Runjie Sun
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View article: Case Report: Ablation as novel x therapy in the regimen for frail hematological malignancies with extramedullary lesion
Case Report: Ablation as novel x therapy in the regimen for frail hematological malignancies with extramedullary lesion Open
Hematological diseases, as a category of malignant tumors originating from the hematopoietic system, have long relied on treatments such as chemotherapy, radiotherapy, and hematopoietic stem cell transplantation. However, challenges remain…
View article: Isoliquiritin targeting m5C RNA methylation improves mitophagy in doxorubicin-induced myocardial cardiotoxicity
Isoliquiritin targeting m5C RNA methylation improves mitophagy in doxorubicin-induced myocardial cardiotoxicity Open
This study showed that ISL may exert cardioprotective role restoring BNIP3-mediated mitophagy by targeting TRDMT1 to alleviate DOX-induced macro-autophagy-dependent protein homeostasis and acquired blocking of mitophagy, providing a new id…
View article: Exploring the barriers to the development of organizational health literacy in health institutions to meet the needs of older patients from multiple perspectives: a mixed-methods study
Exploring the barriers to the development of organizational health literacy in health institutions to meet the needs of older patients from multiple perspectives: a mixed-methods study Open
The two most vulnerable aspects of OHL in medical institutions regarding the needs of older patients are health information and communication. The factors influencing the construction of OHL in medical institutions are multifaceted, encomp…
View article: Paeoniflorin inhibiting the angiogenesis via decreasing MEF2A level to downregulate the expression of LncRNA MALAT1 of exosomes in multiple myeloma
Paeoniflorin inhibiting the angiogenesis via decreasing MEF2A level to downregulate the expression of LncRNA MALAT1 of exosomes in multiple myeloma Open
Background Angiogenesis is a pivotal mechanism driving tumor proliferation, and the epigenetic regulation of angiogenesis represents a cutting-edge area of current research in multiple myeloma (MM). Methods High-throughput sequencing was c…
View article: Exploring the barriers to the development of organizational health literacy in health institutions from the perspective of older patients: a mixed study
Exploring the barriers to the development of organizational health literacy in health institutions from the perspective of older patients: a mixed study Open
Background The 2020 national health literacy monitoring revealed that only 8.49% of individuals aged 65–69 years, a segment of the older population, possess adequate health literacy levels, indicating a low level in China. Studies have dem…
View article: Paeoniflorin Ameliorates BiPN by Reducing IL6 Levels and Regulating PARKIN-Mediated Mitochondrial Autophagy
Paeoniflorin Ameliorates BiPN by Reducing IL6 Levels and Regulating PARKIN-Mediated Mitochondrial Autophagy Open
The present study confirmed that paeoniflorin significantly ameliorated peripheral neuropathy (PN) caused by bortezomib, possibly by reducing IL6 levels to regulate PARKIN-mediated mitochondrial autophagy and mitochondrial damage.
View article: PB1972: PAEONIFLORIN ALLEVIATES BIPN BY REDUCING IL6 LEVELS AND MODULATING PARKIN-MEDIATED MITOPHAGY
PB1972: PAEONIFLORIN ALLEVIATES BIPN BY REDUCING IL6 LEVELS AND MODULATING PARKIN-MEDIATED MITOPHAGY Open
Background: Multiple myeloma (MM)is a common hematological malignant tumor disease. Recent years, the emergence of the proteasome inhibitor bortezomib (BTZ) has greatly improved the remission rate and survival rate of patients with MM. How…
View article: A novel circRNA-miRNA-mRNA network revealed exosomal circ-ATP10A as a biomarker for multiple myeloma angiogenesis
A novel circRNA-miRNA-mRNA network revealed exosomal circ-ATP10A as a biomarker for multiple myeloma angiogenesis Open
The importance of angiogenesis in multiple myeloma (MM) is unquestionable; however, to date, the success of antiangiogenic therapies has been fairly limited. Exosomal circular RNAs (circRNAs) have been proven to be pivotal players in angio…
View article: Baicalin Regulates Autophagy to Intervene with Intestinal Acute Graft-Versus-Host Disease via AMPK/Mtor Pathway and Abnormal Intestinal Flora
Baicalin Regulates Autophagy to Intervene with Intestinal Acute Graft-Versus-Host Disease via AMPK/Mtor Pathway and Abnormal Intestinal Flora Open
Acute graft versus host disease (aGVHD) is the main complication of allogeneic hematopoietic stem cell transplantation and the main cause of death. To verify if baicalin can protect the intestinal mucosal barrier by regulating abnormal aut…
View article: A new point mutation in SIX1 causes Branchio-oto syndrome, thymoma and pure red cell aplasia via mitochondrial apoptosis
A new point mutation in SIX1 causes Branchio-oto syndrome, thymoma and pure red cell aplasia via mitochondrial apoptosis Open
A patient was admitted to the hospital with thymoma, branchio-oto syndrome and pure red aplastic anemia. He had both Six1 and mitochondrial mutations. The Six1 gene has been linked to branchio-oto-renal spectrum disorder and malignant tumo…