Runzhi Chen
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View article: Interventions for patients with prostate cancer on active surveillance: a narrative review
Interventions for patients with prostate cancer on active surveillance: a narrative review Open
Objective To examine contemporary evidence supporting non‐surgical interventions for patients with early prostate cancer (PCa) on active surveillance (AS). Methods A literature search was conducted using the databases PubMed, Medline, and …
View article: The prognostic role of Geriatric 8 in patients with cancer: a meta-analysis and systematic review
The prognostic role of Geriatric 8 in patients with cancer: a meta-analysis and systematic review Open
Objective Previous studies have reported conflicting results regarding the association between the Geriatric 8 (G-8) geriatric screening tool and prognosis in patients with cancer. This meta-analysis aimed to evaluate the prognostic value …
View article: Extrachromosomal Circular <scp>DNA</scp> in Cancer: Mechanisms and Clinical Applications
Extrachromosomal Circular <span>DNA</span> in Cancer: Mechanisms and Clinical Applications Open
Extrachromosomal circular DNA (eccDNA) has emerged as a critical area of cancer research due to its ubiquitous presence in tumour cells and significant role in tumorigenesis, progression and drug resistance. Recent studies demonstrate that…
View article: Prominent Alveolar Bone Graft Substitute Derived from Silk Fibroin/Hyaluronic Acid/Demineralized Dentin Matrix Hybrid Hydrogel
Prominent Alveolar Bone Graft Substitute Derived from Silk Fibroin/Hyaluronic Acid/Demineralized Dentin Matrix Hybrid Hydrogel Open
Bone graft substitutes are commonly used to repair large bone defect, and restoring the alveolar bone defects in height and width is a major challenge in restorative dentistry. In comparison with clinic bone graft substitutes such as bovin…
View article: Heterostructure Engineering Enables MoSe2 with Superior Alkali-Ion Storage
Heterostructure Engineering Enables MoSe2 with Superior Alkali-Ion Storage Open
Molybdenum diselenide (MoSe2) is a promising anode for alkali-ion storage due to its intrinsic advantages. However, MoSe2 still encounters the issues of structural instability and poor rate performance caused by drastic volume change and s…
View article: Roles and Mechanisms of Choline Metabolism in Nonalcoholic Fatty Liver Disease and Cancers
Roles and Mechanisms of Choline Metabolism in Nonalcoholic Fatty Liver Disease and Cancers Open
Choline participates in three major metabolic pathways: oxidation, phosphorylation, and acetylation. Through oxidation, choline is converted to betaine and contributes to methyl metabolism and epigenetic regulation. Through phosphorylation…
View article: SLAM medical imaging enabled by a pre-chirp and gain jointly managed Yb-fiber laser
SLAM medical imaging enabled by a pre-chirp and gain jointly managed Yb-fiber laser Open
We demonstrate a pre-chirp and gain jointly managed Yb-fiber laser that drives simultaneous label-free autofluorescence-multiharmonic (SLAM) medical imaging. We show that a gain managed Yb-fiber amplifier produces high-quality compressed p…
View article: P1214 The crosstalk between oral and intestinal microbiota in inflammatory bowel disease patients
P1214 The crosstalk between oral and intestinal microbiota in inflammatory bowel disease patients Open
Background Background: Previous studies reported that oral microbes can migrate to the gut, but the relationship between oral and intestinal microbiota in inflammatory bowel disease (IBD) is still unclear. Methods Here, we investigated the…
View article: Publisher Correction: Penile implants in low flow priapism
Publisher Correction: Penile implants in low flow priapism Open
View article: EGS P05 Evaluating the predictive value of NSQIP surgical risk calculator in patients undergoing emergency laparoscopic cholecystectomy at a single UK centre
EGS P05 Evaluating the predictive value of NSQIP surgical risk calculator in patients undergoing emergency laparoscopic cholecystectomy at a single UK centre Open
Background Machine learning algorithms for surgical risk predictions have been utilised as an informed consent tool for surgeons and patients. The American College of Surgeons National Surgical Quality Improvement Program (NSQIP) is a surg…
View article: Accuracy of a novel semi-autonomous robotic-assisted surgery system for single implant placement: A case series
Accuracy of a novel semi-autonomous robotic-assisted surgery system for single implant placement: A case series Open
This study provides significant evidence to support the use of sa-RASS as a potential alternative to static guided surgery and dynamic navigation, in dental implant surgery.
