Ruo‐Lan Du
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View article: Hollow Conductive Polymer Nanospheres with Metal–Polyphenol Interfaces for Tunable Hydrogen Peroxide Activation and Energy Conversion
Hollow Conductive Polymer Nanospheres with Metal–Polyphenol Interfaces for Tunable Hydrogen Peroxide Activation and Energy Conversion Open
Hydrogen peroxide (H2O2) is a key oxidant for green chemical processes, yet its catalytic utilization and activation efficiency remain limited by material instability and uncontrolled radical release. Here, we report a dual-functional, hol…
View article: Joint similarity nonnegative matrix factorization model for identification of recurrence-related association patterns in tumor
Joint similarity nonnegative matrix factorization model for identification of recurrence-related association patterns in tumor Open
The high recurrence rate of tumor limits the growth of precision medicine, whereas the exploration of correlations in multimodal data enables mining of features linked to tumor recurrence, ultimately identifying prospective biomarkers. Nev…
View article: Development of Broad-Spectrum Antimicrobial Peptides through the Conjugation of FtsZ-Binding and Cell-Penetrating Peptides
Development of Broad-Spectrum Antimicrobial Peptides through the Conjugation of FtsZ-Binding and Cell-Penetrating Peptides Open
The rapid increase in bacterial resistance to conventional antibiotics has led to a great demand for novel antibacterial agents. Antimicrobial peptides (AMPs) are emerging as next-generation antimicrobial alternative drugs to conventional …
View article: Bone marrow mesenchymal stem cells alleviate neurological dysfunction by reducing autophagy damage via downregulation of SYNPO2 in neonatal hypoxic–ischemic encephalopathy rats
Bone marrow mesenchymal stem cells alleviate neurological dysfunction by reducing autophagy damage via downregulation of SYNPO2 in neonatal hypoxic–ischemic encephalopathy rats Open
Neonatal hypoxic-ischemic encephalopathy (HIE) is worsened by autophagy-induced neuronal damage, with SYNPO2 playing a key role in this process. This study investigates the involvement of SYNPO2 in neuronal autophagy and explores the poten…
View article: Discovery of a novel class of rosmarinic acid derivatives as antibacterial agents: Synthesis, structure-activity relationship and mechanism of action
Discovery of a novel class of rosmarinic acid derivatives as antibacterial agents: Synthesis, structure-activity relationship and mechanism of action Open
Twenty-seven rosmarinic acid derivatives were synthesized, among which compound RA-N8 exhibited the most potent antibacterial ability. The minimum inhibition concentration of RA-N8 against both S. aureus (ATCC 29213) and MRSA (ATCC BAA41 a…
View article: Bibliometric analysis of hot literature on neural circuit research
Bibliometric analysis of hot literature on neural circuit research Open
Numerous brain diseases have been attributed to abnormalities in the connections of neural circuits. Exploration of neural circuits may give enlightenment in treating some intractable brain diseases. Here, we screened all publications on n…
View article: Gossypol acetate: A natural polyphenol derivative with antimicrobial activities against the essential cell division protein FtsZ
Gossypol acetate: A natural polyphenol derivative with antimicrobial activities against the essential cell division protein FtsZ Open
Antimicrobial resistance has attracted worldwide attention and remains an urgent issue to resolve. Discovery of novel compounds is regarded as one way to circumvent the development of resistance and increase the available treatment options…
View article: Unexpected High Species Diversity of Mesolycus Gorham (Coleoptera, Lycidae) from China, with a Preliminary Investigation on Its Phylogenetic Position Based on Multiple Genes
Unexpected High Species Diversity of Mesolycus Gorham (Coleoptera, Lycidae) from China, with a Preliminary Investigation on Its Phylogenetic Position Based on Multiple Genes Open
The lycid genus Mesolycus Gorham, 1883 is mainly distributed in East Palaearctic and Indochinese regions, but poorly studied in China; moreover, its phylogenetic placement remains controversial but has never been rigorously tested. In this…
View article: The differentially expressed proteins related to clinical viral encephalitis revealed by proteomics
The differentially expressed proteins related to clinical viral encephalitis revealed by proteomics Open
To screen out the prospective biomarkers of viral encephalitis (VE), analyze the biological process and signaling pathways involved by differentially expressed proteins (DEPs). A total of 11 cerebrospinal fluid (CSF) samples with VE and 5 …
View article: Corrigendum: MicroRNA339 Targeting PDXK Improves Motor Dysfunction and Promotes Neurite Growth in the Remote Cortex Subjected to Spinal Cord Transection
Corrigendum: MicroRNA339 Targeting PDXK Improves Motor Dysfunction and Promotes Neurite Growth in the Remote Cortex Subjected to Spinal Cord Transection Open
[This corrects the article DOI: 10.3389/fcell.2020.00577.].
