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View article: Performance Verification of High Sensitivity Analyzer for TAT, PIC, TM, and t-PAIC
Performance Verification of High Sensitivity Analyzer for TAT, PIC, TM, and t-PAIC Open
Thrombin–antithrombin complex (TAT), a2-plasmininhibitor–plasmin complex (PIC), thrombomodulin (TM), tissue plasminogen activator–plasminogen activator inhibitor complex (t-PAIC) has been increasingly applied in clinical practice in recent…
View article: Effectiveness and safety of acupuncture therapies for intractable hiccups: a systematic review and network meta-analysis
Effectiveness and safety of acupuncture therapies for intractable hiccups: a systematic review and network meta-analysis Open
Background Intractable hiccups (IH) have diverse causes, including central lesions (e.g., stroke, intracranial injury) and peripheral triggers (e.g., gastrointestinal disease, tumors, chemotherapy, cirrhosis, surgery). IH significantly imp…
View article: Diabetes and Heart Failure: Whats the Connection
Diabetes and Heart Failure: Whats the Connection Open
Diabetes mellitus and heart failure are two common chronic conditions that frequently coexist, producing outcomes worse than either disease alone. This paper investigates how diabetes directly impairs the myocardium, leading to a distinct …
View article: Roles of pH, ionic strength, and sulfate in the aqueous nitrate-mediated photooxidation of green leaf volatiles
Roles of pH, ionic strength, and sulfate in the aqueous nitrate-mediated photooxidation of green leaf volatiles Open
Biotic and abiotic stresses can lead to terrestrial green plants releasing green leaf volatiles (GLVs), which can partition into atmospheric aqueous phases where they can undergo oxidation to form aqueous secondary organic aerosol (aqSOA).…
View article: Butyric acid and valeric acid attenuate stress-induced ferroptosis and depressive-like behaviors by suppressing hippocampal neuroinflammation
Butyric acid and valeric acid attenuate stress-induced ferroptosis and depressive-like behaviors by suppressing hippocampal neuroinflammation Open
Background Depression is closely associated with stress-induced hippocampal damage and dysfunction. Emerging evidence demonstrates that the gut microbiota and its metabolites, acting as probiotics or prebiotics, can modulate brain structur…
View article: NR3C1/PRKACG-mediated impairment of mitochondrial quality control underlies stress-induced hypothalamic neuronal injury
NR3C1/PRKACG-mediated impairment of mitochondrial quality control underlies stress-induced hypothalamic neuronal injury Open
The hypothalamus integrates autonomic, endocrine, and behavioral responses to stress, and stress-induced hypothalamic neuronal injury is implicated in various diseases. However, the underlying molecular mechanisms remain unclear. Mitochond…
View article: Research on Two-Stage Investment Decision-Making in Park-Level Integrated Energy Projects Considering Multi-Objectives
Research on Two-Stage Investment Decision-Making in Park-Level Integrated Energy Projects Considering Multi-Objectives Open
The scientific investment decision of Park-level Integrated Energy System (PIES) projects is of great significance to energy enterprises for improving the efficient utilization of funds, promoting green and low-carbon transformation, and a…
View article: Stress-Induced Cholesterol Metabolic Dysregulation and Differentiation Trajectory Shift in Oligodendrocytes Synergistically Drive Demyelination
Stress-Induced Cholesterol Metabolic Dysregulation and Differentiation Trajectory Shift in Oligodendrocytes Synergistically Drive Demyelination Open
Stress-induced demyelination resulting from oligodendrocyte (OLG) dysfunction is one of the key pathological mechanisms of depression, yet its dynamic regulatory network remains unclear. This study integrates single-cell transcriptomics, l…
View article: Coagulation and Inflammatory Indicators in Pneumonia Patients with Venous Thromboembolism: A Propensity-Score Matching Study
Coagulation and Inflammatory Indicators in Pneumonia Patients with Venous Thromboembolism: A Propensity-Score Matching Study Open
There is a significant activation of both coagulation and fibrinolytic systems in pneumonia patients. VTE in pneumonia patients is associated with the activation of inflammatory system. Monitoring inflammatory and coagulation indicators in…
View article: pH, ionic strength and sulfate influence the aqueous nitrate-mediated photooxidation of green leaf volatiles
pH, ionic strength and sulfate influence the aqueous nitrate-mediated photooxidation of green leaf volatiles Open
Green leaf volatiles (GLVs) are biogenic C5 to C6 unsaturated oxygenated organic compounds that are emitted when vegetation is exposed to herbivores, pathogens, or harsh weather conditions. Increased GLV emissions when vegetation is subjec…
View article: Roles of pH, ionic strength, and sulfate in the aqueous nitrate-mediated photooxidation of green leaf volatiles
Roles of pH, ionic strength, and sulfate in the aqueous nitrate-mediated photooxidation of green leaf volatiles Open
Biotic and abiotic stresses can lead to terrestrial green plants releasing green leaf volatiles (GLVs), which can partition into atmospheric aqueous phases where they can undergo oxidation to form aqueous secondary organic aerosols (aqSOA)…
View article: Managerial Climate Awareness, Institutional Investors, and Firms’ Sustainability Performance: Evidence from China
Managerial Climate Awareness, Institutional Investors, and Firms’ Sustainability Performance: Evidence from China Open
This paper employs a novel database to investigate the influence of pressure-sensitive institutional investors (PSIIs) in China on the relationship between managerial climate awareness and firms’ sustainability performance. The paper demon…
View article: Analysis of the Order Flow Auction under Proposer-Builder Separation on Blockchain
Analysis of the Order Flow Auction under Proposer-Builder Separation on Blockchain Open
We study the impact of the order flow auction (OFA) in the context of the proposer-builder separation (PBS) mechanism in blockchains through a game-theoretic perspective. The OFA is designed to improve user welfare by redistributing maxima…
View article: Hypothesis paper: GDF15 demonstrated promising potential in Cancer diagnosis and correlated with cardiac biomarkers
Hypothesis paper: GDF15 demonstrated promising potential in Cancer diagnosis and correlated with cardiac biomarkers Open
GDF15 demonstrated promising diagnostic potential in cancer identification; higher GDF15, combined with elevated cardiac markers, may play a role in the monitoring and prediction of CTRCD risk.
