Rongcun Yang
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View article: SPP1+ macrophages in tumor immunosuppression: mechanisms and therapeutic implications
SPP1+ macrophages in tumor immunosuppression: mechanisms and therapeutic implications Open
Secreted phosphoprotein 1 (SPP1 + ) macrophages are a recurrent and functionally critical immune cell subset across multiple cancer types. They drive adverse clinical outcomes by promoting immunosuppression, tumor invasion, metastasis, and…
View article: Gut microbiota L-ornithine promotes resistance to obesity through metabolites mediated immunosuppressive macrophages
Gut microbiota L-ornithine promotes resistance to obesity through metabolites mediated immunosuppressive macrophages Open
The gut microbiota plays a pivotal role in modulating obesity pathogenesis, yet the molecular mechanisms underlying its protective effects remain elusive. In this study, we demonstrate that L-ornithine (L-orn), a metabolite produced by Lac…
View article: <b>Gut microbiota butyrate mediated RUNX3 promotes Nr4a1</b> <sup> <b>high</b> </sup> <b>ZFP36</b> <sup> <b>high</b> </sup> <b>resident macrophages via NR4A1/ERK1/2 MAPK to maintain gut homeostasis</b>
<b>Gut microbiota butyrate mediated RUNX3 promotes Nr4a1</b> <sup> <b>high</b> </sup> <b>ZFP36</b> <sup> <b>high</b> </sup> <b>resident macrophages via NR4A1/ERK1/2 MAPK to maintain gut homeostasis</b> Open
Gut homeostasis is critical for systemic health, and its disruption is implicated in various diseases, including metabolic disorders. Gut-resident macrophages play a pivotal role in maintaining intestinal homeostasis, yet the mechanisms un…
View article: Adiponectin Regulated by Indole‐3‐Acetic Acid in Paneth Cells Controls Renewal and Differentiation of Gut Stem Cells
Adiponectin Regulated by Indole‐3‐Acetic Acid in Paneth Cells Controls Renewal and Differentiation of Gut Stem Cells Open
The intestinal epithelium is tightly regulated by intestinal stem cells (ISCs), but the precise mechanisms governing their differentiation remain incompletely understood. We here demonstrate that adiponectin secreted by Paneth cells (PCs) …
View article: A microporous liraglutide-releasing silk fibroin scaffold improves islet transplantation outcomes through anti-inflammatory effect
A microporous liraglutide-releasing silk fibroin scaffold improves islet transplantation outcomes through anti-inflammatory effect Open
Islet transplantation represents one of the most promising therapies for curing type 1 diabetes, yet it encounters significant challenges, including early islet damage due to inflammation and hypoxia, which complicate engraftment and survi…
View article: Regulation of ZFP36 by lncOlfr29 promotes inflammation through NLRP3
Regulation of ZFP36 by lncOlfr29 promotes inflammation through NLRP3 Open
Objective The functional state of macrophages is regulated by multiple factors and closely related to the occurrence and development of various diseases. The aim of this study is to discover a new regulatory factor in macrophages, which ca…
View article: Solved in Unit Domain: JacobiNet for Differentiable Coordinate-Transformed PINNs
Solved in Unit Domain: JacobiNet for Differentiable Coordinate-Transformed PINNs Open
Physics-Informed Neural Networks offer a powerful framework for solving PDEs by embedding physical laws into the learning process. However, when applied to domains with irregular boundaries, PINNs often suffer from instability and slow con…
View article: Gut microbiota derived L-ornithine promotes resistance to obesity through metabolites mediated immunosuppressive macrophages
Gut microbiota derived L-ornithine promotes resistance to obesity through metabolites mediated immunosuppressive macrophages Open
Gut microbiota can affect the occurrence and development of obesity. But the exact mechanism(s) by which obesity is prevented is still not fully understood. In this study, we found that L-ornithine (L-orn) from the gut microbiota lactobaci…
View article: LncRNA29RIK in macrophages promotes LPS-mediated sensitivity to obesity
LncRNA29RIK in macrophages promotes LPS-mediated sensitivity to obesity Open
Lipopolysaccharide (LPS, endotoxin) -mediated signaling of caspase-4 (human) and -11 (rodent) can induce the maturation of inflammatory cytokine IL-1β and cell pyroptosis, which is associated with the pathophysiology of many diseases such …
