Ruimin Wang
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View article: Molecular imaging of aortic fibroblast activation protein through 68Ga-FAPI-PET/CT: Association with aortic dilation
Molecular imaging of aortic fibroblast activation protein through 68Ga-FAPI-PET/CT: Association with aortic dilation Open
Our findings indicate that FAPI uptake is associated with aortic diameter and may provide preliminary insights into early aortic remodeling, suggesting its potential as a marker for future longitudinal studies.
View article: Serum metabolic profiling enables diagnosis, prognosis, and monitoring for brainstem gliomas
Serum metabolic profiling enables diagnosis, prognosis, and monitoring for brainstem gliomas Open
Brainstem gliomas (BSG) is a highly malignant central nervous system childhood tumors with 5-year survival rate <10%. Metabolism during radiotherapy is a dynamic and precisely programmed process, improving clinical outcomes and guiding the…
View article: Association Between Triglyceride‐Glucose Index and Incomplete Device Endothelialization After Left Atrial Appendage Occlusion: A Retrospective Observational Study
Association Between Triglyceride‐Glucose Index and Incomplete Device Endothelialization After Left Atrial Appendage Occlusion: A Retrospective Observational Study Open
Background The triglyceride‐glucose (TyG) index, a biomarker for insulin resistance, has been shown to be associated with cardiovascular diseases. However, its association with delayed device endothelialization after left atrial appendage …
View article: Echinacoside Alleviates Non‐Alcoholic Fatty Liver Disease in Rats: Potential Involvement of <scp>AMPK</scp> Pathway and Autophagy
Echinacoside Alleviates Non‐Alcoholic Fatty Liver Disease in Rats: Potential Involvement of <span>AMPK</span> Pathway and Autophagy Open
The primary objective aims to evaluate the therapeutic efficacy of echinacoside in ameliorating hepatic steatosis and exploring its role in modulating autophagic flux through AMP‐activated protein kinase (AMPK) signaling, positioning it as…
View article: Comparison of prognosis and analysis of related risk factors among three different left atrial appendage occlusion procedures in patients with atrial fibrillation
Comparison of prognosis and analysis of related risk factors among three different left atrial appendage occlusion procedures in patients with atrial fibrillation Open
Background Left atrial appendage occlusion (LAAO) serves as an alternative to oral anticoagulation (OAC) for atrial fibrillation (AF) patients at high risk of bleeding. The aim of this study was to compare the peri-procedural safety, compl…
View article: Correlation Studies Between Double‐Stranded DNA and Diabetes Mellitus
Correlation Studies Between Double‐Stranded DNA and Diabetes Mellitus Open
Background: Diabetes mellitus (DM) is a common chronic endocrine and metabolic disease, and its complications can involve multiple organs and seriously threaten human health. Double‐stranded DNA (dsDNA) plays an important role in the autoi…
View article: [Effects of applying human umbilical cord mesenchymal stem cell exosomes through different pathways to treat full-thickness skin defect wounds in mice].
[Effects of applying human umbilical cord mesenchymal stem cell exosomes through different pathways to treat full-thickness skin defect wounds in mice]. Open
Objective: To investigate the effects of human umbilical cord mesenchymal stem cell (hUCMSC) exosomes in the treatment of full-thickness skin defect wounds in mice through local wound application, subcutaneous injection at the wound margin…
View article: Targeting blood brain barrier—Remote ischemic conditioning alleviates cognitive impairment in female <scp>APP</scp>/<scp>PS1</scp> rats
Targeting blood brain barrier—Remote ischemic conditioning alleviates cognitive impairment in female <span>APP</span>/<span>PS1</span> rats Open
Aims Alzheimer's disease (AD) is a significant global health concern, and it is crucial that we find effective methods to prevent or slow down AD progression. Recent studies have highlighted the essential role of blood vessels in clearing …
View article: A meta-analysis of neurogenic exosomes in the diagnosis of Alzheimer's disease
A meta-analysis of neurogenic exosomes in the diagnosis of Alzheimer's disease Open
Aβ42, T-tau, and P-tau181 in blood neurogenic exosomes can be effectively used as biomarkers for AD and can be applied in the diagnosis, screening, prognosis prediction and disease monitoring of AD.
