Yong Cui
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View article: Dynamic evolution of NK cells and immune remodeling mediated by CRS + HIPEC: prognostic mechanisms and therapeutic implications for malignant peritoneal mesothelioma
Dynamic evolution of NK cells and immune remodeling mediated by CRS + HIPEC: prognostic mechanisms and therapeutic implications for malignant peritoneal mesothelioma Open
Background Malignant peritoneal mesothelioma (MPM) is a highly aggressive peritoneal malignancy with a significant recurrence rate following cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC). There…
View article: Practicability of Activating Transcription Factor 3 as a Serological Marker for Severity Appraisal and Outcome Anticipation in Acute Supratentorial Intracerebral Hemorrhage: A Two‐center Observational Analytical Study
Practicability of Activating Transcription Factor 3 as a Serological Marker for Severity Appraisal and Outcome Anticipation in Acute Supratentorial Intracerebral Hemorrhage: A Two‐center Observational Analytical Study Open
Background Activating transcription factor 3 (ATF3) is a neuroprotective factor and participates in acute brain injury. Here, we intend to determine whether serum ATF3 levels are associated with the severity and clinical outcomes of acute …
View article: Machine-learning-derived prediction models of outcomes for patients with pseudomyxoma peritonei: development and validation in two retrospective cohorts
Machine-learning-derived prediction models of outcomes for patients with pseudomyxoma peritonei: development and validation in two retrospective cohorts Open
Background Pseudomyxoma peritonei (PMP) is a rare clinical syndrome characterized by the accumulation of mucinous ascites in the abdominal cavity. The standard treatment for PMP involves cytoreductive surgery with hyperthermic intraperiton…
View article: Dynamic evolution of NK cells and immune remodeling mediated by CRS+HIPEC: prognostic mechanisms and therapeutic implications for malignant peritoneal mesothelioma
Dynamic evolution of NK cells and immune remodeling mediated by CRS+HIPEC: prognostic mechanisms and therapeutic implications for malignant peritoneal mesothelioma Open
Background: Malignant peritoneal mesothelioma (MPM) is a highly aggressive peritoneal malignancy with a significant recurrence rate following cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC). Thus…
View article: Predicting postoperative complications after pneumonectomy using machine learning: a 10-year study
Predicting postoperative complications after pneumonectomy using machine learning: a 10-year study Open
The combination of machine-learning models and nomograms may contribute to the early prediction and reduction in the incidence of PCNC.
View article: New hopes and challenges in targeted therapy and immunotherapy for primary central nervous system lymphoma
New hopes and challenges in targeted therapy and immunotherapy for primary central nervous system lymphoma Open
Primary central nervous system lymphoma (PCNSL) is non-Hodgkin’s lymphoma (NHL) confined to the central nervous system. Most of the patients eventually develop relapsed/refractory (R/R) PCNSL, and the overall prognosis for PCNSL remains di…
View article: Alterations in gut microbiota and metabolites contribute to postoperative sleep disturbances
Alterations in gut microbiota and metabolites contribute to postoperative sleep disturbances Open
Background The composition of the intestinal flora and the resulting metabolites affect patients' sleep after surgery. Methods We intended to elucidate the mechanisms by which disordered intestinal flora modulate the pathophysiology of pos…
View article: Molecular biomarkers of response to sintilimab combined with lenvatinib for locally advanced hepatitis B virus-associated hepatocellular carcinoma
Molecular biomarkers of response to sintilimab combined with lenvatinib for locally advanced hepatitis B virus-associated hepatocellular carcinoma Open
Background: The efficacy of combining immune checkpoint inhibitors with anti-angiogenic drugs in advanced hepatocellular carcinoma (HCC) varies, and the predictive biomarkers for this therapy remain unclear. Methods: In this single-center …
View article: Machine learning-based models predict postoperative cardiovascular and neurological complications after pneumonectomy: A 10-year retrospective observational study
