Rumen Krastev
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View article: Editorial: Translational development of tailored implants via advanced processing and surface modifications for tissue regeneration
Editorial: Translational development of tailored implants via advanced processing and surface modifications for tissue regeneration Open
View article: <i>In Vitro, Ex Vivo</i> and <i>In Vivo</i> Characterization of Cytocompatibility and Biocompatibility of a Cross-linked Fish Collagen Wound Membrane
<i>In Vitro, Ex Vivo</i> and <i>In Vivo</i> Characterization of Cytocompatibility and Biocompatibility of a Cross-linked Fish Collagen Wound Membrane Open
The results of this study highlight the potential of fish collagen membranes as biocompatible wound healing materials. However, their rapid degradation presents a challenge that needs to be addressed through targeted modifications, such as…
View article: Validation of the Chick Chorioallantoic Membrane (CAM) Model for Biocompatibility Analysis of Biomaterials in the Context of the 3R-cascade: A Pilot Study
Validation of the Chick Chorioallantoic Membrane (CAM) Model for Biocompatibility Analysis of Biomaterials in the Context of the 3R-cascade: A Pilot Study Open
We suggest that bioincompatible biomaterials can already be sorted out in the context of THE preclinical in vivo test phase. Such pre-testing before the required small animal tests might clearly contribute to the 3R-concept to reduc…
View article: Controlling Cellular Behavior by Surface Design of Titanium-based Biomaterials
Controlling Cellular Behavior by Surface Design of Titanium-based Biomaterials Open
The chemical composition of the surface, particularly the presence of free primary amino groups, significantly affects cellular behavior in machined, sand-blasted, and additively manufactured titanium materials, while the impact of surface…
View article: Characterization and modeling of additively manufactured Ti-6Al-4V alloy with modified surfaces for medical applications
Characterization and modeling of additively manufactured Ti-6Al-4V alloy with modified surfaces for medical applications Open
In the field of biomedical implants, additively manufactured titanium alloys, particularly Ti-6Al-4V, hold significant potential due to their biocompatibility and mechanical properties. This study focuses on the characterization and modeli…
View article: Composite polymer/wax coatings as a corrosion barrier of bioresorbable magnesium coronary stents
Composite polymer/wax coatings as a corrosion barrier of bioresorbable magnesium coronary stents Open
View article: Control of Cell Adhesion and Growth on Polysaccharide-Based Multilayer Coatings by Incorporation of Graphene Oxide
Control of Cell Adhesion and Growth on Polysaccharide-Based Multilayer Coatings by Incorporation of Graphene Oxide Open
Controlling cell adhesion, viability, and proliferation on solid surfaces is critical for the successful implantation and proper functioning of temporary and permanent medical devices. While, with temporary or removable implants as well as…
View article: Suitability of R. pulmo Jellyfish-Collagen-Coated Well Plates for Cytocompatibility Analyses of Biomaterials
Suitability of R. pulmo Jellyfish-Collagen-Coated Well Plates for Cytocompatibility Analyses of Biomaterials Open
Cytocompatibility analyses of new implant materials or biomaterials are not only prescribed by the Medical Device Regulation (MDR), as defined in the DIN ISO Norm 10993-5 and -12, but are also increasingly replacing animal testing. In this…
View article: Editorial: Functional surfaces and biomaterials
Editorial: Functional surfaces and biomaterials Open
At the beginning of 2022, Frontiers in Bioengineering and Biotechnology - Biomaterials Section has published a Research Topic on “Functional Surfaces and Biomaterials.” The aim of this Research Topic is to summarize the current state of re…
View article: Republication:<i>In Vitro</i>and<i>Ex Vivo</i>Analysis of Collagen Foams for Soft and Hard Tissue Regeneration
Republication:<i>In Vitro</i>and<i>Ex Vivo</i>Analysis of Collagen Foams for Soft and Hard Tissue Regeneration Open
Collagen sponges represent a promising material for hard and soft tissue regeneration. Future studies could focus on integrating and investigating different additives in the foams.
View article: The Granule Size Mediates the In Vivo Foreign Body Response and the Integration Behavior of Bone Substitutes
The Granule Size Mediates the In Vivo Foreign Body Response and the Integration Behavior of Bone Substitutes Open
The physicochemical properties of synthetically produced bone substitute materials (BSM) have a major impact on biocompatibility. This affects bony tissue integration, osteoconduction, as well as the degradation pattern and the correlated …
View article: Preparation of Cationic Amphiphilic Nanoparticles with Modified Chitosan Derivatives for Doxorubicin Delivery
Preparation of Cationic Amphiphilic Nanoparticles with Modified Chitosan Derivatives for Doxorubicin Delivery Open
Polymeric micelle-like nanoparticles have demonstrated effectiveness for the delivery of some poorly soluble or hydrophobic anticancer drugs. In this study, a hydrophobic moiety, deoxycholic acid (DCA) was first bonded on a polysaccharide,…
View article: Altered Proinflammatory Responses to Polyelectrolyte Multilayer Coatings Are Associated with Differences in Protein Adsorption and Wettability
Altered Proinflammatory Responses to Polyelectrolyte Multilayer Coatings Are Associated with Differences in Protein Adsorption and Wettability Open
A full understanding of the relationship between surface properties, protein adsorption, and immune responses is lacking but is of great interest for the design of biomaterials with desired biological profiles. In this study, polyelectroly…
View article: The Early Fragmentation of a Bovine Dermis-Derived Collagen Barrier Membrane Contributes to Transmembraneous Vascularization—A Possible Paradigm Shift for Guided Bone Regeneration
The Early Fragmentation of a Bovine Dermis-Derived Collagen Barrier Membrane Contributes to Transmembraneous Vascularization—A Possible Paradigm Shift for Guided Bone Regeneration Open
Collagen-based barrier membranes are an essential component in Guided Bone Regeneration (GBR) procedures. They act as cell-occlusive devices that should maintain a micromilieu where bone tissue can grow, which in turn provides a stable bed…
View article: <i>In Vitro</i>and<i>Ex Vivo</i>Analysis of Collagen Foams for Soft and Hard Tissue Regeneration
<i>In Vitro</i>and<i>Ex Vivo</i>Analysis of Collagen Foams for Soft and Hard Tissue Regeneration Open
Collagen sponges represent a promising material for hard and soft tissue regeneration. Future studies could focus on integrating and investigating different additives in the foams.
