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View article: Evaluation of [18F]AlF-EMP-105 for Molecular Imaging of C-Met
Evaluation of [18F]AlF-EMP-105 for Molecular Imaging of C-Met Open
C-Met is a receptor tyrosine kinase that is overexpressed in a range of different cancer types, and has been identified as a potential biomarker for cancer imaging and therapy. Previously, a 68Ga-labelled peptide, [68Ga]Ga-EMP-100, has sho…
View article: Kinetics and efficacy of antibody drug conjugates in 3D tumour models
Kinetics and efficacy of antibody drug conjugates in 3D tumour models Open
Antibody-drug conjugates (ADCs) are emerging targeted agents against cancer. Current studies of ADCs are performed on monolayer cultures which do not mimic the biophysical property of a tumour. Hence, in vitro models that can better predic…
View article: Development and optimisation of cationic lipid nanoparticles for mRNA delivery
Development and optimisation of cationic lipid nanoparticles for mRNA delivery Open
Messenger RNA (mRNA) has been proposed as a therapeutic agent for various diseases, including cancer. To ensure effective transfection of cancer cells, mRNA needs to be transported with a delivery system that protects its integrity and fun…
View article: Automated sulfur-[<sup>18</sup>F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform
Automated sulfur-[<sup>18</sup>F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform Open
The sulfur-[ 18 F]fluoride exchange reaction is a facile 19 F/ 18 F isotopic exchange labelling chemistry which is simple to automated for the preparation of positron emission tomography (PET) radiopharmaceuticals.
View article: Positron Emission Tomography Probes for Imaging Cytotoxic Immune Cells
Positron Emission Tomography Probes for Imaging Cytotoxic Immune Cells Open
Non-invasive positron emission tomography (PET) imaging of immune cells is a powerful approach for monitoring the dynamics of immune cells in response to immunotherapy. Despite the clinical success of many immunotherapeutic agents, their c…
View article: Consideration of Metabolite Efflux in Radiolabelled Choline Kinetics
Consideration of Metabolite Efflux in Radiolabelled Choline Kinetics Open
Hypoxia is a complex microenvironmental condition known to regulate choline kinase α (CHKA) activity and choline transport through transcription factor hypoxia-inducible factor-1α (HIF-1α) and, therefore, may confound the uptake of choline…
View article: Radiolabelling an<sup>18</sup>F biologic<i>via</i>facile IEDDA “click” chemistry on the GE FASTLab™ platform
Radiolabelling an<sup>18</sup>F biologic<i>via</i>facile IEDDA “click” chemistry on the GE FASTLab™ platform Open
A fully automated and efficient radiosynthesis of a novel interleukin-2 radioconjugate from a single FASTLab™ cassette.
View article: Antibody Fragment and Affibody ImmunoPET Imaging Agents: Radiolabelling Strategies and Applications
Antibody Fragment and Affibody ImmunoPET Imaging Agents: Radiolabelling Strategies and Applications Open
Antibodies have long been recognised as potent vectors for carrying diagnostic medical radionuclides, contrast agents and optical probes to diseased tissue for imaging. The area of ImmunoPET combines the use of positron emission tomography…