Runólfur Pálsson
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View article: Outcomes of community-acquired acute kidney injury: a prospective comparative cohort study
Outcomes of community-acquired acute kidney injury: a prospective comparative cohort study Open
Prospective studies on the clinical course and outcome of community-acquired acute kidney injury (CA-AKI) are lacking. We hypothesized that similar to patients with hospital-acquired AKI, CA-AKI patients experience adverse outcomes when co…
View article: Trends in home dialysis over the last decade in Europe: an ERA Registry study
Trends in home dialysis over the last decade in Europe: an ERA Registry study Open
Background Home dialysis therapies could offer benefits to individuals undergoing dialysis. This study examines trends of home dialysis, including home haemodialysis (HHD) and peritoneal dialysis (PD) across European countries from 2012 to…
View article: Prevalence of reduced eGFR in European adults using KDIGO and age-adapted eGFR thresholds
Prevalence of reduced eGFR in European adults using KDIGO and age-adapted eGFR thresholds Open
Background The current definition for chronic kidney disease (CKD) does not account for age-related kidney function decline. Age-adapted CKD definitions have been suggested, but their impact on the estimates of reduced kidney function prev…
View article: New Definition of Light Chain Monoclonal Gammopathy of Undetermined Significance
New Definition of Light Chain Monoclonal Gammopathy of Undetermined Significance Open
Importance Recent studies suggest standard reference intervals for serum free light chains (FLC) are inaccurate and that this problem can only be partially remedied by using separate reference intervals for individuals with impaired kidney…
View article: COVID-19 illness severity and 2-year prevalence of physical symptoms: an observational study in Iceland, Sweden, Norway and Denmark
COVID-19 illness severity and 2-year prevalence of physical symptoms: an observational study in Iceland, Sweden, Norway and Denmark Open
View article: Access to kidney transplantation and re-transplantation from childhood to adulthood: long-term data from the ERA Registry
Access to kidney transplantation and re-transplantation from childhood to adulthood: long-term data from the ERA Registry Open
Background and hypothesis Knowledge regarding access to first kidney transplantation (KT) and subsequent KT in patients commencing kidney replacement therapy (KRT) in childhood is limited. Methods Using European Renal Association (ERA) Reg…
View article: Sequence variants associated with BMI affect disease risk through BMI itself
Sequence variants associated with BMI affect disease risk through BMI itself Open
Mendelian Randomization studies indicate that BMI contributes to various diseases, but it’s unclear if this is entirely mediated by BMI itself. This study examines whether disease risk from BMI-associated sequence variants is mediated thro…
View article: Inherited kidney disease and CAKUT are common causes of kidney failure requiring kidney replacement therapy: an ERA Registry study
Inherited kidney disease and CAKUT are common causes of kidney failure requiring kidney replacement therapy: an ERA Registry study Open
Background Inherited kidney diseases (IKDs) and congenital anomalies of the kidney and urinary tract (CAKUT) are causes of kidney failure requiring kidney replacement therapy (KRT) that major renal registries usually amalgamate into the pr…
View article: Depressive symptom trajectories among general population during the COVID-19 pandemic in Iceland: a prospective cohort study (2020–2023)
Depressive symptom trajectories among general population during the COVID-19 pandemic in Iceland: a prospective cohort study (2020–2023) Open
Introduction While changes in the prevalence of depressive symptoms during the COVID-19 pandemic have been described across populations, few studies have incorporated multidimensional variables to characterise the varying effects of the pa…
View article: Adult outcomes of childhood kidney replacement therapy in Europe from 2008 to 2019: an ERA Registry study
Adult outcomes of childhood kidney replacement therapy in Europe from 2008 to 2019: an ERA Registry study Open
Background Young adults starting kidney replacement therapy (KRT) during childhood and reaching their 18th birthday (i.e. adult survivors of childhood KRT) form a challenging population of interest to nephrologists treating adults, as duri…
View article: Iohexol plasma clearance measurement protocol standardization for adults: a consensus paper of the European Kidney Function Consortium
Iohexol plasma clearance measurement protocol standardization for adults: a consensus paper of the European Kidney Function Consortium Open
View article: Kidney transplantation in Icelandic patients, 2000–2019: are outcomes affected by low volume?
