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Clinical and Molecular Differences Suggest Different Responses to Immune Checkpoint Inhibitors in Microsatellite-Stable Solid Tumors with High Tumor Mutational Burden Open

Imran Nizamuddin, Tarık Demir, Katrina Dobinda, Ruohui Chen, Masha Kocherginsky , et al. · 2025

Background/Objectives: We aim to identify predictors of response to ICIs in patients with advanced solid tumors that exhibiting a TMB ≥ 10 mut/Mb. Methods: Patients treated with ICIs alone at Northwestern University between 1 January 2015 …

Impacts of Reducing Sitting Time or Increasing Sit-to-Stand Transitions on Blood Pressure and Glucose Regulation in Postmenopausal Women: Three-Arm Randomized Controlled Trial Open

Sheri J. Hartman, Andrea Z. LaCroix, Dorothy D. Sears, Loki Natarajan, Rong Zablocki , et al. · 2025

BACKGROUND: Public health and clinical guidelines identify the importance of sedentary behaviors for cardiovascular diseases, particularly among postmenopausal women. The goal of this trial was to compare the behavioral and physiological i…

Nivolumab in combination with R-CHOP for treatment-naïve diffuse large B-cell lymphoma: an evaluation of safety and efficacy Open

Oluwatobi Odetola, Shuo Ma, Jane N. Winter, Barbara Pro, Ishan Roy , et al. · 2025

Approximately 20% of diffuse large B-cell lymphoma have aberrations involving the programmed death ligands 1 and 2 (PD-L1/PD-L2) locus. This justifies the investigation of PD-1 checkpoint inhibitors in the frontline therapy setting in a bi…

Semiparametric Regression Models for Explanatory Variables with Missing Data due to Detection Limit Open

Jasen Zhang, L. G. Shao, Kun Yang, Natalie E. Quach, Shengjia Tu , et al. · 2025

Detection limit (DL) has become an increasingly ubiquitous issue in statistical analyses of biomedical studies, such as cytokine, metabolite and protein analysis. In regression analysis, if an explanatory variable is left-censored due to c…

Table S2 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open

Xiangzhu Zhu, Ruohui Chen, Reid M. Ness, Rishi D. Naik, Harvey J. Murff , et al. · 2025

Table S2: Representativeness of Study Participants

Figure S1 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open

Xiangzhu Zhu, Ruohui Chen, Reid M. Ness, Rishi D. Naik, Harvey J. Murff , et al. · 2025

Figure S1: Participants' study medication adherence

Table S5 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open

Xiangzhu Zhu, Ruohui Chen, Reid M. Ness, Rishi D. Naik, Harvey J. Murff , et al. · 2025

Table S5: Baseline participant characteristics (Evaluable participants vs non-evaluable participants)

Table S6 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open

Xiangzhu Zhu, Ruohui Chen, Reid M. Ness, Rishi D. Naik, Harvey J. Murff , et al. · 2025

Table S6: Adverse events by treatment arms

Table S3 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open

Xiangzhu Zhu, Ruohui Chen, Reid M. Ness, Rishi D. Naik, Harvey J. Murff , et al. · 2025

Table S3: Baseline participant characteristics (All participants)

Table S7 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open

Xiangzhu Zhu, Ruohui Chen, Reid M. Ness, Rishi D. Naik, Harvey J. Murff , et al. · 2025

Table S7: Comparisons of pre- to post-treatment changes in methylation biomarkers CpG for continuous aspirin vs. intermittent aspirin arm

Data from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open

Xiangzhu Zhu, Ruohui Chen, Reid M. Ness, Rishi D. Naik, Harvey J. Murff , et al. · 2025

Aspirin reduces colorectal cancer risk but has a potential for adverse effects. Recent preclinical data suggest that intermittent dosing of aspirin may minimize adverse effects while maintaining efficacy. We conducted a three-arm double-bl…

Table S4 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open

Xiangzhu Zhu, Ruohui Chen, Reid M. Ness, Rishi D. Naik, Harvey J. Murff , et al. · 2025

Table S4: Baseline participant characteristics (Evaluable participants only)

Table S1 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open

Xiangzhu Zhu, Ruohui Chen, Reid M. Ness, Rishi D. Naik, Harvey J. Murff , et al. · 2025

Table S1: Strain information for microbiome analysis

Table S8 from Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Open

Xiangzhu Zhu, Ruohui Chen, Reid M. Ness, Rishi D. Naik, Harvey J. Murff , et al. · 2025

Table S8 Comparisons of pre- (Week 0) to post-treatment (Week 9) changes in endpoint biomarkers for continuous aspirin vs. intermittent aspirin arm

Predicting risk in Hodgkin lymphoma for research and clinical practice Open

Ruohui Chen, Leo I. Gordon · 2025

Optical performances of near-infrared metalenses with process-induced defects Open

Xiao-Fei Liu, Ruohui Chen, Yilin Lu, Chenxu Zhu, Yang Qiu , et al. · 2025

Reprogramming SREBP1-dependent lipogenesis and inflammation in high-risk breast with licochalcone A: a novel path to cancer prevention Open

Atieh Hajirahimkhan, Elizabeth T. Bartom, Carolina H. Chung, Xingyu Guo, Kyli Berkley , et al. · 2024

Background Anti-estrogens have had limited impact on breast cancer (BC) prevention. Novel agents with better tolerability, and efficacy beyond estrogen receptor (ER) positive BC are needed. We studied licochalcone A (LicA) for ER-agnostic …

