Ryoji Yao
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View article: Focusing on the interplay between tumor-associated macrophages and tumor microenvironment: from mechanism to intervention
Focusing on the interplay between tumor-associated macrophages and tumor microenvironment: from mechanism to intervention Open
Immunotherapy has generated promising outcomes in cancer treatment; however, therapeutic responses are hampered by immunosuppression in the tumor microenvironment (TME). This has resulted in increased study of key immune cells in the TME a…
View article: The DYT6 dystonia causative protein THAP1 is responsible for proteasome activity via PSMB5 transcriptional regulation
The DYT6 dystonia causative protein THAP1 is responsible for proteasome activity via PSMB5 transcriptional regulation Open
The proteasome plays a pivotal role in protein degradation, and its impairment is associated with various pathological conditions, including neurodegenerative diseases. It is well understood that Nrf1 coordinates the induction of all prote…
View article: Single-cell RNA sequencing and machine learning provide candidate drugs against drug-tolerant persister cells in colorectal cancer
Single-cell RNA sequencing and machine learning provide candidate drugs against drug-tolerant persister cells in colorectal cancer Open
Drug resistance often stems from drug-tolerant persister (DTP) cells in cancer. These cells arise from various lineages and exhibit complex dynamics. However, effectively targeting DTP cells remains challenging. We used single-cell RNA seq…
View article: RNA sensing induced by chromosome missegregation augments anti-tumor immunity
RNA sensing induced by chromosome missegregation augments anti-tumor immunity Open
View article: Chromatin profiling identifies chondrocyte-specific Sox9 enhancers important for skeletal development
Chromatin profiling identifies chondrocyte-specific Sox9 enhancers important for skeletal development Open
The transcription factor SRY-related HMG box 9 (Sox9) is essential for chondrogenesis. Mutations in and around SOX9 cause campomelic dysplasia (CD) characterized by skeletal malformations. Although the function of Sox9 in this context is w…
View article: Paneth-like cells produced from OLFM4+ stem cells support OLFM4+ stem cell growth in advanced colorectal cancer
Paneth-like cells produced from OLFM4+ stem cells support OLFM4+ stem cell growth in advanced colorectal cancer Open
View article: Hypoxia activates <scp>SREBP2</scp> through Golgi disassembly in bone marrow‐derived monocytes for enhanced tumor growth
Hypoxia activates <span>SREBP2</span> through Golgi disassembly in bone marrow‐derived monocytes for enhanced tumor growth Open
View article: TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation
TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation Open
View article: Mitochondrial one-carbon metabolic enzyme MTHFD2 facilitates mammary gland development during pregnancy
Mitochondrial one-carbon metabolic enzyme MTHFD2 facilitates mammary gland development during pregnancy Open
Mitochondrial one-carbon metabolism is crucial for embryonic development and tumorigenesis, as it supplies one-carbon units necessary for nucleotide synthesis and rapid cell proliferation. However, its contribution to adult tissue homeosta…
View article: Transcriptomic intratumor heterogeneity of breast cancer patient-derived organoids may reflect the unique biological features of the tumor of origin
Transcriptomic intratumor heterogeneity of breast cancer patient-derived organoids may reflect the unique biological features of the tumor of origin Open
View article: Additional file 2 of Transcriptomic intratumor heterogeneity of breast cancer patient-derived organoids may reflect the unique biological features of the tumor of origin
Additional file 2 of Transcriptomic intratumor heterogeneity of breast cancer patient-derived organoids may reflect the unique biological features of the tumor of origin Open
Additional file 2.Table S1: 38 ClustGSs across 10 PDOs.Table S2: Cluster-specific expressed gene lists in P165 and P210.Table S3: Cluster-specific expressed gene lists in PDO180 P6 and PDO210 P8.Table S4: Meta-ClustGSs.Table S5 PDO-specifi…
View article: Integration of human inspection and artificial intelligence‐based morphological typing of patient‐derived organoids reveals interpatient heterogeneity of colorectal cancer
Integration of human inspection and artificial intelligence‐based morphological typing of patient‐derived organoids reveals interpatient heterogeneity of colorectal cancer Open
Colorectal cancer (CRC) is a heterogenous disease, and patients have differences in therapeutic response. However, the mechanisms underlying interpatient heterogeneity in the response to chemotherapeutic agents remain to be elucidated, and…
