Rufei Shen
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View article: The role of dysregulated copper metabolism in diabetes and its complications: a review
The role of dysregulated copper metabolism in diabetes and its complications: a review Open
Copper (Cu) is an essential trace element for the human body. It significantly affects physiological and pathological processes by regulating various biological pathways, such as mitochondrial proteolipid acylation and glycolysis. Abnormal…
View article: Effects of Hormones on Left Heart Structure and Function with Echocardiography in Acromegaly
Effects of Hormones on Left Heart Structure and Function with Echocardiography in Acromegaly Open
Background: The relationship between growth hormone (GH) and changes in cardiac morphology and function in the current study has not been fully elucidated, and this study aimed to assess the effect of hormonal factors on left ventricular s…
View article: Application of a glasses-free 3D laparoscopic system in radical gastrointestinal cancer surgery
Application of a glasses-free 3D laparoscopic system in radical gastrointestinal cancer surgery Open
BACKGROUND The clinical application of autostereoscopic (glass-free) 3D laparoscopic systems in the radical resection of gastrointestinal malignancies remains to be fully evaluated. AIM To compare the surgical outcomes and short-term posto…
View article: A Report of Primary Pyogenic Ventriculitis Caused by Streptococcus Constellatus Diagnosed by Metagenomic Next-Generation Sequencing
A Report of Primary Pyogenic Ventriculitis Caused by Streptococcus Constellatus Diagnosed by Metagenomic Next-Generation Sequencing Open
Key insights from this case include: 1) mNGS is an invaluable tool for the early and accurate diagnosis of primary ventriculitis; 2) MRI is indispensable for identifying characteristic radiological features of the condition; 3) prompt init…
View article: Efficacy of GnRH Pulses in Hypogonadism Secondary to Primary Empty Sella: Case Report
Efficacy of GnRH Pulses in Hypogonadism Secondary to Primary Empty Sella: Case Report Open
This study aims to assess the effectiveness of pulsed gonadotropin-releasing hormone (GnRH) micropump replacement therapy in the treatment of hypogonadotropic hypogonadism (HH) caused by primary empty sella (PES).The efficacy of pulsed GnR…
View article: Effects and plasma proteomic analysis of GLP-1RA versus CPA/EE, in combination with metformin, on overweight PCOS women: a randomized controlled trial
Effects and plasma proteomic analysis of GLP-1RA versus CPA/EE, in combination with metformin, on overweight PCOS women: a randomized controlled trial Open
Purpose Polycystic ovary syndrome (PCOS) is characterized by reproductive dysfunctions and metabolic disorders. This study aims to compare the therapeutic effectiveness of glucagon-like peptide-1 receptor agonist (GLP-1RA) + Metformin (Met…
View article: Differences in Clinical Characteristics and Surgical Outcomes of Patients with Ischemic and Hemorrhagic Pituitary Adenomas
Differences in Clinical Characteristics and Surgical Outcomes of Patients with Ischemic and Hemorrhagic Pituitary Adenomas Open
Objective : Ischemia and hemorrhage of pituitary adenomas (PA) caused important clinical syndrome. However, the differences on clinical characteristics and surgical outcomes between these two kinds apoplexy were less reported.Methods : A r…
View article: Pleiomorphism plurihormonal Pit-1-positive macroadenoma with central hyperthyroidism: a rare case report and literature review
Pleiomorphism plurihormonal Pit-1-positive macroadenoma with central hyperthyroidism: a rare case report and literature review Open
Background Thyrotropin-secreting pituitary neuroendocrine tumors (PitNETs) are rare pituitary adenomas that are occasionally accompanied by hypersecretion of other anterior pituitary hormones, such as growth hormone (GH) and prolactin (PRL…
View article: An Asian case of combined 17α-hydroxylase/17,20-lyase deficiency due to homozygous p.R96Q mutation: A case report and review of the literature
An Asian case of combined 17α-hydroxylase/17,20-lyase deficiency due to homozygous p.R96Q mutation: A case report and review of the literature Open
Background Combined 17α-hydroxylase/17,20-lyase deficiency (17-OHD) is a very rare form of congenital adrenal hyperplasia (CAH) caused by mutations in the CYP17A1 gene. Almost 100 different mutations of the CYP17A1 gene have been reported,…
View article: Clinical Characteristics and Associated Factors of Colonic Polyps in Acromegaly
Clinical Characteristics and Associated Factors of Colonic Polyps in Acromegaly Open
Purpose To investigate the clinical characteristics and associated factors of colonic polyps in patients with acromegaly. Methods Clinical characteristics and colonoscopy findings of 86 acromegaly patients who received treatment were retro…
View article: Plurimorphous plurihormonal Pit-1 positive macroadenoma with central hyperthyroidism: a rare case report and literature review
Plurimorphous plurihormonal Pit-1 positive macroadenoma with central hyperthyroidism: a rare case report and literature review Open
Background Thyrotropin (TSH)-secreting pituitary neuroendocrine tumors (PitNETs) are pretty rare pituitary adenomas, occasionally accompanied by hypersecretion of other anterior pituitary hormones: growth hormone (GH) and prolactin (PRL). …
View article: Identification of Key Genes and Pathways in Peripheral Blood Mononuclear Cells of Type 1 Diabetes Mellitus by Integrated Bioinformatics Analysis
Identification of Key Genes and Pathways in Peripheral Blood Mononuclear Cells of Type 1 Diabetes Mellitus by Integrated Bioinformatics Analysis Open
Background: The onset and progression of type 1 diabetes mellitus (T1DM) is closely related to autoimmunity. Effective monitoring of the immune system and developing targeted therapies are frontier fields in T1DM treatment. Currently, the …
View article: Clinical Characteristics And Associated Factors Of Colonic Polyps In Acromegaly