View article: Evaluation of antibacterial properties of polyelectrolyte multilayer coatings by norm tests
Evaluation of antibacterial properties of polyelectrolyte multilayer coatings by norm tests Open
Medical implants play a central role in modern medicine and both, naturally derived and synthetic materials have been explored as biomaterials for such devices. However, when implanted into living tissue, most materials initiate a host res…
View article: Composite polyelectrolyte multilayers for biofunctionalization of medical devices
Composite polyelectrolyte multilayers for biofunctionalization of medical devices Open
Polyelectrolyte multilayer coatings (PEM) are prepared by alternative layer-by-layer deposition of cationic and anionic polyelectrolyte monolayers on charged surfaces. The thickness of the coatings ranges from nm to few μm. Their propertie…
View article: Degradation, Bone Regeneration and Tissue Response of an Innovative Volume Stable Magnesium-Supported GBR/GTR Barrier Membrane
Degradation, Bone Regeneration and Tissue Response of an Innovative Volume Stable Magnesium-Supported GBR/GTR Barrier Membrane Open
Introduction: Bioresorbable collagenous barrier membranes are used to prevent premature soft tissue ingrowth and to allow bone regeneration. For volume stable indications, only non-absorbable synthetic materials are available. This study i…
View article: Inversely 3D-Printed β-TCP Scaffolds for Bone Replacement
Inversely 3D-Printed β-TCP Scaffolds for Bone Replacement Open
The aim of this study was to predefine the pore structure of β-tricalcium phosphate (β-TCP) scaffolds with different macro pore sizes (500, 750, and 1000 µm), to characterize β-TCP scaffolds, and to investigate the growth behavior of cells…
View article: Balancing Purification and Ultrastructure of Naturally Derived Bone Blocks for Bone Regeneration: Report of the Purification Effort of Two Bone Blocks
Balancing Purification and Ultrastructure of Naturally Derived Bone Blocks for Bone Regeneration: Report of the Purification Effort of Two Bone Blocks Open
The present publication reports the purification effort of two natural bone blocks, that is, an allogeneic bone block (maxgraft®, botiss biomaterials GmbH, Zossen, Germany) and a xenogeneic block (SMARTBONE®, IBI S.A., Mezzovico-Vira, Swit…
View article: Comparison of Material-mediated Bone Regeneration Capacities of Sintered and Non-sintered Xenogeneic Bone Substitutes <i>via</i> 2D and 3D Data
Comparison of Material-mediated Bone Regeneration Capacities of Sintered and Non-sintered Xenogeneic Bone Substitutes <i>via</i> 2D and 3D Data Open
Osteoconductivity index is a reliable measurement parameter for determining the healing capacities of BSM. The observed differences between both measurement methods could be assigned to the resolution capacity of μ-CT data that did not all…
View article: Polyelectrolyte Coatings for Surface Modification of Medical Implants
Polyelectrolyte Coatings for Surface Modification of Medical Implants Open
Polyelectrolyte multi-layer (PEM) coatings are prepared by alternative deposition of single polyelectrolyte monolayers on charged surfaces using the Layer-by-Layer (LbL) dip coating procedure. These are nanometre scaled coatings which allo…
View article: CurvChip - chip platform for investigating cell responses to curved surface features
CurvChip - chip platform for investigating cell responses to curved surface features Open
Surface topographies are often discussed as an important parameter influencing basic cell behavior. Whereas most in-vitro studies deal with microstructures with sharp edges, smooth, curved microscale topographies might be more relevant con…
View article: Biofunctionalization of surfaces using polyelectrolyte multilayers
Biofunctionalization of surfaces using polyelectrolyte multilayers Open
View article: Altruistic Surrogacy – Ethical Issues and Demographic Differences in Public Opinion
Altruistic Surrogacy – Ethical Issues and Demographic Differences in Public Opinion Open
This is the first study of the attitude of Bulgarian people towards the allowing of altruistic surrogacy which is prohibited in Bulgaria. This study used an online survey which was active during one year (July 2010-June 2011) and which was…
View article: Biofunctionalization of surfaces using polyelectrolyte multilayers
Biofunctionalization of surfaces using polyelectrolyte multilayers Open
Biomaterials play a central role in modern strategies in regenerative medicine and tissue engineering to restore the structure and function of damaged or dysfunctional tissue and to direct cellular behavior. Both biologically derived and s…