A doubly robust estimator for the Mann Whitney Wilcoxon Rank Sum Test when applied for causal inference in observational studies Open

Ruohui Chen, Tuo Lin, Lin Liu, Jinyuan Liu, Ruifeng Chen , et al. · 2024

The Mann-Whitney-Wilcoxon rank sum test (MWWRST) is a widely used method for comparing two treatment groups in randomized control trials, particularly when dealing with highly skewed data. However, when applied to observational study data,…

A linear mixed model approach for measurement error adjustment: applications to sedentary behavior assessment from wearable devices Open

Ruohui Chen, Dori E. Rosenberg, Chongzhi Di, Rong Zablocki, Sheri J. Hartman , et al. · 2024

In recent years, wearable devices have become more common to capture a wide range of health behaviors, especially for physical activity and sedentary behavior. These sensor-based measures are deemed to be objective and thus less prone to s…

A phase 1-2 trial of DA-EPOCH-R plus ixazomib for MYC-aberrant lymphoid malignancies: the DACIPHOR regimen Open

Reem Karmali, Carlos Galvez, Mehdi Hamadani, Leo I. Gordon, Jane N. Winter , et al. · 2024

MYC-aberrant non-Hodgkin lymphoma (NHL) is associated with poor outcomes with conventional chemotherapy. Ixazomib is an orally bioavailable proteasome inhibitor that targets drivers of MYC expression and has demonstrated preclinical activi…

A new paradigm for high‐dimensional data: Distance‐based semiparametric feature aggregation framework via between‐subject attributes Open

Jinyuan Liu, Xinlian Zhang, Tuo Lin, Ruohui Chen, Zhong Yuan , et al. · 2023

This article proposes a distance‐based framework incentivized by the paradigm shift toward feature aggregation for high‐dimensional data, which does not rely on the sparse‐feature assumption or the permutation‐based inference. Focusing on …

4 Misinterpreting cognitive change over multiple timepoints: When practice effects meet age-related decline Open

Mark Sanderson‐Cimino, Ruohui Chen, Xin Tu, Jeremy A. Elman, Amy J. Jak , et al. · 2023

Objective: Practice effects (PE) on cognitive testing impede our ability to accurately assess change. In particular, they hamper the detection of mild cognitive impairment (MCI) and progression to dementia by delaying the point at which te…

Selective dysfunction of the crural diaphragm in patients with chronic restrictive and obstructive lung disease Open

Jisha Joshua, Chetna Pathak, Ali Zifan, Ruohui Chen, Atul Malhotra , et al. · 2023

Background Gastroesophageal reflux (GER) is known to be associated with chronic lung diseases. The driving force of GER is the transdiaphragmatic pressure (Pdi) generated mainly by costal and crural diaphragm contraction. The latter also e…

Misinterpreting cognitive change over multiple timepoints: When practice effects meet age-related decline. Open

Mark Sanderson‐Cimino, Ruohui Chen, Xin Tu, Jeremy A. Elman, Amy J. Jak , et al. · 2023

A replacement method of PE adjustment revealed significant PEs across two follow-ups. As expected in these older adults, accounting for PEs revealed cognitive decline. This, in turn, means earlier detection of cognitive deficits, including…

Comparison of the APAS Independence Automated Plate Reader System with the Manual Standard of Care for Processing Urine Culture Specimens Open

Megan Chiu, Peiting Kuo, Khrissa Lecrone, Andrew Garcia, Ruohui Chen , et al. · 2022

Urine cultures are among the highest-volume tests performed in clinical microbiology facilities and require considerable manual labor to perform. We compared the results of our manual SOC workflow with that of the APAS Independence system,…

Post-hoc power analysis: a conceptually valid approach for power based on observed study data Open

Natalie E. Quach, Kun Yang, Ruohui Chen, Justin Tu, Manfei Xu , et al. · 2022

Power analysis is a key component of planning prospective studies such as clinical trials. However, some journals in biomedical and psychosocial sciences request power analysis for data already collected and analysed before accepting manus…

Fitbit Use and Activity Levels From Intervention to 2 Years After: Secondary Analysis of a Randomized Controlled Trial Open

Sheri J. Hartman, Ruohui Chen, Rowena M. Tam, Hari K. Narayan, Loki Natarajan , et al. · 2022

Background There has been a rapid increase in the use of commercially available activity trackers, such as Fitbit, in physical activity intervention research. However, little is known about the long-term sustained use of trackers and behav…

Fitbit Use and Activity Levels From Intervention to 2 Years After: Secondary Analysis of a Randomized Controlled Trial (Preprint) Open

Sheri J. Hartman, Ruohui Chen, Rowena M. Tam, Hari K. Narayan, Loki Natarajan , et al. · 2022

BACKGROUND There has been a rapid increase in the use of commercially available activity trackers, such as Fitbit, in physical activity intervention research. However, little is known about the long-term sustained use of trackers and beha…

What is the impact of restricted access policy on workplace violence in general hospital? A before-after study in a CHINESE tertiary hospital Open

Haonan Jia, Ruohui Chen, Lifeng Wei, Gangyu Zhang, Mingli Jiao , et al. · 2020

Workplace violence against healthcare professionals in a multiethnic area: a cross-sectional study in southwest China Open

Haonan Jia, Huiying Fang, Ruohui Chen, Mingli Jiao, Lifeng Wei , et al. · 2020

Objective The purpose of this study is to examine workplace violence (WPV) towards healthcare professionals in a multiethnic area in China, including prevalence, influencing factors, healthcare professionals’ response to WPV, expected anti…

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