Runfeng Ni
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View article: Arsenic Sulfide Induces Apoptosis in Myelodysplastic Neoplasm Cells Through the Suppression of ABI2
Arsenic Sulfide Induces Apoptosis in Myelodysplastic Neoplasm Cells Through the Suppression of ABI2 Open
The collective findings suggest that ABI2 is significantly overexpressed in MDS and AML, and its expression was correlated with unfavorable prognostic outcomes. Furthermore, As₂S₂ demonstrates therapeutic efficacy in MDS by modulating the …
View article: Prognostic Value of the Extent of Lymphadenectomy for Overall Survival Among Patients with Non-muscle Invasive Bladder Cancer, A Retrospective Cohort Study
Prognostic Value of the Extent of Lymphadenectomy for Overall Survival Among Patients with Non-muscle Invasive Bladder Cancer, A Retrospective Cohort Study Open
Background The purpose of this study was to find out the impact of lymph node dissection (LND) on the prognosis of patients undergoing cystectomy for non-muscle invasive bladder cancer (NMIBC) and determine the minimum number of lymph node…
View article: Efficacy of cystectomy in single-site oligometastatic bladder cancer: a Surveillance, Epidemiology, and End Results (SEER) study of 1,381 patients
Efficacy of cystectomy in single-site oligometastatic bladder cancer: a Surveillance, Epidemiology, and End Results (SEER) study of 1,381 patients Open
Cystectomy in the setting of multimodality protocols may prolong survival in bladder cancer patients with single-site metastasis of the bone and DLNs. It should be considered in a multidisciplinary setting.
View article: Clinical Characteristics of Patients with Urosepsis: A Descriptive Study Based on the MIMIC-IV Database
Clinical Characteristics of Patients with Urosepsis: A Descriptive Study Based on the MIMIC-IV Database Open
Objective This study aimed to compare the clinical characteristics of urosepsis patients with those having other types of sepsis, extract key clinical insights, and identify potential future research avenues. Material and Methods Data from…
View article: Clinicopathologic features and prognosis of incidental prostate cancer after radical cysto-prostatectomy: a comparative study between China and the West
Clinicopathologic features and prognosis of incidental prostate cancer after radical cysto-prostatectomy: a comparative study between China and the West Open
There were significant differences in IPCa detection rates between Chinese and Western populations. The main factors affecting survival were patient age and stage of BCa. However, in the NMIBC population, OS for patients with csIPCa appear…
View article: NingXueShengBan Decoction Regulates Immune Homeostasis by PI3 K/Akt/mTOR and TLR4/NF-κB Signaling Pathways in Immune Thrombocytopenia Patients
NingXueShengBan Decoction Regulates Immune Homeostasis by PI3 K/Akt/mTOR and TLR4/NF-κB Signaling Pathways in Immune Thrombocytopenia Patients Open
Objective Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease. The immune imbalance of T cells is an essential pathological mechanism of ITP, more specific, the balance of Effector T cells (Teff)/Regulatory T cell (Treg) mai…
View article: Efficacy of cytoreductive surgery for metastatic upper tract urothelial carcinoma: a Surveillance, Epidemiology and End Results (SEER) study of 508 patients
Efficacy of cytoreductive surgery for metastatic upper tract urothelial carcinoma: a Surveillance, Epidemiology and End Results (SEER) study of 508 patients Open
BACKGROUND: Cisplatin-based combination chemotherapy alone is currently considered the standard of care for patients with metastatic upper tract urothelial carcinoma (mUTUC). However, less research has been done on the efficacy of other co…
View article: Dioscin alleviates aplastic anemia through regulatory T cells promotion
Dioscin alleviates aplastic anemia through regulatory T cells promotion Open
Objectives: Aplastic anemia (AA) is one of the immune-mediated bone marrow failure disorders caused by multiple factors, including the inability of CD4 + CD25 + regulatory T cells (Tregs) to negatively regulate cytotoxic T lymphocytes (CTL…
View article: Immune suppressive drugs negatively regulate the CD8+ T cells function by acetyltransferase p300 induced canonical and non-canonical autophagy
Immune suppressive drugs negatively regulate the CD8+ T cells function by acetyltransferase p300 induced canonical and non-canonical autophagy Open
Macroautophagy is the mainly regulated form of autophagy that maintains the cellular homeostasis and degraded the transported cargoes. It is initiated by the protein kinase complex which initiation by receiving two signals pathway mTORC1-A…
View article: Dioscin Restores Immunological Tolerance of CD4+CD25+ Regulatory T Cells in Aplastic Anemia Mouse Model
Dioscin Restores Immunological Tolerance of CD4+CD25+ Regulatory T Cells in Aplastic Anemia Mouse Model Open
Background: Aplastic anemia (AA) is an immune-mediated disease of bone marrow failure owing to activated cytotoxic T lymphocytes (CTLs). CD4+CD25+ regulatory T cells (Tregs) could negatively regulate CTLs to maintain self-tolerance and avo…
View article: Dioscin Regulating Bone Marrow Apoptosis in Aplastic Anemia
Dioscin Regulating Bone Marrow Apoptosis in Aplastic Anemia Open
DNS recovered the peripheral pancytopenia and bone marrow failure in AA mice. DNS reduced the key protein of Fas signaling pathway level to inhibit apoptosis of bone marrow cells to treat AA.
View article: A mouse model of irradiation and spleen-thymus lymphocyte infusion induced aplastic anemia
A mouse model of irradiation and spleen-thymus lymphocyte infusion induced aplastic anemia Open
Our data suggest that the improved AA mouse model conforms to the diagnosis standard of AA and simulates the immune internal environment of human AA. The AA mouse model has a longer lifetime and unbalances of Th17/Treg cells caused the des…