Ruochan Chen
YOU?
Author Swipe
Pattern recognition receptors: function, regulation and therapeutic potential Open
Pattern recognition receptors (PRRs) are sensors in the immune system, detecting pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). They serve as essential links between the innate and adaptive…
A novel nomogram for the early identification of coinfections in elderly patients with coronavirus disease 2019 Open
This novel nomogram will assist in the early identification of coinfections in elderly patients with COVID-19.
View article: Serum Creatinine of 1.1 mg/dL Can Indicate Disease Deterioration and 90‐day Mortality in Hospitalized Patients With Cirrhosis in Chinese Population
Serum Creatinine of 1.1 mg/dL Can Indicate Disease Deterioration and 90‐day Mortality in Hospitalized Patients With Cirrhosis in Chinese Population Open
Aims Increased serum creatinine (sCR) is associated with increased mortality in cirrhotic patients, while there remains a lack of evidence‐based sCR cutoffs for indicating disease deterioration and predicting 90‐day liver transplantation (…
Immune aging and infectious diseases Open
The rise in global life expectancy has led to an increase in the older population, presenting significant challenges in managing infectious diseases. Aging affects the innate and adaptive immune systems, resulting in chronic low-grade infl…
View article: Nomograms for predicting short-term mortality in acute-on-chronic liver disease caused by the combination of hepatitis B virus and alcohol
Nomograms for predicting short-term mortality in acute-on-chronic liver disease caused by the combination of hepatitis B virus and alcohol Open
This study aimed to identify predictive factors for the prognosis of acute-on-chronic liver disease (AoCLD) due to both hepatitis B virus (HBV) and alcohol and to develop prognostic models to improve treatment management. AoCLD patients wi…
A novel nomogram for the early identification of coinfections in elderly patients with COVID-19 Open
Background This study aimed to establish a novel, precise, and practical nomogram for use upon hospital admission to identify coinfections among elderly patients with coronavirus disease 2019 (COVID-19) to provide timely intervention, limi…
View article: sTREM-1 as promising prognostic biomarker for acute-on-chronic liver failure and mortality in patients with acute decompensation of cirrhosis
sTREM-1 as promising prognostic biomarker for acute-on-chronic liver failure and mortality in patients with acute decompensation of cirrhosis Open
BACKGROUND Acute decompensation (AD) of cirrhosis is associated with high short-term mortality, mainly due to the development of acute-on-chronic liver failure (ACLF). Thus, there is a need for biomarkers for early and accurate identificat…
View article: The clinical courses of HBV-related acute-on-chronic liver failure and a multi-state model to predict disease evolution
The clinical courses of HBV-related acute-on-chronic liver failure and a multi-state model to predict disease evolution Open
Background and Aims: Acute-on-chronic liver failure (ACLF) is a highly dynamic syndrome. The objective of this study was to delineate the clinical course of patients with HBV-ACLF and to develop a model to estimate the temporal evolution o…
The efficacy and safety of direct-acting antiviral regimens for end-stage renal disease patients with HCV infection: a systematic review and network meta-analysis Open
Background Hepatitis C virus (HCV) infection is an independent risk factor associated with adverse outcomes in patients with end-stage renal disease (ESRD). Due to the wide variety of direct-acting antiviral regimens (DAAs) and the factor …
View article: Investigation on the short‐term outcome and prognostic impact of predisposition, and precipitants in inpatients with chronic liver disease from Chinese AcuTe on CHronic LIver FailurE (CATCH‐LIFE) cohorts
Investigation on the short‐term outcome and prognostic impact of predisposition, and precipitants in inpatients with chronic liver disease from Chinese AcuTe on CHronic LIver FailurE (CATCH‐LIFE) cohorts Open
Aim The study aimed to investigate the short‐term outcomes of hospitalized patients with chronic liver disease (CLDs) and assess the prognostic impact of predisposition and precipitants, which currently remains unclear. Methods The study i…
Repurposing Niclosamide as a Therapeutic Drug against Acute Liver Failure by Suppressing Ferroptosis Open