View article: Gut microbiota derived indole-3-acetic acid ameliorates precancerous inflammatory intestinal milieu to inhibit tumorigenesis through IL-35
Gut microbiota derived indole-3-acetic acid ameliorates precancerous inflammatory intestinal milieu to inhibit tumorigenesis through IL-35 Open
Background Gut microbiota can significantly alter the risk or progression of cancer by maintaining gut immune system homeostasis. However, the exact mechanism by which the gut microbiota and its metabolites influence colorectal tumorigenes…
View article: Maternal high-fat diet disrupts intestinal mucus barrier of offspring by regulating gut immune receptor LRRC19
Maternal high-fat diet disrupts intestinal mucus barrier of offspring by regulating gut immune receptor LRRC19 Open
Maternal high fat diet (MHFD) increased colitis susceptibility in adulthood. However, the mechanism remains unclear. We sought to explore whether novel gut immune receptor leucine-rich repeat C19 (LRRC19) contributed to the impaired mucus …
View article: Exploring effects of gut microbiota on tertiary lymphoid structure formation for tumor immunotherapy
Exploring effects of gut microbiota on tertiary lymphoid structure formation for tumor immunotherapy Open
Anti-tumor immunity, including innate and adaptive immunity is critical in inhibiting tumorigenesis and development of tumor. The adaptive immunity needs specific lymph organs such as tertiary lymphoid structures (TLSs), which are highly c…
View article: Gut microbiota CLA and IL-35 induction in macrophages through Gαq/11-mediated STAT1/4 pathway: an animal-based study
Gut microbiota CLA and IL-35 induction in macrophages through Gαq/11-mediated STAT1/4 pathway: an animal-based study Open
Gut microbiota/metabolites not only participate in the food and energy metabolism but also contribute to the host immune response and homeostasis. The alternation of gut microbiota/metabolites has been widely related to intestinal and extr…
View article: Bile acid derivatives from gut microbiota promote GBPs-mediated activation of caspase-4/11 by LPS through <i>lncRNA57RIK</i>
Bile acid derivatives from gut microbiota promote GBPs-mediated activation of caspase-4/11 by LPS through <i>lncRNA57RIK</i> Open
Lipopolysaccharide (LPS) mediated caspases-4 (humans) and caspase-11 (rodent) (caspase-4/11) signaling can cause maturation of inflammatory cytokine IL-1β and cellular pyroptosis in the macrophages through guanylate-binding proteins (GBPs)…
View article: Gut microbiota metabolite indole-3-acetic acid maintains intestinal epithelial homeostasis through mucin sulfation
Gut microbiota metabolite indole-3-acetic acid maintains intestinal epithelial homeostasis through mucin sulfation Open
The global incidence and prevalence of inflammatory bowel disease (IBD) are gradually increasing. A high-fat diet (HFD) is known to disrupt intestinal homeostasis and aggravate IBD, yet the underlying mechanisms remain largely undefined. H…
View article: Fungi and tumors: The role of fungi in tumorigenesis (Review)
Fungi and tumors: The role of fungi in tumorigenesis (Review) Open
Fungi inhabit different anatomic sites in the human body. Advances in omics analyses of host‑microbiome interactions have tremendously improved our understanding of the effects of fungi on human health and diseases such as tumors. Due to t…
View article: Editor's Note: Delivery of Telomerase Reverse Transcriptase Small Interfering RNA in Complex with Positively Charged Single-Walled Carbon Nanotubes Suppresses Tumor Growth
Editor's Note: Delivery of Telomerase Reverse Transcriptase Small Interfering RNA in Complex with Positively Charged Single-Walled Carbon Nanotubes Suppresses Tumor Growth Open
to concerns about this article (1): in Fig. 2A, the same micrograph was used to represent both the control and LLC cells treated with siRNA, and the figure legend for Fig. 2 did not clarify that the same micrograph was used to represent LL…
View article: Novel tumor-associated macrophage populations and subpopulations by single cell RNA sequencing
Novel tumor-associated macrophage populations and subpopulations by single cell RNA sequencing Open
Tumor-associated macrophages (TAMs) are present in almost all solid tumor tissues. 16They play critical roles in immune regulation, tumor angiogenesis, tumor stem cell activation, tumor invasion and metastasis, and resistance to therapy. H…
View article: Desulfovibrio vulgaris interacts with novel gut epithelial immune receptor LRRC19 and exacerbates colitis