Machine learning-based models predict postoperative cardiovascular and neurological complications after pneumonectomy: A 10-year retrospective observational study Open
Background Reducing postoperative cardiovascular and neurological complications (PCNC) in thoracic surgery is key for improving postoperative survival. Therefore, we aimed to investigate the independent predictors of PCNC, develop machine …
View article: Tumor attached to major intrahepatic vascular for colorectal liver metastases after preoperative chemotherapy
Tumor attached to major intrahepatic vascular for colorectal liver metastases after preoperative chemotherapy Open
Background: Colorectal liver metastases attached major intrahepatic vessels has been considered to be risk factor for survival outcome after liver resection. The present study aimed to clarify the outcomes of R1 surgery (margin<1mm) in CRL…
View article: Tyrosine kinase inhibitors as potential sensitizers of adoptive T cell therapy for hepatocellular carcinoma
Tyrosine kinase inhibitors as potential sensitizers of adoptive T cell therapy for hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is a high-incidence malignant tumor worldwide and lacks effective treatment options. Targeted drugs are the preferred recommendations for the systemic treatment of hepatocellular carcinoma. Immunotherapy is a…
View article: Sintilimab plus Lenvatinib conversion therapy for intermediate/locally advanced hepatocellular carcinoma: A phase 2 study
Sintilimab plus Lenvatinib conversion therapy for intermediate/locally advanced hepatocellular carcinoma: A phase 2 study Open
Introduction Patients with intermediate or locally advanced hepatocellular carcinoma (HCC) who are not eligible for radical treatment typically have a poor overall prognosis. Treatment strategies that can convert unresectable HCC into rese…
View article: Mathematical calculation of the difference in shortening length after two types of proximal femoral varus and an investigation of their applicable conditions: an own-pair design
Mathematical calculation of the difference in shortening length after two types of proximal femoral varus and an investigation of their applicable conditions: an own-pair design Open
Background The shortening length of the lower extremity after the proximal femoral osteotomy is an important issue to be considered in preoperative planning of developmental dysplasia of the hip (DDH) in children. There is still a lack of …
View article: Research Progress of Cell Lineage Tracing and Single-Cell Sequencing Technology in Malignant Skin Tumors
Research Progress of Cell Lineage Tracing and Single-Cell Sequencing Technology in Malignant Skin Tumors Open
Cell lineage tracing and single-cell sequencing have been widely applied in development biology and oncology to reveal the molecular mechanisms in multiple basic biological processes and the differentiation of stem cells, as well as quanti…
View article: Orelabrutinib Combined With Lenalidomide and Immunochemotherapy for Relapsed/Refractory Primary Central Nervous System Lymphoma: A Retrospective Analysis of Case Series
Orelabrutinib Combined With Lenalidomide and Immunochemotherapy for Relapsed/Refractory Primary Central Nervous System Lymphoma: A Retrospective Analysis of Case Series Open
Background Relapsed/refractory (r/r) primary central nervous system lymphoma (PCNSL) is an intractable situation without sound treatment. Bruton’s tyrosine kinase (BTK) represents an attractive drug target in PCNSL. Orelabrutinib is a new-…
View article: Signal enhancement ratio of CE-MRI: a potential biomarker of survival after hepatic arterial infusion chemotherapy in biliary tract cancers
Signal enhancement ratio of CE-MRI: a potential biomarker of survival after hepatic arterial infusion chemotherapy in biliary tract cancers Open
Background The association of contrast-enhanced MRI (CE-MRI) and the overall survival (OS) of biliary tract cancers (BTC) is ambiguous. Thus, the aim of this study is to evaluate the value of signal enhancement ratio (SER) and its early ch…
View article: T2/FLAIR Abnormity Could Be the Early Sign of Glioblastoma Dissemination
T2/FLAIR Abnormity Could Be the Early Sign of Glioblastoma Dissemination Open
