Runmin Wei
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View article: Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolution
Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolution Open
The intestinal epithelium is often a site of pathology, such as in inflammatory bowel disease (IBD), and its maintenance is highly modulated by interactions with the microenvironment. However, a systematic understanding of how the myriad o…
View article: SpatialAgent: An autonomous AI agent for spatial biology
SpatialAgent: An autonomous AI agent for spatial biology Open
Advances in AI are transforming scientific discovery, yet spatial biology, a field that deciphers the molecular organization within tissues, remains constrained by labor-intensive workflows. Here, we present SpatialAgent, a fully autonomou…
View article: Author Correction: Multiplexed, image-based pooled screens in primary cells and tissues with PerturbView
Author Correction: Multiplexed, image-based pooled screens in primary cells and tissues with PerturbView Open
View article: Normal breast tissues harbour rare populations of aneuploid epithelial cells
Normal breast tissues harbour rare populations of aneuploid epithelial cells Open
View article: Highly multiplexed, image-based pooled screens in primary cells and tissues with PerturbView
Highly multiplexed, image-based pooled screens in primary cells and tissues with PerturbView Open
Optical pooled screening (OPS) is a highly scalable method for linking image-based phenotypes with cellular perturbations. However, it has thus far been restricted to relatively low-plex phenotypic readouts in cancer cell lines in culture,…
View article: A spatially resolved single-cell genomic atlas of the adult human breast
A spatially resolved single-cell genomic atlas of the adult human breast Open
View article: A spatially resolved single cell genomic atlas of the adult human breast
A spatially resolved single cell genomic atlas of the adult human breast Open
SUMMARY The adult human breast comprises an intricate network of epithelial ducts and lobules that are embedded in connective and adipose tissue. While previous studies have mainly focused on the breast epithelial system, many of the non-e…
View article: Table S2 from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma
Table S2 from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma Open
GSEA using mSigDB CGP collection
View article: Supplementary Figures S2-S4 from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma
Supplementary Figures S2-S4 from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma Open
Heat Maps
View article: Tables S3-S8 from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma
Tables S3-S8 from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma Open
Gene set overlap analysis results
View article: Data from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma
Data from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma Open
Studies involving transcriptomics have revealed multiple molecular subtypes of hepatocellular carcinoma (HCC). Positron emission tomography/computed tomography (PET/CT) has also identified distinct molecular imaging subtypes, including tho…
View article: Supplementary Figures S2-S4 from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma
Supplementary Figures S2-S4 from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma Open
Heat Maps
View article: Table S1 from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma
Table S1 from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma Open
Functional Annotation Cluster Results
View article: Tables S3-S8 from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma
Tables S3-S8 from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma Open
Gene set overlap analysis results
View article: Table S1 from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma
Table S1 from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma Open
Functional Annotation Cluster Results
View article: Data from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma
Data from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma Open
Studies involving transcriptomics have revealed multiple molecular subtypes of hepatocellular carcinoma (HCC). Positron emission tomography/computed tomography (PET/CT) has also identified distinct molecular imaging subtypes, including tho…
View article: Table S2 from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma
Table S2 from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma Open
GSEA using mSigDB CGP collection
View article: Supplementary Figure S1 from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma
Supplementary Figure S1 from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma Open
SUV Ratios (was previously Figure S4, but renumbered to match call out order)
View article: Supplementary Figure S1 from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma
Supplementary Figure S1 from Transcriptomics Associates Molecular Features with <sup>18</sup>F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma Open
SUV Ratios (was previously Figure S4, but renumbered to match call out order)
View article: Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease
Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease Open
View article: Spatial charting of single-cell transcriptomes in tissues
Spatial charting of single-cell transcriptomes in tissues Open
View article: Spatial charting of single cell transcriptomes in tissues
Spatial charting of single cell transcriptomes in tissues Open
Single cell RNA sequencing (scRNA-seq) methods can profile the transcriptomes of single cells but cannot preserve spatial information. Conversely, spatial transcriptomics (ST) assays can profile spatial regions in tissue sections, but do n…
View article: Peripheral serum metabolomic profiles inform central cognitive impairment
Peripheral serum metabolomic profiles inform central cognitive impairment Open
View article: Author Correction: Analysis of the Human Protein Atlas Image Classification competition
Author Correction: Analysis of the Human Protein Atlas Image Classification competition Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Serum metabolite profiles are associated with the presence of advanced liver fibrosis in Chinese patients with chronic hepatitis B viral infection
Serum metabolite profiles are associated with the presence of advanced liver fibrosis in Chinese patients with chronic hepatitis B viral infection Open
View article: Publisher Correction: Analysis of the Human Protein Atlas Image Classification competition
Publisher Correction: Analysis of the Human Protein Atlas Image Classification competition Open
View article: Serum metabolite profiles are associated with the presence of advanced liver fibrosis in Chinese patients with chronic hepatitis B viral infection
Serum metabolite profiles are associated with the presence of advanced liver fibrosis in Chinese patients with chronic hepatitis B viral infection Open
Background & Aims Accurate and noninvasive diagnosis and staging of liver fibrosis is essential for effective clinical management of chronic liver disease (CLD). We aimed to identify serum metabolite markers that reliably predict the stage…
View article: Publisher Correction: Analysis of the Human Protein Atlas Image Classification competition
Publisher Correction: Analysis of the Human Protein Atlas Image Classification competition Open
View article: Analysis of the Human Protein Atlas Image Classification competition
Analysis of the Human Protein Atlas Image Classification competition Open
Pinpointing subcellular protein localizations from microscopy images is easy to the trained eye, but challenging to automate. Based on the Human Protein Atlas image collection, we held a competition to identify deep learning solutions to s…
View article: Peripheral Serum Metabolomic Profiles Inform Antecedent Central Cognitive Impairment in Older Adults
Peripheral Serum Metabolomic Profiles Inform Antecedent Central Cognitive Impairment in Older Adults Open
The incidence of Alzheimer’s disease (AD) increases with age and is a significant cause of worldwide morbidity and mortality. However, the metabolic perturbations behind the onset of AD remains unclear. In this study, we performed metaboli…