Explanipedia

Rethinking cholera diagnostic test performance, interpretation, and evaluation: a field-based latent-class analysis in Bangladesh Open

Javier Perez‐Saez, Taufiqur Rahman Bhuiyan, Sonia T. Hegde, Ishtiakul Islam Khan, Md Taufiqul Islam , et al. · 2025

Impact of Sociodemographic Variables and Clinical Parameters On Outcome of Pediatric Tetanus Patients: A Retrospective Study From an Infectious Disease Hospital in Bangladesh Open

Humayra Akter, Mursheda Khanam, Farzin Akhter, Rumana Rashid · 2025

Background: Tetanus is a vaccine-preventable disease with high mortality. It is still a major cause of death in the pediatric age group particularly in developing countries. This study aimed to determine the demographic and clinical profil…

A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma Open

Verónica Rendo, Eudocia Q. Lee, Connor C. Bossi, Nicholas Khuu, Michelle A. Rudek , et al. · 2025

Inhibitors of murine double minute homolog 2 (MDM2) represent a promising therapeutic approach for the treatment of TP53 wild-type glioblastomas (GBMs), reactivating p53 signaling to induce cancer cell death. We conducted a surgical window…

Rethinking cholera diagnostic test performance, interpretation and evaluation: a field-based latent-class analysis in Bangladesh Open

Javier Perez‐Saez, Taufiqur Rahman Bhuiyan, Sonia T. Hegde, Ishtiakul Islam Khan, Md Taufiqul Islam , et al. · 2024

Background Accurate and reliable diagnostics, including rapid diagnostic tests (RDTs), are critical components of cholera control programs, though their performance has varied greatly across studies. While poorly understood, this variabili…

1081 MICA/BxCD3 bispecific antibodies with integrated immunomodulatory activity Open

Tian Zhang, Matthew S. Faber, Elizabeth Henderson, Nahee Kim, Jing Qi , et al. · 2024

Author Correction: Clinical surveillance systems obscure the true cholera infection burden in an endemic region Open

Sonia T. Hegde, Ashraful Islam Khan, Javier Perez‐Saez, Ishtiakul Islam Khan, Juan Dent Hulse , et al. · 2024

Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy Open

Rajbharan Yadav, Suzanne Schubbert, Patrick G. Holder, Eugene Y. Chiang, Nargess Kiabi , et al. · 2024

Introduction Interleukin 15 (IL-15) is a potential anticancer agent and numerous engineered IL-15 agonists are currently under clinical investigation. Selective targeting of IL-15 to specific lymphocytes may enhance therapeutic effects whi…

RURAL WOMEN PERCEPTIONS OF DIGITAL MEDIA INFLUENCE ON AWARENESS CREATION ABOUT MATERNAL HEALTH INFORMATION IN PUNJAB, PAKISTAN Open

U TAHIRA, AH KHAN, Faiza Shafique Khan, Rumana Rashid, Shehzad A. Saeed , et al. · 2024

In rural settings, access to maternal health information is often limited, contributing to disparities in maternal healthcare utilization and outcomes. The main objective of the study is to find the rural women perceptions of digital media…

Clinical surveillance systems obscure the true cholera infection burden in an endemic region Open

Sonia T. Hegde, Ashraful Islam Khan, Javier Perez‐Saez, Ishtiakul Islam Khan, Juan Dent Hulse , et al. · 2024

Annual risk of hepatitis E virus infection and seroreversion: Insights from a serological cohort in Sitakunda, Bangladesh Open

Amy Dighe, Ashraful Islam Khan, Taufiqur Rahman Bhuiyan, Md Taufiqul Islam, Zahid Hasan Khan , et al. · 2024

Hepatitis E virus (HEV) is a major cause of acute jaundice in South Asia. Gaps in our understanding of transmission are driven by non-specific symptoms and scarcity of diagnostics, impeding rational control strategies. In this context, ser…

2,4-Dichlorophenoxyacetic Acid and 6-Benzyladenine Stimulate of Indication and Biomass Accumulation in a Phaseolus Vulgaris Callus Culture Open

Rumana Rashid, S. I. Neamah · 2023

Obtaining callus tissue is one of the essential aims of plant tissue culture technology due to its great importance in subsequent experiments. The present study aimed to determine the interactive effects of plant growth regulators in stimu…

