Explanipedia

Unveiling the diagnostic and pro-inflammatory role of crohn’s disease: insights from 16 S-guided discovery and species-specific validation Open

Yao Xu, Runxiang Xie, Yuqing Weng, Yewei Fang, Huimin Chen , et al. · 2025

The identified genera demonstrate potential as diagnostic biomarkers for CD, with R. gnavus playing a key role in the disease's pathogenesis by inducing inflammation in colitis models.

Role and mechanism of gut microbiota-host interactions in the pathogenesis of Crohn’s disease Open

Yao Xu, Runxiang Xie, Yuqing Weng, Yewei Fang, Shuan Tao , et al. · 2025

This review highlights the pivotal role of gut microbiota dysbiosis in driving CD pathogenesis and its progression, while underscoring its potential as a therapeutic target through dietary modulation, microbial interventions, and integrati…

Maternal high-fat diet disrupts intestinal mucus barrier of offspring by regulating gut immune receptor LRRC19 Open

Yue Sun, Shumin Huang, Mengfan Li, Yunwei Yang, Jiahui Ma , et al. · 2025

Maternal high fat diet (MHFD) increased colitis susceptibility in adulthood. However, the mechanism remains unclear. We sought to explore whether novel gut immune receptor leucine-rich repeat C19 (LRRC19) contributed to the impaired mucus …

Alterations of gut microbiome in eosinophilic chronic rhinosinusitis Open

Yibo Liang, Chenting Zhang, Xin Xiong, Xiang Mao, Peiyong Sun , et al. · 2024

We found alterations in the gut microbiome in eCRSwNP patients, and the alterations in the gut microbiome were correlated with the severity of disease.

Desulfovibrio vulgaris interacts with novel gut epithelial immune receptor LRRC19 and exacerbates colitis Open

Runxiang Xie, Yu Gu, Mengfan Li, Lingfeng Li, Yunwei Yang , et al. · 2024

Background The overgrowth of Desulfovibrio , an inflammation promoting flagellated bacteria, has been found in ulcerative colitis (UC) patients. However, the molecular mechanism in promoting colitis remains unestablished. Methods The relat…

Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis Open

Yaping An, Zihan Zhai, Xin Wang, Yiyun Ding, Linlin He , et al. · 2023

Regulation of gut microbiota-bile acids axis by probiotics in inflammatory bowel disease Open

Lingfeng Li, Tianyu Liu, Yu Gu, Xinyu Wang, Runxiang Xie , et al. · 2022

Inflammatory bowel disease (IBD) is characterized by chronic and relapsing inflammation of gastrointestinal tract, with steadily increased incidence and prevalence worldwide. Although the precise pathogenesis remains unclear, gut microbiot…

Prenatal Maternal Stress Exacerbates Experimental Colitis of Offspring in Adulthood Open

Yue Sun, Runxiang Xie, Li Lü, Ge Jin, Bingqian Zhou , et al. · 2021

The prevalence of inflammatory bowel disease (IBD) is increasing worldwide and correlates with dysregulated immune response because of gut microbiota dysbiosis. Some adverse early life events influence the establishment of the gut microbio…

Maternal Emulsifier P80 Intake Induces Gut Dysbiosis in Offspring and Increases Their Susceptibility to Colitis in Adulthood Open

Ge Jin, Qiang Tang, Jiaheng Ma, Xiang Liu, Bingqian Zhou , et al. · 2021

The main findings of this research showed that maternal P80 intake could disrupt the intestinal barrier, induce gut dysbiosis, and promote colitis susceptibility in adulthood. This study will enhance understanding of the prevention of IBD.

Cartilage Oligomeric Matrix Protein promotes epithelial-mesenchymal transition by interacting with Transgelin in Colorectal Cancer Open

Weilong Zhong, Huiqin Hou, Tianyu Liu, Shuai Su, Xiaonan Xi , et al. · 2020

Background and Purpose: The role of the cartilage oligomeric matrix protein (COMP) in epithelial-mesenchymal transition (EMT) in tumor progression has been studied, but its exact regulatory mechanism remains unknown. Methods:…

Stress Triggers Flare of Inflammatory Bowel Disease in Children and Adults Open

Yue Sun, Li Lü, Runxiang Xie, Bangmao Wang, Kui Jiang , et al. · 2019

Inflammatory bowel disease (IBD) is an idiopathic inflammatory disease characterized by chronic and relapsing manifestations. It is noteworthy that the prevalence of IBD is gradually increasing in both children and adults. Currently, the p…

Maternal High Fat Diet Alters Gut Microbiota of Offspring and Exacerbates DSS-Induced Colitis in Adulthood Open

Runxiang Xie, Yue Sun, Jingyi Wu, Shumin Huang, Ge Jin , et al. · 2018

Background: Accumulating evidence shows that high fat diet is closely associated with inflammatory bowel disease. However, the effects and underlying mechanisms of maternal high fat diet (MHFD) on the susceptibility of offspring to …

Chemopreventive Effects of Silibinin on Colitis-Associated Tumorigenesis by Inhibiting IL-6/STAT3 Signaling Pathway Open

Rongjuan Zheng, Jiaheng Ma, Dan Wang, Wenxiao Dong, Sinan Wang , et al. · 2018

Inflammatory bowel disease (IBD), characterized by sustained inflammation, is a latent risk factor of colon tumorigenesis. Silibinin has been reported to be anti-inflammatory and antineoplastic, but its efficacy on colitis-associated cance…

Deoxycholic acid disrupts the intestinal mucosal barrier and promotes intestinal tumorigenesis Open

Li Liu, Wenxiao Dong, Sinan Wang, Yujie Zhang, Tianyu Liu , et al. · 2018

Deoxycholic acid (DCA) induced intestinal low grade inflammation and disrupted the mucosal physical and functional barriers, aggravating intestinal tumorigenesis.

Dietary feeding of freeze-dried whole cranberry inhibits intestinal tumor development in<i>Apc</i>min/+ mice Open

Duochen Jin, Tianyu Liu, Wenxiao Dong, Yujie Zhang, Sinan Wang , et al. · 2017

It is increasingly perceived that dietary components have been linked with the prevention of intestinal cancer. Cranberry is a rich source of phenolic constituents and non-digestible fermentable dietary fiber, which shows anti-proliferatio…

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