Runnan Wang
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View article: Guanine Nucleotide Exchange Factors and Small GTPases: Their Regulation and Functions, Diseases, and Therapeutic Targets
Guanine Nucleotide Exchange Factors and Small GTPases: Their Regulation and Functions, Diseases, and Therapeutic Targets Open
Guanine nucleotide exchange factors (GEFs) and their small GTPase substrates constitute a fundamental regulatory system that governs diverse cellular processes, including cytoskeletal dynamics, membrane trafficking, and transcriptional reg…
View article: Exogenous Trilobatin Enhances Flavonoid Content in Purple Rice Grains and Affects the Flavonoid Biosynthesis Pathway
Exogenous Trilobatin Enhances Flavonoid Content in Purple Rice Grains and Affects the Flavonoid Biosynthesis Pathway Open
Antioxidant activity and flavonoid content are important characteristics of colored rice grains. Previously, we obtained a preliminary understanding of the metabolic markers of antioxidant activity, namely, phlorizin and trilobatin, in dif…
View article: The impact of the COVID-19 surge after the end of China's Zero-COVID policy on the health-related quality of life of IBD patients
The impact of the COVID-19 surge after the end of China's Zero-COVID policy on the health-related quality of life of IBD patients Open
This study highlights the significant impact of the COVID-19 pandemic on the HRQoL of IBD patients. The findings emphasize the need for integrated care addressing both the physical and psychological aspects of IBD.
View article: Activin A plays an essential role in migration and proliferation of hepatic stellate cells via Smad3 and calcium signaling
Activin A plays an essential role in migration and proliferation of hepatic stellate cells via Smad3 and calcium signaling Open
Activin A and hepatic stellate cells (HSCs) are involved in tissue repair and fibrosis in liver injury. This study investigated the impact of activin A on HSC activation and migration. A microfluidic D4-chip was used for examining the cell…
View article: Effects of Controlled-Release Nitrogen Fertilizer at Different Release Stages on Rice Yield and Quality
Effects of Controlled-Release Nitrogen Fertilizer at Different Release Stages on Rice Yield and Quality Open
The replacement of common urea with controlled-release nitrogen fertilizer can improve rice yield and quality, but the effect of controlled-release nitrogen fertilizer on rice yield and quality at different release stages is still unclear.…
View article: Nitrogen fertilizer regulates purple rice seed endophytes and grain amino acid accumulation
Nitrogen fertilizer regulates purple rice seed endophytes and grain amino acid accumulation Open
The effects of different nitrogen (N) application levels on seed endophytes and grain nutritional quality are not yet clear. The impact of four N application levels on endophytes and amino acid accumulation in purple rice seeds was examine…
View article: The clinical characteristics and prognostic risk factors of duodenal lateral wall fistula
The clinical characteristics and prognostic risk factors of duodenal lateral wall fistula Open
Objective: This study aimed to examine the clinical characteristics, prognosis, and high-risk factors affecting the outcomes of duodenal lateral wall fistulas, with the goal of improving treatment strategies. Methods: A retrospective analy…
View article: Lipidomic analysis of grain quality variation in high quality aromatic japonica rice
Lipidomic analysis of grain quality variation in high quality aromatic japonica rice Open
To maintain the purity of the seeds and rice quality of the high-quality rice varieties, five lines with similar field and yield traits were selected from the Nanjing46 population in Liyang and used as study materials, and the original pro…
View article: Temporal Profile of the Microbial Community and Volatile Compounds in the Third-Round Fermentation of Sauce-Flavor baijiu in the Beijing Region
Temporal Profile of the Microbial Community and Volatile Compounds in the Third-Round Fermentation of Sauce-Flavor baijiu in the Beijing Region Open
Sauce-flavor baijiu produced in the Beijing and Guizhou regions has regional characteristic flavors, but the differences in flavor compounds and reasons for their formation remain unclear. The sauce-flavor baijiu brewing process involves s…
View article: Influence of the COVID-19 Outbreak on Health-Related Quality of Life in Inflammatory Bowel Disease Patients in China: A Cross-Sectional Questionnaire-Based Study
Influence of the COVID-19 Outbreak on Health-Related Quality of Life in Inflammatory Bowel Disease Patients in China: A Cross-Sectional Questionnaire-Based Study Open
Background Following the Chinese government's announcement that the zero-COVID policy had ended, there was a rapid and widespread outbreak of COVID-19. In this context, the condition and psychological impact on IBD patients were unknown, a…
View article: The main nutritional components in colored rice grains
The main nutritional components in colored rice grains Open
Colored rice grains contain rich nutrients. To investigate the differences in nutrient composition among different colored rice varieties, LC-MS non-targeted lipidomics and targeted amino acid profiling were used to study the lipid and ami…
View article: Comparison of Metabolites and Main Nutritional Components between Uncooked and Cooked Purple Rice
Comparison of Metabolites and Main Nutritional Components between Uncooked and Cooked Purple Rice Open
Cooking can lead to varying degrees of nutrient loss in purple rice. For this investigation, two varieties of purple rice (YZN1 and YZ6) were chosen as the focal points to explore the metabolites associated with rice nutrition post cooking…
View article: Analysis of Adverse Reactions of Cosmetics in Chinese Han Population in Recent Five Years
Analysis of Adverse Reactions of Cosmetics in Chinese Han Population in Recent Five Years Open