Acute liver failure (ALF) is a severe liver disease with a high mortality rate without effective therapeutic drugs. Ferroptosis is a form of programmed cell death that plays an important role in ALF. In this study, we aimed to identify fer…
Editorial: Gasdermins in the defense against pathogens Open
EDITORIAL article Front. Immunol., 20 June 2023Sec. Molecular Innate Immunity Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1238368
Tuberculosis in Pregnancy after in Vitro Fertilization and Embryo Transfer Open
Background: Worldwide, tuberculosis (TB) remains an important cause of maternal mortality and morbidity, accounting for approximately one-third of annual deaths. Moreover, untimely TB treatment during pregnancy increases the risk of perina…
Tuberculosis in Pregnancy after in Vitro Fertilization and Embryo Transfer: Case Series and Literature Review Open
Background Worldwide, tuberculosis (TB) remains an important cause of maternal mortality and morbidity, accounting for approximately one-third of annual deaths. Moreover, untimely TB treatment during pregnancy increases the risk of perinat…
A novel prognostic nomogram for older patients with acute-on-chronic liver diseases (AoCLD): a nationwide, multicentre, prospective cohort study Open
Background the incidence of acute-on-chronic liver disease (AoCLD) is increasing. Objective to investigate the clinical features and risk factors of AoCLD and construct an effective prognostic nomogram model for older patients with AoCLD. …
Hepatic stellate cell‐released <span>CXCL1</span> aggravates <span>HCC</span> malignant behaviors through the <span>MIR4435‐2HG</span>/<span>miR</span>‐506‐3p/<span>TGFB1</span> axis Open
Hepatic stellate cell (HSC) activation is a critical event in the development of hepatic fibrosis and hepatocellular carcinoma (HCC). By the release of soluble cytokines, chemokines, and chemotaxis, HSCs affect HCC cell phenotypes through …
An M0 Macrophage-Related Prognostic Model for Hepatocellular Carcinoma Open
Background The role of M0 macrophages and their related genes in the prognosis of hepatocellular carcinoma (HCC) remains poorly characterized. Methods Multidimensional bioinformatic methods were used to constructed a risk score model using…
View article: The mechanism of HMGB1 secretion and release
The mechanism of HMGB1 secretion and release Open
High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone that maintains the structure and function of chromosomes. In the …
Safety and Efficacy of Tenofovir Alafenamide Fumarate in Early-Middle Pregnancy for Mothers With Chronic Hepatitis B Open
Background Tenofovir alafenamide fumarate has been used in late pregnancy; however, no data exist regarding its safety and effectiveness in early and middle pregnancy for mothers with hepatitis B virus infection. Aims To design a prospecti…
The Versatile Gasdermin Family: Their Function and Roles in Diseases Open
The gasdermin (GSDM) family, a novel group of structure-related proteins, consists of GSDMA, GSDMB, GSDMC, GSDMD, GSDME/DNFA5, and PVJK/GSDMF. GSDMs possess a C-terminal repressor domain, cytotoxic N-terminal domain, and flexible linker do…
View article: Baseline Neutrophil-to-Lymphocyte Ratio Is Independently Associated With 90-Day Transplant-Free Mortality in Patients With Cirrhosis
Baseline Neutrophil-to-Lymphocyte Ratio Is Independently Associated With 90-Day Transplant-Free Mortality in Patients With Cirrhosis Open
Background: Patients with cirrhosis have an increased risk of short-term mortality, however, few studies quantify the association between neutrophil-to-lymphocyte ratio (NLR) and 90-day transplant-free mortality in cirrhotic patients. Meth…
View article: Impact of Hepatic Encephalopathy on Clinical Characteristics and Adverse Outcomes in Prospective and Multicenter Cohorts of Patients With Acute-on-Chronic Liver Diseases
Impact of Hepatic Encephalopathy on Clinical Characteristics and Adverse Outcomes in Prospective and Multicenter Cohorts of Patients With Acute-on-Chronic Liver Diseases Open
Importance: Hepatic encephalopathy is a severe complication, and its contribution to clinical adverse outcomes in patients with acute-on-chronic liver diseases from the East is unclear. Objective: We aimed to investigate the impact of hepa…
Liver Failure of Wilson's Disease With Manifestations Similar to Porphyria and Uncommon ATP7B Gene Mutation: A Case Report and Literature Review Open
Background: Wilson's disease (WD) is a rare condition; its diagnosis is challenging owing to a wide spectrum of ATP7B genotypes and variable clinical phenotypes, along with environmental factors. Few cases of WD with presentation of skin l…