Ruizhu Lin
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View article: Endothelin-1 is associated with mortality that can be attenuated with high intensity statin therapy in patients with stable coronary artery disease
Endothelin-1 is associated with mortality that can be attenuated with high intensity statin therapy in patients with stable coronary artery disease Open
Background All coronary artery disease (CAD) patients do not benefit equally of secondary prevention. Individualized intensity of drug therapy is currently implemented in guidelines for CAD and diabetes. Novel biomarkers are needed to iden…
View article: Wnt11 in regulation of physiological and pathological cardiac growth
Wnt11 in regulation of physiological and pathological cardiac growth Open
Wnt11 regulates early cardiac development and left ventricular compaction in the heart, but it is not known how Wnt11 regulates postnatal cardiac maturation and response to cardiac stress in the adult heart. We studied cell proliferation/m…
View article: MiR-185-5p regulates the development of myocardial fibrosis
MiR-185-5p regulates the development of myocardial fibrosis Open
View article: Endothelial platelet‐derived growth factor‐mediated activation of smooth muscle platelet‐derived growth factor receptors in pulmonary arterial hypertension
Endothelial platelet‐derived growth factor‐mediated activation of smooth muscle platelet‐derived growth factor receptors in pulmonary arterial hypertension Open
Platelet‐derived growth factor is one of the major growth factors found in human and mammalian serum and tissues. Abnormal activation of platelet‐derived growth factor signaling pathway through platelet‐derived growth factor receptors may …
View article: Systemic blockade of ACVR2B ligands attenuates muscle wasting in ischemic heart failure without compromising cardiac function
Systemic blockade of ACVR2B ligands attenuates muscle wasting in ischemic heart failure without compromising cardiac function Open
Signaling through activin receptors regulates skeletal muscle mass and activin receptor 2B (ACVR2B) ligands are also suggested to participate in myocardial infarction (MI) pathology in the heart. In this study, we determined the effect of …
View article: miR-1468-3p Promotes Aging-Related Cardiac Fibrosis
miR-1468-3p Promotes Aging-Related Cardiac Fibrosis Open
View article: Regulatory Mechanisms of Mitochondrial Function and Cardiac Aging
Regulatory Mechanisms of Mitochondrial Function and Cardiac Aging Open
Aging is a major risk factor for cardiovascular diseases (CVDs), the major cause of death worldwide. Cardiac myocytes, which hold the most abundant mitochondrial population, are terminally differentiated cells with diminished regenerative …
View article: Vezf1 regulates cardiac structure and contractile function
Vezf1 regulates cardiac structure and contractile function Open
View article: Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction
Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction Open
Myocardial infarction (MI)-induced cardiac fibrosis attenuates cardiac contractile function, and predisposes to arrhythmias and sudden cardiac death. Expression of connective tissue growth factor (CTGF) is elevated in affected organs in vi…
View article: Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury
Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury Open
View article: Clinical and Mutational Features of Three Chinese Children with Congenital Generalized Lipodystrophy
Clinical and Mutational Features of Three Chinese Children with Congenital Generalized Lipodystrophy Open
All of our patients exhibited characteristic features of CGL due to mutations in the BSCL2 gene.