View article: Severe Hypothermia Induces Ferroptosis in Cerebral Cortical Nerve Cells
Severe Hypothermia Induces Ferroptosis in Cerebral Cortical Nerve Cells Open
Abnormal shifts in global climate, leading to extreme weather, significantly threaten the safety of individuals involved in outdoor activities. Hypothermia-induced coma or death frequently occurs in clinical and forensic settings. Despite …
View article: Diagnostic efficacy of GDF-15 in assessing myocardial dysfunction among pan-cancer patients
Diagnostic efficacy of GDF-15 in assessing myocardial dysfunction among pan-cancer patients Open
Background Cardiotoxicity represents a significant adverse consequence of cancer therapies, yet there remains a paucity of effective biomarkers for its timely monitoring and diagnosis. This study aims to elucidate the role of Growth Differ…
View article: Machine learning and nomogram novel prognostic models based on LODDS for elderly breast cancer
Machine learning and nomogram novel prognostic models based on LODDS for elderly breast cancer Open
Purpose Breast cancer (BC) is a common malignant tumor in women worldwide. This study is based on three machine learning (RF, XgBoost and GBM) and nomogram to explore the survival prognosis of positive lymph node logarithmic ratio (LODDS),…
View article: [Effect of intestinal nitrate on growth of <i>Klebsiella pneumoniae</i> and its regulatory mechanism].
[Effect of intestinal nitrate on growth of <i>Klebsiella pneumoniae</i> and its regulatory mechanism]. Open
The binary regulatory system NarXL of K. pneumoniae can sense changes in intestinal nitrate concentration and directly regulate the expression of nitrate reductase genes narG and narZ to promote bacterial growth.
View article: Phosphorylated CPI-17 and MLC2 as Biomarkers of Coronary Artery Spasm–Induced Sudden Cardiac Death
Phosphorylated CPI-17 and MLC2 as Biomarkers of Coronary Artery Spasm–Induced Sudden Cardiac Death Open
Coronary artery spasm (CAS) plays an important role in the pathogeneses of various ischemic heart diseases and has gradually become a common cause of life-threatening arrhythmia. The specific molecular mechanism of CAS has not been fully e…
View article: Identification of TAT, PIC, tPAIC, and TM complex as biomarkers for prognosis and early evaluation of non-severe pneumonia and severe pneumonia diagnosis
Identification of TAT, PIC, tPAIC, and TM complex as biomarkers for prognosis and early evaluation of non-severe pneumonia and severe pneumonia diagnosis Open
Background Pneumonia is a major health problem and the most important causes of mortality in all age groups worldwide. We investigated new automation technology to detect plasma biomarkers, including thrombinantithrombin complex (TAT), α2-…
View article: Discovery of protein biomarkers for venous thromboembolism in non-small cell lung cancer patients through data-independent acquisition mass spectrometry
Discovery of protein biomarkers for venous thromboembolism in non-small cell lung cancer patients through data-independent acquisition mass spectrometry Open
Objective Non-small cell lung cancer (NSCLC) patients present a high incidence of venous thromboembolism (VTE) with poor prognosis. It is crucial to identify and diagnose VTE early. The study aimed to identify potential protein biomarkers …
View article: Correlation of Mean Heart Dose and Cardiac Biomarkers with Electrocardiographic Changes in Patients Receiving Thoracic Radiation Therapy
Correlation of Mean Heart Dose and Cardiac Biomarkers with Electrocardiographic Changes in Patients Receiving Thoracic Radiation Therapy Open
Cardiotoxicity is a well-recognized, serious adverse effect of thoracic radiation therapy. This study aimed to evaluate longitudinal electrocardiogram (ECG) changes in patients receiving thoracic radiation therapy and identify correlating …
View article: RETRACTED: How does a good environment affect firms’ productivity? evidence from urban public green spaces in China
RETRACTED: How does a good environment affect firms’ productivity? evidence from urban public green spaces in China Open
The environment is one of the most fundamental factors that affects human economic activities. This article investigates whether good environment affects firms’ productivity. Using the urban public green spaces as the proxy of good environ…
View article: Study on the leakage dispersion law of exposed high-pressure natural gas pipelines in the mountainous environment
Study on the leakage dispersion law of exposed high-pressure natural gas pipelines in the mountainous environment Open
The pipelines in mountainous areas have complex terrain conditions and pass through many densely populated areas. Once a pipeline leakage accident occurs, it will cause serious damage to the surrounding people and the environment. In this …
View article: Application of Computer Virtual Reality Technology in College Physical Education Training
Application of Computer Virtual Reality Technology in College Physical Education Training Open
With the continuous advancement of science and technology, computers have found increasingly diverse applications. One noteworthy application is the integration of "virtual reality" technology into college physical education. This incorpor…