Ruohan Xia
YOU?
Author Swipe
View article: Interactions Between Non-Coding RNAs and HIF-1alpha in the Context of Colorectal Cancer
Interactions Between Non-Coding RNAs and HIF-1alpha in the Context of Colorectal Cancer Open
Hypoxia-inducible factor-1α (HIF-1α), a master regulator of cellular adaptation to hypoxia, drives colorectal cancer (CRC) progression by fueling angiogenesis, metastasis, and therapy resistance. Emerging evidence delineates intricate cros…
View article: Lactate and Lactylation: Dual Regulators of T-Cell-Mediated Tumor Immunity and Immunotherapy
Lactate and Lactylation: Dual Regulators of T-Cell-Mediated Tumor Immunity and Immunotherapy Open
Lactate and its derivative, lactylation, play pivotal roles in modulating immune responses within the tumor microenvironment (TME), particularly in T-cell-mediated cancer immunotherapy. Elevated lactate levels, a hallmark of the Warburg ef…
View article: Ferroptosis: a promising target for fumarate hydratase-deficient tumor therapeutics literature review
Ferroptosis: a promising target for fumarate hydratase-deficient tumor therapeutics literature review Open
This article reviews the anti-tumor effects and mechanisms of FH and ferroptosis, in order to further explore the medical value of ferroptosis in FH-related tumor therapy.
View article: Inhibition of SPARC signal by aerobic exercise to ameliorate atherosclerosis
Inhibition of SPARC signal by aerobic exercise to ameliorate atherosclerosis Open
This study suggested that aerobic exercise ameliorated hyperlipidemia and AS by effectively inhibiting SPARC signal, and vascular smooth muscle cells may contribute greatly to the protection of AS.
View article: Enhanced Mechanical and Hydrophobic Antireflective Nanocoatings Fabricated on Polycarbonate Substrates by Combined Treatment of Water and HMDS Vapor
Enhanced Mechanical and Hydrophobic Antireflective Nanocoatings Fabricated on Polycarbonate Substrates by Combined Treatment of Water and HMDS Vapor Open
Polycarbonate (PC) with high transmittance, stable mechanical performance and environmental resistance is crucial for practical applications. In this work, we report a method for the preparation of a robust antireflective (AR) coating by a…
View article: HD-SiO2/SiO2 Sol@PDMS Superhydrophobic Coating with Good Durability and Anti-Corrosion for Protection of Al Sheets
HD-SiO2/SiO2 Sol@PDMS Superhydrophobic Coating with Good Durability and Anti-Corrosion for Protection of Al Sheets Open
Superhydrophobic coatings with excellent water-repellent properties imply a wide range of application areas. However, improvements are needed in terms of stability and complex processing procedures. In the present study, a superhydrophobic…
View article: Highly Transparent and Zirconia-Enhanced Sol-Gel Hybrid Coating on Polycarbonate Substrates for Self-Cleaning Applications
Highly Transparent and Zirconia-Enhanced Sol-Gel Hybrid Coating on Polycarbonate Substrates for Self-Cleaning Applications Open
To improve the efficacy of polymer-based substrate hybrid coatings, it is essential to simultaneously optimize mechanical strength and preserve the optical properties. In this study, a mixture of zirconium oxide (ZrO2) sol and methyltrieth…
View article: High-intensity exercise is a risk factor for renal medullary carcinoma in individuals with sickle cell trait
High-intensity exercise is a risk factor for renal medullary carcinoma in individuals with sickle cell trait Open
Renal medullary carcinoma (RMC) predominantly occurs in individuals with sickle cell trait (SCT). We found that patients with RMC more frequently participated in high-intensity exercise than matched controls, and renal medullary hypoxia si…
View article: 9p21 Loss Defines the Evolutionary Patterns of Aggressive Renal Cell Carcinomas
9p21 Loss Defines the Evolutionary Patterns of Aggressive Renal Cell Carcinomas Open
Dedifferentiation and acquisition of chromosomal instability in renal cell carcinoma portends dismal prognosis and aggressive clinical behavior. However, the absence of reliable experimental models dramatically impacts the understanding of…
View article: Yap/Taz Deletion in Gli+ Cell-Derived Myofibroblasts Attenuates Fibrosis
Yap/Taz Deletion in Gli+ Cell-Derived Myofibroblasts Attenuates Fibrosis Open
In damaged kidneys, increased extracellular matrix (ECM) and tissue stiffness stimulate kidney fibrosis through incompletely characterized molecular mechanisms. The transcriptional coactivators yes-associated protein (Yap) and transcriptio…
View article: Serum Glucocorticoid–Regulated Kinase 1 Blocks CKD–Induced Muscle Wasting Via Inactivation of FoxO3a and Smad2/3
Serum Glucocorticoid–Regulated Kinase 1 Blocks CKD–Induced Muscle Wasting Via Inactivation of FoxO3a and Smad2/3 Open
Muscle proteolysis in CKD is stimulated when the ubiquitin-proteasome system is activated. Serum glucocorticoid–regulated kinase 1 (SGK-1) is involved in skeletal muscle homeostasis, but the role of this protein in CKD–induced muscle wasti…