2D and 3D multiplexed subcellular profiling of nuclear instability in human cancer Open

Shannon Coy, Brian Cheng, Jong Suk Lee, Rumana Rashid, Lindsay Browning , et al. · 2023

Nuclear atypia, including altered nuclear size, contour, and chromatin organization, is ubiquitous in cancer cells. Atypical primary nuclei and micronuclei can rupture during interphase; however, the frequency, causes, and consequences of …

1193 Synergistic targeting of multiple activating pathways with natural killer cell engagers Open

Tian Zhang, Matthew S. Faber, Erik Pong, Ke Liu, Nahee Kim , et al. · 2023

Background Tumor microenvironment induced antigens present a unique opportunity to effectively target diseased tissue over normal and to modulate the immune suppression they might elicit. MICA and MICB (MICA/B) are stress-induced antigens …

1060 Optimally engineered IL18 Fc-fusion proteins balance potency and pharmacokinetics to promote strong anti-tumor activity Open

Alex Nisthal, Sung‐Hyung Lee, Christine Bonzon, Ruschelle Love, Kendra N. Avery , et al. · 2023

Background Interleukin-18 (IL18) promotes expansion, survival, and cytotoxicity of T and NK cells. Tumor-experienced T cells upregulate the heterodimeric IL18 receptor as evidenced by gene expression correlation between immune checkpoints …

Annual risk of hepatitis E virus infection and seroreversion: insights from a serological cohort in Sitakunda, Bangladesh Open

Amy Dighe, Ashraful Islam Khan, Taufiqur Rahman Bhuiyan, Md Taufiqul Islam, Zahid Hasan Khan , et al. · 2023

Hepatitis E virus (HEV) is a major cause of acute jaundice in South Asia. Gaps in our understanding of transmission are driven by non-specific symptoms and scarcity of diagnostics, impeding rational control strategies. In this context, ser…

Multimorbidity and health-related quality of life amongst Indigenous Australians: A longitudinal analysis Open

Syed Afroz Keramat, Francisco Perales, Khorshed Alam, Rumana Rashid, Rezwanul Haque , et al. · 2023

Background The burden of multimorbidity has been observed worldwide and it has significant consequences on health outcomes. In Australia, health-related quality of life (HRQoL) is comparatively low amongst Aboriginal and/or Torres Strait I…

Obstetric Complications and Adverse Birth Outcomes among Adolescent and Adult Pregnant Women in Dhaka, Bangladesh Open

Israt Jahan, Rumana Rashid, Farzana Sultana Bari, Md. Zafar As Sadiq, Tamanna Islam , et al. · 2023

Background and Objective: The current study aimed to determine the association of maternal age and obstetric complications and adverse birth outcomes among the adolescent and adult pregnant women. Methods: A cross-sectional study was cond…

PB2295: TITLE OF MANUSCRIPT: ESTABLISHING A TRANSNATIONAL HAEMATO-ONCOLOGY CANCER MULTIDISCIPLINARY TEAM DURING THE COVID-19 PANDEMIC IN A RESOURCE LIMITED SETTING Open

Mohammad Aminul Islam, Amin Lutful Kabir, Zahed Khan, Mahbubur Rahman, Mohammad Abdul Aziz , et al. · 2023

Topic: 19. Aggressive Non-Hodgkin lymphoma - Clinical Background: COVID-19 pandemic has created unprecedented hurdles to the delivery of timely care to patients with cancer even in most of developed nations. Patients with haematological ma…

REDCap and the National Mesothelioma Virtual Bank—a scalable and sustainable model for rare disease biorepositories Open

Rumana Rashid, S. Copelli, Jonathan C. Silverstein, Michael J. Becich · 2023

Objective Rare disease research requires data sharing networks to power translational studies. We describe novel use of Research Electronic Data Capture (REDCap), a web application for managing clinical data, by the National Mesothelioma V…

2D and 3D Multiplexed Subcellular Profiling of Nuclear Instability in Human Cancer Open

Shannon Coy, Brian Cheng, Jong Suk Lee, Rumana Rashid, Lindsay Browning , et al. · 2023