View article: [Photobiomodulation Promotes Hippocampal Neurogenesis and Improves Cognitive Function and Anti-Inflammatory Injury in Rats With Chronic Cerebral Hypoperfusion].
[Photobiomodulation Promotes Hippocampal Neurogenesis and Improves Cognitive Function and Anti-Inflammatory Injury in Rats With Chronic Cerebral Hypoperfusion]. Open
PBM can effectively improve the spatial learning and memory function in rats with chronic cerebral hypoperfusion, inhibit the activation of glial cells, reduce inflammatory damage mediated by NLRP3 inflammasome, and promote the regeneratio…
View article: Screening of Reference Genes under Biotic Stress and Hormone Treatment of Mung Bean (Vigna radiata) by Quantitative Real-Time PCR
Screening of Reference Genes under Biotic Stress and Hormone Treatment of Mung Bean (Vigna radiata) by Quantitative Real-Time PCR Open
Mung bean (Vigna radiata) production has been greatly threatened by numerous diseases. Infection with these pathogens causes extensive changes in gene expression and the activation of hormone signal transduction. Quantitative real-time PCR…
View article: Brain-Derived Estrogen Regulates Neurogenesis, Learning and Memory with Aging in Female Rats
Brain-Derived Estrogen Regulates Neurogenesis, Learning and Memory with Aging in Female Rats Open
Although 17β-estradiol (E2) can be locally synthesized in the brain, whether and how brain-derived E2 (BDE2) impacts neurogenesis with aging is largely unclear. In this study, we examined the hippocampal neural stem cells, neurogenesis, an…
View article: Remote Ischemic Conditioning Alleviates Alzheimer’s Disease Pathology in Female TgF344 Rats
Remote Ischemic Conditioning Alleviates Alzheimer’s Disease Pathology in Female TgF344 Rats Open
Alzheimer's disease (AD) has become a global public health crisis and research is urgently needed to explore strategies to prevent, and slow AD progression and improve cognitive function. Growing evidence suggests that blood vessels play a…
View article: Anti-Inflammatory Actions of G-Protein-Coupled Estrogen Receptor 1 (GPER) and Brain-Derived Estrogen Following Cerebral Ischemia in Ovariectomized Rats
Anti-Inflammatory Actions of G-Protein-Coupled Estrogen Receptor 1 (GPER) and Brain-Derived Estrogen Following Cerebral Ischemia in Ovariectomized Rats Open
Global cerebral ischemia can elicit rapid innate neuroprotective mechanisms that protect against delayed neuronal death. Brain-derived 17β-estradiol (BDE2), an endogenous neuroprotectant, is synthesized from testosterone by the enzyme arom…
View article: In vivo imaging of tau deposition in Alzheimer’s disease using both [18F]-THK5317 and [18F]-S16: A pilot human study
In vivo imaging of tau deposition in Alzheimer’s disease using both [18F]-THK5317 and [18F]-S16: A pilot human study Open
Objective To evaluate the effectiveness of a new tracer ( S )-1-(4-(6-(dimethylamino)quinoxalin-2-yl)phenoxy)-3-fluoropropan-2-ol ([ 18 F]-S16), in distinguishing patients with AD from HCs. Methods Paired [ 18 F]-S16 and [ 18 F]-THK5317 sc…
View article: Diagnostic Value of 11C-PIB PET/MR in Cardiac Amyloidosis
Diagnostic Value of 11C-PIB PET/MR in Cardiac Amyloidosis Open
Background The thioflavin T derivative, 11 C-Pittsburgh-B (PIB), is used for Alzheimer's disease imaging because it specifically binds to β-amyloid protein deposits in the brain. The aim of this study was to estimate the diagnostic value o…
View article: <i>ZNF76</i> predicts prognosis and response to platinum chemotherapy in human ovarian cancer
<i>ZNF76</i> predicts prognosis and response to platinum chemotherapy in human ovarian cancer Open