View article: Inhibition of Crmp1 Phosphorylation at Ser522 Ameliorates Motor Function and Neuronal Pathology in Amyotrophic Lateral Sclerosis Model Mice
Inhibition of Crmp1 Phosphorylation at Ser522 Ameliorates Motor Function and Neuronal Pathology in Amyotrophic Lateral Sclerosis Model Mice Open
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder that affects upper and lower motor neurons; however, its pathomechanism has not been fully elucidated. Using a comprehensive phosphoproteomic…
View article: A protocol for efficient CRISPR-Cas9-mediated knock-in in colorectal cancer patient-derived organoids
A protocol for efficient CRISPR-Cas9-mediated knock-in in colorectal cancer patient-derived organoids Open
View article: Comparative Analysis of Patient-Matched PDOs Revealed a Reduction in OLFM4-Associated Clusters in Metastatic Lesions in Colorectal Cancer
Comparative Analysis of Patient-Matched PDOs Revealed a Reduction in OLFM4-Associated Clusters in Metastatic Lesions in Colorectal Cancer Open
View article: Evaluation of the RAS signaling network in response to MEK inhibition using organoids derived from a familial adenomatous polyposis patient
Evaluation of the RAS signaling network in response to MEK inhibition using organoids derived from a familial adenomatous polyposis patient Open
View article: Odf2 haploinsufficiency causes a new type of decapitated and decaudated spermatozoa, Odf2-DDS, in mice
Odf2 haploinsufficiency causes a new type of decapitated and decaudated spermatozoa, Odf2-DDS, in mice Open
View article: Abstract 1949: Mouse model of metastatic colorectal cancer by orthotopic transplantation of patient derived organoids
Abstract 1949: Mouse model of metastatic colorectal cancer by orthotopic transplantation of patient derived organoids Open
Cancer metastasis proceeds through multiple steps and metastatic colonization is formed by disseminated tumor cells with proliferative capacity in distant tissues. In the analysis of metastasis, macroscopically completed lesions are often …
View article: MCRIP1 promotes the expression of lung-surfactant proteins in mice by disrupting CtBP-mediated epigenetic gene silencing
MCRIP1 promotes the expression of lung-surfactant proteins in mice by disrupting CtBP-mediated epigenetic gene silencing Open
Proper regulation of epigenetic states of chromatin is crucial to achieve tissue-specific gene expression during embryogenesis. The lung-specific gene products, surfactant proteins B (SP-B) and C (SP-C), are synthesized in alveolar epithel…
View article: IFN/STAT signaling controls tumorigenesis and the drug response in colorectal cancer
IFN/STAT signaling controls tumorigenesis and the drug response in colorectal cancer Open
Colorectal cancer (CRC) is caused by genetic alterations, and comprehensive sequence analyses have revealed the mutation landscapes. In addition to somatic changes, genetic variations are considered important factors contributing to tumor …
View article: Improved phosphoproteomic analysis for phosphosignaling and active-kinome profiling in Matrigel-embedded spheroids and patient-derived organoids
Improved phosphoproteomic analysis for phosphosignaling and active-kinome profiling in Matrigel-embedded spheroids and patient-derived organoids Open
Many attempts have been made to reproduce the three-dimensional (3D) cancer behavior. For that purpose, Matrigel, an extracellular matrix from Engelbreth-Holm-Swarm mouse sarcoma cell, is widely used in 3D cancer models such as scaffold-ba…
View article: TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling
TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling Open
The mammalian target of rapamycin (mTOR) pathway is commonly activated in human cancers. The activity of mTOR complex 1 (mTORC1) signaling is supported by the intracellular positioning of cellular compartments and vesicle trafficking, regu…
View article: Report on the use of non‐clinical studies in the regulatory evaluation of oncology drugs
Report on the use of non‐clinical studies in the regulatory evaluation of oncology drugs Open
Non‐clinical studies are necessary at each stage of the development of oncology drugs. Many experimental cancer models have been developed to investigate carcinogenesis, cancer progression, metastasis, and other aspects in cancer biology a…
View article: JCA–AACR Joint Symposia in the 73rd Annual Meeting of the Japanese Cancer Association, Yokohama, 25–26 September 2014
JCA–AACR Joint Symposia in the 73rd Annual Meeting of the Japanese Cancer Association, Yokohama, 25–26 September 2014 Open
To integrate and discuss the cutting‐edge science and revolutionized therapeutics of cancer in Japan and the United States, JCA (Japanese Cancer Association)–AACR (American Association for Cancer Research) Joint Symposia were held on 25th …