1079 LAG3-targeted IL15/IL15Rα-Fc (LAG3 x IL15) fusion proteins for preferential TIL expansion via cis delivery of IL15 to LAG3+ cells Open

Matthew J. Bernett, Suzanne Schubbert, Michael Hackett, Lukasz J. Ochyl, Lizett Scott , et al. · 2022

Background Therapeutic approaches utilizing IL2 or IL15 have suffered from low tolerability, fast clearance, and limited therapeutic window due to extensive activity on peripheral T and NK cells. Conversely, selective targeting of tumor-re…

1067 Synergistic combination of natural killer cell engagers (NKEs) with proinflammatory cytokines Open

Tian Zhang, Matthew S. Faber, Erik Pong, Ke Liu, Matthew J. Bernett , et al. · 2022

Background While promoting antigen-dependent T cell responses has proven successful in a subset of patients and in certain tumors, the emergence of resistance and tumor heterogeneity with respect to MHC class I expression suggests addition…

1372 XmAb143, an engineered IL18 heterodimeric Fc-fusion, features improved stability, reduced potency, and insensitivity to IL18BP Open

Alex Nisthal, Sung‐Hyung Lee, Christine Bonzon, Ruschelle Love, Kendra N. Avery , et al. · 2022

Background Interleukin-18 (IL18) is a proinflammatory cytokine that modulates both innate and adaptive immune responses. Mature IL18 promotes the expansion, survival, and cytotoxicity of T and NK cells expressing the heterodimeric IL18 rec…

1073 Costimulatory CD28 trispecific antibodies targeting PDL1 and PDL2 enhance T cell activation in solid tumors Open

Veronica G. Zeng, Juan Manuel Garrido Díaz, Jing Qi, Thuy T. Truong, Matthew A. Dragovich , et al. · 2022

Background T cells in the tumor micro-environment require TCR/MHC engagement and co-stimulatory receptor engagement to achieve optimal activation. Tumor cells lack expression of CD28 ligands, so we hypothesized that activation of CD28 sign…

PROSTHODONTIC MANAGEMENT OF THE MAXILLARY DEFECT SECONDARY TO MUCORMYCOSIS : A CASE REPORT Open

Vijay Tomar, S. Akhil, Puja Vasudeva Dutta, Rumana Rashid, Tapan Kumar Giri , et al. · 2022

Mucormycosis is an opportunistic fungal infection that invades rapidly and is usually seen in the immunocompromisedpatients.Rhinocerebral and pulmonary are the main two forms.Rhinocerebral form starts in the maxillary antrum and invades ra…

MINIMALLY INVASIVE TECHNIQUE FOR ANTERIOR TEETH REPLACEMENT- CASE SERIES Open

Puja Vasudeva Dutta, Rumana Rashid, Vijay Tomar, S Akhil, Tapan Kumar Giri · 2022

Patients are very much concerned nowadays about the replacement of their missing teeth. Missing anterior teeth are a serious concern for patients, be it an aesthetic concern or functional loss. Aesthetics is the harmony between the teeth a…

Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma Open

Shannon Coy, Shu Wang, Sylwia A. Stopka, Jia‐Ren Lin, Clarence Yapp , et al. · 2022

A case-control study to determine the risk factors of dengue fever in Chattogram, Bangladesh Open

Md. Sahidur Rahman, Fatema Mehejabin, Mohammad Arafat Rahman, Rumana Rashid · 2022

Knowledge and prevention practice against dengue vectors among dengue patients and general people in Chattogram, Bangladesh Open

Md. Sahidur Rahman, Fatema Mehejabin, Rumana Rashid · 2022

Background: Due to the absence of an effective vaccine for dengue, community-led vector control strategy could be a sustainable approach for dengue prevention. Therefore, this study aimed to assess people’s knowledge of dengue vectors and …

Single Cell Spatial Analysis Reveals the Topology of Immunomodulatory Purinergic Signaling in Glioblastoma Open

Shannon Coy, Shu Wang, Sylwia A. Stopka, Jia‐Ren Lin, Rumana Rashid , et al. · 2022

Glioblastoma develops an immunosuppressive microenvironment that fosters tumorigenesis and resistance to current therapeutic strategies. Here we use multiplexed tissue imaging and single-cell RNA-sequencing to characterize the composition,…

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