Runshun Zhang
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View article: The relationship between dietary intake of B vitamins and H. pylori seropositivity
The relationship between dietary intake of B vitamins and H. pylori seropositivity Open
Introduction The association of vitamins with Helicobacter pylori (H. pylori) infection is of great interest yet currently remains controversial. Most studies have focused on serum levels of vitamins, whereas we aimed to detect a correlati…
View article: Prevalence and risk factors of malnutrition in elderly hospitalized patients with post-stroke dysphagia
Prevalence and risk factors of malnutrition in elderly hospitalized patients with post-stroke dysphagia Open
Stroke has emerged as a major public health issue. Dysphagia affects more than half of stroke survivors and is frequently accompanied by malnutrition, particularly in elderly patients. This study investigated the prevalence and risk factor…
View article: Prevalence and risk factors of malnutrition in elderly hospitalized patients with post-stroke dysphagia
Prevalence and risk factors of malnutrition in elderly hospitalized patients with post-stroke dysphagia Open
Background Stroke has emerged as a major public health issue. Dysphagia affects more than half of stroke survivors and is frequently accompanied by malnutrition, particularly in elderly patients. This study investigated the prevalence and …
View article: The advanced lung cancer inflammation index has an L-shaped association with prognosis in American adults with metabolic dysfunction-associated fatty liver disease: a cohort study
The advanced lung cancer inflammation index has an L-shaped association with prognosis in American adults with metabolic dysfunction-associated fatty liver disease: a cohort study Open
Background Regular monitoring and follow-up of patients with metabolic dysfunction-associated fatty liver disease (MAFLD) are of paramount importance in ensuring effective management of the condition. The ALI was assessed as a composite me…
View article: Ursolic and oleanolic acids suppress MNNG induced malignant transformation of human gastric mucosal epithelium by regulating the PI3 K/AKT pathway
Ursolic and oleanolic acids suppress MNNG induced malignant transformation of human gastric mucosal epithelium by regulating the PI3 K/AKT pathway Open
Berberine hydrochloride (Ber) is the primary active compound in the traditional Chinese medicine 'Huanglian'. Ursolic acid (UA) and oleanolic acid (OA) are the main triterpenoids extracted from 'Tengligen'. Notably, both Ber and UA/OA exhi…
View article: Cross-Domain Neural Collaborative Filtering forPersonalized Herbal Prescription Recommendation
Cross-Domain Neural Collaborative Filtering forPersonalized Herbal Prescription Recommendation Open
Objective: Herbal prescriptions hold significant importance in Traditional Chinese Medicine (TCM) diagnosis and treatment, embodying millennia of clinical case summaries and wisdom. Despite numerous proposed methods for herbal prescription…
View article: Dietary folate intake and all-cause mortality and cardiovascular mortality in American adults with non-alcoholic fatty liver disease: Data from NHANES 2003 to 2018
Dietary folate intake and all-cause mortality and cardiovascular mortality in American adults with non-alcoholic fatty liver disease: Data from NHANES 2003 to 2018 Open
Background The relationship between dietary folate intake and prior mortality in adult patients with Non-alcoholic Fatty Liver Disease (NAFLD) has not been clearly studied. We aimed to examine the relationship between dietary folate intake…
View article: The ratio of omega-6 fatty acids to omega-3 fatty acids mediating the effect of gastroesophageal reflux disease on pancreatic cancer risk: a two-step mediation Mendelian randomisation study
The ratio of omega-6 fatty acids to omega-3 fatty acids mediating the effect of gastroesophageal reflux disease on pancreatic cancer risk: a two-step mediation Mendelian randomisation study Open
Introduction: Pancreatic cancer (PC) is the third most common cause of cancer-related deaths worldwide, with the 5-year survival rate for patients with PC in developed countries being only 9–10%. Gastroesophageal reflux disease (GERD) is k…
View article: Lingdan: enhancing encoding of traditional Chinese medicine knowledge for clinical reasoning tasks with large language models
Lingdan: enhancing encoding of traditional Chinese medicine knowledge for clinical reasoning tasks with large language models Open
Objective The recent surge in large language models (LLMs) across various fields has yet to be fully realized in traditional Chinese medicine (TCM). This study aims to bridge this gap by developing a large language model tailored to TCM kn…
View article: TCM-FTP: Fine-Tuning Large Language Models for Herbal Prescription Prediction
TCM-FTP: Fine-Tuning Large Language Models for Herbal Prescription Prediction Open
Traditional Chinese medicine (TCM) has relied on specific combinations of herbs in prescriptions to treat various symptoms and signs for thousands of years. Predicting TCM prescriptions poses a fascinating technical challenge with signific…
View article: ISPO: An Integrated Ontology of Symptom Phenotypes for Semantic Integration of Traditional Chinese Medical Data
ISPO: An Integrated Ontology of Symptom Phenotypes for Semantic Integration of Traditional Chinese Medical Data Open
Symptom phenotypes are one of the key types of manifestations for diagnosis and treatment of various disease conditions. However, the diversity of symptom terminologies is one of the major obstacles hindering the analysis and knowledge sha…
View article: Head-to-head comparison of 68Ga-FAPI-04 PET/CT and 18F-FDG PET/CT in the evaluation of primary digestive system cancer: a systematic review and meta-analysis
Head-to-head comparison of 68Ga-FAPI-04 PET/CT and 18F-FDG PET/CT in the evaluation of primary digestive system cancer: a systematic review and meta-analysis Open
Introduction Althoug 18 F-FDG positron emission tomography/computed tomography (PET/CT) is widely accepted as a diagnostic tool for detecting digestive cancers, 68 Ga-FAPI-04 PET/CT may perform better in detecting gastrointestinal malignan…
View article: A multi‐modal clustering method for traditional Chinese medicine clinical data via media convergence
A multi‐modal clustering method for traditional Chinese medicine clinical data via media convergence Open