Kidney transplantation in Icelandic patients, 2000–2019: are outcomes affected by low volume? Open
Background In Iceland, a small number of kidney transplants from living donors (LDs) are performed at Landspitali University Hospital (LUH) in Reykjavik, while deceased donor transplants have until recently invariably been carried out abro…
View article: #2556 Therapeutic monitoring in patients with APRT deficiency using UPLC-MS/MS-based plasma assay
#2556 Therapeutic monitoring in patients with APRT deficiency using UPLC-MS/MS-based plasma assay Open
Background and Aims Adenine phosphoribosyltransferase (APRT) deficiency is a rare disorder of purine metabolism, characterized by urinary excretion of the poorly soluble 2,8-dihydroxyadenine (DHA), leading to nephrolithiasis and chronic ki…
View article: #2050 APRT deficiency: insights from in vitro modelling of DHA-induced kidney injury and identification of therapeutic target
#2050 APRT deficiency: insights from in vitro modelling of DHA-induced kidney injury and identification of therapeutic target Open
Background and Aims Adenine phosphoribosyltransferase (APRT) deficiency is a rare autosomal recessive disorder of adenine metabolism that results in renal excretion of 2,8-dihydroxyadenine (DHA) in excessive amounts, leading to kidney ston…
View article: #2214 Incidence, risk factors and outcome of calciphylaxis in Iceland
#2214 Incidence, risk factors and outcome of calciphylaxis in Iceland Open
Background and Aims Calciphylaxis is a rare and serious medical condition that primarily affects patients with end-stage kidney disease (ESKD). The disorder is characterized by calcium deposition in blood vessels and soft tissues, resultin…
View article: #2333 Risk of NDI and CKD in individuals treated with lithium
#2333 Risk of NDI and CKD in individuals treated with lithium Open
Background and Aims Nephrogenic diabetes insipidus (NDI) is a known side effect of lithium treatment. Lithium has also been associated with the development of chronic kidney disease (CKD). The aims of this study were to examine the risk fa…
View article: #2422 Iohexol plasma clearance measurement protocol standardization—a consensus of the European Kidney Function Consortium
#2422 Iohexol plasma clearance measurement protocol standardization—a consensus of the European Kidney Function Consortium Open
Background and Aims International consensus supports the development of standardized protocols for measured glomerular filtration rate (mGFR) to facilitate the adoption of mGFR determination in both clinical and research settings. Method T…
View article: Serum Lithium Concentration and the Risk of Chronic Kidney Disease
Serum Lithium Concentration and the Risk of Chronic Kidney Disease Open
Introduction Lithium is an important treatment option for individuals with mood disorders, but its use has been linked to the development of chronic kidney disease (CKD). Existing studies on this association have reported conflicting resul…
View article: Changes in the epidemiology of kidney replacement therapy across Europe in 2020—the first year of the COVID-19 pandemic: an ERA Registry study
Changes in the epidemiology of kidney replacement therapy across Europe in 2020—the first year of the COVID-19 pandemic: an ERA Registry study Open
Background In 2020, the coronavirus disease 2019 (COVID-19) pandemic caused disruptions in kidney replacement therapy (KRT) services worldwide. The aim of this study was to assess the effect of the COVID-19 pandemic in 2020 on the incidenc…
View article: Incidence and outcomes of kidney replacement therapy for end-stage kidney disease due to primary glomerular disease in Europe: findings from the ERA Registry
Incidence and outcomes of kidney replacement therapy for end-stage kidney disease due to primary glomerular disease in Europe: findings from the ERA Registry Open
Background Primary glomerular disease (PGD) is a major cause of end-stage kidney disease (ESKD) leading to kidney replacement therapy (KRT). We aimed to describe incidence (trends) in individuals starting KRT for ESKD due to PGD and to exa…
View article: Optimization and validation of a UPLC-MS/MS assay for simultaneous quantification of 2,8-dihydroxyadenine, adenine, allopurinol, oxypurinol and febuxostat in human plasma
Optimization and validation of a UPLC-MS/MS assay for simultaneous quantification of 2,8-dihydroxyadenine, adenine, allopurinol, oxypurinol and febuxostat in human plasma Open
View article: Risk of Chronic Kidney Disease in Individuals on Lithium Therapy: Results of a Nationwide, Retrospective Cohort Study in Iceland
Risk of Chronic Kidney Disease in Individuals on Lithium Therapy: Results of a Nationwide, Retrospective Cohort Study in Iceland Open
View article: Trends of perceived disruption in healthcare services during the pandemic: findings from the COVID-19 National Resilience Cohort in Iceland
Trends of perceived disruption in healthcare services during the pandemic: findings from the COVID-19 National Resilience Cohort in Iceland Open
Background Coronavirus disease 2019 (COVID-19) caused major disruptions in healthcare services worldwide. Yet, little is known about the association between perceived disruption in healthcare services and socio-demographic factors, pre-exi…
View article: COVID-19 illness severity and 2-year prevalence of physical symptoms: an observational study in Iceland, Sweden, Norway and Denmark
COVID-19 illness severity and 2-year prevalence of physical symptoms: an observational study in Iceland, Sweden, Norway and Denmark Open
View article: Fixing the Achilles heel of electronic medical records: Vital information must be defined, concise, accurate and easily accessible
Fixing the Achilles heel of electronic medical records: Vital information must be defined, concise, accurate and easily accessible Open
View article: P950: PRIOR CANCER AND RISK OF MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE (MGUS): A POPULATION-BASED STUDY IN ICELAND AND SWEDEN
P950: PRIOR CANCER AND RISK OF MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE (MGUS): A POPULATION-BASED STUDY IN ICELAND AND SWEDEN Open
Topic: 14. Myeloma and other monoclonal gammopathies - Clinical Background: Second primary malignancies (SPM) can be a complication of cancer therapy or be due to shared genetic or environmental risk factors. SPM are well known after multi…
View article: Were cancer patients worse off than the general population during the COVID-19 pandemic? A population-based study from Norway, Denmark and Iceland during the pre-vaccination era
Were cancer patients worse off than the general population during the COVID-19 pandemic? A population-based study from Norway, Denmark and Iceland during the pre-vaccination era Open
View article: Physical and cognitive impact following SARS-CoV-2 infection in a large population-based case-control study
Physical and cognitive impact following SARS-CoV-2 infection in a large population-based case-control study Open
View article: COVID-19 illness severity and 2-year prevalence of physical symptoms: an observational study in Iceland, Sweden, Norway and Denmark
COVID-19 illness severity and 2-year prevalence of physical symptoms: an observational study in Iceland, Sweden, Norway and Denmark Open
Background Persistence of physical symptoms after SARS-CoV-2 infection is a major public health concern, although evidence from large observational studies remain scarce. We aimed to assess the prevalence of physical symptoms in relation t…
View article: Correction: Iceland screens, treats, or prevents multiple myeloma (iStopMM): a population-based screening study for monoclonal gammopathy of undetermined significance and randomized controlled trial of follow-up strategies
Correction: Iceland screens, treats, or prevents multiple myeloma (iStopMM): a population-based screening study for monoclonal gammopathy of undetermined significance and randomized controlled trial of follow-up strategies Open