Desulfovibrio vulgaris interacts with novel gut epithelial immune receptor LRRC19 and exacerbates colitis Open
Background The overgrowth of Desulfovibrio , an inflammation promoting flagellated bacteria, has been found in ulcerative colitis (UC) patients. However, the molecular mechanism in promoting colitis remains unestablished. Methods The relat…
View article: <i>LNCGM1082</i> in Gut Epithelial Cells Promotes Expulsion of Infected Epithelial Cells and Release of IL-18
<i>LNCGM1082</i> in Gut Epithelial Cells Promotes Expulsion of Infected Epithelial Cells and Release of IL-18 Open
Inflammasome NLRC4 (NLR family CARD domain containing 4) can protect mucosal barriers such as intestine from invading bacterial pathogens. However, it was incompletely clear how NLRC4 was activated in intestinal epithelial cells. In this s…
View article: The Roles of Gut Microbiota Metabolites in the Occurrence and Development of Colorectal Cancer: Multiple Insights for Potential Clinical Applications
The Roles of Gut Microbiota Metabolites in the Occurrence and Development of Colorectal Cancer: Multiple Insights for Potential Clinical Applications Open
Colorectal cancer (CRC) is one of the most common cancers worldwide. The occurrence and development of CRC are related to multiple risk factors such as gut microbiota. Indeed, gut microbiota plays an important role in the different phases …
View article: Muscularis macrophages controlled by NLRP3 maintain the homeostasis of excitatory neurons
Muscularis macrophages controlled by NLRP3 maintain the homeostasis of excitatory neurons Open
Peristaltic movements in gut are essential to propel ingested materials through the gastrointestinal tract. Intestinal resident macrophages play an important role in this physiological function through protecting enteric neurons. However, …
View article: Gut fungal mycobiome: A significant factor of tumor occurrence and development
Gut fungal mycobiome: A significant factor of tumor occurrence and development Open
A variety of bacteria, viruses, fungi, protists, archaea and protozoa coexists within the mammalian gastrointestinal (GI) tract such as that fungi are detectable in all intestinal and colon segments in almost all healthy adults. Although f…
View article: Muscularis macrophages controlled by NLRP3 maintain the homeostasis of excitatory neurons
Muscularis macrophages controlled by NLRP3 maintain the homeostasis of excitatory neurons Open
Peristaltic movements in gut are essential to propel ingested materials through the gastrointestinal tract. Intestinal resident macrophages play an important role in this physiological function through protecting enteric neurons. However, …
View article: Gut microbiota derived bile acid metabolites maintain the homeostasis of gut and systemic immunity
Gut microbiota derived bile acid metabolites maintain the homeostasis of gut and systemic immunity Open
Bile acids (BAs) as cholesterol-derived molecules play an essential role in some physiological processes such as nutrient absorption, glucose homeostasis and regulation of energy expenditure. They are synthesized in the liver as primary BA…
View article: Bile acid derivatives from gut microbiota promote GBPs-mediated activation of caspase- 4/11 by LPS through lncRNA57RIK
Bile acid derivatives from gut microbiota promote GBPs-mediated activation of caspase- 4/11 by LPS through lncRNA57RIK Open
Background: Gut microbiota contributes to the regulation of host immune response and homeostasis. Bile acid (BA) derivatives from gut microbiota can affect the differentiation and function of the immune cells. However, it is incompletely c…
View article: Data from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells
Data from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells Open
Myeloid-derived suppressor cells (MDSC) are regulators of immune responses in cancer. The differentiation and function of these MDSCs may be regulated through multiple factors, such as microRNAs. However, the effect of long noncoding RNAs …
View article: Figure S1-S9 from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells
Figure S1-S9 from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells Open
Figure S1. Characterization of inflammatory cytokine and tumor mediated MDSCs. Figure S2. Characteristics of lnc-C/EBPβ. Figure S3. Sequences of mouse lnc-C/EBPβ and humanlnc-C/EBPβ. Figure S4. The suppressive MDSC isolated from tumors …