View article: Penile implants in low flow priapism
Penile implants in low flow priapism Open
View article: Strip Perforation of the Danger Zone in Mandibular Molars: A Case Report and Literature Review
Strip Perforation of the Danger Zone in Mandibular Molars: A Case Report and Literature Review Open
Background The danger zone (DZ) commonly refers to the area of mesial roots in mandibular molars, which is more vulnerable to perforations in cases of over-instrumentation. Midroot perforations may lead to a dubious prognosis and ultimatel…
View article: DNA methylation and miR‐92a‐3p‐mediated repression of HIP1R promotes pancreatic cancer progression by activating the PI3K/AKT pathway
DNA methylation and miR‐92a‐3p‐mediated repression of HIP1R promotes pancreatic cancer progression by activating the PI3K/AKT pathway Open
Pancreatic cancer (PAAD) is a highly malignant tumour characterized of high mortality and poor prognosis. Huntingtin‐interacting protein 1‐related (HIP1R) has been recognized as a tumour suppressor in gastric cancer, while its biological f…
View article: A Novel Somatic Mutation Implicates ATP6V0D1 in Proinsulin Processing
A Novel Somatic Mutation Implicates ATP6V0D1 in Proinsulin Processing Open
Context Prohormone convertase 1/3 (PC1/3), encoded by protein convertase subtilisin kexin type 1 (PCSK1), converts inactive prohormones into biologically active peptides. Somatic mutations of insulinomas are associated with genetic defects…
View article: The use of hormone stimulation in male infertility
The use of hormone stimulation in male infertility Open
Infertility affects 15% of couples worldwide and in approximately 50% of cases the cause is secondary to an abnormality of the sperm. However, treatment options for male infertility are limited and empirical use of hormone stimulation has …
View article: Bibliometric analysis of research trends in stem cell therapy for knee osteoarthritis over the period 2001–2021
Bibliometric analysis of research trends in stem cell therapy for knee osteoarthritis over the period 2001–2021 Open
Stem cell therapy is a promising treatment for knee osteoarthritis, but few bibliometric studies have been performed on the subject. Bibliometric analysis is helpful for identifying the most influential studies in a specific field and can …
View article: On the frequency spanning of SPM-enabled spectral broadening: analytical solutions
On the frequency spanning of SPM-enabled spectral broadening: analytical solutions Open
We present an analytical treatment of ultra-short pulses propagating in an optical fiber in the strong nonlinearity regime, in which the interaction between self-phase modulation (SPM) and group-velocity dispersion (GVD) substantially broa…
View article: Understanding and treating ejaculatory dysfunction in men with diabetes mellitus
Understanding and treating ejaculatory dysfunction in men with diabetes mellitus Open
Diabetes mellitus is a rapidly rising metabolic disorder with important systemic complications. Global figures have demonstrated the prevalence of diabetes mellitus has almost quadrupled from 108 million in 1980 to 422 million in 2014, wit…
View article: The management of erectile dysfunction in men with diabetes mellitus unresponsive to phosphodiesterase type 5 inhibitors
The management of erectile dysfunction in men with diabetes mellitus unresponsive to phosphodiesterase type 5 inhibitors Open
Introduction Erectile dysfunction is associated with diabetes mellitus with an estimated prevalence of 52.5% in the diabetic population. The first‐line therapy for erectile dysfunction is phosphodiesterase type 5 inhibitors, but data sugge…
View article: Metagenome-Assembled Genomes Reveal Mechanisms of Carbohydrate and Nitrogen Metabolism of Schistosomiasis-Transmitting Vector <i>Biomphalaria Glabrata</i>
Metagenome-Assembled Genomes Reveal Mechanisms of Carbohydrate and Nitrogen Metabolism of Schistosomiasis-Transmitting Vector <i>Biomphalaria Glabrata</i> Open
The spread of aquatic gastropod Biomphalaria glabrata , an intermediate host of Schistosoma mansoni , exacerbates the burden of schistosomiasis disease worldwide. This study provides insights into the importance of microbiome for basic bio…
View article: Apatinib plus 5-fluorouracil as a third or subsequent-line treatment option for metastatic colorectal cancer: a phase-II, single-arm, prospective study
Apatinib plus 5-fluorouracil as a third or subsequent-line treatment option for metastatic colorectal cancer: a phase-II, single-arm, prospective study Open
ClinicalTrials.gov Identifier: NCT03210064.
