Ruiling Feng
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View article: Microstructure change rule during the consolidation process of peat soil from Yunnan province
Microstructure change rule during the consolidation process of peat soil from Yunnan province Open
View article: Clinical characteristics and treatment response of patients with SLE complicated with thrombotic thrombocytopenic purpura
Clinical characteristics and treatment response of patients with SLE complicated with thrombotic thrombocytopenic purpura Open
Background SLE complicated with thrombotic thrombocytopenic purpura (SLE-TTP) is a rare but potentially fatal condition. Current studies regarding SLE-TTP are limited to case reports and literature reviews. This study presents a cohort of …
View article: Baseline profile peripheral Tfh cells predict immune-related adverse events in immune checkpoint inhibitor therapy of gastrointestinal cancer
Baseline profile peripheral Tfh cells predict immune-related adverse events in immune checkpoint inhibitor therapy of gastrointestinal cancer Open
Background Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are limited by immune-related adverse events (irAEs). This study aimed to assess peripheral T cell profiles to identify irAEs biomarkers and construct predi…
View article: DOSE-DEPENDENT EFFICACY AND SAFETY OF LOW-DOSE IL-2 IN THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS
DOSE-DEPENDENT EFFICACY AND SAFETY OF LOW-DOSE IL-2 IN THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS Open
O008 / #335 Topic: AS24 - SLE-Treatment ABSTRACT CONCURRENT SESSION 01: FINDINGS FROM LUPUS CLINICAL TRIALS 22-05-2025 1:40 PM - 2:40 PM Background/Purpose Interleukin-2 (IL-2) has shown potential in immune modulation for autoimmune diseas…
View article: Early detection and analysis of accurate breast cancer for improved diagnosis using deep supervised learning for enhanced patient outcomes
Early detection and analysis of accurate breast cancer for improved diagnosis using deep supervised learning for enhanced patient outcomes Open
Early detection of breast cancer (BC) is essential for effective treatment and improved prognosis. This study compares the performance of various machine learning (ML) algorithms, including convolutional neural networks (CNNs), logistic re…
View article: Impact of disease duration on systemic clinical profile in Sjogren’s syndrome
Impact of disease duration on systemic clinical profile in Sjogren’s syndrome Open
Therefore, early identification of symptoms and initiation of therapies are imperative for mitigating the risk of significant complications in pSS patients.
View article: A Comprehensive Dataset on Microbiome Dynamics in Rheumatoid Arthritis from a Large-Scale Cohort Study
A Comprehensive Dataset on Microbiome Dynamics in Rheumatoid Arthritis from a Large-Scale Cohort Study Open
Alterations in intestinal microbiota have been identified as a key risk factor in rheumatoid arthritis (RA). This study presents a multidimensional gut microbiota profile from a large cohort of RA patients, stratified by disease stage and …
View article: Rituximab Maintenance Therapy for Systemic Lupus Erythematosus Complicated with Thrombotic Thrombocytopenic Purpura: Relapse Prophylaxis and Long-Term Disease Control
Rituximab Maintenance Therapy for Systemic Lupus Erythematosus Complicated with Thrombotic Thrombocytopenic Purpura: Relapse Prophylaxis and Long-Term Disease Control Open
View article: B lymphocyte subset-based stratification in primary Sjögren's syndrome: implications for lymphoma risk and personalized treatment
B lymphocyte subset-based stratification in primary Sjögren's syndrome: implications for lymphoma risk and personalized treatment Open
Objective This study aimed to perform a detailed stratification analysis of B lymphocyte subsets in patients with primary Sjögren's syndrome (pSS) and to investigate their associations with lymphoma risk, clinical phenotypes, and disease a…
View article: Combination therapy with belimumab and low‐dose interleukin‐2 in a patient with anti‐MDA5 antibody dermatomyositis overlapping with systemic lupus erythematosus
Combination therapy with belimumab and low‐dose interleukin‐2 in a patient with anti‐MDA5 antibody dermatomyositis overlapping with systemic lupus erythematosus Open