Ovarian cancer (OV) is the most lethal gynecologic malignancy. One major reason of the high mortality of the disease is due to platinum-based chemotherapy resistance. Increasing evidence reveal the important biological functions and clinic…
View article: Customized Deep Eutectic Solvents as Green Extractants for Ultrasonic-Assisted Enhanced Extraction of Phenolic Antioxidants from Dogbane Leaf-Tea
Customized Deep Eutectic Solvents as Green Extractants for Ultrasonic-Assisted Enhanced Extraction of Phenolic Antioxidants from Dogbane Leaf-Tea Open
This study evaluates the application of eco-friendly deep eutectic solvents (DESs) in the extraction of phenolic antioxidants from dogbane leaf-tea (DLT). The results showed DESs with lower viscosity allowed an efficient extraction of sign…
View article: Functional Abnormality Associated With Tau Deposition in Alzheimer’s Disease – A Hybrid Positron Emission Tomography/MRI Study
Functional Abnormality Associated With Tau Deposition in Alzheimer’s Disease – A Hybrid Positron Emission Tomography/MRI Study Open
Objective: To investigate the characteristics of tau deposition and its impact on functional connectivity (FC) in Alzheimer’s disease (AD). Methods: Hybrid PET/MRI scans with [ 18 F]-THK5317 and neuropsychological assessments were undertak…
View article: Photobiomodulation Promotes Hippocampal CA1 NSC Differentiation Toward Neurons and Facilitates Cognitive Function Recovery Involving NLRP3 Inflammasome Mitigation Following Global Cerebral Ischemia
Photobiomodulation Promotes Hippocampal CA1 NSC Differentiation Toward Neurons and Facilitates Cognitive Function Recovery Involving NLRP3 Inflammasome Mitigation Following Global Cerebral Ischemia Open
Our recent study revealed that photobiomodulation (PBM) inhibits delayed neuronal death by preserving mitochondrial dynamics and function following global cerebral ischemia (GCI). In the current study, we clarified whether PBM exerts effec…
View article: YAP‐TEAD mediates PPAR α–induced hepatomegaly and liver regeneration in mice
YAP‐TEAD mediates PPAR α–induced hepatomegaly and liver regeneration in mice Open
Background and Aims Peroxisome proliferator–activated receptor α (PPARα, NR1C1) is a ligand‐activated nuclear receptor involved in the regulation of lipid catabolism and energy homeostasis. PPARα activation induces hepatomegaly and plays a…
View article: SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate
SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate Open
Loss-of-function mutations in sorting nexin 14 (SNX14) cause autosomal recessive spinocerebellar ataxia 20, which is a form of early-onset cerebellar ataxia that lacks molecular mechanisms and mouse models. We generated Snx14-deficient mou…
View article: Constitutive androstane receptor promoted- hepatomegaly and liver regeneration is partially via yes-associated protein activation
Constitutive androstane receptor promoted- hepatomegaly and liver regeneration is partially via yes-associated protein activation Open
Background & Purpose: The constitutive androstane receptor (CAR) belongs to nuclear receptor superfamily. The administration of CAR agonist TCPOBOP to mice leads to hepatomegaly but the mechanism is unclear. Yes-associated protein (YAP) is…
View article: Constitutive androstane receptor promoted- hepatomegaly and liver regeneration is partially via yes-associated protein activation
Constitutive androstane receptor promoted- hepatomegaly and liver regeneration is partially via yes-associated protein activation Open
Background & Purpose: The constitutive androstane receptor (CAR) belongs to nuclear receptor superfamily. The administration of CAR agonist TCPOBOP to mice leads to hepatomegaly but the mechanism is unclear. Yes-associated protein (YAP) is…