View article: Differences between cultured cortical neurons by trypsin and papain digestion
Differences between cultured cortical neurons by trypsin and papain digestion Open
The objective of this study was to compare the efficiency of trypsin and papain in neuronal digestion and determine which enzyme is more efficient. Cortical tissues were obtained from Sprague–Dawley (SD) rats. According to the different di…
View article: Discovery of FtsZ inhibitors by virtual screening as antibacterial agents and study of the inhibition mechanism
Discovery of FtsZ inhibitors by virtual screening as antibacterial agents and study of the inhibition mechanism Open
S2727 (Dacomitinib) was virtually screened out from a compound library via targeting the PC 190723 binding site of FtsZ and its inhibition effect on the functions of FtsZ was demonstrated by biological assays.
View article: Proteomics Study on the Cerebrospinal Fluid of Patients with Encephalitis
Proteomics Study on the Cerebrospinal Fluid of Patients with Encephalitis Open
These findings demonstrated that NLGN2 and LRRC4B proteins were upregulated in the NED group and could be potential biomarkers for the diagnosis of encephalitis, but still needs a lot of multiomics studies to be used in clinical.
View article: Anticolorectal Cancer Effects of AUCAN: Effects to Suppress Proliferation, Metastasis, and Invasion of Tumor Cells
Anticolorectal Cancer Effects of AUCAN: Effects to Suppress Proliferation, Metastasis, and Invasion of Tumor Cells Open
Background . Colorectal cancer (CRC) is an underlying deadly malignancy with poor prognosis, lacking effective therapies currently available to improve the prognosis. C 18 H 17 NO 6 (AUCAN), a kind of dibenzofuran extracted from a special …
View article: A single-nucleotide polymorphism induced alternative splicing in Tacr3 involves in hypoxic-ischemic brain damage
A single-nucleotide polymorphism induced alternative splicing in Tacr3 involves in hypoxic-ischemic brain damage Open
Single-nucleotide polymorphism (SNP) and Alternative splicing (AS) were found to be implicated in certain diseases, nevertheless, the contributions of mRNA SNPs and AS to pathogenesis in developing rat brains with hypoxic-ischemic encephal…
View article: C<sub>18</sub>H<sub>17</sub>NO<sub>6</sub>and Its Combination with Scutellarin Suppress the Proliferation and Induce the Apoptosis of Human Glioma Cells via Upregulation of Fas-Associated Factor 1 Expression
C<sub>18</sub>H<sub>17</sub>NO<sub>6</sub>and Its Combination with Scutellarin Suppress the Proliferation and Induce the Apoptosis of Human Glioma Cells via Upregulation of Fas-Associated Factor 1 Expression Open
Background . Glioma is the most common malignant brain tumor and the patients are prone to poor prognosis. Due to limited treatments, new drug exploration has become a general trend. Therefore, the objective of this study is to investigate…
View article: eIF5A regulating survivin to improve neural remodeling in rats with traumatic brain injury
eIF5A regulating survivin to improve neural remodeling in rats with traumatic brain injury Open
Objective Traumatic brain injury (TBI) induces severe brain damage which results in motor dysfunction and the therapy is poorly satisfactory. This study was designed to detect the role of eIF5A in rats with TBI, and investigate the underly…
View article: Tuning the Morphology and Chiroptical Properties of Discrete Gold Nanorods with Amino Acids
Tuning the Morphology and Chiroptical Properties of Discrete Gold Nanorods with Amino Acids Open
The synthesis of discrete nanostructures with a strong, persistent, stable plasmonic circular dichroism (PCD) signal is challenging. We report a seed‐mediated growth approach to obtain discrete Au nanorods with high and stable chiroptical …
View article: Study of Benzofuroquinolinium Derivatives as a New Class of Potent Antibacterial Agent and the Mode of Inhibition Targeting FtsZ
Study of Benzofuroquinolinium Derivatives as a New Class of Potent Antibacterial Agent and the Mode of Inhibition Targeting FtsZ Open
New generation of antibacterial agents are urgently needed in order to fight the emergence of multidrug-resistant bacteria. FtsZ is currently identified as a promising target for new types of antimicrobial compounds development because of …