View article: Efficacy and Safety of Low-Dose Interleukin 2 for Behçet’s Syndrome: a phase 2 randomized double-blind placebo-controlled clinical trial
Efficacy and Safety of Low-Dose Interleukin 2 for Behçet’s Syndrome: a phase 2 randomized double-blind placebo-controlled clinical trial Open
Behçet’s syndrome (BS), a chronic relapsing systemic vasculitis, leads to recurrent oral aphthous ulcers, severely impacting quality of life. We conducted a randomized double-blind placebo-controlled clinical trial to evaluate the efficacy…
View article: Metabolic impact of low dose IL-2 therapy for primary Sjögren’s Syndrome in a double-blind, randomized clinical trial
Metabolic impact of low dose IL-2 therapy for primary Sjögren’s Syndrome in a double-blind, randomized clinical trial Open
View article: Predictive biomarkers for low-dose IL-2 therapy efficacy in systemic lupus erythematosus: a clinical analysis
Predictive biomarkers for low-dose IL-2 therapy efficacy in systemic lupus erythematosus: a clinical analysis Open
View article: Immune skew of follicular helper T cells and effector T cells in patients with Sjögren’s syndrome
Immune skew of follicular helper T cells and effector T cells in patients with Sjögren’s syndrome Open
View article: Multidimensional profile of gut microbiota in a large cohort of stratified rheumatoid arthritis
Multidimensional profile of gut microbiota in a large cohort of stratified rheumatoid arthritis Open
It is unknown if dysbiosis of microbiota plays a role in the initiation and severity of rheumatoid arthritis (RA). In a comprehensive study of 2297 individuals, including 1,064 RA patients and 1,233 healthy controls, we uncovered an age-re…
View article: Distribution of blood lead and cadmium levels in healthy children aged 0 to 18 years and analysis of related influencing factors in Henan, China: data findings from 2017 to 2022
Distribution of blood lead and cadmium levels in healthy children aged 0 to 18 years and analysis of related influencing factors in Henan, China: data findings from 2017 to 2022 Open
View article: LSO-088 Ld-IL2 synthesis with belimumab in the treatment of systemic lupus erythematosus patients
LSO-088 Ld-IL2 synthesis with belimumab in the treatment of systemic lupus erythematosus patients Open
Background Belimumab and low dose IL2 (Ld-IL2) has been identified effective in the treatment of systemic lupus erythematosus (SLE). However, the application of combined therapy for SLE has not been documented in the real-life clinical set…
View article: [Retracted] Pan‐Cancer Analysis of Prognostic and Immune Infiltrates for the TMEM65, Especially for the Breast Cancer
[Retracted] Pan‐Cancer Analysis of Prognostic and Immune Infiltrates for the TMEM65, Especially for the Breast Cancer Open
Introduction . Transmembrane protein 65 (TMEM65) is an inner mitochondrial membrane protein, which played important role in mediating autophagy, smooth muscle contraction, protein glycosylation, and immune response. In recent years, the in…
View article: Efficacy and Safety of Low-Dose Interleukin 2 for Primary Sjögren Syndrome
Efficacy and Safety of Low-Dose Interleukin 2 for Primary Sjögren Syndrome Open
Importance Primary Sjögren syndrome (pSS) is a systemic autoimmune disease associated with dysregulated immune cells, with no efficient therapy. There is a need to study potential therapeutic approaches. Objective To investigate the effica…
View article: Dynamics of T follicular helper cells in patients with rheumatic diseases and subsequent antibody responses in a three‐dose immunization regimen of <scp>CoronaVac</scp>
Dynamics of T follicular helper cells in patients with rheumatic diseases and subsequent antibody responses in a three‐dose immunization regimen of <span>CoronaVac</span> Open
Given increased acceptance of the CoronaVac, there is an unmet need to assess the safety and immunogenic changes of CoronaVac in patients with rheumatic diseases (RD). Here we comprehensively analysed humoral and cellular responses in pati…
View article: Low Dose Interleukin-2 Ameliorates Sjögren’s Syndrome in a Murine Model
Low Dose Interleukin-2 Ameliorates Sjögren’s Syndrome in a Murine Model Open
Sjögren’s syndrome (SS) is a systemic autoimmune disease with no efficient treatment, and it is associated with dysregulated immune cells and impaired interleukin (IL)-2 signaling. IL-2 is critical for the development and maintenance of Tr…