View article: Simultaneous label-free autofluorescence-multiharmonic microscopy driven by femtosecond sources based on self-phase modulation enabled spectral selection
Simultaneous label-free autofluorescence-multiharmonic microscopy driven by femtosecond sources based on self-phase modulation enabled spectral selection Open
Nonlinear optical microscopy technique has unique advantages in tissue imaging, such as enhanced contrast, high resolution, and label-free deep optical sectioning capabilities. Nonlinear optical microscopy also has multiple imaging modalit…
View article: Particle swarm optimization of SPM-enabled spectral selection to achieve an octave-spanning wavelength-shift
Particle swarm optimization of SPM-enabled spectral selection to achieve an octave-spanning wavelength-shift Open
SPM-enabled spectral selection (SESS) constitutes a powerful fiber-optic technique to generate wavelength broadly tunable femtosecond pulses. In the current demonstration, the maximum tuning range is 400 nm and the energy conversion effici…
View article: Overexpression of Circular RNA circ_0013587 Reverses Erlotinib Resistance in Pancreatic Cancer Cells Through Regulating the miR-1227/E-Cadherin Pathway
Overexpression of Circular RNA circ_0013587 Reverses Erlotinib Resistance in Pancreatic Cancer Cells Through Regulating the miR-1227/E-Cadherin Pathway Open
Background Erlotinib, a small-molecule epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, demonstrated therapeutic efficacy against pancreatic cancer. However, acquired resistance to erlotinib in pancreatic cancer is widely…
View article: Pre-Chirp-Managed Adiabatic Soliton Compression in Pressure-Gradient Hollow-Core Fibers
Pre-Chirp-Managed Adiabatic Soliton Compression in Pressure-Gradient Hollow-Core Fibers Open
Post-pulse-compression is demanded to produce energetic few-cycle pulses. We propose pre-chirp-managed adiabatic soliton compression (ASC) in gas-filled pressure-gradient hollow-core fibers to suppress the detrimental pedestals and therefo…
View article: MP31-04 DOES INTRACYTOPLASMIC MORPHOLOGICALLY SELECTED SPERM INJECTION IMPROVE LIVE BIRTH RATES COMPARED TO ICSI IN MEN WITH INFERTILITY AND RAISED SPERM DNA FRAGMENTATION?
MP31-04 DOES INTRACYTOPLASMIC MORPHOLOGICALLY SELECTED SPERM INJECTION IMPROVE LIVE BIRTH RATES COMPARED TO ICSI IN MEN WITH INFERTILITY AND RAISED SPERM DNA FRAGMENTATION? Open
You have accessJournal of UrologyInfertility: Therapy (MP31)1 Sep 2021MP31-04 DOES INTRACYTOPLASMIC MORPHOLOGICALLY SELECTED SPERM INJECTION IMPROVE LIVE BIRTH RATES COMPARED TO ICSI IN MEN WITH INFERTILITY AND RAISED SPERM DNA FRAGMENTATI…
View article: Ex vivo and in vivo fluorescence detection and imaging of adenosine triphosphate
Ex vivo and in vivo fluorescence detection and imaging of adenosine triphosphate Open
View article: Ex Vivo and In Vivo Fluorescence Detection and Imaging of Adenosine Triphosphate
Ex Vivo and In Vivo Fluorescence Detection and Imaging of Adenosine Triphosphate Open
Background Ex vivo and in vivo detection and imaging of adenosine triphosphate (ATP) is critically important for the diagnosis and treatment of diseases, which still remains challenges up to present.ResultsWe herein demonstrate that ATP co…
View article: Pre-chirp managed divided-pulse amplification using composite birefringent plates for pulse division and recombination: en route toward GW peak power
Pre-chirp managed divided-pulse amplification using composite birefringent plates for pulse division and recombination: en route toward GW peak power Open
Pre-chirp managed amplification (PCMA) allows the generation of optical pulses with a duration well below 100 fs. However, the pulse peak power is limited to 30 times improvement in both pulse energy and peak power compared with current Yb…