Media convergence is a media change led by technological innovation. Applying media convergence technology to the study of clustering in Chinese medicine can significantly exploit the advantages of media fusion. Obtaining consistent and co…
View article: DRONet: effectiveness-driven drug repositioning framework using network embedding and ranking learning
DRONet: effectiveness-driven drug repositioning framework using network embedding and ranking learning Open
As one of the most vital methods in drug development, drug repositioning emphasizes further analysis and research of approved drugs based on the existing large amount of clinical and experimental data to identify new indications of drugs. …
View article: Phenonizer: A Fine‐Grained Phenotypic Named Entity Recognizer for Chinese Clinical Texts
Phenonizer: A Fine‐Grained Phenotypic Named Entity Recognizer for Chinese Clinical Texts Open
Biomedical named entity recognition (BioNER) from clinical texts is a fundamental task for clinical data analysis due to the availability of large volume of electronic medical record data, which are mostly in free text format, in real‐worl…
View article: Using the Symptom Patient Similarity Network to Explore the Difference between the Chinese and Western Medicine Pathways of Ischemic Stroke and its Comorbidities
Using the Symptom Patient Similarity Network to Explore the Difference between the Chinese and Western Medicine Pathways of Ischemic Stroke and its Comorbidities Open
Background and Objectives. The development of network medicine provides new opportunities for disease research. Ischemic stroke has a high incidence, disability, and recurrence rate, and one of the reasons is that it is often accompanied b…
View article: Correlation between TCM Syndromes and Type 2 Diabetic Comorbidities Based on Fully Connected Neural Network Prediction Model
Correlation between TCM Syndromes and Type 2 Diabetic Comorbidities Based on Fully Connected Neural Network Prediction Model Open
Objective. To predict the major comorbidities of type 2 diabetes based on the distribution characteristics of syndromes, and to explore the relationship between TCM syndromes and comorbidities of type 2 diabetes. Methods. Based on the elec…
View article: Study on the TCM Syndromes Evolution and Chinese Herbal Characteristics of Type 2 Diabetes Patients with Different Courses of Disease in TCM “Heat Stage”: A Real-World Study
Study on the TCM Syndromes Evolution and Chinese Herbal Characteristics of Type 2 Diabetes Patients with Different Courses of Disease in TCM “Heat Stage”: A Real-World Study Open
Objective. The purpose of this study is to analyze and summarize the syndrome distribution, syndrome evolution, and Chinese herb medicine characteristics of T2D in heat stage. Method. In this study, 228 heat-stage T2D patients were divided…
View article: Network Patterns of Herbal Combinations in Traditional Chinese Clinical Prescriptions
Network Patterns of Herbal Combinations in Traditional Chinese Clinical Prescriptions Open
As a well-established multidrug combinations schema, traditional Chinese medicine (herbal prescription) has been used for thousands of years in real-world clinical settings. This paper uses a complex network approach to investigate the reg…
View article: Topological Analysis of the Language Networks of Ancient Traditional Chinese Medicine Books
Topological Analysis of the Language Networks of Ancient Traditional Chinese Medicine Books Open
This study aims to explore the topological regularities of the character network of ancient traditional Chinese medicine (TCM) book. We applied the 2‐gram model to construct language networks from ancient TCM books. Each text of the book w…
View article: Analysis of disease comorbidity patterns in a large-scale China population
Analysis of disease comorbidity patterns in a large-scale China population Open
Background Disease comorbidity is popular and has significant indications for disease progress and management. We aim to detect the general disease comorbidity patterns in Chinese populations using a large-scale clinical data set. Methods …
View article: Disease phenotype synonymous prediction through network representation learning from PubMed database
Disease phenotype synonymous prediction through network representation learning from PubMed database Open
Synonym mapping between phenotype concepts from different terminologies is difficult because terminology databases have been developed largely independently. Existing maps of synonymous phenotype concepts from different terminology databas…
View article: Herb Target Prediction Based on Representation Learning of Symptom related Heterogeneous Network
Herb Target Prediction Based on Representation Learning of Symptom related Heterogeneous Network Open
Traditional Chinese Medicine (TCM) has received increasing attention as a complementary approach or alternative to modern medicine. However, experimental methods for identifying novel targets of TCM herbs heavily relied on the current avai…
View article: HerGePred: Heterogeneous Network Embedding Representation for Disease Gene Prediction
HerGePred: Heterogeneous Network Embedding Representation for Disease Gene Prediction Open
The discovery of disease-causing genes is a critical step towards understanding the nature of a disease and determining a possible cure for it. In recent years, many computational methods to identify disease genes have been proposed. Howev…
View article: Heterogeneous network embedding for identifying symptom candidate genes
Heterogeneous network embedding for identifying symptom candidate genes Open
Objective Investigating the molecular mechanisms of symptoms is a vital task in precision medicine to refine disease taxonomy and improve the personalized management of chronic diseases. Although there are abundant experimental studies and…
View article: Additional file 1: of Heterogeneous network propagation for herb target identification
Additional file 1: of Heterogeneous network propagation for herb target identification Open
â HIT_herb_target.xls. 23,453 herb-target associations between 1016 herbs and 1214 targets were collected and integrated from the HIT database. (XLS 1200Â kb)
View article: Additional file 2: of Heterogeneous network propagation for herb target identification
Additional file 2: of Heterogeneous network propagation for herb target identification Open
â CHPA_herb_efficacy.xls. 3487 herb-efficacy associations between 742 herbs and 360 efficacies were collected from the Chinese pharmacopoeia (CHPA, 2015 edition). (XLS 200Â kb)