View article: Prevalence of Congenital Heart Disease in Chinese Children With Different Birth Weights and Its Relationship to the Neonatal Birth Weight
Prevalence of Congenital Heart Disease in Chinese Children With Different Birth Weights and Its Relationship to the Neonatal Birth Weight Open
Objective This study aimed to examine the prevalence and the related risk factors of congenital heart disease (CHD) in children with different birth weights in China and the relationship between the subtypes of CHD and birth weight (BW). M…
View article: Intestinal butyrate-metabolizing species contribute to autoantibody production and bone erosion in rheumatoid arthritis
Intestinal butyrate-metabolizing species contribute to autoantibody production and bone erosion in rheumatoid arthritis Open
The imbalance between pathogenic and beneficial species of the intestinal microbiome and metabolism in rheumatoid arthritis (RA) remains unclarified. Here, using shotgun-based metagenome sequencing for a treatment-naïve patient cohort and …
View article: Comparison of the deep immune profiling of B cell subsets between healthy adults and Sjögren’s syndrome
Comparison of the deep immune profiling of B cell subsets between healthy adults and Sjögren’s syndrome Open
Our study presented a reliable analysis by flow cytometry to cover the principal B cell subtypes. These different stages of B lymphocytes may have implications for evaluating the activation of pSS and other autoimmune diseases and treatmen…
View article: Overexpression of galectin2 (LGALS2) predicts a better prognosis in human breast cancer.
Overexpression of galectin2 (LGALS2) predicts a better prognosis in human breast cancer. Open
In conclusion, LGALS2 has potential as a valuable biomarker for envisaging a satisfactory prognosis in patients with breast tumours, particularly those with luminal and basal B types, all stages and grade III tumours.
View article: Sonoelastography of salivary glands for diagnosis and clinical evaluation in primary Sjögren's syndrome
Sonoelastography of salivary glands for diagnosis and clinical evaluation in primary Sjögren's syndrome Open
To explore the performance of sonoelastography (SE) in diagnosis and clinical evaluation of primary Sjögren's syndrome (pSS).SE examination of major salivary glands was conducted for 79 pSS patients, 39 disease controls and 15 healthy subj…
View article: Salivary gland ultrasonography in primary Sjögren’s syndrome from diagnosis to clinical stratification: a multicentre study
Salivary gland ultrasonography in primary Sjögren’s syndrome from diagnosis to clinical stratification: a multicentre study Open
Background To determine the diagnostic accuracy of major salivary gland ultrasonography (SGUS) in primary Sjögren’s syndrome (pSS) using the novel Outcome Measures in Rheumatology Clinical Trials (OMERACT) scoring system in a large-scale m…
View article: Beta-Lapachone Attenuates BMSC-Mediated Neuroblastoma Malignant Transformation by Inhibiting Gal-3/Gal-3BP/IL6 Axis
Beta-Lapachone Attenuates BMSC-Mediated Neuroblastoma Malignant Transformation by Inhibiting Gal-3/Gal-3BP/IL6 Axis Open
The inflammatory factor IL6 secreted by bone marrow mesenchymal stem cells (BMSCs) in the tumor microenvironment (TME) facilitates the survival and therapeutic resistance of neuroblastoma (NB). Here, we found that IL6 expression in primary…
View article: Low-Dose Interleukin-2 as an Alternative Therapy for Refractory Lupus Nephritis
Low-Dose Interleukin-2 as an Alternative Therapy for Refractory Lupus Nephritis Open
Low-dose IL-2 therapy may have a promising role in the treatment of refractory LN as an alternative and safe therapeutic approach. It may be used as multi-target combination therapy in clinical practice.
View article: Salivary Gland Ultrasonography In Primary Sjögren's Syndrome From Diagnosis To Clinical Stratification: A Multicentre Study
Salivary Gland Ultrasonography In Primary Sjögren's Syndrome From Diagnosis To Clinical Stratification: A Multicentre Study Open
Background: To determine the diagnostic accuracy of major salivary gland ultrasonography (SGUS) in primary Sjögren’s syndrome (pSS) using the novel Outcome Measures in Rheumatology Clinical Trials (OMERACT) scoring system in a large-scale …