Clinical Characteristics And Associated Factors Of Colonic Polyps In Acromegaly Open
Purpose: This study investigates the clinical characteristics and the associated factors of colonic polyps in patients with acromegaly.Methods: We retrospectively reviewed clinical characteristics and colonoscopy findings of 86 acromegalic…
View article: Effects of GLP-1R agonist or co-cyprindiol, in combination with metformin, on polycystic ovary syndrome in overweight women: A Randomized Clinical Trial
Effects of GLP-1R agonist or co-cyprindiol, in combination with metformin, on polycystic ovary syndrome in overweight women: A Randomized Clinical Trial Open
Objective:Polycystic ovary syndrome (PCOS) is characterized by reproductive dysfunctions and metabolic disorders. This study aims to compare the therapeutic effectiveness of glucagon-like peptide-1 receptor agonist (GLP-1RA) + Metformin (M…
View article: Case Report: A Deletion Variant in the DCAF17 Gene Underlying Woodhouse-Sakati Syndrome in a Chinese Consanguineous Family
Case Report: A Deletion Variant in the DCAF17 Gene Underlying Woodhouse-Sakati Syndrome in a Chinese Consanguineous Family Open
Woodhouse-Sakati syndrome (WSS, MIM 241080) is a rare neuroendocrine disease characterized by hair loss, hypogonadism, diabetes, hearing loss, and extrapyramidal syndrome, and is usually caused by mutations in the DCAF17 gene as an inherit…
View article: Effect of GLP-1 RA+Metformin versus CPA/EE+Metformin on overweight women with polycystic ovary syndrome -supplementary tables and figures
Effect of GLP-1 RA+Metformin versus CPA/EE+Metformin on overweight women with polycystic ovary syndrome -supplementary tables and figures Open
supplementary tables and figures
View article: Effect of GLP-1 RA+Metformin versus CPA/EE+Metformin on overweight women with polycystic ovary syndrome
Effect of GLP-1 RA+Metformin versus CPA/EE+Metformin on overweight women with polycystic ovary syndrome Open
supplmentry table and supplmentry Figure
View article: Adrenal artery ablation for primary aldosteronism without apparent aldosteronoma: An efficacy and safety, proof‐of‐principle trial
Adrenal artery ablation for primary aldosteronism without apparent aldosteronoma: An efficacy and safety, proof‐of‐principle trial Open
Primary aldosteronism (PA) is associated with resistant hypertension and cardiovascular events. There are some limitations of current medical and surgical therapies for PA. To determine the efficacy and safety of catheter‐based adrenal art…
View article: Short-term versus 6-week prednisone in the treatment of subacute thyroiditis: a randomized controlled trial
Short-term versus 6-week prednisone in the treatment of subacute thyroiditis: a randomized controlled trial Open
Background Moderate-to-severe subacute thyroiditis is commonly treated with 6-8 weeks glucocorticoids; however, no studies have described short-term prednisone treatment for subacute thyroiditis. We evaluated the efficacy of this treatment…
View article: Min Long_characteristics，octreotide application of TSHomas_Supplemental Tables and Figures
Min Long_characteristics，octreotide application of TSHomas_Supplemental Tables and Figures Open
Supplemental tables and figures for the clinical characteristics and octreotide preoperative application value of TSHomas
View article: Alteration of gut microbiota induced by DPP-4i treatment improves glucose homeostasis
Alteration of gut microbiota induced by DPP-4i treatment improves glucose homeostasis Open
Our findings demonstrate an important effect of DPP-4i on the gut microbiota, revealing a new hypoglycemic mechanism and an additional benefit of it. Furthermore, modulating the microbial composition, and the functional shift arising from …
View article: Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases
Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases Open
Asprosin is a white adipose tissue-derived hormone that increases abnormally in mammals with insulin resistance. However, the role of asprosin in polycystic ovary syndrome (PCOS), a disease partly characterized by insulin resistance, and i…
View article: DPP-4 Inhibitors as Treatments for Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
DPP-4 Inhibitors as Treatments for Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis Open
Objective . Several clinical studies have reported the application of dipeptidyl peptidase-4 (DPP-4) inhibitors as treatments for type 1 diabetes mellitus (T1DM). This study aims to review the outcomes of these existing studies and to disc…
View article: Metformin inhibits proliferation and growth hormone secretion of GH3 pituitary adenoma cells
Metformin inhibits proliferation and growth hormone secretion of GH3 pituitary adenoma cells Open
Metformin is an anti-hyperglycemic agent used to treat diabetes, and recent evidence suggests it has antitumor efficacy. Because growth hormone-secreting pituitary adenoma (GH-PA) patients have a high incidence of diabetes frequently treat…
View article: Identification and association of RAC1 gene polymorphisms with mRNA and protein expression levels of Rac1 in solid organ (kidney, liver, heart) transplant recipients
Identification and association of RAC1 gene polymorphisms with mRNA and protein expression levels of Rac1 in solid organ (kidney, liver, heart) transplant recipients Open
The activation of Ras-related C3 botulinum toxin substrate 1 (Rac1) is critical in the renal, hepatic and cardiac diseases that lead to the requirement for transplantation, however, no investigations have been performed in Chinese populati…
View article: Decreased Peripheral Mitochondrial DNA Copy Number is Associated with the Risk of Heart Failure and Long-term Outcomes
Decreased Peripheral Mitochondrial DNA Copy Number is Associated with the Risk of Heart Failure and Long-term Outcomes Open
Mitochondrial DNA (mtDNA) copy number variation (CNV), which reflects the oxidant-induced cell damage, has been observed in a wide range of human diseases. However, whether it correlates with heart failure, which is closely related to oxid…