Runtian Wang
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View article: Emerging Strategies of Cell and Gene Therapy Targeting Tumor Immune Microenvironment
Emerging Strategies of Cell and Gene Therapy Targeting Tumor Immune Microenvironment Open
Immunotherapy has profoundly transformed the landscape of cancer treatment and offered therapeutic opportunities to reverse the immunosuppressive microenvironment. However, intratumoral heterogeneity and the evolution toward immune evasion…
View article: Precise nano-system-based drug delivery and synergistic therapy against androgen receptor-positive triple-negative breast cancer
Precise nano-system-based drug delivery and synergistic therapy against androgen receptor-positive triple-negative breast cancer Open
View article: c-MYC mediates the crosstalk between breast cancer cells and tumor microenvironment
c-MYC mediates the crosstalk between breast cancer cells and tumor microenvironment Open
The MYC oncogenic family is dysregulated in diverse tumors which is generally linked to the poor prognosis of tumors. The members in MYC family are transcription factors which are responsible for the regulation of various genes expression.…
View article: HMGB1-Positive Tumor-Associated Neutrophils Promote Immune Evasion in Non-Small Cell Lung Cancer Via PANoptosis
HMGB1-Positive Tumor-Associated Neutrophils Promote Immune Evasion in Non-Small Cell Lung Cancer Via PANoptosis Open
View article: Boosting immunogenic cell death via Hollow MnO 2 based multiple stimuli- responsive drug delivery systems for improved cancer immunotherapy
Boosting immunogenic cell death via Hollow MnO 2 based multiple stimuli- responsive drug delivery systems for improved cancer immunotherapy Open
Cancer treatment by inducing tumor cell immunogenic cell death (ICD) is a hot research direction. However, ICD activation by single pathway is often limited in practical application due to its low efficiency. In addition, the low pH and an…
View article: Cutting edges and therapeutic opportunities on tumor-associated macrophages in lung cancer
Cutting edges and therapeutic opportunities on tumor-associated macrophages in lung cancer Open
Lung cancer is a disease with remarkable heterogeneity. A deep understanding of the tumor microenvironment (TME) offers potential therapeutic strategies against this malignant disease. More and more attention has been paid to the roles of …
View article: Inhibition of MYC suppresses programmed cell death ligand-1 expression and enhances immunotherapy in triple-negative breast cancer
Inhibition of MYC suppresses programmed cell death ligand-1 expression and enhances immunotherapy in triple-negative breast cancer Open
Background: Cancer immunotherapy has emerged as a promising strategy against triple-negative breast cancer (TNBC). One of the immunosuppressive pathways involves programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1), bu…
View article: Microenvironment components and spatially resolved single-cell transcriptome atlas of breast cancer metastatic axillary lymph nodes
Microenvironment components and spatially resolved single-cell transcriptome atlas of breast cancer metastatic axillary lymph nodes Open
As an indicator of clinical prognosis, lymph node metastasis of breast cancer has drawn great attention. Many reports have revealed the characteristics of metastatic breast cancer cells, however, the effect of breast cancer cells on the mi…
View article: Cuproptosis predicts the risk and clinical outcomes of lung adenocarcinoma
Cuproptosis predicts the risk and clinical outcomes of lung adenocarcinoma Open
Copper is an essential microelement for the body and a necessary coregulator for enzymatic reactions, yet an unbalanced copper level promotes reactive oxidation and cytotoxicity, which ultimately induces cell death. Several small molecules…
View article: ERβ Suppresses the AR Oncogenic Effects in Triple-Negative Breast Cancer
ERβ Suppresses the AR Oncogenic Effects in Triple-Negative Breast Cancer Open
View article: Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis
Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis Open
Molecular mechanisms underlying breast cancer lymph node metastasis remain unclear. Using single-cell sequencing, we investigated the transcriptome profile of 96,796 single cells from 15 paired samples of primary tumors and axillary lymph …
View article: A six-gene signature related with tumor mutation burden for predicting lymph node metastasis in breast cancer
A six-gene signature related with tumor mutation burden for predicting lymph node metastasis in breast cancer Open
Our results indicated that TMB was associated with lymph node metastasis of BC. We built a TMB-related signature consisting of six genes which might function as a novel biomarker for predicting lymph node metastasis in BC.
View article: Study on synthesis and adsorption properties of ReO4− ion imprinted polymer
Study on synthesis and adsorption properties of ReO4− ion imprinted polymer Open
View article: Application of Tissue Engineering in Skeleton: A Review on Recent Trends and Advances
Application of Tissue Engineering in Skeleton: A Review on Recent Trends and Advances Open
Due to the biological properties of bone and cartilage, tissue engineering, a new solution with no limit on supply, has gained much attention and many investigations over the past few years. In this review, three basic elements of tissue e…