PurposeNewly emerged or constantly enlarged contrast-enhancing (CE) instead of T2/FLAIR lesions were the necessary sign for the diagnosis of glioblastoma (GBM) progression. This study aimed to investigate whether the T2/FLAIR abnormal tran…
View article: Neoadjuvant chemoradiotherapy plus postoperative adjuvant XELOX chemotherapy versus postoperative adjuvant chemotherapy with XELOX regimen for local advanced gastric cancer-A randomized, controlled study
Neoadjuvant chemoradiotherapy plus postoperative adjuvant XELOX chemotherapy versus postoperative adjuvant chemotherapy with XELOX regimen for local advanced gastric cancer-A randomized, controlled study Open
Objective: The aim of this study was to compare the clinical efficacy of neoadjuvant chemoradiotherapy (NACRT) combined with postoperative adjuvant XELOX (Oxaliplatin +Capecitabine) chemotherapy and postoperative adjuvant chemotherapy (ACT…
View article: Nomograms for predicting cancer-specific survival in patients with primary central nervous system lymphoma: a population- based analysis
Nomograms for predicting cancer-specific survival in patients with primary central nervous system lymphoma: a population- based analysis Open
Nomograms predicting the 1-, 3- and 5-year OS and CSS of patients with PCNSL were established in this study. The validated nomograms showed relatively good performance and may be used clinically to evaluate patients' individualized risk an…
View article: Identification of CDKL3 as a critical regulator in development of glioma through regulating RRM2 and the JNK signaling pathway
Identification of CDKL3 as a critical regulator in development of glioma through regulating RRM2 and the JNK signaling pathway Open
Glioma is one of the most commonly diagnosed intracranial malignancies. The molecular mechanism underlying the development of glioma is still largely unknown. In this study, we present the first report concerning the function and mechanism…
View article: Magnetic resonance imaging (MRI) versus computed tomography (CT) for the diagnosis of lymph node metastasis in preoperative rectal cancer
Magnetic resonance imaging (MRI) versus computed tomography (CT) for the diagnosis of lymph node metastasis in preoperative rectal cancer Open
The protocol is out of date and does not meet the current methodological standards of Cochrane. Withdrawn by Cochrane Colorectal group, currently no plans to revise/republish.
View article: A novel method using a single lumen tube and extraluminal bronchial blocker for one-lung ventilation in severe tracheal stenosis: a case report
A novel method using a single lumen tube and extraluminal bronchial blocker for one-lung ventilation in severe tracheal stenosis: a case report Open
Double-lumen tubes (DLT) and bronchial blockers (BB) are usually used to functionally isolate the lungs during thoracic surgery. However, for patients with tracheal stenosis, management of one lung ventilation (OLV) in the anesthesia is st…
View article: Higher Cho/NAA Ratio in Postoperative Peritumoral Edema Zone Is Associated With Earlier Recurrence of Glioblastoma
Higher Cho/NAA Ratio in Postoperative Peritumoral Edema Zone Is Associated With Earlier Recurrence of Glioblastoma Open
Objective: To explore the prognostic significance of metabolic parameters in postoperative peritumoral edema zone (PEZ) of patients with glioblastoma (GBM) based on proton magnetic resonance spectroscopy (MRS). Methods: The postoperative M…
View article: Use of Radiomics to Predict Response to Immunotherapy of Malignant Tumors of the Digestive System
Use of Radiomics to Predict Response to Immunotherapy of Malignant Tumors of the Digestive System Open
BACKGROUND Despite the promising results of immunotherapy in cancer treatment, new response patterns, including pseudoprogression and hyperprogression, have been observed. Radiomics is the automated extraction of high-fidelity, high-dimens…
View article: MRI-based radiomics model for preoperative prediction of 5-year survival in patients with hepatocellular carcinoma
MRI-based radiomics model for preoperative prediction of 5-year survival in patients with hepatocellular carcinoma Open
Background Recurrence is the major cause of mortality in patients with resected HCC. However, without a standard approach to evaluate prognosis, it is difficult to select candidates for additional therapy. Methods A total of 201 patients w…