This study complements the data reported on cosmetic adverse reactions in the Chinese Han population and suggests that in future clinical diagnosis and data collection, emphasis should be placed on patch testing, combining the patch test w…
View article: Research on Sensitive Fluorescence Detection of Fe<sup>3+</sup> and Cr<sub>2</sub>O<sub>7</sub> <sup>2-</sup> in River Based on Ln-MOF Materials
Research on Sensitive Fluorescence Detection of Fe<sup>3+</sup> and Cr<sub>2</sub>O<sub>7</sub> <sup>2-</sup> in River Based on Ln-MOF Materials Open
Excessive release of Fe 3+ and Cr 2 O 7 2- would threaten public health and environmental safety. Seeking an effective probe for Fe 3+ and Cr 2 O 7 2- sensing by a simple and rapid approach in real water samples is significantly desirable.…
View article: Research Progress in Crop Root Biology and Nitrogen Uptake and Use, with Emphasis on Cereal Crops
Research Progress in Crop Root Biology and Nitrogen Uptake and Use, with Emphasis on Cereal Crops Open
The biological characteristics of crop roots are closely related to the efficient utilization of nitrogen and have become a research hotspot in agricultural cultivation and breeding in recent years. The root system and root microbiota play…
View article: Metabolomics revealed metabolite biomarkers of antioxidant properties and flavonoid metabolite accumulation in purple rice after grain filling
Metabolomics revealed metabolite biomarkers of antioxidant properties and flavonoid metabolite accumulation in purple rice after grain filling Open
The correlation between flavonoids, phenolic metabolites and the total antioxidant capacity is well established. However, specific biomarkers of metabolites with antioxidant properties in purple rice grains remain unidentified. This study …
View article: Integrated 16S and metabolomics revealed the mechanism of drought resistance and nitrogen uptake in rice at the heading stage under different nitrogen levels
Integrated 16S and metabolomics revealed the mechanism of drought resistance and nitrogen uptake in rice at the heading stage under different nitrogen levels Open
The normal methods of agricultural production worldwide have been strongly affected by the frequent occurrence of drought. Rice rhizosphere microorganisms have been significantly affected by drought stress. To provide a hypothetical basis …
View article: The Key Metabolites in Rice Quality Formation of Conventional japonica Varieties
The Key Metabolites in Rice Quality Formation of Conventional japonica Varieties Open
To understand differences in the quality of different conventional japonica rice varieties and variations in metabolites related to rice quality, the quality of three conventional japonica varieties was determined, and the metabolites of t…
View article: Metabolites Associated with the Main Nutrients in Two Varieties of Purple Rice Processed to Polished Rice
Metabolites Associated with the Main Nutrients in Two Varieties of Purple Rice Processed to Polished Rice Open
Under the same nitrogen fertilizer and cultivation conditions, the nutrients of rice are strongly affected during the processing of brown rice to polished rice, especially in special rice varieties. In this study, twenty-two amino acids in…
View article: The Inflammatory Factor SNP May Serve as a Promising Biomarker for Acitretin to Alleviate Secondary Failure of Response to TNF-a Monoclonal Antibodies in Psoriasis
The Inflammatory Factor SNP May Serve as a Promising Biomarker for Acitretin to Alleviate Secondary Failure of Response to TNF-a Monoclonal Antibodies in Psoriasis Open
Psoriasis is a common immune-mediated inflammatory skin disease. Although biological agents have achieved good clinical efficacy in the treatment of moderate-to-severe psoriasis, the phenomenon of secondary non-response (SNR) has been grad…
View article: The Relationship Between Parent-Adolescent Communication and Depressive Symptoms: The Roles of School Life Experience, Learning Difficulties and Confidence in the Future
The Relationship Between Parent-Adolescent Communication and Depressive Symptoms: The Roles of School Life Experience, Learning Difficulties and Confidence in the Future Open
More father-adolescent communication, higher confidence in the future, better school-life experiences, and fewer academic difficulties were associated with lower levels of depressive symptoms. Both mother-adolescent communication and fathe…
View article: Prevalence of Metabolic Syndrome in Chinese Patients With Erythrodermic Psoriasis: A Case-Control Study
Prevalence of Metabolic Syndrome in Chinese Patients With Erythrodermic Psoriasis: A Case-Control Study Open
Erythroderma psoriasis (EP) is a rare and severe form of psoriasis, which is a chronic inflammatory skin disease that usually occurs simultaneously with cardiovascular disease (CVD). Metabolic syndrome (MetS) is a significant precursor of …
View article: Relationship between Different Psoriasis Types and Thyroid Dysfunction: A Retrospective Analysis
Relationship between Different Psoriasis Types and Thyroid Dysfunction: A Retrospective Analysis Open
Objective. The aim of this study was to investigate the relationship between different psoriasis types and thyroid dysfunction. Methods. The data of patients diagnosed with psoriasis between January 2013 and October 2018 who underwent thyr…
View article: The effects of acupuncture for patients with psoriasis
The effects of acupuncture for patients with psoriasis Open
Introduction: Psoriasis is a common chronic relapsing inflammatory skin disease, which may have considerable detrimental effects on the quality of life. Considering high costs and side effects associated with the use of conventional medica…
View article: Activin A as a Novel Chemokine Induces Migration of L929 Fibroblasts by ERK Signaling in Microfluidic Devices
Activin A as a Novel Chemokine Induces Migration of L929 Fibroblasts by ERK Signaling in Microfluidic Devices Open
Activin A, a member of the transforming growth factor-beta (TGF-β) superfamily, contributes to tissue healing and fibrosis. As the innate tissue cells, fibroblasts also play an important role in wound healing and fibrosis. Herein, this stu…