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View article: Tumor arachidonic acid synthesis impairs metabolic fitness of CXCR6+ resident memory CD8+ T cells and drives immunotherapy resistance in hepatocellular carcinoma
Tumor arachidonic acid synthesis impairs metabolic fitness of CXCR6+ resident memory CD8+ T cells and drives immunotherapy resistance in hepatocellular carcinoma Open
Lipid metabolic reprogramming in the hepatocellular carcinoma (HCC) tumor microenvironment (TME) drives immunosuppression, yet the critical mediators orchestrating tumor-immune crosstalk remain elusive. Here, we identify arachidonic acid (…
View article: Polyunsaturated fatty acids promote M2-like TAM deposition via dampening RhoA-YAP1 signaling in the ovarian cancer microenvironment
Polyunsaturated fatty acids promote M2-like TAM deposition via dampening RhoA-YAP1 signaling in the ovarian cancer microenvironment Open
Background Peritoneal metastases frequently occur in epithelial ovarian cancer (EOC), resulting in poor prognosis and survival rates. Tumor-associated-macrophages (TAMs) massively infiltrate into ascites spheroids and are multi-polarized a…
View article: Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor‑associated macrophages
Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor‑associated macrophages Open
Tumor‑associated macrophages (TAMs) are pivotal components in colorectal cancer (CRC) progression, markedly influencing the tumor microenvironment through their polarization into the pro‑inflammatory M1 or pro‑tumorigenic M2 phenotypes. Re…
View article: Polyunsaturated Fatty Acids Promote Protumoral Macrophage Polarization via a RhoA-YAP1 Signaling Pathway in the Ovarian Cancer Microenvironment
Polyunsaturated Fatty Acids Promote Protumoral Macrophage Polarization via a RhoA-YAP1 Signaling Pathway in the Ovarian Cancer Microenvironment Open
Tumor-associated macrophages (TAMs) are crucially associated with tumor development and progression; however, it remains unclear how the tumor microenvironment (TME) rewires the metabolic circuits and preferentially induces TAMs to polariz…