Runhua Han
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View article: RNA Binding Proteins KhpA and KhpB Interact with Small Regulatory RNAs and Affect Global Gene Expression in <i>Deinococcus radiodurans</i>
RNA Binding Proteins KhpA and KhpB Interact with Small Regulatory RNAs and Affect Global Gene Expression in <i>Deinococcus radiodurans</i> Open
Small regulatory RNAs (sRNAs) in bacteria often associate with RNA-binding proteins to gain intracellular stability and/or to enable regulatory efficiency. While much of the current knowledge about those sRNA binding proteins is derived fr…
View article: The RNA-binding protein ProQ directly binds and regulates virulence genes in enterohemorrhagic Escherichia coli O157:H7
The RNA-binding protein ProQ directly binds and regulates virulence genes in enterohemorrhagic Escherichia coli O157:H7 Open
ProQ has recently emerged as a major post-transcriptional regulator in bacteria through directly binding to diverse mRNAs and small regulatory RNAs (sRNAs). However, the impact of ProQ in many pathogenic bacteria remains poorly understood.…
View article: Correction: A novel small RNA regulates locus of enterocyte effacement and site-specific colonization of enterohemorrhagic Escherichia coli O157:H7 in gut
Correction: A novel small RNA regulates locus of enterocyte effacement and site-specific colonization of enterohemorrhagic Escherichia coli O157:H7 in gut Open
[This corrects the article DOI: 10.3389/fcimb.2024.1517328.].
View article: A novel small RNA regulates Locus of Enterocyte Effacement and site-specific colonization of enterohemorrhagic Escherichia coli O157:H7 in gut
A novel small RNA regulates Locus of Enterocyte Effacement and site-specific colonization of enterohemorrhagic Escherichia coli O157:H7 in gut Open
Enterohemorrhagic Escherichia coli (EHEC) is a contagious foodborne pathogen that specifically colonizes the human large intestine, which is regulated by different environmental stimuli within the gut. Transcriptional regulation of EHEC vi…
View article: Initiatives and approaches for antifungal research
Initiatives and approaches for antifungal research Open
Fungal infections have emerged as a major global health concern now but are often overshadowed by the focus on bacterial infections. With the increasing prevalence and mortality associated with fungal diseases, the Fungal Priority Pathogen…
View article: Selective 8-oxo-rG stalling occurs in the catalytic core of polynucleotide phosphorylase (PNPase) during degradation
Selective 8-oxo-rG stalling occurs in the catalytic core of polynucleotide phosphorylase (PNPase) during degradation Open
RNA oxidation, predominantly through the accumulation of 8-oxo-7,8-dihydroguanosine (8-oxo-rG), represents an important biomarker for cellular oxidative stress. Polynucleotide phosphorylase (PNPase) is a 3′-5′ exoribonuclease that has been…
View article: Genetically Encoded Biosensor Engineering for Application in Directed Evolution
Genetically Encoded Biosensor Engineering for Application in Directed Evolution Open
Although rational genetic engineering is nowadays the favored method for microbial strain improvement, building up mutant libraries based on directed evolution for improvement is still in many cases the better option. In this regard, the d…
View article: Scripts to analyze cell size of bacteria
Scripts to analyze cell size of bacteria Open
Scripts to analyze the cell size of bacteria
View article: An Overlooked and Underrated Endemic Mycosis—Talaromycosis and the Pathogenic Fungus Talaromyces marneffei
An Overlooked and Underrated Endemic Mycosis—Talaromycosis and the Pathogenic Fungus Talaromyces marneffei Open
Talaromycosis is an invasive mycosis endemic in tropical and subtropical Asia and is caused by the pathogenic fungus Talaromyces marneffei . Approximately 17,300 cases of T. marneffei infection are diagnosed annually, and the reported mort…
View article: Abstract 2733: Mapping oxidative stress response RNA-protein networks
Abstract 2733: Mapping oxidative stress response RNA-protein networks Open
View article: PNPase and RhlB Interact and Reduce the Cellular Availability of Oxidized RNA in <i>Deinococcus radiodurans</i>
