoyun Shen, Haoqin Liang, Jin-jing Geng, Qion-yi Li , et al. · 2019

Background: Bovine parvovirus (BPV) and bovine viral diarrhea virus (BVDV) are commonly etiologies causing diarrhea in dairy herds. BPV is a member of bocaparvovirus genus with a non-enveloped capsid. BVDV, belonging to Pestivirus genus in…

儿科皮肤病专家和风湿病专家对 CLASI 的评估 Open

Carolyn J. Kushner, M. Tarazi, Rebecca G. Gaffney, Ruofei Feng, Kaveh Ardalan , et al. · 2019

术语“红斑狼疮”指的是一系列相关疾病。多达 70–80% 的狼疮患者将在他们疾病进程的一些时间点发生皮损(异常斑片)。影响皮肤的狼疮类型统称为皮肤红斑狼疮(CLE)。皮肤红斑狼疮疾病面积和严重程度指数 (CLASI) 是对 CLE 患者中皮肤症状严重程度进行分类的一种工具。能够准确可靠地测量皮损是监测某种疾病任何改善或恶化的一种重要方式,有助于在临床试验中观察某种治疗是否有效。已知 CLASI 在成人中是一种可靠(准确)的测量手段,但来自美国的研究者们进行了这项研究,以验证…

SAT0512 Safety and efficacy of lenabasum in refractory skin-predominant dermatomyositis subjects treated in an open label extension of trial jbt101-dm-001 Open

Victoria P. Werth, Basil Patel, Josef Concha, Joyce Okawa, David R. Pearson , et al. · 2018

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