PNPase and RhlB Interact and Reduce the Cellular Availability of Oxidized RNA in <i>Deinococcus radiodurans</i> Open
Oxidative RNA damage can be caused by oxidative stress, such as hydrogen peroxide, ionizing radiation, and antibiotic treatment. 8-oxo-7,8-dihydroguanine (8-oxoG), a major type of oxidized RNA, is highly mutagenic and participates in a var…
View article: Defining Suitable Reference Genes for qRT-PCR in Plagiodera versicolora (Coleoptera: Chrysomelidae) under Different Biotic or Abiotic Conditions
Defining Suitable Reference Genes for qRT-PCR in Plagiodera versicolora (Coleoptera: Chrysomelidae) under Different Biotic or Abiotic Conditions Open
Plagiodera versicolora (Coleoptera: Chrysomelidae) is one of the most destructive pests of the Salicaceae worldwide, which has established complex interactions with surrounding organisms. Uncovering the molecular mechanisms of some antagon…
View article: Differing Dietary Nutrients and Diet-Associated Bacteria Has Limited Impact on Spider Gut Microbiota Composition
Differing Dietary Nutrients and Diet-Associated Bacteria Has Limited Impact on Spider Gut Microbiota Composition Open
Spiders are a key predator of insects across ecosystems and possess great potential as pest control agents. Unfortunately, it is difficult to artificially cultivate multiple generations of most spider species. Since gut bacterial flora has…
View article: Differing Dietary Nutrients and Diet-associated Bacteria has Limited Impact on Spider Gut Microbiota Composition
Differing Dietary Nutrients and Diet-associated Bacteria has Limited Impact on Spider Gut Microbiota Composition Open
Spiders are a key predator of insects across ecosystems and possess great potential as pest control agents. Unfortunately, it is difficult to artificially cultivate multiple generations of most spider species. Since gut bacterial flora has…
View article: A small RNA regulates pprM, a modulator of pleiotropic proteins promoting DNA repair, in Deinococcus radiodurans under ionizing radiation
A small RNA regulates pprM, a modulator of pleiotropic proteins promoting DNA repair, in Deinococcus radiodurans under ionizing radiation Open
View article: Signal Recognition Particle RNA Contributes to Oxidative Stress Response in Deinococcus radiodurans by Modulating Catalase Localization
Signal Recognition Particle RNA Contributes to Oxidative Stress Response in Deinococcus radiodurans by Modulating Catalase Localization Open
The proper functioning of many proteins requires their transport to the correct cellular compartment or their secretion. Signal recognition particle (SRP) is a major protein transport pathway responsible for the co-translational movement o…
View article: Magnesium Sensing Regulates Intestinal Colonization of Enterohemorrhagic Escherichia coli O157:H7
Magnesium Sensing Regulates Intestinal Colonization of Enterohemorrhagic Escherichia coli O157:H7 Open
Sensing specific gut metabolites is an important strategy for inducing crucial virulence programs by enterohemorrhagic Escherichia coli (EHEC) O157:H7 during colonization and infection. Here, we identified a virulence-regulating pathway wh…
View article: Multiple Small RNAs Interact to Co-regulate Ethanol Tolerance in Zymomonas mobilis
Multiple Small RNAs Interact to Co-regulate Ethanol Tolerance in Zymomonas mobilis Open
sRNAs represent a powerful class of regulators that influences multiple mRNA targets in response to environmental changes. However, very few direct sRNA-sRNA interactions have been deeply studied in any organism. Zymomonas mobilis i…
View article: A Small Regulatory RNA Contributes to the Preferential Colonization of Escherichia coli O157:H7 in the Large Intestine in Response to a Low DNA Concentration
A Small Regulatory RNA Contributes to the Preferential Colonization of Escherichia coli O157:H7 in the Large Intestine in Response to a Low DNA Concentration Open
Enterohemorrhagic Escherichia coli (EHEC) serotype O157:H7 (O157) is one of the most notorious human pathogens, causing severe disease in humans worldwide. O157 specifically colonizes the large intestine of mammals after passing thr…